Yr Athro Keith Harding

Clinical Professor

Yr Ysgol Meddygaeth

: hardingkg@cardiff.ac.uk
: +44 29207 44505
: UHW Main Building

As Dean of Clinical Innovation I am leading a team who are driving forward The Clinical Innovation Partnership. This creative initiative is aimed at delivering better patient healthcare and wealth creation in Wales. The partnership between Cardiff and Vale University Health Board and Cardiff University will help develop innovative ways of driving forward aspects of clinical care that benefit patients throughout Wales.

The Wound Healing team have obtained significant funding from Welsh Government to create the first Wound Healing Innovation Centre in the world and is moving forward to influence Welsh Government policy and service delivery in this area.

As Professor of Wound Healing I have a longstanding interest in wound healing. I have a distinguished track record of research in wound healing. My clinical practice is exclusively focused on treating patients with complex wound healing problems with a wide range of aetiologies.

Professor Keith Harding CBE FRCGP FRCP FRCS FLSW has had a longstanding interest in wound healing. He has undergone training in both general surgery and general practice. He was appointed as the first Director of the Wound Healing Research Unit in 1991. From 2011 – 2013 he was Director of TIME Institute (Translation, Innovation, Methodology and Engagement) and Head of Wound Healing Research Unit, School of Medicine, Cardiff University and Clinical Lead for Wound Healing in the Cardiff & Vale NHS Trust. In September 2013 he was appointed as Dean of Clinical Innovation at Cardiff University and in 2014 was appointed as Medical Director of the Welsh Wound Innovation Centre. His clinical practice is exclusively focused on treating patients with wound healing problems with a wide range of aetiologies. He holds external professorial appointments at universities in the UK and Australia. He has authored over 350 publications in the field of wound healing and has written a number of chapters and books in this area. He is the Editor-in-Chief of the International Wound Journal published by Wiley. He was the First President of the European Pressure Ulcer Advisory Panel, First Recorder of the European Wound Management Association and is a Past President of the European Tissue Repair Society. He was Chair of the International Working Group on Wound Healing in Diabetic Foot Disease, Chair of the Expert Working Group that produced a range of International Consensus Documents from 2004 – 2011. Has obtained funding of over £45 million from a range of academic, commercial and clinical sources since the Wound Healing Research Unit was created in 1991. He was awarded the CBE in the New Year Honours list in January 2013 for Services to Medicine and Health Care. In 2013 he was awarded £4.2 million to set up the Welsh Wound Innovation Initiative part of which has enabled the setting up of the first Wound Healing Centre in the World. The centre is designed to coordinate academic activity, both in terms of teaching and research, in addition to providing a coordinated approach to the care of patients with wounds. In 2014 he was awarded the The Learned Society of Wales Fellowship.

Anrhydeddau a Dyfarniadau

2017

Kyaw, B., Järbrink, K., Martinengo, L., Car, J., Harding, K. and Schmidtchen, A. 2017. Need for improved definition of “chronic wounds” in clinical studies. Acta Dermato-Venereologica 98(1), pp. 157-158. (10.2340/00015555-2786)
Rangaraj, A., Ye, L., Sanders, A., Price, P. E., Harding, K. G. and Jiang, W. G. 2017. Molecular and cellular impact of Psoriasin (S100A7) on the healing of human wounds. Experimental and Therapeutic Medicine 13(5), pp. 2151-2160. (10.3892/etm.2017.4275)
Clokie, M., Greenway, A. L., Harding, K. G., Jones, N. J., Vedhara, K., Game, F. and Dhatariya, K. K. 2017. New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK annual professional conference symposium. Diabetic Medicine 34(3), pp. 305-315. (10.1111/dme.13313)
Hachach-Haram, N., Bystrzonowski, N., Kanapathy, M., Smith, O., Harding, K. G., Mosahebi, A. and Richards, T. 2017. A prospective, multicentre study on the use of epidermal grafts to optimise outpatient wound management. International Wound Journal 14(1), pp. 241-249. (10.1111/iwj.12595)
Feng, Y., Sanders, A. J., Morgan, L. D., Owen, S., Ruge, F., Harding, K. G. and Jiang, W. G. 2017. In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing. Scientific Reports 7(1), article number: 6715. (10.1038/s41598-017-06886-6)

