An evaluation of steric hindrance of APP processing by 2B12 as a treatment for amyloid-related pathology in a murine preclinical model of Alzheimer’s disease
Aims of Project
This project will investigate the potential of this approach to inhibit Ab production in vivo using an APP mouse model of AD. The project will follow two complimentary lines of research with two main aims. The first aim is to determine whether microinfusion of the antibody into brain structures implicated in the Ab-related memory deficits in mice will affect Ab plaque deposition and cognitive function. The second aim is to characterise the effect of immunizing mice with the antibody or peptide on amyloid pathology, inflammatory processes, and cognition. The project will encourage the development of a range of neuroscience skills, including stereotaxic skills, immunohistochemistry, PCR and ELISA techniques and the development and use of cognitive tests in mouse models of AD.
Funder
The Alzheimer’s Society UK
Duration
3 years
