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My research has focused on developing evidence and guidelines for targeted physical interventions in neurodegenerative diseases, and in particular Huntington's disease (HD). The Cardiff HD Physiotherapy Group have adopted the Medical Research Council (MRC) Framework for design and evaluation of complex interventions to provide a structure that should ultimately lead to full scale, robust controlled clinical trials. Over the course of the last 6 years, the Cardiff group have validated outcome measures, consulted service users to develop appropriate interventions, and conducted case studies and several larger feasibility studies (MOVE TO EXERCISE, COMMET-HD and TRAIN-HD). Two larger scale studies are currently underway: ExeRT-HD and Engage-HD. More information about our current and past studies can be found at www.actvehd.co.uk
As co-lead facilitator of the European Huntington's Disease Network (EHDN) Physiotherapy Working Group, I work to facilitate communication between physiotherapists and healthcare professionals from across European countries. One of the group's major projects has been the development and on-going revision of a Physiotherapy Guidance Document for people with HD. This document incorporates basic science and clinical research to date, as well as expert consensus, for physiotherapy interventions targeted at all stages of HD. This work has required large-scale collaboration from physiotherapists working across Europe in the field of HD, and has resulted in the establishment of an international group of physiotherapy academics and clinicians working together to further develop existing evidence in support of physiotherapy for people with HD.
Bywgraffiad
Qualifications
- Ed.D. 1996 Movement Science, Teachers College, Columbia University, New York, New York USA
- Ed.M. 1994 Movement Science, Teachers College, Columbia University
- M.A. 1993 Movement Science, Teachers College, Columbia University
- B.S. 1989 Physical Therapy, University of Connecticut, Storrs, Connecticut USA
Editorial work
- Reviewer for Physical Therapy, Journal of Neurologic Physical Therapy, and Pediatric Physical Therapy
Association memberships
- European Huntington's Disease Network (EHDN) - Physiotherapy Working Group, co-lead facilitator
- Chartered Society of Physiotherapists
- American Physical Therapy Association - Neurology section member
Aelodaethau proffesiynol
- Registered by Health Professions Council, UK
- Chartered Society of Physiotherapists
- Association of Chartered Physiotherapists Interested in Neurology
- Licensed Physical Therapist in Connecticut, New York and Massachusetts, USA
Cyhoeddiadau
2022
- Drew, C., Hamana, K., Williams-Thomas, R., Playle, R., Busse, M. and Quinn, L. 2022. J16 Exploring the acceptability and key components for success of a 12 month physical activity intervention in early to mid-stage Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry 93, article number: A100. (10.1136/jnnp-2022-ehdn.266)
- Quinn, L. et al. 2022. Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease. Parkinsonism & Related Disorders 101, pp. 75-89. (10.1016/j.parkreldis.2022.06.013)
- Fritz, N. E., Busse, M., Muratori, L. M., Rao, A. K., Kloos, A., Kegelmeyer, D. and Quinn, L. 2022. An MDS evidence-based review on treatments for Huntington's disease [Letter]. Movement Disorders 37(7), pp. 1566-1567. (10.1002/mds.29059)
- Atkins, K. J., Friel, C. P., Andrews, S. C., Chong, T. T., Stout, J. C. and Quinn, L. 2022. A qualitative examination of apathy and physical activity in Huntington's and Parkinson's disease. Neurodegenerative Disease Management 12(3), pp. 129-139. (10.2217/nmt-2021-0047)
- Desai, R. et al. 2022. Postural control and gait measures derived from wearable inertial measurement unit devices in Huntington's disease: recommendations for clinical outcomes. Clinical Biomechanics 96, article number: 105658. (10.1016/j.clinbiomech.2022.105658)
