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Prof Chris McGuigan  -  BSc PhD

Staff Photo
Position:Professor of Medicinal Chemistry

Telephone:+44 (0)29 208 74537
Fax:+44 (0)29 208 74537


 Ser Cymru, the National Research Network in Health and Life Sciences is launched. 

Life Science HUB

Prof McGuigan has been appointed by Business Minister Edwina Hart to Chair the Task and Finish Group for the LifeScience HUB at Cardiff Bay.  


First human data on novel anti-cancer ProTide NUC1031,
3D image of NUC-1031

3D structure/image of NUC-1031 anti-cancer drug based on gemcitabine  464.7 Kb


New first in man, trial for anti-cancer ProTide, with Nucana Biomed, started November 2012.  

ABPI Annual Lecture for 2012
Ups and Downs of a Drug Hunter - from the Lab to Patients 

Related Links
Chris McGuigan's Lab page
The Presidents Research Scholarships


Professor Chris McGuigan graduated Bachelor of Science in 1979 with First Class Honours from the University of Birmingham where he also obtained his Ph.D. in Anticancer Drug Design, 1982.


Research Interests

  • Anti-cancer drug discovery, engineering new nucleosides to overcome the known resistance mechanisms of current drugs. collaborative with Nucana BioMed in Edinburgh.
  • Major interest in new drug discovery and development for cancer, HIV, hepatitis B and C, shingles, osteoarthritis, measles and influenza. This involves synthetic organic and organo-phosphorus chemistry, purification methods and spectroscopy, particularly high field NMR, and close collaboration with virologists and biochemists throughout Europe, and USA.
  • Antiviral Drug Discovery via ProTides. Our collaborative projects with GSK, NC, Roche Palo Alto and Inhibitex GA are now completed. Major potency enhancements were observed with a number of antiviral agents.
3D structure of FV-100, a potential anti-shingles drug

FV100. The World's most potent inhibitor of VZV (cause of chickenpox and shingles). Our lab discovered this agent and out-licensed it to Inhibitex.  See - FV100 - the story.  FV100 is now licenced to Synergy Pharma.


3D structure of INV-189 anti-hep C drug

INX189. The most powerful inhibitor of hepatitis C virus in its class.  Discovered in our lab in 2008 and  outlicensed to Inhibitex and entered phase 2 trials with BMS. 




Member of the School's  Medicinal Chemistry Research Discipline 

Teaching Profile

I lecture to years 2-4 of the M.Pharm. Degree:
•    M.Pharm 2.  Module 2106 - Pro-Drugs.  Module 2108 - NMR
•    M.Pharm 3.  Module 3101 - Chirality and Drug Action, Antivirals
•    M.Pharm 4.  Module 4112 - Workshops on Med.Chem.  Module 4112 - Publication workshop, 
     NMR workshop.

We also run M.Pharm. Research Projects in our laboratory each year.