2016

Phillips, C. J., Humphreys, I., Fletcher, J., Harding, K. G., Chamberlain, G. and Macey, S. 2016. Estimating the costs associated with the management of patients with chronic wounds using linked routine data. International Wound Journal 13(6), pp. 1193-1197. (10.1111/iwj.12443)
Feng, Y., Sanders, A., Ruge, F., Morris, C., Harding, K. and Jiang, W. 2016. Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing. International Journal of Molecular Medicine 38(5), pp. 1349-1358. (10.3892/ijmm.2016.2733)
White, J., Ivins, N. M., Wilkes, A., Carolan-Rees, G. and Harding, K. G. 2016. Non-contact low-frequency ultrasound therapy compared with UK standard of care for venous leg ulcers: a single-centre, assessor-blinded, randomised controlled trial. International Wound Journal 13(5), pp. 833-842. (10.1111/iwj.12389)
Harding, K. G. et al. 2016. Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers. International Wound Journal 13(4), pp. 442-448. (10.1111/iwj.12450)
Palumbo, F. et al. 2016. New surfactant-based dressing product to improve wound closure rates of nonhealing wounds: A European multicenter study including 1036 patients. Wounds 28(7), pp. 233-240.
Jones, A. M., Griffiths, J. L., Sanders, A. J., Owen, S., Ruge, F., Harding, K. and Jiang, W. G. 2016. The clinical significance and impact of interleukin 15 on keratinocyte cell growth and migration. International Journal of Molecular Medicine 38, pp. 679-686. (10.3892/ijmm.2016.2687)
Bartlett, A., Sanders, A. J., Ruge, F., Harding, K. G. and Jiang, W. G. 2016. Potential implications of interleukin-7 in chronic wound healing. Experimental and Therapeutic Medicine 12(1), pp. 33-40. (10.3892/etm.2016.3263)
Kanapathy, M., Hachach-Haram, N., Bystrzonowski, N., Harding, K. G., Mosahebi, A. and Richards, T. 2016. Epidermal grafting versus split-thickness skin grafting for wound healing (EPIGRAAFT): study protocol for a randomised controlled trial. Trials 17(1), article number: 245. (10.1186/s13063-016-1352-y)
Harding, K., Vanscheidt, W., Partsch, H., Caprini, J. A. and Comerota, A. J. 2016. Adaptive compression therapy for venous leg ulcers: a clinically effective, patient-centred approach. International Wound Journal 13(3), pp. 317-325. (10.1111/iwj.12292)
Harding, K. 2016. Challenging passivity in venous leg ulcer care – the ABC model of management. International Wound Journal 13(6), pp. 1378-1384. (10.1111/iwj.12608)
Feng, Y., Sanders, A., Morgan, L., Harding, K. and Jiang, W. 2016. Potential roles of suppressor of cytokine signaling in wound healing. Regenerative Medicine 11(2), pp. 193-209. (10.2217/rme.16.4)
Wang, S., Ye, L., Sanders, A. J., Ruge, F., Harding, K. G. and Jiang, W. G. 2016. Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes. International Journal of Molecular Medicine 37(2), pp. 293-298. (10.3892/ijmm.2015.2434)
Rawlings, C. R., Fremlin, G. A., Nash, J. and Harding, K. G. 2016. A rheumatology perspective on cutaneous vasculitis: assessment and investigation for the non-rheumatologist. International Wound Journal 13(1), pp. 17-21. (10.1111/iwj.12437)
Harries, R., Torkington, J. and Harding, K. G. 2016. Advances in Acellular Matrices (ECM) for Wound Healing. In: Albanna, M. Z. and Holmes, J. H. eds. Skin Tissue Engineering and Regenerative Medicine. Elsevier Inc, pp. 125-139.
Fletcher, J., Harding, K. G. and Richards, A. J. 2016. Treatment strategies for wound infection. In: Edwards-Jones, V. ed. Essential Microbiology for Wound Care. Oxford University Press, pp. 149-163.

2015

Lauchli, S., Swanson, T., Serena, T. and Harding, K. G. 2015. The use of a point-of-care test for bacterial protease activity in chronic wounds. Wounds International 6(4), pp. 22-28.
Nunan, R. et al. 2015. Ephrin-Bs drive junctional downregulation and actin stress fiber disassembly to enable wound re-epithelialization. Cell Reports 13(7), pp. 1380-1395. (10.1016/j.celrep.2015.09.085)
Tilbrook, H. et al. 2015. Aspirin for venous ulcers: Randomised trial (AVURT): study protocol for a randomised controlled trial. Trials 16, article number: 513. (10.1186/s13063-015-1039-9)
Harding, K. G. and Queen, D. 2015. Founder of Leg Club model awarded Order of the British Empire in recent Queen's Birthday Honours. International Wound Journal 12(5), pp. 497-497. (10.1111/iwj.12486)
Harding, K. G. 2015. Wounds and wound healing: new insights, fresh challenges. British Journal of Dermatology 173(2), pp. 318-319. (10.1111/bjd.14036)
Jones, N. J. and Harding, K. G. 2015. International Working Group on the Diabetic Foot Guidance on the prevention and management of foot problems in diabetes. International Wound Journal 12(4), pp. 373-374. (10.1111/iwj.12475)
Harries, R., Cai, J., Li, J., Owen, S., Harding, K. G., Torkington, J. and Jiang, W. G. 2015. PTH-329 Expression of pigment epithelium-derived factor in colorectal cancer [Abstract]. Gut 64(S1), pp. A554. (10.1136/gutjnl-2015-309861.1215)
Queen, D., Botros, M. and Harding, K. G. 2015. Is leg pain a significant contributor to health care budget pain?. International Wound Journal 12(3), pp. 235. (10.1111/iwj.12459)
Bradbury, S. E., Walkley, N., Ivins, N. M. and Harding, K. G. 2015. Clinical evaluation of a novel topical negative pressure device in promoting healing in chronic wounds. Advances in Wound Care 4(6), pp. 346-357. (10.1089/wound.2014.0596)
Harding, K. G. 2015. Innovation and wound healing. Journal of Wound Care 24(S4), pp. 7-13. (10.12968/jowc.2015.24.Sup4b.7)
Harding, K. G. 2015. Prologue: transformational healing solutions. Journal of Wound Care 24(S4b), pp. 4-5. (10.12968/jowc.2015.24.Sup4b.4)
Glasbey, J., Sanders, A. J., Bosanquet, D. C., Ruge, F., Harding, K. G. and Jiang, W. 2015. Expression of hepatocyte growth factor-like protein in human wound tissue and its biological functionality in human keratinocytes. Biomedicines 3(1), pp. 110-123. (10.3390/biomedicines3010110)
Harding, K. G. and Queen, D. 2015. Can 2015 be a transformative year for diagnostics in wound care?. International Wound Journal 12(1), pp. 1. (10.1111/iwj.12420)
Holloway, S., Harding, K. G., Stechmiller, J. K. and Schultz, G. 2015. Acute and chronic wound healing. In: Baranoski, S. and Ayello, E. A. eds. Wound Care Essentials - Practice Principles 4th Edition. Lippincott Williams and Wilkins, pp. 82-98.

