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I am a clinician (Endocrinologist) and I awarded a PhD in molecular endocrinology last June 2016: I have been trained in both clinical and basic research, with particular focus on thyroid diseases. I have also had exposure to undergraduate teaching, in particular as a facilitator for medical students (Year 1-2) in case-based learning lessons (C21 programme). I have also been involved in UG medic assessments. My long-term goal for my scientific career is to become an independent investigator at a leading academic institution, expert in the field of thyroid autoimmunity.
Bywgraffiad
CAREER OVERVIEW:
- Apr 2014 – Present: Clinical Research Fellow, Division of Infection & Immunity, School of Medicine, Cardiff University, UK
- May 2013 – Mar 2014: Research Associate, IMEM, School of Medicine, Cardiff University, UK
- Mar 2008 – Apr 2013: Trainee in Endocrinology and Metabolism, University Hospital of Pisa, Italy
EDUCATION AND QUALIFICATIONS:
- Jun 2016: PhD (Molecular Endocrinology), School of Medicine, Cardiff University, UK.
- Jan 2015: Postgraduate Certificate in Biomedical Research (PGCert) with distinction (research skills & environment, data analysis, biomedical laboratory techniques), Cardiff University, UK
- Jul 2013: Full specialist registration in Endocrinology and Diabetes Mellitus with license to practice, UK General Medical Council
- Apr 2013: Specialist Certificate in Endocrinology and Metabolism, School of Medicine, University Hospital of Pisa, Italy: highest mark (110/110) summa cum laude
- Feb 2008: Italian Full License to Practise.
- Jul 2007: Degree in Medicine and Surgery (MBBS equivalent), School of Medicine, University of Pisa, Italy: highest mark (110/110) summa cum laude and additional distinction ("dignità di stampa della tesi”) for very high final grade point average
Anrhydeddau a Dyfarniadau
FELLOWSHIPS AND GRANTS
- Jan 2014 – Dec 2014 PI on 2013 Tenovus Innovation Grant (Tenovus Cancer Care, Wales, UK). Thyroid autoimmunity (TPOAb) as a biomarker of outcome in women with breast cancer - large scale study from the TACT trial.
- May 2011 – Feb 2012 PI on grant 3E Program Exchange in Endocrinology Expertise – 2010 (UEMS). TPO and NIS expression as putative antigens in patients with breast cancer and thyroid autoimmunity.
PRIZES AND AWARDS
- Oct 2015: ETA Travel Award Grant at the 15th ITC 2015 (18th-23rd Oct), Orlando, Florida, USA and Finalist of the ITC 2015 Trainee Poster Contest
- Sep 2014: ETA Travel Award Grant at the ETA 2014 (6th-10th Sep), Santiago de Compostela, Spain
- May 2012: ESE Basic Science Meeting Grant at the ICE/ECE 2012 (5th–9th May), Florence, Italy
- Oct 2011: Winner of the Poster Prize at the I National Meeting of Oncological Endocrinology, Rome, Italy
- Dec 2010: Oral Communication Prize at the XXVIII Giornate Italiane della Tiroide (GIT), Campobasso, Italy
Aelodaethau proffesiynol
- Member of the British Society for Immunology (BSI)
- Member of the Society for Endocrinology (SfE)
- Member of the British Thyroid Association (BTA)
- Member of the European Society of Endocrinology (ESE)
- Member of the European Thyroid Association (ETA)
Ymrwymiadau siarad cyhoeddus
- 2015: 15th International Thyroid Congress, Lake Buena Vista Florida USA
- 2011: 35° Annual Meeting of European Thyroid Association (ETA), Kraków (Poland)
- 2009: 8th European Congress on Menopause (EMAS), London, UK
Cyhoeddiadau
2023
- Dayan, C. M. et al. 2023. Endocrine and multiple sclerosis outcomes in patients with autoimmune thyroid events in the alemtuzumab CARE-MS studies. Multiple Sclerosis Journal - Experimental, Translational and Clinical 9, article number: 1. (10.1177/20552173221142741)
2022
- Campi, I. et al. 2022. Therapy with different dose regimens of rituximab in patients with active moderate-to-severe Graves' Orbitopathy. Frontiers in Endocrinology 12, article number: 790246. (10.3389/fendo.2021.790246)
2021
- Draman, M. S. et al. 2021. Expression of endogenous putative TSH binding protein in orbit. Current Issues in Molecular Biology 43(3), pp. 1794-1804. (10.3390/cimb43030126)
2020
- Muller, I. et al. 2020. SARS-CoV-2-related atypical thyroiditis. Lancet Diabetes and Endocrinology 8(9), pp. 739-741. (10.1016/S2213-8587(20)30266-7)
- Muller, I. and Barrett-Lee, P. J. 2020. The antigenic link between thyroid autoimmunity and breast cancer. Seminars in Cancer Biology 64, pp. 122-134. (10.1016/j.semcancer.2019.05.013)
- Muller, I. et al. 2020. CATS II long-term anthropometric and metabolic effects of maternal sub-optimal thyroid function in offspring and mothers. Journal of Clinical Endocrinology and Metabolism 105(7), article number: dgaa129. (10.1210/clinem/dgaa129)
