Welsh School of Pharmacy

Peer Reviewed Articles

Pearton M, Kang SM, Song JM, Anstey AV, Ivory M, Compans RW and  Birchall JC. Changes in human langerhans cells following intradermal injection of influenza virus-like particle vaccines. PLoS One (2010) e12410.

Bains B, Birchall JC, Toon R and Taylor G. In vitro reporter gene transfection via plasmid DNA delivered via metered dose inhaler. J. Pharm. Sci. 99:  (2010) 3089-3099.

Ng KW, Pearton M, Coulman S, Anstey A, Gateley C, Morrissey A, Allender C and Birchall J. Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour. Vaccine 27 (2009) 5948-5955.

Coulman SA, Anstey A, Gateley C, Morrissey A, McLoughlin P, Allender C and Birchall JC. Microneedle mediated delivery of nanoparticles into human skin. Int. J. Pharm. 366 (2009) 190-200.

Haq MI, Smith E, John DN, Kalavala M, Edwards C, Anstey A, Morrissey A and Birchall JC. Clinical administration of microneedles: skin puncture, pain and sensation. Biomed Microdevices 11 (2009) 35-47.

Birchall JC, Jones BE, Morrissey A and Jones BE. A comparison of the puncturing properties of gelatin and hypromellose capsules for use in dry powder inhalers. Drug Dev. Ind. Pharm. 34 (2008) 870-876.

Pearton M, Allender C, Brain K Anstey A, Gateley C, Wilke N, Morrissey A and Birchall JC. Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations. Pharm. Res. 25 (2008) 407-416.

Birchall JC. Pulmonary delivery of nucleic acids. Expert Opin. Drug Deliv. 4 (2007) 575-578.

Brain K, Coulman SA and Birchall JC. Delivering drugs through the skin. Chemist and Druggist 268 (2007) 17-20.

Seville PC, Learoyd TP, Li H-Y, Williamson IJ and Birchall JC. Amino acid modified spray-dried powders with enhanced aerosolisation properties for pulmonary drug delivery. Powder Tech. 178 (2007) 40-50.

Collins E, Birchall JC, Williams JL and Gumbleton M. Nuclear localisation and pDNA condensation in non-viral gene delivery. J. Gene Med. 9 (2007) 265-274.

Birchall, J., Coulman, S., Anstey, A., Gateley, C., Sweetland, H., Gershonowitz, A., Neville, L. & Levin, G. 2006. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation. International Journal of Pharmaceutics 312(1-2), pp. 15-23.

Birchall, J. C. 2006. Microneedle array technology: the time is right but is the science ready? Expert Review of Medical Devices 3(1), pp. 1-4.

Coulman, S., Allender, C. & Birchall, J. 2006. Microneedles and other physical methods for overcoming the stratum corneum barrier for cutaneous gene therapy. Critical Reviews in Therapeutic Drug Carrier Systems 23(3), pp. 205-258.

Li, H. Y. & Birchall, J. 2006. Chitosan-modified dry powder formulations for pulmonary gene delivery. Pharmaceutical Research 23(5), pp. 941-950.

Li, H.-Y. & Birchall, J. C. 2006. The use of chitosan as a dispersibility enhancer in dry powder formulations for pulmonary gene therapy. J. Aerosol Med. 19(1).

Birchall, J., Coulman, S., Pearton, M., Allender, C., Brain, K., Anstey, A., Gateley, C., Wilke, N. & Morrissey, A. 2005. Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles. Journal of Drug Targeting 13(7), pp. 415-421.

Coulman, S. A., Barrow, D., Anstey, A., Gateley, C., Morrissey, A., Wilke, N., Allender, C. & Birchall, J. C. 2005. Microneedle facilitated gene delivery to human skin. British Journal of Dermatology 152(4), pp. 846-846.

Li, H. Y., Seville, P. C., Williamson, I. J. & Birchall, J. C. 2005. The use of absorption enhancers to enhance the dispersibility of spray-dried powders for putmonary gene therapy. Journal of Gene Medicine 7(8), pp. 1035-1043.

Li, H. Y., Seville, P. C., Williamson, I. J. & Birchall, J. C. 2005. The use of amino acids to enhance the aerosolisation of spray-dried powders for pulmonary gene therapy. Journal of Gene Medicine 7(3), pp. 343-353.

Chabri, F., Bouris, K., Jones, T., Barrow, D., Hann, A., Allender, C., Brain, K. & Birchall, J. 2004. Microfabricated silicon microneedles for nonviral cutaneous gene delivery. British Journal of Dermatology 150(5), pp. 869-877.

Li, H. Y., Neill, H., Innocent, R., Seville, P., Williamson, I. & Birchall, J. C. 2003. Enhanced dispersibility and deposition of spray-dried powders for pulmonary gene therapy. Journal of Drug Targeting 11(7), pp. 425-432.

