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Dr Amal Gadalla

Dr Amal Gadalla

Research Associate

School of Medicine

Email
gadallaa1@cardiff.ac.uk
Telephone
+44 (0)29 2251 0786
Campuses
5th floor, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
Users
Available for postgraduate supervision

Overview

I am a Research Associate at the Division of Population Medicine. My wide research interest is dynamics, transmission and control of infectious diseases using bioinformatics and statistical modelling tools. I have particular research interest in drug resistance. I am currently investigating immunological markers as predictors for uncomplicated urinary tract infections in females.

My academic background is microbiology, molecular biology and epidemiology. I am very interested in bioinformatics and statistical analyses, specially modelling and machine learning classification methods.

I am very keen to network with people with similar interest/experience.

Biography

Qualifications

  • 2015 – PhD Biochemistry and Molecular Biology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Thesis title: "Influence of season, drug resistance, genetic complexity and anti-malarials on persistence and transmission of the malaria parasite Plasmodium falciparum"
  • 2008 – MSc Biomedical Sciences (Immunology), Sudan Academy for Sciences, Khartoum, Sudan. Thesis title: "IgG profile against MSP3 antigen in asymptomatic carriers of Plasmodium falciparum in Eastern Sudan"
  • 2004 – BSc (1st Class Honours) Medical Laboratory Sciences (major Microbiology), Faculty of Medical Laboratory Sciences, University of Gezira, Sudan.

Career

Previous posts

  • 2016 - 2017 Technical expert,International Atomic Energy Agency, mission to Sultan Qaboos University, Muscat, Oman.
  • 2014 - 2016 Research fellow, Biochemistry and Molecular Biology, Sultan Qaboos University, Muscat, Oman.
  • 2004 - 2010. Researcher, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan.

Previous projects

  • Diversity and transmission potential of imported malaria to malaria-free countries, Sultan Qaboos University, Muscat, Oman.
  • Theileria parasite in Oman, molecular biology and disease, Sultan Qaboos University, Muscat, Oman.
  • Identification of Plasmodium falciparum early gametocyte-specific expression in natural infections. Sultan Qaboos University, Muscat, Oman. In collaboration with University of Edinburgh, Edinburgh, UK, Queensland Institute of Medical Research, Queensland, Australia and Istituto Superiore di Sanit√†, Italy.
  • Validation of the use of isotope-based molecular techniques in malaria control. Tropical Medicine Research Institute, Khartoum, Sudan.
  • Molecular genetics of P. falciparum isolates in Sudan: Gametocytaemia and drug resistance markers. Tropical Medicine Research Institute, Khartoum, Sudan

Honours and awards

  • 2017 - Jamal Elnefeidi Award for Research on Malaria, Sudan
  • 2016 – American Society of Tropical Medicine and Hygiene (ASTMH) Travel Award
  • 2016 – European Molecular Biology Laboratory (EMBL), Advanced Training Centre Corporate Partnership Programme (CPP) Fellowship Travel Award
  • 2016 – British Society of Parasitology Spring Meeting Travel Award
  • 2013 – 6th Multilateral Initiative on Malaria Pan-African Malaria Conference Travel Award
  • 2012 – Training fellowship award. International Atomic Energy Agency (IAEA)
  • 2010 – PhD scholarship, Sultan Qaboos University, Muscat, Oman.
  • 2007 – MSc scholarship, Sudan Academy for Sciences, Khartoum, Sudan
  • 2003 – Academic Excellence Award, University of Gezira, Sudan

Professional memberships

  • International Society of Infectious Diseases, member
  • SM Tropical Medicine Journal, member of the Editorial Board
  • British Society of Parasitology, member

