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Dr Ryan Moseley

Dr Ryan Moseley

Reader in Tissue Repair

School of Dentistry

Email
moseleyr@cardiff.ac.uk
Telephone
+44 (0) 29 2251 0649 (Ext. 10649).
Campuses
Room 413, 4th Floor, University Dental Hospital, Heath Park, Cardiff, CF14 4XY
Comment
Media commentator
Users
Available for postgraduate supervision

Overview

Research Group

Regenerative Biology Group

My research specialises in the mechanisms underlying cellular wound healing responses in oral (bone, oral mucosa, dental pulp, gingiva) and dermal (normal skin, chronic skin wounds, fibrotic skin) tissues during health and disease.  By understanding these mechanisms, my Research Group develops novel cellular, biomaterial, pharmaceutical and other strategies to promote normal tissue repair and improved wound management in these patients.  Such research activities include the translational development of a novel class of natural and semi-synthetic compounds, termed epoxy-tiglianes, for the treatment of non-healing chronic skin wounds and dermal scarring/fibrosis, with industrial and academic collaborators based in Australia:

https://www.cardiff.ac.uk/research/impact-and-innovation/research-impact/rainforest-helps-treat-patients-chronic-wounds

I have successfully managed numerous projects in these research areas, supported by non-commercial and commercial funding sources worldwide (>£3.3M to date).  These include the MRC, NHMRC (Australia), Wellcome Trust, Dunhill Medical Trust, Life Sciences Research Network Wales (Sêr Cymru), NISCHR, Malaysian Government, Iraqi Government; and Kingdom of Saudi Arabia Government, in addition to industrial partners including Convatec Wound Care Ltd., Johnson and Johnson Wound Management Ltd. (now Systagenix Wound Management Ltd.), Peplin Inc. (now owned by LEO Pharma A/S), QBiotics Group and Phillips Research.

My research has culminated in numerous published peer-reviewed papers, filed patents with industrial partners in the dermal wound healing sector; and many local, national and international conference prizes for staff and students under my supervision.

Biography

I graduated with a 2.1 BSc (Honours) degree in Biochemistry from Swansea University in 1991, before commencing an MRC-funded, PhD at the School of Dentistry, University of Wales College of Medicine (UWCM) in 1992.  I completed my PhD in 1996, before embarking on Postdoctoral Researcher positions at UWCM/Cardiff University, funded by the British Heart Foundation (1996-98), Wellcome Trust (1998-00) and Johnson & Johnson Wound Management Ltd. (2002-08); in addition to being appointed as a Locum Lecturer in Oral Biochemistry within the School of Dentistry (2000-02).  In 2008, I was appointed Lecturer in Tissue Repair within the School of Dentistry and as Director of the CITER MSc Programme in Tissue Engineering (2008-2018), being promoted to Senior Lecturer in 2012 and then to Reader in 2017.

Qualifications

  • 2010:  Postgraduate Certificate in University Teaching and Learning (PCUTL).  Cardiff University, UK.
  • 1996:  PhD (Oral Biochemistry), Thesis entitled ‘Structural Changes in Periodontal Proteoglycans by Reactive Oxygen Species’.  School of Dentistry, University of Wales College of Medicine, UK.
  • 1993:  Diploma in Biomedical Methods, University of Wales College of Medicine, UK.
  • 1991:  BSc (Honours) Degree in Biochemistry,  Swansea University, UK.