2014

Nunan, R., Harding, K. G. and Martin, P. 2014. Clinical challenges of chronic wounds: searching for an optimal animal model to recapitulate their complexity. Disease Models & Mechanisms 7(11), pp. 1205-1213. (10.1242/dmm.016782)
Jones, A. M., Sanders, A. J., Ruge, F., Harding, K. G. and Jiang, W. G. 2014. The expression of interleukin 17c (IL-17c) in chronic wounds and its effect on an in vitro model of keratinocyte cell migration [Abstract]. Wound Repair and Regeneration 22(5), pp. A85-A85. (10.1111/wrr.12218)
Jiang, W. G., Sanders, A. J., Cox, E. D., Bosanquet, D. C., Ruge, F., Lane, J. and Harding, K. G. 2014. A gene expression signature that predicted the clinical outcome of chronic wounds [Abstract]. Wound Repair and Regeneration 22(5), pp. A84-A84. (10.1111/wrr.12218)
Martin, T. A., Ruge, F., Harding, K. G. and Jiang, W. G. 2014. Brain-derived neurotrophic factor (bdnf) is a novel therapeutic agent in human wound healing [Abstract]. Wound Repair and Regeneration 22(5), pp. A91. (10.1111/wrr.12218)
Harding, K. G. and Queen, D. 2014. Are personal health records the answer to better clinican-patients interaction for the treatment of wounds?. International Wound Journal 11(5), pp. 455. (10.1111/iwj.12382)
Mudge, E. J., Richards, A. J. and Harding, K. G. 2014. Wound dressings and debridement. In: Hinchliffe, R. J. et al. eds. The Diabetic Foot. JP Medical Ltd, pp. 231-241.
Harding, K. G. and Griffiths, I. 2014. Spanning the globe – an international collaboration over 10 361 miles [Editorial]. International Wound Journal 11(4), pp. 343. (10.1111/iwj.12331)
Bosanquet, D. C., Ye, L., Harding, K. G. and Jiang, W. G. 2014. FERM family proteins and their importance in cellular movements and wound healing [review]. International Journal of Molecular Medicine 34(1), pp. 3-12. (10.3892/ijmm.2014.1775)
Harding, K. G. and Queen, D. 2014. Ten good reasons - to support the International Wound Journal. International Wound Journal 11(3), pp. 233. (10.1111/iwj.12297)
Jones, A. M., Sanders, A. J., Ruge, F., Harding, K. G. and Jiang, W. G. 2014. The effect of interleukin-17B on an in vitro model of human keratinocyte cell migration during wound healing. British Journal of Surgery 101(s4), pp. 28., article number: O97. (10.1002/bjs.9508)
Jones, A. M., Sanders, A. J., Griffiths, J. L., Ruge, F., Harding, K. G. and Jiang, W. G. 2014. The effect of interleukin 15 on an in vitro model of human keratinocyte cell migration in wound healing. British Journal of Surgery 101(S4), pp. 25., article number: O86. (10.1002/bjs.9508)
Queen, D. and Harding, K. G. 2014. Social media can revolutionise health care provider-patient relationship [Editorial]. International Wound Journal 11(2), pp. 109. (10.1111/iwj.12268)
Harding, K. G. et al. 2014. Effectiveness of an aceullar synthetic matrix in the treatment of hard-to-heal leg ulcers. International Wound Journal 11(2), pp. 129-137. (10.1111/iwj.12115)
Bosanquet, D. and Harding, K. 2014. Wound duration and healing rates: Cause or effect?. Wound Repair and Regeneration 22(2), pp. 143-150. (10.1111/wrr.12149)
Queen, D. and Harding, K. G. 2014. Is 2014 the year of the wound?. International Wound Journal 11(1), pp. 1. (10.1111/iwj.12222)
McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
Mudge, E. J., Price, P. E., Walkley, N. and Harding, K. G. 2014. A randomized controlled trial of larval therapy for the debridement of leg ulcers: results of a multicenter, randomized, controlled, open, observer blind, parallel group study. Wound Repair and Regeneration 22(1), pp. 43-51. (10.1111/wrr.12127)
Mudge, E. J., Ivins, N. M., Walkley, N. and Harding, K. G. 2014. Pilot study comparing Kendall AMD antimicrobial foam dressing with ALLEVYN Ag hydrocellular antimicrobial dressing in venous leg ulcers. Wounds UK 10(1), pp. 30-39.
Frugtniet, B., Martin, T. A., Harding, K. G. and Jiang, W. G. 2014. nWASP (neural Wiskott-Aldrich syndrome protein) is a novel therapeutic target in human wound healing [Conference Abstract]. Wound Repair and Regeneration 22(5), pp. A80-A80. (10.1111/wrr.12218)
Feng, Y., Sanders, A. J., Ruge, F., Harding, K. G. and Jiang, W. G. 2014. Expression of the suppressor of cytokine signalling (SOCS) family members in chronic wound tissue. Wound Repair and Regeneration 22(5), pp. A79-A79. (10.1111/wrr.12218)

