Miss Siân Rebecca Morgan
Telephone:+44(0)29 208 70202
Location:Room 3.13, Maindy Road
The cornea is a remarkably specialised tissue. In addition to having a high level of mechanical strength, necessary to maintain its precise curvature, uniquely amongst connective tissues it is almost completely transparent to visible light. Correct corneal shape and transparency are critical for good vision, as the cornea provides most of the eye’s focussing power, and both of these features are dependent on the arrangement of fibrous collagen and associated macromolecules found in the tissue’s extracellular matrix (ECM). Changes in matrix structure are associated with loss of corneal shape and transparency following injury and the onset of pathology. Millions of people worldwide opt to have corneal refractive surgery to remedy visual disorders such as myopia, astigmatism and keratoconus. Following these procedures there is a risk of complications from scar formation, cell loss, and corneal oedema, which may adversely affect the surgical outcome. Through my PhD research into novel wound healing treatments, it is hoped that these factors can be better understood and ultimately used to improve the overall outcome of such procedures. New treatments to stabilise corneas by crosslinking the proteins are also being investigated in my project. Additionally, to explore how corneal collagen organisation determines tissue shape a pathological avian species in which the eye globe enlarges and the cornea flattens post-hatch has been utilised.