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Prof Jean-Yves Maillard  -  BSc PhD


Career Profile

After completing a PhD on “the mechanisms of action biocides against viruses” at the Welsh School of Pharmacy, and a brief spell as an officer in the French Health Corp (St Anne’ hospital, Toulon, France), I was fortunate to be appointed as a Lecturer at the Welsh School of Pharmacy at Cardiff. In 2001, I accepted a position of Senior Lecturer at the School of Pharmacy and Biomolecular Sciences at Brighton, before returning to Cardiff in 2004. My return to Cardiff enabled me to redevelop Pharmaceutical Microbiology Research within the Welsh School of Pharmacy. I was made Professor of Pharmaceutical Microbiology in July 2013.

 

Dr J-Y Maillard receiving the 2012 AD Russell Memorial lecture prize from the SfAM President Prof M Adams

Dr J-Y Maillard receiving the 2012 AD Russell Memorial lecture prize from the SfAM President Prof M Adams

Awards & prizes 

AD Russell Memorial Lecture Award (2012)
This lecture award is given at the annual January Conference by a microbiologist who has made substantial contribution to the field of Applied Microbiology. This Memorial Lecture was instituted in 2005 to commemorate the life and works of the late A. Denver Russell (1936-2004), Professor of Pharmaceutical Microbiology and a long-time member of the Society.

AD Russell Memorial Teleclass Lecture Award (2012)
This lecture award is given annually by a microbiologist who has made substantial contribution to the field of Applied Microbiology. This Memorial Teleclass Lecture Award was instituted in 2011 to commemorate the life and works of the late A. Denver Russell (1936-2004), Professor of Pharmaceutical Microbiology and contributor to the Teleclass program.

Royal Pharmaceutical Society of Great Britain Academic Excellence Award, joint recipient (2007)

British Pharmaceutical Conference Science Medal (2004)
An award given under the auspices of the Royal Pharmaceutical Society of Great Britain and the Academy of Pharmaceutical Sciences for a scientist working in a pharmaceutical or allied discipline in industry or academia, who has a proven record of independent research and whose published work shows outstanding promise. Invitations for this award are invited world-wide.  

W.H. Pierce Memorial prize (2004)
This prestigious prize is awarded each year at the annual Summer Conference to the young microbiologist (under 40) who has made a substantial contribution to the science of applied microbiology.

Federation of European Microbiology Societies (FEMS) Research Fellowship (1998)
FEMS Research Fellowships are meant to assist young European scientists in pursuing research up to 3 months in a European country different from that in which she/he lives.

 

Research Interest

My research focuses on antimicrobial biocides, an area of continuing global importance due in part to the rise in hospital acquired infections (HAIs) and emerging microbial resistance.  

 

Scientific & Professional Service 
 

Membership of learned bodies

  • Member of the Society for Applied Microbiology 
  • Member of the Healthcare Infection Society 

External service to public/professional bodies 

  • Member of the CH/216/0-/01 Antimicrobial Hard Surfaces group (2012-)
  • Member of the AHRAI/HIS Task force on sporicidal disinfectants (2010-)
  • External examiner of Microbiology, Biotechnology, and Food Science & Microbiology degrees at the University of Surrey (2012-)
  • External examiner of the Master of Pharmacy in Pharmaceutical Sciences at Manchester University (2005-2010)
  • External scientific expert of the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR – European Commission) (2007-2010)
  • External scientific expert of the Scientific Committee on Consumer Safety (SCCS – European Commission) (2009-2010)
  • Hearing scientific expert of the European Food Safety Authority (EFSA) (2009-2010)
  • Chief Editor, Letters in Applied Microbiology (2004-)
  • Editorial board member, Journal of Antimicrobial Chemotherapy (2004-)
  • Editorial Board member, letters in Applied Microbiology, Journal of Applied Microbiology (2000-)

Professional lectures

  • 2012 TELECLASS (New York, USA): AD Russell memorial Teleclass Lecture recipient: Innate Resistance to Sporicides and Potential Failure to Decontaminate
  • 2011 TELECLASS (New York, USA): Host of the AD Russell memorial Webinar: The Spaulding Classification, Disinfection and Sterilization:
    Is it Time to Reconsider? Given by Dr G McDonnell
  • 2007 TELECLASS (New York, USA): Bacterial resistance to biocides in the healthcare environment: is it of any real significance?
  • 2007 CCFRA (Campden, UK); Health and Safety Executive course: Mechanisms of action of biocides
  • 2007 CCFRA (Campden, UK); Health and Safety Executive course: Bacterial resistance to biocides in the healthcare environment 
  • 2005 TELECLASS (New York, USA): Factors Influencing Biocide Effectiveness
  • 2005-2006 European Continuing Education College (ECEC; London, UK): Preservatives