2021
- Muratori, L. M., Quinn, L., LI, X., Youdan, G., Busse, M. and Fritz, N. E. 2021. Measures of postural control and mobility during dual-tasking as candidate markers of instability in Huntington's Disease. Human Movement Science 80, article number: 102881. (10.1016/j.humov.2021.102881)
- Karen, K. et al. 2021. Quantification of daily-living gait quantity and quality using a wrist-worn accelerometer in Huntington's Disease. Frontiers in Neurology 12, article number: 719442. (10.3389/fneur.2021.719442)
- Hamana, K., Quinn, L., Gambling, T. and Busse, M. 2021. An exploration of physical activity experiences throughout the Huntington's disease journey: supporting development of theoretically underpinned complex interventions. Disability and Rehabilitation 43(11), pp. 1565-1575. (10.1080/09638288.2019.1671501)
2020
- Quinn, L., Kegelmeyer, D., Kloos, A., Rao, A. K., Busse-Morris, M. and Fritza, N. E. 2020. Clinical recommendations to guide physical therapy practice for Huntington disease. Neurology 94(5), pp. 217-228. (10.1212/WNL.0000000000008887)
2019
- Playle, R., Dimitropoulou, P., Kelson, M., Quinn, L. and Busse-Morris, M. 2019. Exercise interventions in Huntington's disease: An individual patient data meta-analysis. Movement Disorders Clinical Practice 6(7), pp. 567-575. (10.1002/mdc3.12809)
- Drew, C. J. G. et al. 2019. Physical activity and exercise outcomes in Huntington Disease (PACE-HD): Protocol for a 12-Month trial within cohort evaluation of a physical activity intervention in people with Huntington Disease. Physical Therapy 99(9), pp. 1201-1210. (10.1093/ptj/pzz075)
2018
- Busse, M. et al. 2018. J09 A new trial design for evaluating exercise outcomes in Huntington's Disease. Journal of Neurology, Neurosurgery and Psychiatry 89(Supp 1), pp. A100 - A101. (10.1136/jnnp-2018-EHDN.269)
- Steventon, J. et al. 2018. Alterations in the metabolic and cardiorespiratory response to exercise in Huntington's Disease. Parkinsonism and Related Disorders 54, pp. 56-61. (10.1016/j.parkreldis.2018.04.014)
- Poile, V., Youdan, G., Sheeran, L., Quinn, L. and Busse, M. 2018. Wearable technologies for assessment of physical activity in hd: preliminary analysis of movement variability and wear time. Journal of Neurology, Neurosurgery and Psychiatry 89(S1), pp. A62., article number: F64. (10.1136/jnnp-2018-EHDN.165)
- Mestre, T. A. et al. 2018. Rating scales and performance-based measures for assessment of functional ability in Huntington's Disease: Critique and recommendations. Movement Disorders Clinical Practice 5(4), pp. 361-372. (10.1002/mdc3.12617)
- Mestre, T. et al. 2018. Quality of life measures in Huntington’s Disease: critique and recommendations for measures assessing patient health‐related quality of life and caregiver quality of life. Movement Disorders 33(5), pp. 742-749. (10.1002/mds.27317)
2017
- Fritz, N. et al. 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review. Journal of Huntington's Disease 6(3), pp. 217-235. (10.3233/JHD-170260)
- Quinn, L. and Busse, M. 2017. The role of rehabilitation therapy in Huntington disease. In: Feigen, A. S. and Anderson, K. E. eds. Handbook of Clinical Neurology: Huntington Disease., Vol. 144. Elsevier: Monograph Series, pp. 151-165., (10.1016/B978-0-12-801893-4.00013-4)
- Fritz, N., Busse-Morris, M., Jones, K., Khalil, H. and Quinn, L. 2017. A classification system to guide physical therapy management in Huntington’s disease: a case series. Journal of Neurologic Physical Therapy 41(3), pp. 156-163. (10.1097/NPT.0000000000000188)
- Quinn, L. et al. 2017. Physical therapy and exercise interventions in Huntington's disease: a mixed methods systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 15(7), pp. 1783-4433. (10.11124/JBISRIR-2016-003274)
