Skip to content
Skip to navigation menu

 

Adenosine receptors in breast cancer

Introduction

Breast cancer is mainly treated by surgery followed by adjuvant drug therapy. However, resistance to the drugs used, such as tamoxifen, is a major clinical problem. There is, therefore, much interest in the development of novel therapies. Adenosine is known to prevent the growth of a number of different cancer cells and consequently has therapeutic potential.


Aims of Project

We have previously shown that increasing extracellular and intracellular adenosine levels by a variety of pharmacological agents inhibited the proliferation of oestrogen receptor-positive, tamoxifen-sensitive and -resistant breast cancer cells. Importantly, the tamoxifen-resistant cells were more sensitive to the effects of adenosine, raising the possibility that manipulations of adenosine levels could be useful as a therapy for this disease. I have a new project which will aim to extend and enhance these studies, providing important information on clinically used anti-cancer agents which increase adenosine levels and investigating the underlying mechanisms of action of these agents.