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Prof Andrew Quantock 


Staff Photos
Position:Director of Research

Telephone:+44 (0)29 2087 5064
Fax:+44 (0)29 2087 4859
Extension:75064
Location:Room 3.28, Maindy Road

Career Overview

The aim of my research is to better understand corneal ultrastructure, especially in relation to factors that may influence corneal transparency. I have spent over 20 years studying the organisation of collagen fibrils and proteoglycan macromolecules in various corneal diseases and dystrophies, and am now trying to better appreciate the molecular changes that accompany the development of corneal transparency. I have also worked and retain and interest in tissue engineering of the corneal epithelial, stromal and endothelial layers. I have strong international collaborations with leading investigators in the USA and Japan, am a Silver Fellow of ARVO (The Association for Research in Vision and Ophthalmology), and served on the Cornea section of the ARVO Annual Meeting Programme Committee from 2005 to 2008 (co-chair in 2007/08). I am Visiting Professor at Kyoto Prefectural University of Medicine and Doshisha University, also in Kyoto, and in collaboration with scientists there was fortunate enough to be recognised in 2004 by the award of the Daiwa Adrian Prize for excellence in Anglo-Japanese research. I am and have been principal or co-investigator on a programme and project grants from the BBSRC, EPSRC, MRC, and Wellcome trust totalling over £6 million, with current work focusing on new minimally invasive surgeries for corneal endothelial dysfunction, as well as understanding corneal cell and matrix development at high resolution and in three dimensions

 

Teaching Overview:

My main teaching in the School is on the first year module, Geometrical Optics, and in my supervision of third year project students. I also supervise the research projects of between four and six third year undergraduates each year, and within the university I teach on a third year “Tissue Engineering”module in the School of Biosciences and on the Masters degree in the Cardiff Institute for Tissue Engineering and Repair.

 

Selected Publications

Hayashida Y, Akama TO, Beecher N, Lewis P, Young RD, Meek KM, Kerr B, Hughes CE, Caterson B, Tanigami A, Nakayama J, Fukada MN, Tano Y, Nishida K, Quantock AJ. Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O sulfotransferase. Proc Natl Acad Sci USA 2006;103:13333-13338.

Quantock AJ, Young RD, Akama TO. Structural and biochemical aspects of keratan sulphate in the cornea. Cell Mol Life Sci 2010;67:891-906.

Bushby AJ, P'ng KM, Young RD, Pinali C, Knupp C, Quantock AJ. Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy. Nature Protocols 2011;6:845-858.

Forrest MP, Hill MJ, Quantock AJ, Blake DJ. The emerging roles of TCF4 in disease and development. Trends Mol Med 2014, e-pub ahead of print. doi: 10.1016/j.molmed.2014.01.010.

Young RD, Knupp C, Pinali C, Png KMY, Ralphs JR, Bushby AJ, Starborg T, Kadler KE, Quantock AJ. Three-dimensional aspects of matrix assembly by cells in the developing cornea. Proc Natl Acad Sci USA 2014;111:687-692.