- Taylor, P. N., Muller, I., Nana, M., Velasco, I. and Lazarus, J. H. 2020. Indications for treatment of subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy. Best Practice and Research: Clinical Endocrinology and Metabolism 34(4), article number: 101436. (10.1016/j.beem.2020.101436)
- Hales, C. et al. 2020. Controlled antenatal thyroid screening II: Effect of treating maternal sub-optimal thyroid function on child behaviour. Journal of Clinical Endocrinology and Metabolism 105(3), article number: dgz098. (10.1210/clinem/dgz098)
2019
- Taylor, P. N. et al. 2019. New insights into the pathogenesis and nonsurgical management of Graves orbitopathy. Nature Reviews Endocrinology 16(2), pp. 104-116. (10.1038/s41574-019-0305-4)
- Taylor, P. N., Eligar, V., Muller, I., Scholz, A., Dayan, C. and Okosieme, O. 2019. Combination thyroid hormone replacement; knowns and unknowns. Frontiers in Endocrinology 10, article number: 706. (10.3389/fendo.2019.00706)
- Muller, I., Moran, C., Lecumberri, B., Decallonne, B., Robertson, N., Jones, J. and Dayan, C. 2019. 2019 European thyroid association guidelines on the management of thyroid dysfunction following immune reconstitution therapy. European Thyroid Journal 8(4), pp. 173-185. (10.1159/000500881)
- Pearce, S. H. et al. 2019. Antigen-specific immunotherapy with thyrotropin receptor peptides in Graves' hyperthyroidism: a phase I study. Thyroid 29(7), pp. 1003-1011. (10.1089/thy.2019.0036)
- Wilson, N. et al. 2019. Role of hyaluronan in human adipogenesis: Evidence from in-vitro and in-vivo studies. International Journal of Molecular Sciences 20(11), article number: 2675. (10.3390/ijms20112675)
- Draman, M. S. et al. 2019. Prostaglandin F2-alpha eye drops (bimatoprost) in Graves' orbitopathy: a randomized controlled double-masked crossover trial (BIMA Trial). Thyroid Journal Program 29(4), pp. 563-572. (10.1089/thy.2018.0506)
- Taylor, P. N., Razvi, S., Muller, I., Wass, J., Dayan, C. M., Chatterjee, K. and Boelaert, K. 2019. Liothyronine cost and prescriptions in England. Lancet Diabetes and Endocrinology 7(1), pp. 11-12. (10.1016/S2213-8587(18)30334-6)
2018
- Muller, I. et al. 2018. Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years.. Thyroid 28(12), pp. 1682-1693. (10.1089/thy.2018.0232)
- Muller, I. and Premawardhana, L. 2018. Hypercalcaemia with undetectable parathormone levels. BMJ 363(8175), article number: k4074. (10.1136/bmj.k4074)
- Muller, I., Taylor, P. and Lazarus, J. 2018. Thyroid function in pregnancy. Annals of Thyroid (10.21037/aot.2018.10.05)
- Pariani, N. et al. 2018. Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features. Journal of Clinical Endocrinology & Metabolism 108(8), pp. 3010-3018. (10.1210/jc.2018-00359)
- Zhang, L. et al. 2018. Combining micro-RNA and protein sequencing to detect robust biomarkers for Graves' disease and orbitopathy. Scientific Reports 8(1), article number: 8386. (10.1038/s41598-018-26700-1)
- Hales, C. et al. 2018. Controlled antenatal thyroid screening II: effect of treating maternal sub-optimal thyroid function on child cognition. Journal of Clinical Endocrinology and Metabolism 103(4), pp. 1583-1591. (10.1210/jc.2017-02378)
2017
- Muller, I. et al. 2017. TPOAb and thyroid function are not associated with breast cancer outcome: evidence from a large-scale study using data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). European Thyroid Journal 6(4), pp. 197-207. (10.1159/000460246)
2016
- Muller, I., Zhang, L., Giani, C., Dayan, C. M., Ludgate, M. E. and Grennan-Jones, F. 2016. The sodium iodide symporter is unlikely to be a thyroid/breast shared antigen. Journal of Endocrinological Investigation 39(3), pp. 323-331. (10.1007/s40618-015-0368-6)
- Muller, I. 2016. Autoimmune responses to thyroid/breast shared antigens to develop novel and specific therapies and diagnostics. PhD Thesis, Cardiff University.
2014
- Muller, I. and Rees, D. A. 2014. Melasma and endocrine disorders. Journal of Pigmentary Disorders S1, article number: 1. (10.4172/2376-0427.1000S1001)
- Muller, I. et al. 2014. Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?. International Journal of Cancer 134(7), pp. 1706-1714. (10.1002/ijc.28493)
- Hales, C. et al. 2014. The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol. BMC Endocrine Disorders 14(1), article number: 95. (10.1186/1472-6823-14-95)
2007
- Fiore, E. et al. 2007. Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer. Journal of Endocrinological Investigation 30(9), pp. 734-738. (10.1007/BF03350810)