Miss Georgina Mason
Myfyriwr ymchwil, Infection & Immunity, Yr Ysgol Meddygaeth
Mae'r cynnwys hwn ar gael yn Saesneg yn unig.
Trosolwg
Ymchil
Traethawd ymchwil
Development of immune-modulators for preventing immune suppression by cancer-associated LAG3+CD4+ T-cells
Cyhoeddiadau
2023
- Chen, Y. et al. 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42(8), article number: 112827. (10.1016/j.celrep.2023.112827)
2021
- Burnell, S. E. A., Capitani, L., MacLachlan, B. J., Mason, G. H., Gallimore, A. M. and Godkin, A. 2021. Seven mysteries of LAG-3: a multi-faceted immune receptor of increasing complexity. Immunotherapy Advances 2(1), article number: ltab025. (10.1093/immadv/ltab025)
- Teijeira Crespo, A. et al. 2021. Pouring petrol on the flames: using oncolytic virotherapies to enhance tumour immunogenicity. Immunology 163(4), pp. 389-398. (10.1111/imm.13323)
- MacLachlan, B. J., Mason, G. H., Greenshields Watson, A., Triebel, F., Gallimore, A., Cole, D. K. and Godkin, A. 2021. Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor. European Journal of Immunology 51(2), pp. 331-341. (10.1002/eji.202048753)
2020
- Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
2019
- MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
- Mason, G. 2019. Small molecule disruption of the LAG-3/HLA-II interaction: implications for modulating T-cell responses. PhD Thesis, Cardiff University.
2017
- MacLachlan, B. J. et al. 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments(120), article number: e54991. (10.3791/54991)