Honours and awards

  • 2021:  Oral presentation prize, Cardiff University School of Dentistry Research Day.  Cardiff, UK (PhD student, Edward Gait-Carr).
  • 2020:  Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Vildan Celiksoy).
  • 2019:  Poster prize, Cardiff University School of Dentistry Research Day.  Cardiff, UK (Postdoctoral Research Associate, Dr Jordanna Dally).
  • 2018:  Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Nadia Alaidaroos).
  • 2017:  Poster prize, European Tissue Repair Society (ETRS) Meeting.  Brussels, Belgium (PhD student, Glyn Morris).
  • 2017:  Oral presentation prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting.  Cardiff, UK (PhD student, Glyn Morris).
  • 2015:  Oral presentation prize, Sêr Cymru (Life Sciences Research Network Wales) Meeting.  Cardiff, UK (PhD student, Jordanna Dally).
  • 2015:  Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Jordanna Dally).
  • 2014:  Poster prize, European Tissue Repair Society (ETRS) Meeting.  Edinburgh, UK (PhD student, Rachael Moses).
  • 2013:  Poster prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Rachael Moses).
  • 2012:  British Society for Oral and Dental Research (BSODR) Unilever poster prize, Pan European (PER)/International Association for Dental Research (IADR) Meeting.  Helsinki, Finland (PhD student, Amr Alraies).
  • 2012:  Poster prize, Cardiff University Stem Cell Research Day.  Cardiff, UK (PhD student, Amr Alraies).
  • 2010:  Jackson Prize for Burns and Plastic Surgery Research, Society for Academic and Research Surgery Conference.  London, UK (PhD student, Joseph Hardwicke).
  • 2008:  Poster prize, Cardiff University Metabolism, Regeneration and Repair Group Meeting.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2007:  Oral presentation prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting.  Abergavenny, UK (PhD student, Joseph Hardwicke).
  • 2007:  Oral presentation prize, Cardiff University Metabolism, Regeneration and Repair Group Meeting.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2007:  Poster prize, International Symposium on Polymer Therapeutics Meeting.  Berlin, Germany (PhD student, Joseph Hardwicke).
  • 2006:  Oral presentation prize, Cardiff University Postgraduate Research Day.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2006:  Poster prize, Cardiff Institute of Tissue Engineering & Repair (CITER) Meeting.  Cardiff, UK (PhD student, Joseph Hardwicke).
  • 2003:  Oral presentation prize, European Tissue Repair Society (ETRS) Meeting.  Cardiff, UK (MD student, Joanna Hilton).
  • 1998-2000:  Honorary Research Fellow.  School of Dentistry, University of Birmingham.  Birmingham, UK.

Professional memberships

  • Member of the Association of Science Educators in Dentistry (ASEiD).
  • Member of the British Society for Oral and Dental Research (BSODR).
  • Member of the Cardiff Institute for Tissue Engineering and Repair (CITER).
  • Member of the European Tissue Repair Society (ETRS).
  • Fellow of the Higher Education Academy (HEA).
  • Member of the International Association for Dental Research (IADR).
  • Member of the MediWales, Natural Compounds Special Interest Group.
  • Member of STEM Learning.

Academic positions

  • 2012-17: Senior Lecturer in Tissue Repair and Programme Director, CITER MSc in Tissue Engineering. Stem Cells, Wound Repair and Regeneration, Oral and Biomedical Sciences, School of Dentistry, Cardiff University, UK.
  • 2008-12: Lecturer in Tissue Repair and Programme Director, CITER MSc in Tissue Engineering. Wound Biology Group, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, UK.
  • 2002-08: Senior Postdoctoral Research Officer. Wound Biology Group, Tissue Engineering and Reparative Dentistry, School of Dentistry, Cardiff University, UK.
  • 2000-02: Locum Lecturer in Oral Biochemistry. Matrix Biology and Tissue Repair Research Unit, Department of Dental Health and Biological Sciences, School of Dentistry, University of Wales College of Medicine, UK.
  • 1998-00: Postdoctoral Research Fellow, funded by The Wellcome Trust. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, UK.
  • 1996-98: Postdoctoral Research Fellow, funded by The British Heart Foundation. Department of Cardiology and the Institute of Nephrology, University of Wales College of Medicine, UK.

Speaking engagements

Invited Speaker Presentations

  • 2021:  School of Dentistry Research Day, Cardiff University, UK.
  • 2019:  International Undergraduate/Postgraduate Student Summer School.  Cardiff University, UK.
  • 2018:  5th International Conference on Advances in Skin, Wound Care and Tissue Science and the 14th International Conference on Clinical Dermatology.  Rome, Italy.
  • 2018.  International Conference on Wound Care, Tissue Repair and Regenerative Medicine:  Fostering Advances in Wound Healing and Tissue Regeneration Techniques.  London, UK.
  • 2018:  International Translational and Regenerative Medicine Conference.  Rome, Italy.
  • 2018:  Cardiff Institute for Tissue Engineering and Repair (CITER), Life Sciences Research Network Wales (LSRNW) and MediWales Workshop on ‘Natural Compound Research for Tissue Repair and Regeneration in Wales’.  St Fagans National Museum of History, Cardiff, UK.
  • 2018:  International Undergraduate/Postgraduate Student Summer School.  Cardiff University, UK.
  • 2017:  2nd International Conference on Advances in Skin, Wound Care and Tissue Science.  Frankfurt, Germany.
  • 2014:  LEO Pharma A/S.  Ballerup, Denmark.
  • 2011:  LEO Pharma A/S.  Ballerup, Denmark.
  • 2010:  Peplin Science Meeting.  Maidenhead, UK.
  • 2005:  Wound Healing Research Unit.  Cardiff University, UK.
  • 2002:  Johnson and Johnson Wound Management Ltd.  Gargrave, UK.
  • 2000:  School of Dentistry, University of Birmingham.  Birmingham, UK.
  • 1997:  Bristol Heart Institute, Bristol Royal Infirmary.  Bristol, UK.
  • 1995:  Oral Healthcare Division, SmithKline Beecham.  Weybridge, UK.