Seville, P. C., Birchall, J. C. & Kellaway, I. W. 2003. Stability, deposition and biological functionality of non-viral gene delivery vectors for pulmonary administration. Journal of Controlled Release 87(1-3), pp. 291-293.

Seville, P. C., Harris, N. C., Juggins, E. C., Young, J. M., Birchall, J. C. & Kellaway, I. W. 2003. Characterisation of non-viral gene delivery vectors for pulmonary administration. Journal of Controlled Release 87(1-3), pp. 288-291.

Seville, P. C., Kellaway, I. W. & Birchall, J. C. 2003. Preparation of dry powder gene delivery systems for pulmonary administration. J. Aerosol Med. 16(1).

Seville, P. C., Kellaway, I. W. & Birchall, J. C. 2002. Preparation of dry powder dispersions for non-viral gene detivery by freeze-drying and spray-drying. Journal of Gene Medicine 4(4), pp. 428-437.

Birchall, J. C., Waterworth, C. A., Luscombe, C., Parkins, D. A. & Gumbleton, M. 2001. Statistical modelling of the formulation variables in non-viral gene delivery systems. Journal of Drug Targeting 9(3), pp. 169-184.

Books & Book Chapters

Birchall JC and Brain KR. Microneedles. In Dermatological and Cosmeceutical Development: Absorption, Efficacy, and Toxicology (Ed. Walters K and &  Roberts M), Taylor & Francis Group,  New York (2009).

Birchall, J. C. 2006. Stratum corneum bi-passed or removed. In: Barry, B. & Touitou, E. eds. Enhancement in Drug Delivery. Florida, USA: CRC Press, pp. 337-352.

Birchall, J. 2004. Cutaneous Gene Delivery. In: M., A. ed. Polymeric Gene Delivery: Principles and Applications. CRC Press.

Abstracts

Pearton, M., Gateley, C., Anstey, A., Wilke, N., Morrissey, A., Allender, C., Brain, K. & Birchall, J. C. 2007. Microneedle facilitated delivery of pDNA to the epidermis. Biochemical Society Transactions (In press).

Birchall, J. 2006. Pulmonary delivery of nucleic acid derived therapies. Journal of Pharmacy and Pharmacology 58, pp. A96-A96.

Birchall, J., Coulman, S., Anstey, A., Gateley, C., Sweetland, H., Gershonowitz, A., Neville, L. & Levin, G. 2006. Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation. International Journal of Pharmaceutics 312(1-2), pp. 15-23.

Birchall, J. C. 2006. Biological and clinical exploitation of microfabricated microneedles. Perspectives in Percutaneous Penetration 10A, p. 107.

Clemo, R., Birchall, J. C. & John, D. N. 2006. Pilot studies on public perception of microneedle technology. Perspectives in Percutaneous Penetration 10A, p. 124.

Clemo, R., John, D. N., Anstey, A. & Birchall, J. C. 2006. Microfabricated microneedles in clinical practice: Healthcare professional perceptions on microneedle technology. Perspectives in Percutaneous Penetration 10A, p. 125.

Clemo, R., John, D. N., Anstey, A. & Birchall, J. C. 2006. The Potential of Microfabricated Microneedle Technology in Clinical Practice - an Exploratory Study of Healthcare Professionals and the Public. Int. J. Pharm. Pract. 14, pp. B125-126.

Coulman, S. A., Allender, C., Gateley, C., Anstey, A., Wilke, N., Morrissey, A. & Birchall, J. C. 2006. Microneedle arrays facilitate cutaneous gene delivery and expression. Perspectives in Percutaneous Penetration 10A, p. 118.

Pearton, M., Gateley, C., Anstey, A., Wilke, N., Morrissey, A., Allender, C., Brain, K. & Birchall, J. C. 2006. Microneedle mediated delivery of pDNA loaded hydrogels to the epidermis. Perspectives in Percutaneous Penetration 10A, p. 119.

Pearton, M., Gateley, C., Anstey, A., Wilke, N., Morrissey, A., Allender, C., Brain, K. & Birchall, J. C. 2006. Microneedle facilitated delivery of pDNA encoding HBsAg to human skin: potential for genetic vaccination. Journal of Pharmacy and Pharmacology 58, pp. A65-A65.

Wilke, N., Pearton, M., Coulman, S., Allender, C., Brain, K., Birchall, J. & Morrissey, A. 2006. Assessment of penetration efficiency of microneedle arrays applied to human skin. Perspectives in Percutaneous Penetration 10A, p. 123.

Yildiz, A., Ozsoy, Y., Araman, A., Birchall, J. & Gumbleton, M. 2006. Heparin microparticles for pulmonary administration. Proceedings from The 33rd International Symposium on Controlled Release of Bioactive Materials.

