Dr Ryan Moseley

Dr Ryan Moseley

Reader in Tissue Repair

School of Dentistry

Media commentator

Mae'r cynnwys hwn ar gael yn Saesneg yn unig.

Research group

Stem Cells, Wound Repair & Regeneration.

Professional memberships

British Society for Oral and Dental Research (BSODR); Cardiff Institute for Tissue Engineering and Repair (CITER); European Tissue Repair Society (ETRS); From Plants to Products (P2P) Network; Higher Education Academy (HEA, Fellow Status); International Association for Dental Research (IADR); MediWales, Natural Compounds Special Interest Group.

Previous academic positions

2012-2017: Senior Lecturer in Tissue Repair & Programme Director, CITER MSc in Tissue Engineering. Stem Cells, Wound Repair and Regeneration, Oral and Biomedical Sciences, School of Dentistry, Cardiff University.

2008-2012: Lecturer in Tissue Repair & Programme Director, CITER MSc in Tissue Engineering. Wound Biology Group, Tissue Engineering & Reparative Dentistry, School of Dentistry, Cardiff University.

2002-2008: Senior Postdoctoral Research Officer. Wound Biology Group, Tissue Engineering & Reparative Dentistry, School of Dentistry, Cardiff University.

2000-2002: Locum Lecturer in Oral Biochemistry. Matrix Biology & Tissue Repair Research Unit, Department of Dental Health & Biological Sciences, School of Dentistry, University of Wales College of Medicine, Cardiff.

1998-2000: Postdoctoral Research Fellow, funded by The Wellcome Trust. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, Cardiff.

1996-1998: Postdoctoral Research Fellow, funded by The British Heart Foundation. Department of Cardiology & Institute of Nephrology, University of Wales College of Medicine, Cardiff.

Qualifications

2010: Postgraduate Certificate in University Teaching and Learning (PCUTL). Human Resource Directorate, Cardiff University.

1996: PhD in Oral Biochemistry, funded by the Medical Research Council. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, Cardiff.  PhD Thesis entitled ‘Structural Changes in Periodontal Proteoglycans by Reactive Oxygen Species’.

1993: Diploma in Biomedical Methods. University of Wales College of Medicine, Cardiff.

1991: Upper Second Class BSc (Honours) Degree in Biochemistry. Department of Biochemistry, Swansea University.

Dr Moseley is currently Reader in Tissue Repair and Programme Director of the MSc in Tissue Engineering, organized by the Cardiff Institute of Tissue Engineering and Repair (CITER).

He obtained his BSc in Biochemistry at Swansea University in 1991, before commencing his MRC-funded, PhD at the School of Dentistry, University of Wales College of Medicine (UWCM) in 1992.  He obtained his PhD in 1996, before embarking on Postdoctoral Researcher positions at UWCM / Cardiff University (funded by the British Heart Foundation, Wellcome Trust and Johnson & Johnson Wound Management).  In 2008, Dr Moseley was appointed Lecturer in Tissue Repair within the School of Dentistry and as Director of the CITER MSc Programme in Tissue Engineering, being promoted to Senior Lecturer in 2012 and to Reader in 2017.

Dr Moseley’s research focus on the mechanisms underlying cellular wound healing responses in oral (bone, oral mucosa, dental pulp) and dermal (normal skin, chronic wound) tissues during health and disease.  By understanding these mechanisms, his Research Group aims to develop cellular, biomaterial and pharmaceutical strategies to promote repair in these tissues.

Dr Moseley has successfully managed numerous projects in these research areas, supported by non-commercial and commercial funding sources worldwide (>£2.0M to date), including the MRC, NHMRC (Australia), Wellcome Trust, NISCHR, Life Sciences Research Network Wales (Sêr Cymru), Malaysian Government, Iraqi Government, Saudi Arabian Government, Convatec Wound Care Ltd., Systagenix Wound Management Ltd., Peplin Inc. (now owned by LEO Pharma A/S); and Qbiotics Ltd.

Such research has culminated in numerous peer-reviewed papers, filed patents with industrial partners in the dermal wound healing sector; and many local, national and international conference prizes for students under his supervision.  He also acts as an ad hoc reviewer for national and international grant funding bodies, journals and as an examiner of a number of Postgraduate (MSc, MD, PhD) research degree theses, in addition to being a member of the Editorial Boards for the Journal of Dentistry and Oral Biology and the Journal of Oral Biology.

