Dr Rachel Hargest

2022

• Zeng, J., Sanders, A. J., Lin, Y., Hargest, R., Ruge, F. and Jiang, W. G. 2022. EPLIN, a putative tumour suppressor in colorectal cancer, implications in drug resistance. International Journal of Molecular Sciences 23(23), article number: 15232. (10.3390/ijms232315232)
• Sui, L. et al. 2022. Death associated protein-3 (DAP3) and DAP3 binding cell death enhancer-1 (DELE1) in human colorectal cancer, and their impacts on clinical outcome and chemoresistance. International Journal of Oncology 62(1), article number: 7. (10.3892/ijo.2022.5455)
• Sui, L., Zeng, J., Ye, L., Martin, T., Jiang, W. and Hargest, R. 2022. P-282 Impact of death-associated protein-3 (DAP3) and DAP3 binding cell death enhancer 1 (DELE1) on drug sensitivity in colorectal cancer cells. Annals of Oncology 33, pp. S347. (10.1016/j.annonc.2022.04.371)
• Soliman, F., Ye, L., Jiang, W. and Hargest, R. 2022. Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer. Clinical Colorectal Cancer 21(2), pp. e126-e134. (10.1016/j.clcc.2021.11.008)

2021

• Martin, T. A., Li, A. X., Sanders, A. J., Ye, L., Frewer, K., Hargest, R. and Jiang, W. G. 2021. NUPR1 and its potential role in cancer and pathological conditions (Review). International Journal of Oncology 58(5), article number: 21. (10.3892/ijo.2021.5201)
• Sui, L., Ye, L., Sanders, A. J., Yang, Y., Hao, C., Hargest, R. and Jiang, W. G. 2021. Expression of death associated proteins DAP1 and DAP3 in human pancreatic cancer. Anticancer Research 41(5), pp. 2357-2362. (10.21873/anticanres.15010)
• Liu, C., Jiang, W., Zhang, L., Hargest, R. and Martin, T. A. 2021. SIPA1 Is a modulator of HGF/MET induced tumour metastasis via the regulation of tight junction-based cell to cell barrier function. Cancers 13(7), article number: 1747. (10.3390/cancers13071747)
• Hargest, R. 2021. Five thousand years of minimal access surgery: 1850 to 1990: Technological developments. Journal of the Royal Society of Medicine 114(1), pp. 19-29. (10.1177/0141076820967918)

2020

• Gong, W., Martin, T. A., Sanders, A. J., Hargest, R., Jiang, A., Sun, P. and Jiang, W. G. 2020. Influence of anaesthetics on the production of cancer cell motogens, stromal cell-derived factor-1 and hepatocyte growth factor by fibroblasts. Oncology Letters 21(2), article number: 140. (10.3892/ol.2020.12401)
• Liu, C., Jiang, W., Hargest, R. and Martin, T. 2020. The role of SIPA1 in the development of cancer and metastases (Review). Molecular and Clinical Oncology 13(4), article number: 32. (10.3892/mco.2020.2102)
• Badder, L. M. et al. 2020. 3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors. PLoS ONE 15(8), article number: e0235319. (10.1371/journal.pone.0235319)
• Scurr, M. J. et al. 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research (10.1158/1078-0432.CCR-19-3087)

2019

• Besneux, M. et al. 2019. The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design. Cancer Immunology, Immunotherapy 68, pp. 247-256. (10.1007/s00262-018-2266-1)

2018

• Soliman, F. and Hargest, R. 2018. Intestinal failure in gastrointestinal fistula patients. Surgery (Oxford) 36(5), pp. 245-251. (10.1016/j.mpsur.2018.03.001)
• Sahnan, K. et al. 2018. Developing a core outcome set for fistulising perianal Crohn's disease. Gut (10.1136/gutjnl-2017-315503)
• Hargest, R. 2018. Randomized controlled trial of standard closure of a stoma site vs biological mesh reinforcement: study protocol of the ROCSS trial. Colorectal Disease 20(2), pp. O46-O54. (10.1111/codi.13997)

