Dr Robert Jenkins

2024

• Czubala, M. A. et al. 2024. Tissue-specific transcriptional programming of macrophages controls the microRNA transcriptome targeting multiple functional pathways. Journal of Biological Chemistry, article number: 107244. (10.1016/j.jbc.2024.107244)
• Gurney, M. et al. 2024. Lentiviral vector preparation for efficient gene and microRNA modulation of peritoneal cavity tissue-resident macrophages in vivo in mice. Journal of Visualized Experiments 204, article number: e64926. (10.3791/64926)

2022

• Millrine, D., Jenkins, R. H., Hughes, S. T. O. and Jones, S. A. 2022. Making sense of IL-6 signalling cues in pathophysiology. FEBS Letters 596(5), pp. 567-588. (10.1002/1873-3468.14201)

2021

• Jenkins, R. H., Hughes, S. T., Cardus Figueras, A. and Jones, S. A. 2021. Unravelling the broader complexity of IL-6 involvement in health and disease. Cytokine 148, article number: 155684. (10.1016/j.cyto.2021.155684)
• Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11(1), article number: 16499. (10.1038/s41598-021-94984-x)
• Khalid, U. et al. 2021. Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. Scientific Reports 11(1), article number: 9862. (10.1038/s41598-021-89195-3)

2020

• Midgley, A. C. et al. 2020. Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions. American Journal of Pathology 190(6), pp. 1236-1255. (10.1016/j.ajpath.2020.02.012)
• Ipseiz, N., Czubala, M. A., Bart, V. M., Davies, L. C., Jenkins, R. H., Brennan, P. and Taylor, P. R. 2020. Effective in vivo gene modification in mouse tissue-resident peritoneal macrophages by intraperitoneal delivery of lentiviral vectors. Molecular Therapy - Methods and Clinical Development 16, pp. 21-31. (10.1016/j.omtm.2019.10.004)

2019

• Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
• Khalid, U. et al. 2019. A urinary microRNA panel that is an early predictive biomarker of delayed graft function following kidney transplant. Scientific Reports 9, article number: 3584. (10.1038/s41598-019-38642-3)

2018

• Beltrami, C. et al. 2018. Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. American Journal of Pathology 188(9), pp. 1982-1992. (10.1016/j.ajpath.2018.06.006)

2017

• Lopez-Anton, M. et al. 2017. miR-21 promotes fibrogenesis in peritoneal dialysis. American Journal of Pathology 187(7), pp. 1537-1550. (10.1016/j.ajpath.2017.03.007)

2016

• Khalid, U., Ablorsu, E., Szabo, L., Jenkins, R. H., Bowen, T., Chavez, R. and Fraser, D. J. 2016. MicroRNA-21 (miR-21) expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation. Clinical Transplantation 30(2), pp. 99-104. (10.1111/ctr.12679)
• Chavez, R., Fraser, D. J., Bowen, T., Jenkins, R. H., Nesargikar, P., Pino-Chavez, G. and Khalid, U. 2016. Kidney ischaemia reperfusion injury in the rat: the EGTI scoring system as a valid and reliable tool for histological assessment. Journal of Histology and Histopathology 3, article number: 1. (10.7243/2055-091X-3-1)