Speaking engagements

Conferences

  • Amal Gadalla, JJ Valletta, TJ McKinley, Kathy Hughes, Ann Smith, Julian Marchesi, Kerenza Hood, Micaela Gal, Clive Gregory, Mandy Wootton, Chris Butler and Nick Francis. Bacterial microbiome in culture negative urinary tract infections. Poster Presentation. Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies, Wellcome Genome Conference Centre, Virtual Conference 04 - 06 November 2020.
  • Amal Gadalla, Ida Friberg, Ann Kift-Morgan, Jingjing Zhang, Matthias Eberl, Mandy Wootton, Micaela Gal, Christopher Butler and Nick Francis. Identification of clinical and immunological markers for uncomplicated urinary tract infections in women. Oral presentation. South West SAPC Regional Meeting, Plymouth, 13th and 14thMarch 2018.
  • Amal Gadalla, Ryan Farid, Pietro Alano, Joanne Thompson, Giulia Siciliano, Lisa Ranford-Cartwright, James McCarthy and Hamza Babiker Early and late P. falciparum gametocyte-specific transcription following treatment with Chloroquine and Sulphadoxine/ Pyrimethamine. Poster Presentation. American Society of Tropical Medicine and Hygiene, 13-17 November 2016, Atlanta, GA, USA.
  • Amal Gadalla, Thomas Churcher, Elkhansaa Nassir, Abdel-Muhsin A Abdel-Muhsin and Hamza Babiker. Within-host growth advantage of wild-genotype over drug resistance genotypes of Plasmodium falciparum in absence of therapy. Oral Presentation. 12th Annual BioMalPar I EVIMalaR Conference: Biology and Pathology of the Malaria Parasite 18 - 20 May 2016, EMBL Advanced Training Centre, Heidelberg, Germany.
  • Amal Gadalla, Petra Schneider, Sarah Reece and Hamza Babiker. Impact of season and drug resistance on P. falciparum transmission: insights into optimized malaria control. Oral Presentation. British Society of Parasitology, Spring Meeting, 11-13 April 2016, London. UK.
  • Amal Gadalla, Petra Schneider, Elkhansaa Nassir, Abdel-Muhsin A Abdel-Muhsin, Thomas Churcher, Sarah Reece and Hamza Babiker. Gametocytes and multiple-clone carriage among long lasting asymptomatic Plasmodium falciparum carriers in absence of therapy. Oral Presentation. 6th MIM Pan-African Malaria Conference, 6 – 11 October 2013, Durban, South Africa.
  • Amal Gadalla, Petra Schneider, Elkhansaa Nassir, Abdel-Muhsin A Abdel-Muhsin, Sarah Reece and Hamza Babiker. Gametocytes and multiple-clone carriage among long lasting asymptomatic Plasmodium falciparum falciparum carriers in absence of therapy. Oral Presentation. 9th Annual BioMalPar I EVIMalaR Conference: Biology and Pathology of the Malaria Parasite 13 - 15 May 2013, EMBL Advanced Training Centre, Heidelberg, Germany.
  • Amal Gadalla, Petra Schneider, Sarah Reece and Hamza Babiker. Factors influencing gametocytogenesis of Plasmodium falciparum. Poster Presentation British Society of Parasitology meeting, Glasgow, 02-05 April 2012.
  • Amal Gadalla, Salah Eldin Al-zaki, Nahla Gadalla, Izdihar Mukhtar, Tellal Ageep, Fathi A Mansour, Moawia Mukhtar and Badria El-Sayed. IgG profile against MSP3 antigen in asymptomatic carriers of Plasmodium falciparum in eastern Sudan. Poster Presentation. 13th International Congress of Infectious Diseases, Kuala Lumpur, Malaysia, 19 – 22 June 2008. http://www.isid.org/publications/ICID_Archive.shtml.

Committees and reviewing

Journal reviewer, PloS ONE

Publications

2019

2018

2016

Teaching

  • Lecturing 2018 – current: Population Medicine Intercalated BSc degree for Medicine undergraduate students, Cardiff University.
  • Tutorials 2018 – current: Epidemiology and Evidence Based Medicine for Medicine undergraduate students, Cardiff University.
  • Part-time tutor 2016: Tutoring A-level students at Birmingham Tuition Centre, Solihull, Birmingham, UK. Subject: A-level biology (AQA examination Board).
  • Part-time tutor 2014 – 2015: Tutoring undergraduate students at College of Nursing and College of Medicine and Health Sciences, Sultan Qaboos University. Duties: tutorials preparation, delivering and assessment on courses; Molecular biology, Enzymology & Metabolism and Biochemistry.
  • Part-time teaching assistant 2014 – 2015: Assisting in teaching at College of Medicine and Health Sciences, Sultan Qaboos University. Duties: preparation and marking exams questions, managing students’ grades data and preparing statistical summary to report students’ performance.

 

Research Intersest:

  1. Antimicrobial resistance
  2. Urinary tract infection
  3. Biomarkers
  4. Microbiome and resistome

Current Research Projects:

  • Bacterial microbiome and diagnosis of urinary tract infection in women.
  • Evaluation of DNA sequencing approaches in identification of urinary bacterial microbiome.
  • Effect of antibiotic consumption on self-reported recovery from uncomplicated urinary tract infection in women.

Research Grants:

  • Quantitative mapping of the microbiome and resistome in urinary tract infection among women: a pump-priming interdisciplinary study Applicants: Gadalla A, Francis N, Connor T, Marchesi J, Hughes K, E Mahenthiralingam, Butler C. Funder: ISSF3 Population Award. Amount: £43,322 . Duration: April 2019-July 2021

Supervision

Past projects

Research supervision:

  • 2019 – current: Mentoring a PhD student during project design and data analysis in collaboration with School of Medicine and Health Sciences, Sultan Qaboos University. Project title: Genetic and demographic determinants of Mycobacterium tuberculosis antimicrobial resistance in Oman.
  • 2018 – 2019: Population Medicine Intercalated BSc project, Cardiff University. Project title: Effect of antibiotic consumption on self-reported recovery from uncomplicated urinary tract infection in women.
  • 2018: Student Selected Component Tutor (Year 3 Student), Cardiff University. Project title: Changes in the gut flora associated with the use of antibiotics to treat uncomplicated urinary tract infections.
  • 2018: Summer Project for Clinical Epidemiology student, Cardiff University. Project title: Symptoms that define recovery from uncomplicated urinary tract infection. 
  • 2015 – 2016: Mentoring and evaluate laboratory experiments for a PhD student. Project title: Identification of sexual stage-specific expression in Theileria parasites in Oman.
  • 2015: Mentoring an MSc student during project design and data analysis. Project title: Detection and phylogenetic characterization of Theileria parasites in Oman.
  • 2013: Mentoring an MSc student during data analysis. Project title: Effect of sleep-deprivation and obstructive sleep apnea on cytokine level, neutrophil function and proliferative potential of lymphocyte population.

Engagement

Media engagment