Yr Athro Nick Allen

2020

• Comella-Bolla, A.et al. 2020. Human pluripotent stem cell-derived neurons are functionally mature in vitro and integrate into the mouse striatum following transplantation. Molecular Neurobiology 57(6), pp. 2766-2798. (10.1007/s12035-020-01907-4)
• Cook, S. R.et al. 2020. Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons. AMRC Open Research 2, article number: 21. (10.12688/amrcopenres.12903.1)
• Smith-Geater, C.et al. 2020. Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation. Stem Cell Reports 14(3), pp. 406-419. (10.1016/j.stemcr.2020.01.015)

2019

• Baker, E.et al. 2019. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease. PLoS ONE 14(7), article number: e0218111. (10.1371/journal.pone.0218111)
• Garcia, V. J.et al. 2019. Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support. Frontiers in Neuroscience 13, article number: 669. (10.3389/fnins.2019.00669)
• Harwood, J. C.et al. 2019. Nucleosome dynamics of human iPSC during neural differentiation. EMBO reports 20(6), article number: e46960. (10.15252/embr.201846960)

2018

• Telezhkin, V.et al. 2018. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflügers Archiv European Journal of Physiology 470(9), pp. 1359-1376. (10.1007/s00424-018-2155-7)
• Merkouris, S.et al. 2018. Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library. Proceedings of the National Academy of Sciences 115(30), pp. E7023-E7032. (10.1073/pnas.1806660115)

2017

• Haenseler, W.et al. 2017. A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response. Stem Cell Reports 8(6), pp. 1727-1742. (10.1016/j.stemcr.2017.05.017)
• Lim, R. G.et al. 2017. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 20(5), pp. 648-660. (10.1038/nn.4532)
• Bowles, K. R.et al. 2017. SMAD transcription factors are altered in cell models of HD and regulate HTT expression. Cellular Signalling 31, pp. 1-14. (10.1016/j.cellsig.2016.12.005)

2016

• Kemp, P. J.et al. 2016. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 594(22), pp. 6583-6594. (10.1113/JP270655)
• Howard-Jones, R. A.et al. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95(8), pp. 882-888. (10.1177/0022034516637579)
• Telezhkin, V.et al. 2016. Forced cell-cycle exit and modulation of GABAA, CREB and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology, article number: ajpcell.00166.2015. (10.1152/ajpcell.00166.2015)
• Gee, H. Y.et al. 2016. FAT1 mutations cause a glomerulotubular nephropathy. Nature Communications 7, article number: 10822. (10.1038/ncomms10822)
• Precious, S. V.et al. 2016. Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells?. Neurogenesis 3(1), article number: e1127311. (10.1080/23262133.2015.1127311)

2015

• Straccia, M.et al. 2015. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy - Methods & Clinical Development 2, article number: 15030. (10.1038/mtm.2015.30)
• Celiz, A. D.et al. 2015. Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials 27(27), pp. 4006-4012. (10.1002/adma.201501351)
• Martín-Flores, N.et al. 2015. RTP801 is involved in mutant Huntingtin-induced cell death. Molecular Neurobiology 53(5), pp. 2857-2868. (10.1007/s12035-015-9166-6)
• Jones, A. J.et al. 2015. Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Scientific Reports 5, article number: 11694. (10.1038/srep11694)
• Mort, M. E.et al. 2015. Huntingtin exists as multiple splice forms in human brain. Journal of Huntington's Disease 4(2), pp. 161-171. (10.3233/JHD-150151)

2013

• Rushton, D. J.et al. 2013. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS ONE 8(11), pp. e81031. (10.1371/journal.pone.0081031)

2012

• Mattis, V. B.et al. 2012. Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11(2), pp. 264-278. (10.1016/j.stem.2012.04.027)
• Wray, S.et al. 2012. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS ONE 7(8), article number: e43099. (10.1371/journal.pone.0043099)
• Feyeux, M.et al. 2012. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells. Human Molecular Genetics 21(17), pp. 3883-3895. (10.1093/hmg/dds216)

2011

• Patani, R.et al. 2011. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nature Communications 2, article number: 214. (10.1038/ncomms1216)
• Kelly, C.et al. 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20(4), pp. 503-513. (10.3727/096368910X546580)
• Hollins, A. J.et al. 2011. Transplantation of differentiated human embryonic stem cells into a Huntington's Disease model: The challenges of generating neural cells suitable for replacement therapy in neurodegenerative disease. Cell Transplantation 20(4), pp. 563-564.
• Decembrini, S.et al. 2011. Comparative Analysis of the Retinal Potential of Embryonic Stem Cells and Amniotic Fluid-Derived Stem Cells. Stem Cells and Development 20(5), pp. 851-863. (10.1089/scd.2010.0291)

2010

• Ewan, K. B. R.et al. 2010. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Research 70(14), pp. 5963-5973. (10.1158/0008-5472.CAN-10-1028)
• Odeh, H.et al. 2010. Mutations in Grxcr1 Are The Basis for Inner Ear Dysfunction in the Pirouette Mouse. American Journal of Human Genetics 86(2), pp. 148-160. (10.1016/j.ajhg.2010.01.016)