Workshop/Conference Session Chair

  • 2018:  International Conference on Wound Care, Tissue Repair and Regenerative Medicine:  Fostering Advances in Wound Healing and Tissue Regeneration Techniques.  London, UK.
  • 2018:  Cardiff Institute for Tissue Engineering and Repair (CITER), Life Sciences Research Network Wales (LSRNW) and MediWales Workshop on ‘Natural Compound Research for Tissue Repair and Regeneration in Wales’.  St Fagans National Museum of History, Cardiff, UK.
  • 2017:  British Society for Oral and Dental Research (BSODR) Annual Meeting,  Plymouth, UK.
  • 2017:  Cardiff Institute for Tissue Engineering and Repair (CITER) Workshop on ‘Ageing’.  Cardiff, UK.
  • 2017:  Cardiff Institute for Tissue Engineering and Repair (CITER) Annual Scientific Meeting.  Cardiff, UK.
  • 2012:  2nd South West Regional Regenerative Medicine Meeting, Cardiff, Bath and Bristol Universities.  Bristol, UK.
  • 2012:  Stem Cell Research Day, Cardiff University.  Cardiff, UK.

Workshop/Conference Organising Committees

  • 2017-18:  5th International Conference on Advances in Skin, Wound Care and Tissue Science and the 14th International Conference on Clinical Dermatology.  Rome, Italy.
  • 2017-18:  International Conference on Wound Care, Tissue Repair and Regenerative Medicine:  Fostering Advances in Wound Healing and Tissue Regeneration Techniques.  London, UK.
  • 2017-18:  Cardiff Institute for Tissue Engineering and Repair (CITER), Life Sciences Research Network Wales (LSRNW) and MediWales Workshop on ‘Natural Compound Research for Tissue Repair and Regeneration in Wales’.  St Fagans National Museum of History, Cardiff, UK.
  • 2016-17:  Cardiff Institute for Tissue Engineering and Repair (CITER) Workshop on ‘Ageing’.  Cardiff, UK.

Committees and reviewing

Editorial Boards

  • Biomolecules.
  • Current Research in Regenerative Medicine.
  • Dermato.
  • Future Pharmacology.
  • Journal of Oral Biology.
  • Review Editor, Regenerative Dentistry Editorial Board for Frontiers in Dentistry.

Lead Guest Editorships for Journal Special Issues

  • 2020-21:  Cellular and Molecular Mechanisms of Wound Healing.  Biomolecules.  Dr R Moseley, Dr AC Midgley (Nankai University, China) and Dr R Steadman (Cardiff University, UK).  https://www.mdpi.com/journal/biomolecules/special_issues/Wound_Healing_Biomolecules
  • 2020-21:  MSC Heterogeneity:  Emerging Molecular Characteristics Distinguishing Superior Quality Sub-populations for Regenerative MedicineStem Cells International.  Dr R Moseley, Professor AJ Sloan (University of Melbourne, Australia), Dr LC Davies (Karolinska Institute, Sweden) and Dr JS Colombo (University of Nevada Las Vegas, USA).  https://www.hindawi.com/journals/sci/si/642162/

    Grant and Manuscript Reviewer

    • Grant reviewer for funders, including BBSRC, EPSRC, MRC, National Institute for Health Research (NIHR), Marie Skłodowska-Curie COFUND Fellowship Programme, AO Foundation, Austrian Research Promotion Agency (FFG), Qatar National Research Fund (QNRF), Dunhill Medical Trust, and Kidney Research UK.  
    • Manuscript reviewer for >50 journals, including Biomaterials, Journal of Investigative Dermatology, Journal of Dental Research, Stem Cell Research and Therapy, ACS Applied Materials & Interfaces, Scientific Reports, Free Radicals in Biology and Medicine, Biochemical Pharmacology, Journal of Controlled Release, Acta Biomaterialia, Biomolecules, Antioxidants, and Pharmaceutics.