Coulman, S. A., Barrow, D., Anstey, A., Gateley, C., Morrissey, A., Wilke, N., Allender, C. & Birchall, J. C. 2005. Microneedle facilitated gene delivery to human skin. British Journal of Dermatology 152(4), pp. 846-846.

Li, H. Y., Jeans, C., Birchall, J. C. & Taylor, G. 2005. Nanoparticles for pulmonary drug delivery. J. Pharm. Pharmacol. 57(Suppl.), p. S20.

Morrissey, A., Wilke, N., Coulman, S. A., Pearton, M., Anstey, A., Gateley, C., Allender, C., Brain, K. & Birchall, J. C. 2005. Determination of mechanical properties of silicon and polymer microneedles. IFMBE Proc. 11(1).

Pearton, M., Barrow, D., Anstey, A., Gateley, C., Morrissey, A., Wilke, N., Allender, C., Brain, K. & Birchall, J. C. 2005. Disruption of stratum corneum by microfabricated microneedles for gene delivery from hydrogels. British Journal of Dermatology 152(4), pp. 842-842.

Pearton, M., Barrow, D., Gateley, C., Anstey, C., Wilke, N., Morrissey, A., Allender, C., Brain, K. & Birchall, J. C. 2005. Hydrogels based on PLGA-PEG-PLGA triblock co-polymers as sustained release reservoirs for the delivery of pDNA to microneedle treated human skin. J. Pharm. Pharmacol. 57(Suppl.), pp. S12-13.

Coulman, S. A., Allender, C., Barrow, D., Gateley, C., Anstey, A. & Birchall, J. C. 2004. Non-viral gene delivery to epidermal keratinocytes. Perspectives in Percutaneous Penetration 9A, p. 33.

Coulman, S. A., Allender, C., Barrow, D., Gateley, C., Anstey, A. & Birchall, J. C. 2004. Microneedle facilitated cutaneous delivery of a non-viral gene complex to the viable epidermis. J. Pharm. Pharmacol. 56(9; Suppl.), p. S10.

Li, H.-Y., Seville, P. C., Williamson, I. J. & Birchall, J. C. 2004. Dispersibility of spray-dried formulations for pulmonary drug delivery. J. Pharm. Pharmacol. 56(9; Suppl.), pp. S9-10.

Pearton, M., Gateley, C., Anstey, A., Allender, C. J., Brain, K. R. & Birchall, J. C. 2004. Microfabricated microneedles provide “athways”for the sustained release of plasmid DNA from Carbopol-940 hydrogels. Perspectives in Percutaneous Penetration 9A, p. 34.

Seville, P. C., Harris, N. C., Juggins, E. C., Young, J. M., Kellaway, I. W. & Birchall, J. C. 2003. Characterisation of non-viral gene delivery vectors for pulmonary administration. J. Controlled Release 87(Proceedings of the 7th European Symposium on Controlled Drug Delivery).

Birchall, J. C. 2002. Gene delivery to skin. Perspectives in Percutaneous Penetration 8A, p. 15.

Chabri, F., Bouris, K., Allender, C. J., Birchall, J. C., Barrow, D. A. & Brain, K. R. 2002. Investigation of a microfabricated delivery system to deliver non-viral gene vectors through human skin. Perspectives in Percutaneous Penetration 8A, p. 97.

John, D. N., Birchall, J. C. & Druce, L. A. 2002. Final year MPharm drug delivery projects - do they help in the professional development of pre-registration pharmacy graduates. J. Pharm. Pharmacol. 54(Suppl.), pp. S86-87.

Chabri, F., Allender, C., Birchall, J. C. & Brain, K. 2001. Investigation of a microfabricated delivery system to deliver non-viral gene vectors through viable human skin. Proceedings from the 9th Annual Meeting of the European Society of Gene Therapy (96).

Collins, E. J., Birchall, J. C., Richardson, J. & Gumbleton, M. 2001. Physical and chemical barriers to non-viral gene therapy. Proceedings from The 28th International Symposium on Controlled Release of Bioactive Materials, p. 1129.

Al-Mousa, S., Birchall, J. C., Nicholls, P. J. & Gumbleton, M. 2000. Evidence for a role of caveolae in the internalisation of non-viral gene delivery vectors. AAPS Pharm. Sci. 2(Suppl.).

Birchall, J. C., Waterworth, C. A., Luscombe, C., Parkins, D. A. & Gumbleton, M. 2000. Central composite design in modelling the surface response of multicomponent non-viral gene delivery systems. AAPS Pharm. Sci. 2(Suppl.).

Collins, E. J., Birchall, J. C., Richardson, J. & Gumbleton, M. 2000. Spectrofluorometric pDNA condensation study: Influence of poly-cationic peptide complexation and exposure to mucus. AAPS Pharm. Sci. 2(Suppl.).