2013

Harding, K., Posnett, J. and Vowden, K. 2013. A new methodology for costing wound care. International Wound Journal 10(6), pp. 623-629. (10.1111/iwj.12006)
Bosanquet, D. C., Ye, L., Harding, K. G. and Jiang, W. 2013. Expressed in high metastatic cells (Ehm2) is a positive regulator of keratinocyte adhesion and motility: The implication for wound healing. Journal of Dermatological Science 71(2), pp. 115-121. (10.1016/j.jdermsci.2013.04.008)
Liu, C. et al. 2013. Molecular angiogenic events of a two-herb wound healing formula involving MAPK and Akt signaling pathways in human vascular endothelial cells. Wound Repair and Regeneration 21(4), pp. 579-587. (10.1111/wrr.12055)
Bosanquet, D. C., Rangaraj, A., Richards, A. J., Riddell, A., Saravolac, V. M. and Harding, K. G. 2013. Topical steroids for chronic wounds displaying abnormal inflammation. Annals of the Royal College of Surgeons of England 95(4), pp. 291-296. (10.1308/003588413X13629960045634)
Harding, K. G., Sumner, M. and Cardinal, M. 2013. A prospective, multicentre, randomised controlled study of human fibroblast-derived dermal substitute (Dermagraft) in patients with venous leg ulcers. International Wound Journal 10(2), pp. 132-137. (10.1111/iwj.12053)

2012

Bosanquet, D. C., Harding, K. G., Ruge, F., Sanders, A. J. and Jiang, W. G. 2012. Expression of IL-24 and IL-24 receptors in human wound tissues and the biological implications of IL-24 on keratinocytes. Wound Repair and Regeneration 20(6), pp. 896-903. (10.1111/j.1524-475X.2012.00840.x)
Saravolac, V., Sanders, A. J., Bosanquet, D. C., Jiang, W. G. and Harding, K. G. 2012. Potential role of focal adhesion kinase (FAK) in epithelial protein lost in neoplasm (EPLIN)- regulated migration of hacat cells [Abstract]. Wound Repair and Regeneration 20(5), pp. A110. (10.1111/j.1524-475X.2012.00834.x)
Saravolac, V., Sanders, A. J., Bosanquet, D. C., Jiang, W. G. and Harding, K. G. 2012. Relationship of extracellular signal-regulated kinase (ERK) and epithelial protein lost in meoplasm(EPLIN) in hacat cell migration [Abstract]. Wound Repair and Regeneration 20(5), pp. A110. (10.1111/j.1524-475X.2012.00834.x)
Bosanquet, D. C., Ye, L., Saravolac, V., Sanders, A. J., Rangaraj, A., Harding, K. G. and Jiang, W. G. 2012. Ehm2 promotes wounds healing; the involvement of FAK and NWasp [Abstract]. Wound Repair and Regeneration 20(5), pp. A86. (10.1111/j.1524-475X.2012.00834.x)
Colmont, C. S., Harding, K. G., Piguet, V. and Patel, G. K. 2012. Human skin cancer stem cells: a tale of mice and men. Experimental Dermatology 21(8), pp. 576-580. (10.1111/j.1600-0625.2012.01533.x)
Annakesavan, A., Sanders, A. J., Jiang, D. G., Harding, K. G. and Jiang, W. G. 2012. Role of VEGI/DR3 interactions in keratinocyte growth and migration: Implications to wound healing. British Journal of Surgery 99, pp. 11-12.
Harding, K. G. and Queen, D. 2012. A 25-year wound care journey within the evolution of wound care. Advances in Skin & Wound Care 25(2), pp. 66-70. (10.1097/01.ASW.0000411406.13178.c5)
Jiang, W. G., Sanders, A. J., Ruge, F. and Harding, K. G. 2012. Influence of interleukin-8 (IL-8) and IL-8 receptors on the migration of human keratinocytes, the role of PLC-γ and potential clinical implications. Experimental and Therapeutic Medicine 3(2), pp. 231-236. (10.3892/etm.2011.402)
Jiang, W., Sanders, A., Ruge, F. and Harding, K. 2012. Influence of interleukin-8 (IL-8) and IL-8 receptors on the migration of human keratinocytes, the role of PLC-gamma and potential clinical implications. Experimental and Therapeutic Medicine 3(2), pp. 231-236. (10.3892/etm.2011.402)
Bosanquet, D., Ye, L., Harding, K. G. and Jiang, W. G. 2012. Role of HuR in keratinocyte migration and wound healing. Molecular Medicine Reports 5(2), pp. 529-534. (10.3892/mmr.2011.675)