Conference organiser

  • SfAM (2012) Microbial resistance to antibiotics and biocides (Edinburgh, UK)
  • SfAM (2010) Advances in biocide development (London, UK)
  • ASM (2004) Biocide and antibiotic resistance in bacteria: an update; New Orleans, USA.
  • ASM (2004) Biocide and antibiotic resistance in bacteria: policies and issues: where do we go from here? New Orleans, USA.
  • RPSGB (2002) Current problems in infection controls; Manchester (UK)
  • SfAM (2001) Antibiotic and biocide resistance in bacteria: Perception and realities for prevention and treatment of infection; Swansea, Wales
  • SfAM (1999) Isolation and inactivation of difficult micro-organisms; London, UK
  • SfAM (1998) Revival of injured micro-organisms after antimicrobial treatments; London, UK
  • SfAM (1998) Novel approaches to chemotherapeutic agents; London, UK
  • SfAM (1997) Disinfection methods, efficacy, and legislation; London, UK
  • SfAM (1996) Viricides; Bradford, UK 

 

Other Information 

Invited Keynote Speaker by conference organising committee

  • 2014 National CHICA-Canada conference, Halifax (Canada): Bacterial Resistance to Microbicides: Is our Future Futile?
  • 2013 AIPI 2013, Montreal (Canada): Bacterial Resistance to Microbicides: Is our Future Futile?
    2013 MAC-EPID symposium, Ann Harbor (USA): Microbicide resistance in Healthcare settings: a cause for concerns?
  • 2013 INFORMA 2013, Berlin (Germany): Development of Efficacy Tests for the Decontamination of Environmental Surfaces.
  • 2013 INFORMA 2013, Berlin (Germany): Evening Seminar: Novel delivery systems for biocides.
    2012 ICAR 2012, Lisbon: Microbicide usage in consumer products and emerging antimicrobial resistance – a position document
  • 2012 Healthcare Infection Society, Liverpool: Efficacy and limitations of sporicidal wipes: the need for an appropriate test.
  • 2012 Community and Hospital Infection Control Association (CHICA)-Canada, Kingston:Biocides: usage, abuse and microbial resistance
  • 2012 IBBS meeting, Winchester on Antimicrobial Strategies for Biofilm Control: Antimicrobial wipes for surface decontamination: usage, efficacy, potential and drawbacks.
  • 2012 Society for Applied Microbiology Summer conference, Edinburgh: Bacterial resistance and cross-resistance: overrated story or real concern?
  • 2012 Workshop (Unilever, UK): Mechanisms of bacterial resistance and cross-resistance to biocides- an overview
  • 2012 Teleclass: AD Russell Memorial 2012 Teleclass: Innate Resistance to Sporicides and Potential Failure to Decontaminate
  • 2012 BSI workshop, London: The need for new surface efficacy test
  • 2012 Society for Applied Microbiology, London: AD Russell Memorial lecture: Biocides against emerging and new pathogens: a cause for concern?
  • Société Française de Microbiologie; Programme Colloque Antiseptiques et Désinfectants (2011) Biocidal products: diversity, label claim, efficacy test and activity - abusing the system (a UK prospective)", Toulouse, France
  • Infection Prevention Society (2011): “Kill Clostridium difficile spores!”: does it really do what it says on the can? Bournemouth, UK
  • Infection Prevention Society, Welsh Branch (2011): Sporicides Disinfectants / Wipes do they really work? Cardiff, UK
  • INFORMA; Sterilization of Medical Devices (2011): Chemical sterilization for heat-sensitive medical devices, London, UK.
  • Infection Prevention Society, London Branch (2011): Sporicidal disinfectants: do they work? London, UK
  • Central Sterilizing Club (2010): What do we need and what are the issues? London, UK
  • Lead Infection Control Nurse meeting (2010): Control of Clostridium difficile on surfaces: do sporicides work? Abergavenny (Wales)
  • Society for Industrial Microbiology (2010): Mode-of-action and resistance to oxidizing agents: recent advances. Washington DC (USA)
  • Public Service Events (2010): Infection Control conference Infection: Control Does surface disinfection work? London, UK
  • Infection Prevention Society (2010): Control of Clostridium difficile on surfaces: do sporicides work? Bournemouth, UK
  • VLA /BSAC AMR Meeting (2010):  Biocides and biocide resistance– an overview. Warwick, UK
  • SfAM Winter conference (2010): Bacterial mechanisms of resistance to biocides: significance in practice. London, UK
  • ARHAI and the Hospital Infection Society Workshop on Sporicides in the Healthcare Setting (2009): Incidence of sporicide resistance and risk to the population. London, UK
  • Abildgaard Symposium on the response of bacterial pathogens to biocides (2009), Biocides, bacterial resistance and multidrug resistance: from laboratory investigations to in situ reality. Copenhagen, DK
  • Royal Pharmaceutical Society of Great Britain (2009): Use of antimicrobial biocides in biomaterials, advantages, risks and unknown. London, UK
  • Sheffield Teaching Hospital/Hospital infection Society (2009): What is the role of disinfectants in infection control? Sheffield, UK
  • School of Pharmacy, University of Nancy (2009): Mechanisms of bacterial resistance to antiseptics. Nancy, France
  • CCFRA (2008): Cleaning and Disinfection Symposium I: Mechanisms of microbial resistance to biocides. Campden, UK
  • INTERTECH PIRA (2008): Bacterial resistance to microbicides: myth or reality? Tampa, USA
  • INTERTECH PIRA (2007): The Quest of Antimicrobial efficacy. Orlando, USA
  • Society for Applied Microbiology (2007): Biocide action and resistance: from laboratory to practice. Birmingham, UK
  • CEA/Steris (2006), Mechanisms of action of peroxygens. Paris, France
  • 6th International conference of the Hospital Infection Society (2006): Bacterial resistance to biocides in the healthcare environment: should it be of a genuine concern? Amsterdam, The Netherlands
  • Pacifichem (2005), Efficacy and mycobactericidal action of aldehydes: a quantitative structure-activity relationship analysis. Hawaii, USA
  • CITER (2005) Cardiff: Evaluating antimicrobial efficacy against biofilms. Cardiff, Wales
  • Biosciences Workshop (2005): The use of biocidal agents: Enhancing the control of microbial infection and spoilage. Cardiff, Wales
  • CTFA (2005): A rapid method for preservative efficacy testing. Newark, USA