- Busse, M. et al. 2017. Physical activity self-management and coaching compared to social interaction in Huntington’s disease: Results from the ENGAGE-HD randomized, controlled, pilot feasibility trial. Physical Therapy 97(6), pp. 625-639. (10.1093/ptj/pzx031)
- Khalil, H., Busse-Morris, M. and Quinn, L. 2017. A pilot study of a minimally supervised home exercise and walking program for people with Parkinson’s disease in Jordan. Neurodegenerative Disease Management 7(1) (10.2217/nmt-2016-0041)
2016
- Drew, C. et al. 2016. Integrating technology into complex intervention trial processes: a case study. Trials 17(1), article number: 551. (10.1186/s13063-016-1674-9)
- Jones, C. et al. 2016. The societal cost of Huntington’s disease: are we underestimating the burden?. European Journal of Neurology 23(10), pp. 1588-1590. (10.1111/ene.13107)
- Quinn, L. et al. 2016. A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease. Parkinsonism and Related Disorders 31, pp. 46-52. (10.1016/j.parkreldis.2016.06.023)
- Fritz, N. E., Hamana, K., Kelson, M., Rosser, A., Busse, M. and Quinn, L. 2016. Motor-cognitive dual-task deficits in individuals with early-mid stage Huntington's disease. Gait and Posture 49, pp. 283-289. (10.1016/j.gaitpost.2016.07.014)
- Quinn, L. et al. 2016. Development and delivery of a physical activity intervention for people with Huntington Disease. Journal of Neurologic Physical Therapy 40(2), pp. 71-80. (10.1097/NPT.0000000000000119)
2015
- Dawes, H. et al. 2015. Exercise testing and training in people with Huntington's diseas. Clinical Rehabilitation 29(2), pp. 196-206. (10.1177/0269215514540921)
2014
- Quinn, L. et al. 2014. Task-specific training in Huntington disease: a randomized controlled feasibility trial. Physical Therapy 94(11), pp. 1555-1568. (10.2522/ptj.20140123)
- Collett, J. et al. 2014. Insights into gait disorders: walking variability using phase plot analysis, Huntington's Disease. Gait and Posture 40(4), pp. 694-700. (10.1016/j.gaitpost.2014.08.001)
- Jones, K., Hamana, K., Quinn, L., Rosser, A. and Busse, M. 2014. Physiotherapy task orientated approach: A case report. Journal of neurology, neurosurgery and psychiatry 85(1), article number: A68. (10.1136/jnnp-2014-309032.192)
- Busse, M. et al. 2014. Supporting physical activity engagement in people with Huntington's disease (ENGAGE-HD): study protocol for a randomized controlled feasibility trial. Trials 15(1), article number: 487. (10.1186/1745-6215-15-487)
2013
- Busse, M. et al. 2013. A randomized feasibility study of a 12-week community-based exercise program for people with Huntington's Disease. Journal of Neurologic Physical Therapy 37(4), pp. 149-158., article number: 1557-0576/13/3704-0149. (10.1097/NPT.0000000000000016)
- Khalil, H., Quinn, L., Van Deursen, R. W. M., Dawes, H., Playle, R. A., Rosser, A. E. and Busse, M. 2013. What effect does a structured home-based exercise programme have on people with Huntington's disease? A randomized, controlled pilot study. Clinical Rehabilitation 27(7), pp. 646-658. (10.1177/0269215512473762)
- Quinn, L. et al. 2013. Reliability and minimal detectable change of physical performance measures in individuals with pre-manifest and manifest Huntington disease. Physical Therapy 93(7), pp. 942-956. (10.2522/ptj.20130032)
- Muratori, L. M., Lamberg, E. M., Quinn, L. and Duff, S. V. 2013. Applying principles of motor learning and control to upper extremity rehabilitation. Journal of Hand Therapy 26(2), pp. 94-103. (10.1016/j.jht.2012.12.007)
- Quinn, L., Busse, M. and Dal Bello-Haas, V. 2013. Management of upper extremity dysfunction in people with Parkinson disease and Huntington disease: facilitating outcomes across the disease lifespan. Journal of Hand Therapy 26(2), pp. 148-155. (10.1016/j.jht.2012.11.001)
- Quinn, L., Busse, M. and Rosser, A. E. 2013. Critical features in the development of exercise-based interventions for people with Huntington's disease. European Neurological Review 8(1), pp. 10-13.