2011

Annakesavan, A., Patel, G. K. and Harding, K. G. 2011. Recurrence of diffuse large B cell lymphoma presenting as a chronic non healing wound - case report [Abstract]. Wound Repair and Regeneration 19(2), pp. A10. (10.1111/j.1524-475X.2010.00670.x)
Rangaraj, A., Ye, L., Harding, K. G. and Jiang, W. G. 2011. Psoriasin (S100A7) gene and its functions in keratinocytes, the main cell types during wound healing [Abstract]. Wound Repair and Regeneration 19(2), pp. A45. (10.1111/j.1524-475X.2010.00670.x)
Rangaraj, A., Ye, L., Harding, K. G. and Jiang, W. G. 2011. BCL-2 interaction killer, BIK in keratinocyte cellular function and wound healing [Abstract]. Wound Repair and Regeneration 19(2), pp. A45. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Sanders, A. J., Parr, C., Harding, K. G. and Jiang, W. G. 2011. The role of metastasis suppressor 1 (MTSS1) in angiogenesis [Abstract]. Wound Repair and Regeneration 19(2), pp. A14. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Ye, L., Saravolac, V., Sanders, A. J., Rangaraj, A., Harding, K. G. and Jiang, W. G. 2011. Keratinocyte migration, wound healing and the role of the novel protein EHM2 [Abstract]. Wound Repair and Regeneration 19(2), pp. A14. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Harding, K. G. and Jiang, W. G. 2011. Keratinocyte migration and MTSS1 (metastasis suppressor 1) [Abstract]. Wound Repair and Regeneration 19(2), pp. A14. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Ye, L., Saravolac, V., Sanders, A. J., Rangaraj, A., Harding, K. G. and Jiang, W. G. 2011. The role of HuR in keratinocyte migration and wound healing [Abstract]. Wound Repair and Regeneration 19(2), pp. A14. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Davies, W. L., May, K., Harding, K. G. and Patel, G. K. 2011. Acute generalised exanthematous pustulosis following intravitreal Ranibizumab. International Wound Journal 8(3), pp. 317-319. (10.1111/j.1742-481X.2011.00799.x)
Sanders, A. J., Jiang, D. G., Jiang, W. G., Harding, K. G. and Patel, G. K. 2011. Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. International Wound Journal 8(5), pp. 500-507. (10.1111/j.1742-481X.2011.00823.x)
Richards, A. J., Hagelstein, S. M., Patel, G. K., Ivins, N. M., Sweetland, H. M. and Harding, K. G. 2011. Early use of negative pressure therapy in combination with silver dressings in a difficult breast abscess. International Wound Journal 8(6), pp. 608-611. (10.1111/j.1742-481X.2011.00838.x)
Minhas, U., Martin, T. A., Ruge, F., Harding, K. G. and Jiang, W. G. 2011. Pattern of expression of CCN family members Cyr61, CTGF and NOV in human acute and chronic wounds. Experimental and Therapeutic Medicine 2(4), pp. 641-645. (10.3892/etm.2011.256)

2010

Pukstad, B. . S. et al. 2010. Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of Dermatological Science 59(2), pp. 115-122. (10.1016/j.jdermsci.2010.05.003)
Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
Hill, K. E., Malic, S., McKee, R., Rennison, T., Harding, K. G., Williams, D. W. and Thomas, D. W. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65(6), pp. 1195-1206. (10.1093/jac/dkq105)
Rangaraj, A., Ye, L., Patel, G. K., Price, P. E., Harding, K. G. and Jiang, W. G. 2010. The molecular and cellular roles of Psoriasin (S100A4) in human cutaneous wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
Rangaraj, A., Ye, L., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
Minhas, U., Sanders, A. J., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. Activated leukocyte cell adhesion molecule (ALCAM) - biological impact on vascular endothelial cells [Abstract]. Wound Repair and Regeneration 18(6), pp. A89. (10.1111/j.1524-475X.2010.00633.x)
Jiang, W. G., Sanders, A. J. and Harding, K. G. 2010. Expression of vegi, vascular endothelial growth inhibitor, and its impact on cellular functions of keratinocytes [Abstract]. Wound Repair and Regeneration 18(6), pp. A84. (10.1111/j.1524-475X.2010.00633.x)
Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins, in human wound tissues and the cellular impact of WAVEs on keratinocytes [Abstract]. Wound Repair and Regeneration 18(6), pp. A84. (10.1111/j.1524-475X.2010.00633.x)
Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes. Wound Repair and Regeneration 18(6), pp. 594-604. (10.1111/j.1524-475X.2010.00630.x)
Moore, K. et al. 2010. Surface bacteriology of venous leg ulcers and healing outcome. Journal of Clinical Pathology 63(9), pp. 830-834. (10.1136/jcp.2010.077032)
Ghafoor, S. Z. . A., MacRae, E. A., Harding, K. G. and Patel, G. K. 2010. Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy. International Wound Journal 7(5), pp. 418-422. (10.1111/j.1742-481X.2010.00697.x)
Patel, G. K., Davies, W. L., Price, P. E. and Harding, K. G. 2010. Ulcerated tophaceous gout. International Wound Journal 7(5), pp. 423-427. (10.1111/j.1742-481X.2010.00700.x)
Patel, G. K. and Harding, K. G. 2010. Nicorandil ulcer: moves beyond the mucosa. Annals of the Royal College of Surgeons of England 92(6), pp. 451-452. (10.1308/003588410X12699663905195)