2017

• Osman, B., Roushias, S., Hargest, R. and Narahari, K. 2017. Migration of ventriculoperitoneal shunt to urethral and rectal orifices. BMJ Case Reports 2017, article number: 220187. (10.1136/bcr-2017-220187)
• Zabkiewicz, C., Resaul, J., Hargest, R., Jiang, W. G. and Ye, L. 2017. Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance. Endocrine-Related Cancer 24(10), pp. R349-R366. (10.1530/ERC-17-0139)
• Zabkiewicz, C., Resaul, J., Hargest, R., Jiang, W. G. and Ye, L. 2017. Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival. Cancer Genomics and Proteomics 14(4), pp. 241-251. (10.21873/cgp.20035)
• Lee, M., Heywood, N., Sagar, P. M., Brown, S. R., Fearnhead, N. and Hargest, R. 2017. Association of Coloproctology of Great Britain and Ireland consensus exercise on surgical management of fistulating perianal Crohn's disease. Colorectal Disease 19(5), pp. 418-429. (10.1111/codi.13672)
• Gu, Y. et al. 2017. NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway. Oncotarget 8(5), pp. 7753-7765. (10.18632/oncotarget.13949)

2016

• Hargest, R. 2016. Feasibility study from a randomized controlled trial of standard closure of a stoma sitevsbiological mesh reinforcement. Colorectal Disease 18(9), pp. 889-896. (10.1111/codi.13310)
• Cornish, J. et al. 2016. Hughes Abdominal Repair Trial (HART) - Abdominal wall closure techniques to reduce the incidence of incisional hernias: study protocol for a randomised controlled trial. Trials 17(1), pp. 454. (10.1186/s13063-016-1573-0)
• Teagle, A. R., Birchall, J. C. and Hargest, R. 2016. Gene therapy for pyoderma gangrenosum: optimal transfection conditions and effect of drugs on gene delivery in the HaCaT cell line using cationic liposomes. Skin Pharmacology and Physiology 29, pp. 119-129. (10.1159/000444859)
• Satherley, L., Sun, P. H., Ke, J., Mason, M. D., Hargest, R., Jiang, W. G. and Ye, L. 2016. Prostate Apoptosis Response-4 (PAR4) suppresses growth and invasion of breast cancer cells and is positively associated with patient survival. Anticancer Research 36(3), pp. 1227-1236.
• Greensmith, M., Cho, J. and Hargest, R. 2016. Changes in surgical training opportunities in Britain and South Africa. International Journal of Surgery 25, pp. 76-81. (10.1016/j.ijsu.2015.11.052)

2015

• Collins, R. J., Jiang, W. G., Hargest, R., Mason, M. D. and Sanders, A. J. 2015. EPLIN: a fundamental actin regulator in cancer metastasis?. Cancer and Metastasis Reviews 34(4), pp. 753-764. (10.1007/s10555-015-9595-8)
• Soliman, F., Sturgeon, G. and Hargest, R. 2015. Revisiting an ancient treatment for transphincteric fistula-in-ano 'There is nothing new under the sun' Ecclesiastes 1v9. Journal of the Royal Society of Medicine 108(12), pp. 482-489. (10.1177/0141076815588322)
• Li, J., Ye, L., Sun, P., Satherley, L., Hargest, R., Zhang, Z. and Jiang, W. G. 2015. MTA1 is up-regulated in colorectal cancer and is inversely correlated with lymphatic metastasis. Cancer Genomics and Proteomics 12(6), pp. 339-346.
• Satherley, L., Ye, L., Hargest, R. and Jiang, W. G. 2015. Downstream of tyrosine kinase 7 (DOK7) variant expression and function in human colorectal cancer [Abstract]. European Journal of Cancer 51(S3), pp. S27. (10.1016/S0959-8049(15)30004-6)
• Ji, J., Jia, S., Jia, Y., Ji, K., Hargest, R. and Jiang, W. G. 2015. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. British Journal of Cancer 113(6), pp. 921-933. (10.1038/bjc.2015.285)
• Ji, K., Cui, Y., Hargest, R. and Jiang, W. G. 2015. VILIP-1 plays a suppressive role in the motility of colorectal cancer cells and the inhibition involves the regulation of mmps via jnk signalling pathway. Anticancer Research 35(7), pp. 4332-4333.
• Satherley, L., Jiang, W. G., Hargest, R., Torkington, J. and Davies, M. 2015. Expression of lymphangiogenic factors Vegf-C and Vegf-D and impact of Vegf-D knockout on tubule formation in human colorectal cancer [Abstract]. British Journal of Surgery 102(s1), pp. 8-8., article number: 700. (10.1002/bjs.9735)