Undergraduate Teaching

BDS Dental Undergraduates

  • Lecture and provide revision tutorials to Year 2 BDS on oral biology/biochemistry for the ‘Oral Ecosystems’ Theme, including (i) dental-pulp complex, (ii) prenatal jaw development, (iii) alveolar bone and cementum; and (iv) osseointegration.
  • Provide practical sessions to Year 2 BDS on (i) dentinogenesis, (ii) the dental-pulp complex, (iii) amelogenesis, (iv) enamel structure; and (v) prenatal jaw development.
  • Organize all Year 2 BDS revision tutorial sessions.
  • Setting/assessment of Year 2 BDS Problem Based Learning (PBL) Exercises.
  • Setting/marking of in-course assessments and examination papers for Year 2 BDS.
  • Supervision of Year 5 BDS final year research projects.
  • Academic and personal tutor to a number of year 2 BDS students.

BSc Biosciences

  • Lecture and provide revision tutorials to Year 3 BSc undergraduates in the School of Biosciences on (i) tissue engineeering and repair in skin, for the ‘Tissue Engineering/Tissue Regeneration’ Module.
  • Setting/marking of in-course assessments and examination papers.

Postgraduate Teaching

MSc in Tissue Engineering

  • Director of the CITER MSc Programme in Tissue Engineering.
  • Responsible for overall Module/Programme structure, organization, timetabling and review, student recruitment; and Programme quality assurance.
  • Provide lectures and revision tutorials on (i) modelling of cell-extracellular matrix interactions in vitro; and (ii) large-scale tissue/organ engineering in vitro, for the ‘Tissue Engineering: Concept-Clinical Practice’ Module.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

MSc in Implantology

  • Provide lectures and revision tutorials on (i) the principles of osseointegration; (ii) cytokines and growth factors in bone repair; and (iii) proteinase and bone repair; for the ‘Implantology’ and ‘Cellular and Molecular Biology’ Modules.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

MSc in Clinical Dentistry

  • Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) proteinase and bone repair; as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Orthodontics

  • Provide lectures on (i) cytokines and growth factors in bone repair, as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Oral Biology

  • Involved in student recruitment.
  • Provide lectures on (i) Fibroblast heterogeneity and wound healing, for the 'Tissue Repair, Regeneration and Scientific Methods’ Module.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

My research focusses on various aspects of basic and translational research, related to the mechanism underlying contrasting wound healing responses in oral (e.g. bone, oral mucosa, dental pulp) and dermal (e.g. normal skin, chronic wound) tissues, during health and disease.  Such studies have furthered our understanding of oral and dermal tissues, enabling my research to also develop cellular, biomaterial and pharmaceutical strategies to promote tissue repair and disease management in patients.

Recent Grant Awards

Qbiotics Ltd. (2012-2015).  Stimulatory effects of epoxy-tiglianes on dermal fibroblast and keratinocyte wound healing responses. £119,806.

Sêr Cymru (Life Sciences Research Network Wales) & QBiotics Ltd. (2014-2017).  Pharmaceutical evaluation of novel tigliane compounds as modulators of dermal fibroblast-myofibroblast differentiation, scar tissue resolution and fibrosis; and elucidation of their underlying mechanisms of action. £105,190.

Iraqi Government, Ministry for Higher Education and Scientific Research (2014-17).  Altered bone cell biology associated with type 2 diabetes mellitus:  Consequences for periodontal disease. £90,000.

National Institute for Social Care and Health Research (NISCHR) (2014-17).  Role of microRNA-7 in impaired TGF-b1-driven differentiation in chronic wound fibroblasts. £66,000.

Australian National Health and Medical Research Council (NHMRC) (2015-18).  Development of a novel drug for chronic and infected wounds. AU$467,975.

Saudi Arabian Government, Ministry of Defence (2015-18).  Role of oxidative stress responses in clonal variations in dental pulp progenitor cell ageing and regenerative potential. £87,000.

QBiotics Ltd. (2016-18).  Elucidation of the underlying mechanisms of action by which novel epoxy-tigliane pharmaceuticals promote preferential wound healing. £251,706.