2009

Jeffcoate, W. J. et al. 2009. Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes. Health Technology Assessment 13(54), pp. 1-124. (10.3310/hta13540)
Bus, S. A., Van Deursen, R. W. M., Kanade, R., Wissink, M., Manning, E. A., van Baal, J. G. and Harding, K. G. 2009. Plantar pressure relief in the diabetic foot using forefoot offloading shoes. Gait & Posture 29(4), pp. 618-622. (10.1016/j.gaitpost.2009.01.003)
Minhas, U., Martin, T. A., Price, P. E., Harding, K. G. and Jiang, W. G. 2009. CCN family proteins in wound healing - a pivotal role? [Abstract]. Wound Repair and Regeneration 17(4), pp. A74. (10.1111/j.1524-475X.2009.00519.x)
Cook, H., Stephens, P., Davies, K. J., Harding, K. G. and Thomas, D. W. 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24, pp. A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
Baharestani, M. M. et al. 2009. Dilemmas in measuring and using pressure ulcer prevalence and incidence: an international consensus. International Wound Journal 6(2), pp. 97-104. (10.1111/j.1742-481X.2009.00593.x)
Cooper, R. A., Ameen, H., Price, P. E., McCulloch, D. A. and Harding, K. G. 2009. A clinical investigation into the microbiological status of ‘locally infected’ leg ulcers. International Wound Journal 6(6), pp. 453-462. (10.1111/j.1742-481X.2009.00640.x)
Woo, K. Y., Coutts, P. M., Price, P. E., Harding, K. G. and Sibbald, R. G. 2009. A randomized crossover investigation of pain at dressing change comparing 2 foam dressings. Advances in Skin & Wound Care 22(7), pp. 304-310. (10.1097/01.ASW.0000305483.60616.26)

2008

Kanade, R., Van Deursen, R. W. M., Harding, K. G. and Price, P. E. 2008. Investigation of standing balance in patients with diabetic neuropathy at different stages of foot complications. Clinical Biomechanics 23(9), pp. 1183-1191. (10.1016/j.clinbiomech.2008.06.004)
Price, P. E. et al. 2008. Dressing-related pain in patients with chronic wounds: an international patient perspective. International Wound Journal 5(2), pp. 159-171. (10.1111/j.1742-481X.2008.00471.x)
Cairns, S., Leaper, D. J. and Harding, K. G. 2008. Cell regeneration therapy as an adjunct to healing in recalcitrant wounds [Abstract]. Wound Repair and Regeneration 16(6), pp. A78. (10.1111/j.1524-475X.2008.00424.x)
Cairns, S. et al. 2008. Characterisation of biofilms within medical devices [Abstract]. Wound Repair and Regeneration 16(6), pp. A70. (10.1111/j.1524-475X.2008.00424.x)
Riddell, A. D., Leaper, D. J. and Harding, K. G. 2008. The effects of nicorandil on wound healing (case series) [Abstract]. Wound Repair and Regeneration 16(6), pp. A80. (10.1111/j.1524-475X.2008.00424.x)
Heard, G. F., Williams, G. L., Harding, K. G. and Stephenson, B. M. 2008. Unremitting anal ulceration following haemorrhoidectomy. Colorectal Disease 10(7), pp. 732. (10.1111/j.1463-1318.2007.01455.x)
Robson, M. C. et al. 2008. Guidelines for the prevention of venous ulcers. Wound Repair and Regeneration 16(2), pp. 147-150. (10.1111/j.1524-475X.2008.00355.x)
Gottrup, F. et al. 2008. Reducing wound pain in venous leg ulcers with Biatain Ibu: A randomized, controlled double-blind clinical investigation on the performance and safety. Wound Repair and Regeneration 16(5), pp. 615-625. (10.1111/j.1524-475X.2008.00412.x)
Harding, K. G. 2008. Five years and counting [Editorial]. International Wound Journal 5(1), pp. 3. (10.1111/j.1742-481X.2008.00433.x)
Harding, K. G. 2008. WUWHS-Toronto and beyond [Editorial]. International Wound Journal 5(2), pp. 118. (10.1111/j.1742-481X.2008.00460.x)
Woo, K. Y., Harding, K. G., Price, P. E. and Sibbald, G. 2008. Minimising wound-related pain at dressing change: evidence-informed practice. International Wound Journal 5(2), pp. 144-157. (10.1111/j.1742-481X.2008.00486.x)
Moffatt, C. J. et al. 2008. A randomised controlled 8-week crossover clinical evaluation of the 3M™ Coban™ 2 Layer Compression System versus Profore™ to evaluate the product performance in patients with venous leg ulcers. International Wound Journal 5(2), pp. 267-279. (10.1111/j.1742-481X.2008.00487.x)
Seeley, M. A. and Harding, K. G. 2008. The effects of education and training on clinical practice in wound healing. International Wound Journal 5(5), pp. 660-664. (10.1111/j.1742-481X.2008.00519.x)
Apelqvist, J. et al. 2008. Vacuum Assisted Closure: Recommendations for Use: A Consensus Document. International Wound Journal 5(S4), pp. iii-19. (10.1111/j.1742-481X.2008.00537.x)
Folestad, A. et al. 2008. Would Exudate and the Role of Dressings: A Consensus Document. International Wound Journal 5(S1), pp. iii-12. (10.1111/j.1742-481X.2008.00439.x)
Kanade, R., Van Deursen, R. W. M., Price, P. E. and Harding, K. G. 2008. What happens to the contra-lateral foot with diabetic plantar ulceration?. Clinical Biomechanics 23(5), pp. 676-677. (10.1016/j.clinbiomech.2008.03.018)
Kanade, R., Van Deursen, R. W. M., Price, P. E. and Harding, K. G. 2008. What happens to the contra-lateral foot following diabetic foot amputations?. Clinical Biomechanics 23(5), pp. 677-678. (10.1016/j.clinbiomech.2008.03.019)