2012
- Quinn, L. and Busse, M. 2012. Development of physiotherapy guidance and treatment-based classifications for people with Huntington's disease. Neurodegenerative Disease Management 2(1), pp. 11-19. (10.2217/nmt.11.67)
- Quinn, L. and Busse, M. 2012. Physiotherapy clinical guidelines for Huntington’s disease. Neurodegenerative Disease Management 2(1), pp. 21-31. (10.2217/nmt.11.86)
- Busse, M. et al. 2012. A randomised feasibility study of a 12-week exercise programme in Huntington’s disease (HD). Journal of Neurology, Neurosurgery & Psychiatry 83, pp. A58-A59. (10.1136/jnnp-2012-303524.182)
- Hamana, K. et al. 2012. Perspectives of participating in a 12-week exercise programme for people with early -mid stage Huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 83(S. 1), pp. A59. (10.1136/jnnp-2012-303524.183)
- Khalil, H., Quinn, L., Van Deursen, R. W. M., Martin, R., Rosser, A. E. and Busse, M. 2012. Adherence to use of a home-based exercise DVD in people with Huntington Disease: participants' perspectives. Physical Therapy 92(1), pp. 69-82. (10.2522/ptj.20100438)
- Busse, M. et al. 2012. Q12 A randomised feasibility study of a 12-week exercise programme in Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83(S1), pp. A58-A59. (10.1136/jnnp-2012-303524.182)
- Hamana, K. et al. 2012. Q13 Perspectives of participating in a 12-week exercise programme for people with early -mid stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.183)
- Khalil, H., Quinn, L., Van Deursen, R. W. M., Dawes, H., Playle, R., Rosser, A. E. and Busse, M. 2012. Q15 A pilot study of an exercise intervention to improve motor function in people with Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.185)
- Jones, K. et al. 2012. Q14 Sub maximal exercise testing in people with early stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.184)
- Busse, M., Khalil, H., Quinn, L., Brooks, S. P. and Rosser, A. E. 2012. Practice, progress and future directions for physical therapies in Huntington's Disease. Journal of Huntington's Disease 1(2), pp. 175-185. (10.3233/JHD-120025)
- Jones, K. et al. 2012. Sub maximal exercise testing in people with early stage Huntington’s Disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S. 1), article number: A59. (10.1136/jnnp-2012-303524.184)
2011
- Busse, M., Quinn, L. and Quarrell, O. 2011. Huntington's disease. In: Stokes, M. and Stack, E. eds. Physical Management for Neurological Conditions 3rd ed. Elsevier, pp. 141-162.
2010
- Quinn, L., Busse, M., Khalil, H., Richardson, S., Rosser, A. E. and Morris, H. R. 2010. Client and therapist views on exercise programmes for early-mid stage Parkinson's disease and Huntington's disease. Disability & Rehabilitation 32(11), pp. 917-928. (10.3109/09638280903362712)
- Quinn, L. and Gordon, J. 2010. Documentation for rehabilitation: a guide to clinical decision making (2nd ed.). Maryland Heights, MO: W.B. Saunders.
2009
- McConlogue, A. and Quinn, L. 2009. Analysis of physical therapy goals in a school-based setting: a pilot study. Physical & Occupational Therapy in Pediatrics 29(2), pp. 154-169. (10.1080/01942630902787244)
- Farrell, A., O'Sullivan, C. and Quinn, L. 2009. Parent perspectives on early childhood assessment: a focus group inquiry. Early Childhood Services - An International Journal of Effectiveness 3(1)
2008
- Busse, M., Khalil, H., Quinn, L. and Rosser, A. E. 2008. Physical therapy intervention for people with Huntington disease. Physical Therapy 88(7), pp. 820-31. (10.2522/ptj.20070346)
2007
- Quinn, L. and Dalbello-Haas, V. 2007. Progressive central nervous system disorders. In: Cameron, M. H. and Monroe, L. G. eds. Physical Rehabilitation - Evidence-Based Examination, Evaluation, and Intervention. St. Louis, MO: W.B. Saunders, pp. 436-472.