2015

• Nesargikar, P., Spiller, B., Jenkins, R., Khalid, U., Fraser, D. and Chavez, R. 2015. Modulation of leukocytes and endothelium by anti-thymocyte globulin confers protection against renal ischemia reperfusion injury in rats. Transplant International 28(54), pp. 61., article number: O158. (10.1111/tri.12700)
• Khalid, U., Jenkins, R. H., Simpson, K., Ablorsu, E., Bowen, T., Fraser, D. J. and Chavez, R. 2015. Urinary microrna expression predicts delayed graft function in kidney transplantation [Abstract]. Transplant International 28(S4), pp. 367-367. (10.1111/tri.12702)
• Nesargikar, P., Pino-Chavez, G., Spiller, O. B., Fraser, D. J., Jenkins, R. H. and Chavez, R. 2015. Single dose sCR1 attenuates renal ischemia reperfusion injury in rats despite early reconstitution of the complement system [Abstract]. Transplant International 28(S4), pp. 62-62. (10.1111/tri.12700)
• Beltrami, C. et al. 2015. Stabilization of urinary microRNAs by association with exosomes and argonaute 2 protein. Non-Coding RNA 1(2), pp. 151-166. (10.3390/ncrna1020151)
• Midgley, A. C., Druggal, L., Jenkins, R., Hascall, V., Steadman, R., Phillips, A. O. and Meran, S. 2015. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. Journal of Biological Chemistry 290(18), pp. 11218-11234. (10.1074/jbc.M114.625939)
• Jenkins, R., Liao, C., Wallace, L., Bowen, T., Topley, N., Taylor, P. and Fraser, D. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30(iii262) (10.1093/ndt/gfv180.15)

2014

• Khalid, U., Bowen, T., Fraser, D. and Jenkins, R. 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42(4), pp. 1219-1223. (10.1042/BST20140093)
• Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184(4), pp. 996-1009. (10.1016/j.ajpath.2013.12.028)

2013

• Bowen, T., Jenkins, R. H. and Fraser, D. J. 2013. MicroRNAs, transforming growth factor Beta-1, and tissue fibrosis. The Journal of Pathology 229(2), pp. 274-285. (10.1002/path.4119)

2012

• Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding. Biochemical Journal 443(2), pp. 407-416. (10.1042/BJ20111861)
• Jenkins, R. H., Martin, J., Phillips, A. O., Bowen, T. and Fraser, D. J. 2012. Pleiotropy of microRNA-192 in the kidney. Biochemical Society Transactions 40(4), pp. 762-767. (10.1042/BST20120085)

2011

• Martin, J., Jenkins, R. H., Bennagi, R., Krupa, A., Phillips, A. O., Bowen, T. and Fraser, D. J. 2011. Post-transcriptional regulation of transforming growth factor beta-1 by microrna-744. PLoS ONE 6(10), article number: e25044. (10.1371/journal.pone.0025044)
• Jenkins, R. H. and Fraser, D. J. 2011. BMP-6 emerges as a potential major regulator of fibrosis in the kidney [Commentary]. American Journal of Pathology 178(3), pp. 964-965. (10.1016/j.ajpath.2010.12.010)

2010

• Jenkins, R. H., Bennagi, R., Martin, J., Phillips, A. O., Redman, J. E. and Fraser, D. J. 2010. A conserved stem loop motif in the 5'Untranslated Region regulates transforming growth factor-β1 translation. PLoS One 5(8), article number: e12283. (10.1371/journal.pone.0012283)
• Krupa, A., Jenkins, R. H., Luo, D. D., Lewis, A. G., Phillips, A. O. and Fraser, D. J. 2010. Loss of microRNA-192 promotes fibrogenesis in diabetic nephropathy. Journal of the American Society of Nephrology 21(3), pp. 438-447. (10.1681/ASN.2009050530)

2009

• Webber, J. P., Jenkins, R. H., Meran, S., Phillips, A. O. and Steadman, R. 2009. Modulation of TGFβ1-dependent myofibroblast differentiation by hyaluronan. American Journal of Pathology 175(1), pp. 148-160. (10.2353/ajpath.2009.080837)

2007

• Kastner, S., Thomas, G. J., Jenkins, R. H., Davies, M. and Steadman, R. 2007. Hyaluronan induces the selective accumulation of matrix- and cell-associated proteoglycans by mesangial cells. American Journal of Pathology 171, pp. 1811-1821. (10.2353/ajpath.2007.070085)

2004

• Jenkins, R. H., Thomas, G. J., Williams, J. D. and Steadman, R. 2004. Myofibroblastic differentiation leads to hyaluronan accumulation through reduced hyaluronan turnover. The Journal of Biological Chemistry 279(40), pp. 41453-41460. (10.1074/jbc.M401678200)