2007

Conway, K. P., Price, P. E., Harding, K. G. and Jiang, W. G. 2007. The role of vascular endothelial growth inhibitor in wound healing. International Wound Journal 4(1), pp. 55-64. (10.1111/j.1742-481X.2006.00295.x)
Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
Mendonca, D. A., Drew, P. J., Harding, K. G. and Price, P. E. 2007. A pilot study on the effect of topical negative pressure on quality of life. Journal of Wound Care 16(2), pp. 49-53.
Kanade, R., Van Deursen, R. W. M., Burton, J., Davies, V. J., Harding, K. G. and Price, P. E. 2007. Re-amputation occurrence in the diabetic population in South Wales, UK. International Wound Journal 4(4), pp. 344-352. (10.1111/j.1742-481X.2007.00313.x)
Conway, K. P., Ruge, F., Price, P. E., Harding, K. G. and Jiang, W. G. 2007. Hepatocyte growth factor regulation: an integral part of why wounds become chronic. Wound Repair and Regeneration 15(5), pp. 683-692. (10.1111/j.1524-475X.2007.00296.x)
Gottrup, F. et al. 2007. Less pain with Biatain-Ibu: initial findings from a randomised, controlled, double-blind clinical investigation on painful venous leg ulcers. International Wound Journal 4(s1), pp. 24-34. (10.1111/j.1742-481X.2007.00312.x)
Williams, D. T., Harding, K. G. and Price, P. E. 2007. The influence of exercise on foot perfusion in diabetes. Diabetic Medicine 24(10), pp. 1105-1111. (10.1111/j.1464-5491.2007.02218.x)

2006

Kanade, R. V., Van Deursen, R. W. M., Harding, K. G. and Price, P. E. 2006. Walking performance in people with diabetic neuropathy: benefits and threats. Diabetologia 49(8), pp. 1747-54. (10.1007/s00125-006-0309-1)
Patel, G. K., Wilson, C. H., Harding, K. G., Finlay, A. Y. and Bowden, P. E. 2006. Numerous keratinocyte subtypes involved in wound re-epithelialization. Journal of Investigative Dermatology 126(2), pp. 497-502. (10.1038/sj.jid.5700101)
Williams, D. T., Price, P. E. and Harding, K. G. 2006. The influence of diabetes and lower limb arterial disease on cutaneous foot perfusion. Journal of Vascular Surgery 44(4), pp. 770-775. (10.1016/j.jvs.2005.06.040)
Kanade, R., Van Deursen, R. W. M., Harding, K. G. and Price, P. E. 2006. Difficulties in recruiting subjects with partial foot amputations for kinesiological research. The Foot 16(4), pp. 224-225. (10.1016/j.foot.2006.08.002)
Kanade, R., Van Deursen, R. W. M., Price, P. E. and Harding, K. G. 2006. Risk of plantar ulceration in diabetic patients with single-leg amputation. Clinical Biomechanics 21(3), pp. 306-313. (10.1016/j.clinbiomech.2005.10.005)
Fleck, T. et al. 2006. The management of deep sternal wound infections using vacuum assisted closure™ (V.A.C.®) therapy. International Wound Journal 3(4), pp. 273-280. (10.1111/j.1742-481X.2006.00273.x)
Conway, K. P., Price, P. E., Harding, K. G. and Jiang, W. G. 2006. The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing. Wound Repair and Regeneration 14(1), pp. 2-10. (10.1111/j.1743-6109.2005.00081.x)

2005

Beuker, B. J., Van Deursen, R. W. M., Price, P. E., Manning, E. A., Van Baal, J. G. and Harding, K. G. 2005. Plantar pressure in off-loading devices used in diabetic ulcer treatment. Wound Repair and Regeneration 13(6), pp. 537-542. (10.1111/j.1524-475X.2005.00075.x)
Williams, D. T., Harding, K. G. and Price, P. E. 2005. An evaluation of the efficacy of methods used in screening for lower-limb arterial disease in diabetes. Diabetes Care 28(9), pp. 2206-10. (10.2337/diacare.28.9.2206)
Williams, D. T., Pugh, N. D., Coleman, D. P., Harding, K. G. and Price, P. E. 2005. The laboratory evaluation of lower limb perfusion in diabetes mellitus. A clinical review. British Journal of Diabetes and Vascular Disease 5(2), pp. 64-70.
Rayman, G. et al. 2005. Sustained silver-releasing dressing in the treatment of diabetic foot ulcers. British Journal of Nursing 14(2), pp. 109-114.
Williams, D., Enoch, S., Miller, D., Harris, K., Price, P. E. and Harding, K. G. 2005. Effect of sharp debridement using curette on recalcitrant nonhealing venous leg ulcers: A concurrently controlled, prospective cohort study. Wound Repair and Regeneration 13(2), pp. 131-137. (10.1111/j.1067-1927.2005.130203.x)