Efficacy Test Service

We have developed practical reproducible efficacy test protocols that mimics the real environment. These tests have helped manufacturers to understand better the efficacy of their biocidal products in the real world and provided important documentation on activity where standard efficacy tests are not available.

 

The 3-Stage Test for measuring the efficacy of antimicrobial wipes (disinfectant and sporicidal wipes) has been used by manufacturers to measure the activity of their products against key pathogens such as spore of Clostridium difficile and methicillin-resistant Staphylococcus aureus. For further information see the following peer-reviewed publications:
Siani H et al. Am J Infect Control 2011;39(3): 212-218
Williams GJ et al. Infect Control Hosp Epidemiol 2009;30(6); 570-573
Williams GJ et al. J Hosp Infect 2007; 67(4): 329-335

 

The Ex-Vivo Test for measuring the activity of an antiseptic on skin against microbial pathogens. This test which is based on the used of excised pig skin, provide manufacturers with an understanding of the efficacy of their product against key pathogens such as methicillin-resistant Staphylococcus aureus, Acinetobacter baumanii. For further information see the following peer-reviewed publications:
Messager S et al. J Appl Microbiol 2004; 97(6): 1149-1160
Messager S et al. J Hosp Infect  2004; 58: 115-121.

 

In collaboration with the HIS/ARHAI, we are currently finalizing the development of a Sporicidal Suspension Test for the Use of Clostridium difficile. This test will offer manufacturer of sporicidal product an appropriate protocol for claims make against spores of C. difficile. For further information refers to the editorial: http://www.sciencedirect.com/science/article/pii/S0195670110005013

 

Forthcoming test: Antimicrobial Surface Test: we are finalizing the development of an antimicrobial test to replace the ISO 22196. Our test is based on the formation of wet or dried microbial inoculum and the deposition of the inoculum on test surfaces. For further information, click here.

 

With the Biocide Product Regulation, manufacturers of biocidal products are required to provide evidence that their product will not cause an increase in biocide resistance in the target micro-organisms. We have validated a Test to Predict the Development of Bacterial Resistance to a Biocide. In essence this test is based on measuring a change in antimicrobial  (both biocide and antibiotic) susceptibility profile before and after biocide exposure. The test is standardised and biocide exposure reflects the condition of usage of the product.

 

We have helped the healthcare industry with specific microbiological test issue by designing specific testing protocols to answer a specific problem. For example of the ad hoc test performed please see the following publications: 
Yusop N et al. J Pharm Pharmacol 2011; 63(2): 164-168
Panousi MN et al. Lett Appl Microbiol 2009; 48: 648-651
Pinto F et al. Lett Appl Microbiol 2009; 48: 379-382.