Prof Andrew Quantock
Telephone:+44 (0)29 2087 5064
Fax:+44 (0)29 2087 4859
Location:Room 3.28, Maindy Road
The aim of my research is to better understand corneal ultrastructure, especially in relation to factors that may influence corneal transparency. I have spent over 20 years studying the organisation of collagen fibrils and proteoglycan macromolecules in various corneal diseases and dystrophies, and am now trying to better appreciate the molecular changes that accompany the development of corneal transparency. I have also worked and retain and interest in tissue engineering of the corneal epithelial, stromal and endothelial layers.
My research employs a number of biophysical techniques such as electron microscopy and structural x-ray diffraction studies using radiation from powerful synchrotron sources, most notably SPring-8 in Japan, ESRF in France, and more recently DIAMOND in Oxfordshire.
I have very strong international collaborations with leading investigators in the USA and Japan. I am Visiting Professor at The Department of Ophthalmology, Kyoto Prefectural University of Medicine, and in collaboration with scientists there was fortunate enough to be recognised in 2004 by the award of the Daiwa Adrian Prize for excellence in Anglo-Japanese research. I have been an ARVO member since 1988, and served on the Cornea section of the ARVO Annual Meeting Programme Committee from 2005 to 2008 (co-chair in 2007/08). The task of this committee is to organised the cornea programme at the 10,000-delegate annual ARVO meeting in Florida. I am and have been principal or co-investigator on a programme and project grants from all the relevant government Research Councils (BBSRC, EPSRC, MRC) totalling over £4million, with current EPSRC-funded work focusing on high-pressure cryo-vitrification of corneal tissue for electron microscopy and the preservation of native hydrated structure.
My main teaching in the School is on the first year module, Geometrical Optics, and in my supervision of third year project students. I also supervise the research projects of between four and six third year undergraduates each year, and within the university I teach on a third year “Tissue Engineering”module in the School of Biosciences and on the Masters degree in the Cardiff Institute for Tissue Engineering and Repair.
Hayashida Y, Akama TO, Beecher N, Lewis P, Young RD, Meek KM, Kerr B, Hughes CE, Caterson B, Tanigami A, Nakayama J, Fukada MN, Tano Y, Nishida K, Quantock AJ. Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O sulfotransferase. Proc Natl Acad Sci U.S.A. 2006;103:13333-13338.
Quantock AJ, Young RD. Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function. Dev Dyn 2008;237:2607-2621.
Knupp C, Pinali C, Lewis PN, Parfitt GJ, Young RD, Meek KM, Quantock AJ. The architecture of the cornea and structural basis of its transparency. Adv Prot Chem Struct Biol 2009;78:25-49.
Quantock AJ, Young RD, Akama TO. Structural and biochemical aspects of keratan sulphate in the cornea. Cell Mol Life Sci 2010;67:891-906.
Bushby AJ, P'ng KM, Young RD, Pinali C, Knupp C, Quantock AJ. Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy. Nature Protocols 2011;6:845-858.