Medical Research Council (MRC) (2016-17).  Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis. £62,485.

Wellcome Trust (2017-18).  Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis. £49,995.

Medical Research Council (MRC) (2017-18).  Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts. £62,492.

Recent Awards

2012:  BSODR Unilever Poster Prize (Amr Alraies).

2012:  Cardiff University, Stem Cell Research Day Poster Prize (Amr Alraies).

2013:  Cardiff University, Postgraduate Research Day Poster Prize (Rachael Moses).

2014:  ETRS Poster Prize (Rachael Moses).

2015:  Cardiff University, Postgraduate Research Day Poster Prize (Jordanna Dally).

2015:  Sêr Cymru (Life Sciences Research Network Wales) PhD Student Oral Presentation Prize (Jordanna Dally).

2017:  ETRS Poster Prize (Glyn Morris).

2017:  CITER Oral Presentation Prize (Glyn Morris).

Filed Patents

Convatec Wound Care Ltd. EP1245239 and US2003040690, relating to the antioxidant properties of wound dressing-based biomaterials.

Systagenic Wound Management Ltd. EP1889069, GB2426335, US2009299161 and WO2006123091, relating to the use of total antioxidant capacity as a prognostic/diagnostic biomarker of chronic wound infection and healing.

Systagenic Wound Management Ltd. GB2447865, US2010166694, US2012010099 and WO2008119974, relating to the quantification of various cytokines and growth factors as prognostic/diagnostic biomarkers of diabetic foot ulcer wound infection and healing.

Peplin Inc. (LEO Pharma A/S). AU20050906601, AU2006317523, AU20100213362, BRPI0618926, CA2629899, CA2752389, CN101360506, CN102316866, DK2395993, EP1965818, EP2395993, IL214133, JP2009517345, JP2012517450, JP5638008, KR20080077625, NZ568168, NZ594184, RU2011137530, RU2491050, US2009215884, US2012041064, US2016317486, WO2007059584; and WO2010091472, relating to the application of ingenol mebutate and related compounds, in the promotion of dermal wound healing and reduced scarring.

Qbiotics Ltd. AU20140253608, CA2909653, CN105308052, EA201591996, EP2986615, HK1214256, JP2016522801, KR20160023651, MX2015014607, PH12015502405, SG11201508588X, US2016068499, US2017144981; and WO2014169356, relating to the application of epoxy-tigliane compounds, such as EBC-46 and EBC-211, in the promotion of dermal wound healing and reduced scarring.

External Collaborators

Dr Glen Boyle, QIMR Berghofer Medical Research Institute, Australia.

Dr Steven Ogbourne & Dr Fraser Russell, University of the Sunshine Coast, Australia.

Dr Ernest Azzopardi, ABM University Health Board & Swansea University, UK.

Dr Sim Singhrao, University of Central Lancashire, UK.

Dr Paul Reddell, QBiotics Ltd., Australia.

Dr Thomas Larsson, LEO Pharma A/S, Denmark.

Postgraduate Students

Lead Supervisor

  • Jordanna Dally (PhD student, Year 3).  Pharmaceutical evaluation of novel tigliane compounds as modulators of dermal fibroblast-myofibroblast differentiation, scar tissue resolution and fibrosis; and elucidation of their underlying mechanisms of action (in collaboration with the School of Medicine, Cardiff University).
  • Nadia Alaidaroos (PhD student, Year 2).  Role of oxidative stress responses in clonal variations in dental pulp progenitor cell ageing and regenerative potential.

Co-Supervisor

  • Ahmed Al-Qarakhli (PhD student, Year 3).  Altered bone cell biology associated with type 2 diabetes mellitus:  Consequences for periodontal disease.
  • Glyn Morris (PhD student, Year 3).  Role of microRNA-7 in the age-related impairment of TGF-β1-driven differentiation in chronic wound fibroblasts (in collaboration with the School of Medicine, Cardiff University).

Postdoctoral Staff

  • Dr Rachael Moses.  Elucidation of the underlying mechanisms of action by which novel epoxy-tigliane pharmaceuticals promote preferential wound healing responses (in collaboration with the School of Medicine, Cardiff University).
  • Dr Emma Woods.  Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis (in collaboration with the School of Medicine, Cardiff University).

Areas of expertise