2005
- Rao, A. K., Quinn, L. and Marder, K. S. 2005. Reliability of spatiotemporal gait outcome measures in Huntington's disease. Movement Disorders 20(8), pp. 1033-1037. (10.1002/mds.20482)
2002
- Quinn, L. and Rao, A. 2002. Physical Therapy for People with Huntington Disease: Current Perspectives and Case Report. Neurology Report 26(3), pp. 145-153.
- Weiss Coffey, S., Wilder, E., Majsak, M. J., Stolove, R. and Quinn, L. 2002. The Effects of a Progressive Exercise Program With Surface Electromyographic Biofeedback on an Adult With Fecal Incontinence. Physical Therapy 82(8), pp. 798-811.
- Duff, S. and Quinn, L. 2002. Motor learning and motor control. In: Cech, D. and Martin, S. eds. Functional Movement Development: Across the Lifespan (2nd ed.). Philadelphia, PA: W. B. Saunders, pp. 86-117.
2001
- Reilmann, R., Kirsten, F., Quinn, L., Henningsen, H., Marder, K. and Gordon, A. M. 2001. Objective Assessment of progression in Huntington's Disease: a 3 year follow-up study. Neurology 57(5), pp. 920-924.
- Quinn, L., Reilmann, R., Marder, K. and Gordon, A. 2001. Altered movement trajectories and force control during object transport in Huntington's Disease. Movement Disorders 16(3), pp. 469-480. (10.1002/mds.1108)
2000
- Gordon, A. M., Quinn, L., Reilmann, R. and Marder, K. 2000. Coordination of Prehensile Forces during Precision Grip in Huntington's Disease. Experimental Neurology 163(1), pp. 136-148. (10.1006/exnr.2000.7348)
1999
- Louis, E. D., Lee, P., Quinn, L. and Marder, K. 1999. Dystonia in Huntington's Disease: prevalence and clinical characteristics. Movement Disorders 14(1), pp. 95-101. (10.1002/1531-8257(199901)14:1<95::AID-MDS1016>3.0.CO;2-8)
- Gordon, J. and Quinn, L. 1999. Guide to Physical Therapist Practice: A Critical Appraisal. Neurology Report 23(3), pp. 122-128.
1997
- Quinn, L., Hamel, V., Flanagan, J. R., Kaminski, T. and Rubin, A. 1997. Control of multijoint arm movements in Huntington's Disease. Neurorehabilitation and Neural Repair 11(1), pp. 47-60. (10.1177/154596839701100108)
Addysgu
I have previously taught at New York Medical College in Valhalla, NY, where I continue to serve on faculty as Senior Lecturer. As Associate Professor at NYMC from 1996-2003, I coordinated course curriculum related to neurological physiotherapy and paediatrics, and lectured in topics related to neuroscience, motor control and motor learning, functional outcomes and clinical documentation. At Cardiff University, I currently lecture on topics related to the neural basis of motor learning and motor control.
Funded Research Projects
Current
Jacques and Gloria Gossweiller Foundation. Principal Investigator. Exercise Rehabilitation Trial in Huntington's Disease - ExeRT-HD.
NHS/ NISCHR National Institute of Health Research. Move to Exercise. Home-based exercise for people with Huntington's disease.
2012-3
Huntington's Disease Association. TRAIN-HD. Task-related TRAINing in people with Huntington's Disease.
2010-12
National Institute for Social Care and Health Research Health Research Funding Scheme: Can community supported exercise benefit subjective wellbeing, physical activity levels and abilities in people with Huntington's disease? A randomised feasibility study and process evaluation - COMMET-HD.
2009-12
European Huntington's Disease Network. Reliability and minimal detectable change of measures of participation, functional activities and impairments in individuals with Huntington's disease.
2007-2008
Chief Medical Officer for Wales Research Budget. Development and evaluation of a DVD resource for people with a neurodegenerative disease who may be at risk of falls.