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Current clinical studies

Our research is focused on finding therapies for Huntington's disease.

We are investigating cell replacement therapy for Huntington's disease, using a multidisciplinary approach that includes behavioural psychology, developmental biology, cell and stem cell biology, genetics and immunology in preparation for future trials in regenerative medicine. We are also exploring genetic factors that delay disease onset.

Alongside our disease modifying therapy research, we are global leaders in developing and evaluating lifestyle interventions for Huntington’s Disease. Our pioneering research has shown exercise and physical activity to be a successful and innovative new element in HD management.

We undertake a broad range of research studies aiming to improve our understanding of Huntington's disease and develop and evaluate new therapies. These range from observational studies aiming to learn more about how the disease appears and changes over time, to trialling new therapies and interventions to slow the progress of Huntington's disease and improve patient outcomes.

The HD public and patient community have collaborated in our research for many years to ensure that it is relevant to their needs and concerns. The benefits are seen through, not only the excellent recruitment to our trials, attendance at public events and training days that we have hosted but also for the impact that our family members tell us this has had on their lives.

Current clinical studies


The purpose of this study is to collect information from study participants, allowing researchers to understand more about the disease, with the aim of accelerating the discovery and development of potential treatments for Huntington's Disease (HD).

HD Clarity

A multi-site cerebrospinal fluid collection initiative to facilitate therapeutic development for Huntington’s disease.


Physical activity and exercise outcomes in Huntington’s disease.


The DOMINO-HD study (Multi-Domain Lifestyle Targets for Improving ProgNOsis) is exploring how digital technologies, such as wearable fitness trackers, can be used to support people with Huntington’s disease (HD).

Commercial studies


We are a clinical trial site for the Roche Huntington’s Disease Natural History study, the Phase 3 GENERATION HD1 huntingtin lowering trial and the subsequent open label extension study.