2014

• Teagle, A. and Hargest, R. 2014. Management of pyoderma gangrenosum. Journal of the Royal Society of Medicine 107(6), pp. 228-236. (10.1177/0141076814534407)
• Satherley, L., Ye, L., Hargest, R. and Jiang, W. G. 2014. DOK7 expression in colorectal cancer cells and association with clinical and prognostic outcome [Abstract]. British Journal of Surgery 101(S4), pp. 12., article number: O34. (10.1002/bjs.9508)
• Jia, Y., Ye, L., Ji, K., Zhang, L., Hargest, R., Ji, J. and Jiang, W. G. 2014. Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy. British Journal of Cancer 110(2), pp. 421-429. (10.1038/bjc.2013.712)
• Power, K., Davies, M. M., Hargest, R., Phillips, S., Torkington, J. and Morris, C. 2014. A case-control study of risk factors for wound infection in a colorectal unit. Annals of the Royal College of Surgeons of England 96(1), pp. 37-40. (10.1308/003588414X13824511650137)
• Jia, Y. et al. 2014. Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death. Oncology Reports 31(1), pp. 175-182. (10.3892/or.2013.2866)
• Ji, K., Ye, L., Ruge, F., Hargest, R., Mason, M. D. and Jiang, W. G. 2014. Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. BMC Cancer 14, article number: 723. (10.1186/1471-2407-14-723)

2013

• Scurr, M. et al. 2013. Escalating regulation of 5T4-specific IFN- + CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy. Cancer Immunology Research 1(6), article number: 416. (10.1158/2326-6066.CIR-13-0035)
• Scurr, M. J. et al. 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a (10.1038/mi.2013.62)
• Frewer, N. et al. 2013. Potential implication of IL-24 in lymphangiogenesis of human breast cancer. International Journal of Molecular Medicine 31(5), pp. 1097-1104. (10.3892/ijmm.2013.1319)
• Chong, R. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211-219. (10.1016/j.jconrel.2012.12.030)
• Frewer, K., Sanders, A. J., Owen, S., Frewer, N., Hargest, R. and Jiang, W. G. 2013. A role for WISP2 in colorectal cancer cell invasion and motility. Cancer Genomics and Proteomics 10(4), pp. 187-196.
• Chong, R. H. et al. 2013. Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept. Journal of Controlled Release 166(3), pp. 211. (10.1016/j.jconrel.2012.12.030)

2012

• Blake, P., Delicata, R., Cross, N., Sturgeon, G. and Hargest, R. 2012. Large bowel obstruction due to colorectal carcinoma can be safely treated by colonic stent insertion - case series from a UK district general hospital. Colorectal Disease 14(12), pp. 1489-1492. (10.1111/j.1463-1318.2012.03035.x)
• Ji, K. et al. 2012. Expression of signal-induced proliferation-associated gene 1 (SIPA1), a rapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells. Cancer Genomics and Proteomics 9(5), pp. 321-327.

2011

• Chong, R., Coulman, S., Saller, V., Pearton, M., Shah, A., Hargest, R. and Birchall, J. C. 2011. Nucleic acid delivery to skin for the potential treatment of dermatopathogenic conditions [Abstract]. Human Gene Therapy 22(10), pp. A82-A82.
• Teagle, A., Birchall, J. C. and Hargest, R. 2011. The effect of drugs commonly used for pyoderma gangrenosum on the efficiency of gene transfer to human keratinocytes. Human Gene Therapy 22(10), pp. A94-A94.
• Teagle, A., Birchall, J. C. and Hargest, R. 2011. The effect of drugs commonly used for pyoderma gangrenosum on the efficiency of gene transfer to human keratinocytes [Abstract]. British Journal of Surgery 98, pp. 40-40. (10.1002/bjs.7577/abstract)

2010

• Hardwicke, J., Wright, T. C., Hargest, R. and Dickson, W. 2010. The use of the Flexi-Seal®Faecal Management System in laparostomy wounds involving enterocutaneous fistula. Annals of the Royal College of Surgeons of England 92(4), pp. e12-e14. (10.1308/147870810X12659688851834)
• Zimbwa, T. A., Owen, R., Thomas, G., Hargest, R. and Williams, G. T. 2010. An unusual complication of colitis. Gut 59(3), pp. 364-364. (10.1136/gut.2009.179689)

2009

• Stephens, M. and Hargest, R. 2009. The post-CCT subconsultant grade: the case against / the case for. Bulletin of The Royal College of Surgeons of England 91(4), pp. 124-126. (10.1308/147363509X423788)

2008

• Ganapathi, S., Evans, G. and Hargest, R. 2008. Bilateral breast metastases of a renal carcinoma: a case report and review of the literature. BMJ Case Reports 2008(Nov 12), article number: bcr0620080239. (10.1136/bcr.06.2008.0239)