2009

• Wilkinson, W. J.et al. 2009. Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels. British Journal of Pharmacology 158(3), pp. 862-871. (10.1111/j.1476-5381.2009.00354.x)
• Kelly, C. M.et al. 2009. Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nature Methods 6(4), pp. 271-273. (10.1038/nmeth.1308)
• Patani, R.et al. 2009. Activin/nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. PLoS ONE 4(10), article number: e7327. (10.1371/journal.pone.0007327)
• Allen, N. D. and Baird, D. M. 2009. Telomere length maintenance in stem cell populations. Biochimica et Biophysica Acta-Molecular Basis of Disease 1792(4), pp. 324-328. (10.1016/j.bbadis.2009.02.004)

2008

• Bilican, B.et al. 2008. Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level. PLoS ONE 3(8), article number: e2863. (10.1371/journal.pone.0002863)
• Chandran, S., Caldwell, M. and Allen, N. D. 2008. Introduction: stem cells and brain repair. Philosophical Transactions of the Royal Society B-Biological Sciences 363((1489)), pp. 5-7. (10.1098/rstb.2006.2008)
• Allen, N. D. 2008. Temporal and epigenetic regulation of neurodevelopmental plasticity. Philosophical Transactions of the Royal Society B - Biological Sciences 363(1489), pp. 23-28. (10.1098/rstb.2006.2010)
• Wilkinson, W. J.et al. 2008. Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels [Abstract]. Purinergic Signalling 4(S1), pp. 26. (10.1007/s11302-008-9116-0)

2007

• Nikoletopoulou, V.et al. 2007. Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6. Cell Stem Cell 1(5), pp. 529-540. (10.1016/j.stem.2007.08.011)
• Joannides, A. J.et al. 2007. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 130(5), pp. 1263-1275. (10.1093/brain/awm070)
• Battersby, A.et al. 2007. Comparative proteomic analysis reveals differential expression of Hsp25 following the directed differentiation of mouse embryonic stem cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773(2), pp. 147-156. (10.1016/j.bbamcr.2006.08.030)

2006

• Bouhon, I. A.et al. 2006. Embryonic stem cell derived neural progenitors display temporal restriction to neural patterning. Stem Cells 24(8), pp. 1908-1913. (10.1634/stemcells.2006-0031)
• Joannides, A.et al. 2006. Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion. Stem Cells 24(2), pp. 230-235. (10.1634/stemcells.2005-0243)
• Joannides, A. J.et al. 2006. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 25(3), pp. 731-737. (10.1634/stemcells.2006-0562)
• Rosser, A. E. and Allen, N. D. 2006. Help for huntington's: stem cells for neurodegenerative disease. The Biochemist 28, pp. 19-24.

2005

• Calo, L.et al. 2005. Nurr1 co-localizes with EphB1 receptors in the developing ventral midbrain, and its expression is enhanced by the EphB1 ligand, ephrinB2. Journal of Neurochemistry 92(2), pp. 235-245. (10.1111/j.1471-4159.2004.02853.x)
• Bouhon, I. A.et al. 2005. Neural differentiation of mouse embryonic stem cells in chemically defined medium. Brain Research Bulletin 68(1-2), pp. 62-75. (10.1016/j.brainresbull.2005.08.022)

2004

• Odeh, H.et al. 2004. Characterization of two transgene insertional mutations at pirouette, a mouse deafness locus. Audiology and Neuro-Otology 9(5), pp. 303. (10.1159/000080701)
• Stopps, M.et al. 2004. Design and application of a novel brain slice system that permits independent electrophysiological recordings from multiple slices. Journal of Neuroscience Methods 132(2), pp. 137-148. (10.1016/j.jneumeth.2003.08.015)

2003

• Chandran, S.et al. 2003. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development Vol 13(26), pp. 6599-6609. (10.1242/dev.00871)
• Ciani, L.et al. 2003. Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype. Molecular and Cellular Biology 23(10), pp. 3575-3582. (10.1128/MCB.23.10.3575-3582.2003)
• Zou, X.et al. 2003. Block in development at the pre-B-II to immature B cell stage in mice without lgk and iga light chain. The Journal of Immunology 170(3), pp. 1354-1361.

2002

• Isles, A. R.et al. 2002. A possible role for imprinted genes in inbreeding avoidance and dispersal from the natal area in mice. Proceedings of the Royal Society B: Biological Sciences 269(1492), pp. 665-670. (10.1098/rspb.2001.1911)
• Ma, D.et al. 2002. Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice. European Journal of Neuroscience 16(12), pp. 2317-2323. (10.1046/j.1460-9568.2002.02303.x)
• Erven, A.et al. 2002. A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil. European Journal of Neuroscience 16(8), pp. 1433-1441. (10.1046/j.1460-9568.2002.02213.x)

2001

• Mooslehner, K. A.et al. 2001. Mice with Very Low Expression of the Vesicular Monoamine Transporter 2 Gene Survive into Adulthood: Potential Mouse Model for Parkinsonism. Molecular and Cellular Biology 21(16), pp. 5321-5331. (10.1128/MCB.21.16.5321-5331.2001)
• Isles, A. R.et al. 2001. Urinary odour preferences in mice. Nature 409(6822), pp. 783-784. (10.1038/35057323)
• Isles, A. R.et al. 2001. Genetic imprinting: urinary odour preferences in mice. Nature 409(6822), pp. 783-784. (10.1038/35057323)
• Cui, W.et al. 2001. Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia 34(4), pp. 272-282. (10.1002/glia.1061)
• Isles, A. R.et al. 2001. Conditional ablation of neurones in transgenic mice. Journal of Neurobiology 47(3), pp. 183-193. (10.1002/neu.1026)