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Dr Emma Thomas-Jones

Senior Research Fellow and Deputy Director Infections Inflammation and Immunity Division

Email
thomas-jonese@cardiff.ac.uk
Telephone
+44 (0)29 2068 7520
Campuses
708F, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
Welsh speaking
Users
Available for postgraduate supervision

Overview

I am a Senior Research Fellow and Deputy Director for Infections, Inflammation & Immunity Research Division at the Centre for Trials Research .

My research areas are in common infections in primary care (e.g. UTI), biomarkers for infections and sepsis. I conduct evidence-based research testing the effectiveness of interventions with the aim of reducing antibiotic resistance.

I have extensive knowledge and experience in trial methodology and research governance.

Biography

Education and qualifications

  • 1997: PhD "The estimation of circulating plasma volume using fluorescently labelled hydroxyethyl starch”. School of Molecular and Medical Biosciences, University of Wales, Cardiff.
  • 1993: BSc in Biochemistry and Physiology (Joint Honours), University of Wales, College of Cardiff.

Career overview

  • 2020 - onwards: Deputy Director of Infections, Inflammation and Immunity Division, at Centre for Trials Research.
  • 2019 - onwards: Senior Research Fellow, Centre for Trials Research, Cardiff University.
  • 2011 - 2019: Research Fellow (Senior Trial Manager), Centre for Trials Research, Cardiff University.
  • 2010 – 2011: Acting Research Fellow (Senior Trial Manager), South East Wales Trials Unit, Cardiff University
  • 2009 – 2010: Research Associate (Trial Manager), South East Wales Trials Unit, Cardiff University.
  • 1999 – 2008: Senior Scientist, Molecular Light Technology (GenProbe Inc.), Cardiff
  • 1997 – 1999: Research Associate, School of Biosciences, University of Wales, Cardiff.

Professional memberships

  • Member of the Society for Academic Primary Care (SAPC).

Committees and reviewing

  • Grant reviewer for the Health and Care Research Wales Research for Patient and Public Benefit (RfPPB),  NIHR School of Primary Care Research
  • Grant reviewer for Cardiff Univeristy MRC Confidence in Concept and MRC Proximity to Discovery funding awards
  • Member of Cwm Taf Research and Development Committee
  • Member of HCRW Primary Care Research Strategy Committee
  • Steering committee member for South West Hub Research Forum
  • Journal reviewer for the BMJ, BMJ Open, British Journal of General Practice, Trials, and BMC Series (Infectious Diseases, Family Practice).

Publications

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

Research Interests

  • Infections, Inflammation and Immunity
  • Biomarkers and Point of Care Devices
  • Primary Care
  • Sepsis
  • Antimicrobial stewardship

Grants

2020: NIHR COVID Rapid Recovery Call - Procalcitonin: Evaluation of Antibiotic use in COVID-19 Hospitalised patients (The PEACH Study). (Principial Investigator for CU and CTR study lead). £731,859

2020: Sêr Cymru (Welsh Governement) - COPE CYMRU - COVID-19 public experiences in Wales: A longitudinal mixed-methods study of attitudes, beliefs and behaviour in response to the coronavirus pandemic. (Co-Chief Investigator). £127,871

2020: Health and Care Research Wales (Research for Patient and Public Benefit RfPPB) - PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation- a collaboratiVE study (PERCEIVE). (Co-applicant). £229,225 

2020: Health Care Research Wales (Welsh Government Infrastructure Funding) - PRIME CENTRE. (Co-applicant). £4.8M

2020: NIHR Efficacy and Mechanism Evaluation (EME) - MR-Pro-adrenomedullin (MR-proADM) and ImmunoExpert Evaluation of procalcitonin-guided antibiotic duration in Children with Infection for Stratification of Effectiveness (PRECISE). (Co-Chief Investigator and CTR study lead). £385,451

2019: NIHR Efficacy and Mechanism Evaluation (EME) - Intravenous Immunoglobulin in Autoimmune Encephalitis in Adults: A Randomised Double-Blind Placebo-Controlled Trial (ENCEPH-IG). (Principal Investigator for CU and CTR study lead). £2,734,732.

2019: NIHR Health Technology Assessment (HTA) - PROcalcitonin and NEWS evaluation for Timely identification of sepsis and Optimal use of antibiotics in the Emergency Department (PRONTO). (Principal Investigator for CU and CTR study lead), ££1,964,286.

2019: NIHR Health Technology Assessment (HTA) - Azithromycin therapy for Chronic Lung Disease of Prematurity – AZTEC Trial.(Co-applicant), £2,518,929.

2018: NIHR Health Technology Assessment (HTA) - "Management of Hidrandenitis Suppurativa (THESEUS). (Co-applicant and CTR study lead), £629,000

2017: NIHR Health Technology Assessment (HTA) - “Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH). (Principal Investigator and CTR study lead), £1.5M

2017: NIHR Health Technology Assessment (HTA) - Primary care management of lower urinary tract symptoms in men: Development and validation of a diagnostic and decision-making aid (PRIMUS). (Co-applicant and CTR study lead), £1.6M

2016: Health and Care Research Wales (RfPPB) - A phase II clinical trial examining the use of perineural catheters after major lower limb amputation in adults with critical limb ischaemia (PLACEMENT) (Principal Investigator and CTR study lead), £210,552.

2015: Health and Care Research Wales. Clinical Trials Unit infrastructure funding 2015-18. (Co-applicant), £2.9m

2014: NIHR Health Service & Delivery Research (HS&DR) - Paediatric early warning system (PEWS): Utilisation and Mortality Avoidance (PUMA). (Co-applicant and CTR Study Lead), £1.9M

2013: Health and Care Research Wales RfPPB - Supporting antibiotic prescribing decisions for diabetic foot ulcer infections: an investigation of the diagnostic accuracy of inflammatory biomarkers. (Co-applicant and SEWTU study lead), £195,920.

2011: NIHR Health Technology Assessment (HTA) - Oral Steroids for the Resolution of otitis media with effusion (OME) In Children (OSTRICH) (Co-applicant and SEWTU study lead), £1.3M

Supervision

I am interested in supervising PhD students in the areas of:

  • Biomarker guided antimicrobial decision making
  • Antimicrobial resistance
  • Clinical trials methodology

Past projects

  • Co-supervisor (33%) for Dr Brenig Gwylim - Investigating healthcare professionals’ risk perception and the utility of statistical outcome prediction tools in arterial surgery through a groin incision and major lower limb amputation surgery by utilising an international collaborative multicentre cohort study method (PhD by publication, in progress).
  • Co-supervisor (33%) for Dr Graeme Ambler - Development of a core outcome set for studies involving patients undergoing major lower limb amputation for peripheral arterial disease: study protocol for a systematic review and identification of a core outcome set using a Delphi survey (PhD by publication; awarded 2020).