2004

Williams, D. T., Hilton, J. R. and Harding, K. G. 2004. Diagnosing foot infection in diabetes. Clinical Infectious Diseases 39(Supp.2), pp. S83-S86. (10.1086/383267)
Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
Miller, D. R., Enoch, S., Williams, D. T., Haglestein, S., Price, P. E. and Harding, K. G. 2004. Development of foot drop following compression therapy. Wounds 16(8), pp. 270-272.
Miller, D. R., Enoch, S., Blow, M., Harding, K. G., Price, P. E. and Chantelau, E. 2004. Effectiveness of a new brand of stock 'diabetic' shoes to protect against diabetic foot ulcer relapse. A prospective cohort study. Diabetic Medicine 21(6), pp. 646-648.
Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
Enoch, S., Miller, D. R., Price, P. E. and Harding, K. G. 2004. Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature. International Wound Journal 1(3), pp. 165-175. (10.1111/j.1742-4801.2004.00056.x)
Jeffcoate, W. J., Price, P. E. and Harding, K. G. 2004. Wound healing and treatments for people with diabetic foot ulcers. Diabetes/Metabolism Research and Reviews 20(S1), pp. S78-S89. (10.1002/dmrr.476)
Price, P. E. and Harding, K. G. 2004. Cardiff Wound Impact Schedule: the development of a condition-specific questionnaire to assess health-related quality of life in patients with chronic wounds of the lower limb. International Wound Journal 1(1), pp. 10-17. (10.1111/j.1742-481x.2004.00007.x)
Miller, D. R., Enoch, S., Williams, D. T., Price, P. E. and Harding, K. G. 2004. Value of wound biopsy in chronic venous ulceration. Phlebology 19(2), pp. 65-68.
Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)

2003

Williams, D. T., Price, P. E. and Harding, K. G. 2003. The clinical evaluation of lower limb perfusion in diabetic foot disease. British Journal of Diabetes and Vascular Disease 3(6), pp. 394-398.
Enoch, S., Williams, D., Price, P. and Harding, K. 2003. Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers [Commentary]. British Journal of Surgery 90(10), pp. 1307-1307.
Edwards, R., Price, P. E. and Harding, K. G. 2003. Topical nitrates in refactory wounds: a potential role in the management of wounds in microvascular disease. Wound Repair and Regeneration 11(5), pp. A36-A36.
Williams, D. T., Price, P. E. and Harding, K. G. 2003. Do diabetic patients with foot disease require special consideration when deliberating on intervention for lower limb vascular disease?. Wound Repair and Regeneration 11(5), pp. A18-A18.
Williams, D. T., Price, P. E. and Harding, K. G. 2003. Sharp debridement of intransigent venous leg ulcers stimulates healing. Wound Repair and Regeneration 11(5), pp. A20-A20.
Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
Williams, D. T., Price, P. E. and Harding, K. G. 2003. Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology: response to Moulik, Mtonga, and Gill. Diabetes Care 26(11), pp. 3199-3200. (10.2337/diacare.26.11.3199)

2002

Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
Wall, S. J., Bevan, D., Thomas, D. W., Harding, K. G., Edwards, D. R. and Murphy, G. 2002. Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology 119(1), pp. 91-98. (10.1046/j.1523-1747.2002.01779.x)
Wall, S. J., Bevan, D., Thomas, D. W., Harding, K. G., Edwards, D. R. and Murphy, G. 2002. Differential expression of matrix matalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology 119(1), pp. 91-98. (10.1046/j.1523-1747.2002.01779.x)

2001

Harding, K. G., Price, P. E., Robinson, B., Thomas, S. and Hofman, D. 2001. Cost and dressing evaluation of hydrofiber and alginate dressings in the mManagement of community-based patients with chronic leg ulceration. Wounds 13(6), pp. 229-236.
Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
Martin, T. A., Harding, K. G. and Jiang, W. G. 2001. Matrix-bound fibroblasts regulate angiogenesis by modulation of VE-cadherin. European Journal of Clinical Investigation 31(11), pp. 931-938. (10.1046/j.1365-2362.2001.00914.x)

2000

Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)

1995

Bale, S., Finlay, I. G. and Harding, K. G. 1995. Pressure sore prevention in a hospice. Journal of Wound Care 4(10), pp. 465-468.
Salaman, R. A., Hallett, M. B., Lane, I. F. and Harding, K. G. 1995. Compression Therapy reduces neutrophil priming in venous ulcer disease. British Journal of Surgery 82(11), pp. 1553-1554.
Glaser, A. et al. 1995. Quality of life. The Lancet 346(8972), pp. 444-445. (10.1016/S0140-6736(95)92817-0)

Yr Athro Keith Harding

Anrhydeddau a Dyfarniadau

Aelodaethau proffesiynol

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Pobl

Cyfeiriaduron

Switsfwrdd y Brifysgol

Ein lleoliad

Yr Athro Keith Harding

Trosolwg

Bywgraffiad

Anrhydeddau a Dyfarniadau

Aelodaethau proffesiynol

Cyhoeddiadau

2024

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Past projects

Newyddion cysylltiedig

£50,000 ar gyfer partneriaeth â Chanolfan Arloesedd Clwyfau Cymru

WWIC yn helpu i ddenu buddsoddiad £3m o Awstralia

Partneriaeth ar gyfer gofal cleifion yn nodi BioCymru 2017