    Conference Prize Reviewer

    • 2020:  Senior Colgate Prize Reviewer.  British Society for Oral and Dental (BSODR) Research Meeting (Virtual).
    • 2019:  Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Leeds, UK).
    • 2018:  Mineralised Tissue (MINTIG) Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (London, UK).
    • 2018:  Senior Colgate Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (London, UK).
    • 2016:  Senior Colgate Prize Reviewer.  Pan European (PER) Dental Research Meeting (Jerusalem, Israel).
    • 2015:  Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Cardiff, UK).
    • 2014:  Young Investigators’ Oral Presentation Reviewer.  European Tissue Repair Society (ETRS) Conference (Edinburgh, UK).
    • 2013:  Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Bath, UK).
    • 2012:  Mineralised Tissue (MINTIG) Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (Helsinki, Finland).
    • 2011:  Senior Colgate Prize Reviewer.  British Society for Oral and Dental Research (BSODR) Meeting (Sheffield, UK).
    • 2010:  Mineralised Tissue (MINTIG) Prize Reviewer.  Pan European (PER)/International Association for Dental Research (IADR) Meeting (Barcelona, Spain).
    • 2009:  Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Dental Research (BSDR) Meeting (Glasgow, UK).
    • 2008:  Senior Colgate Prize Reviewer.  Pan European (PER) Dental Research Meeting (London, UK).
    • 2007:  Mineralised Tissue (MINTIG) Prize Reviewer.  British Society for Dental Research (BSDR) Meeting (Durham, UK).

    External Thesis Examiner

    • 2021:  PhD Examiner.  King's College London, UK.
    • 2019:  PhD Examiner.  King's College London, UK.
    • 2018:  PhD Examiner.  Queen Mary University of London, UK.
    • 2018:  MRes Examiner.  Swansea University, UK.
    • 2015:  PhD Examiner.  Swansea University, UK.
    • 2012:  PhD Examiner.  University of Birmingham, UK.
    • 2009:  MRes Examiner.  Swansea University, UK.

    Internal Thesis Examiner

    • 2020:  PhD Examiner.   School of Dentistry.
    • 2017:  PhD Examiner.   School of Medicine.
    • 2016:  PhD Examiner.   School of Dentistry.
    • 2016:  PhD Examiner.   School of Medicine.
    • 2014:  PhD Examiner.   School of Dentistry.
    • 2014:  PhD Examiner.   School of Medicine.
    • 2012:  PhD Examiner.   School of Medicine.
    • 2012:  MD Examiner.     School of Medicine.
    • 2012:  MScD Examiner. School of Dentistry.
    • 2010:  MScD Examiner. School of Dentistry.

    External Committees and Responsibilities

    • 2021-present:  Board Member.  European Tissue Repair Society (ETRS).
    • 2021-present:  Leader of the Regenerative Dentistry Research Group.  British Society for Oral and Dental Research (BSODR), UK.

    University Committees and Responsibilities

    • 2021-present:  Member of the School Board.  School of Dentistry, Cardiff University, UK.
    • 2021-present:  Member of the Cardiff University Biobank Review Committee.  Cardiff University, UK.
    • 2019-present:  Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Executive Board.  Cardiff University, UK.
    • 2018-present:  Deputy Director of International.  School of Dentistry, Cardiff University, UK.
    • 2018-19:  Deputy Chair of the Cardiff Institute for Tissue Engineering and Repair (CITER) Research Committee.  Cardiff University, UK.
    • 2016-present:  Member of the Admissions and Monitoring Committee for Postgraduate Research Programmes.  School of Dentistry, Cardiff University, UK.
    • 2016-19:  Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Research Committee.  Cardiff University, UK.
    • 2015-present:  International Student Mobility Exchange Coordinator.  School of Dentistry, Cardiff University, UK.
    • 2015-present:  Member of the Student International Mobility Group and College Student International Committee.  College of Life and Biomedical Sciences, Cardiff University, UK.
    • 2015-17:  Member of the Web Editorial Board.  School of Dentistry, Cardiff UniversIty, UK.
    • 2014-17:  Member of the Research Ethics Committee.  School of Dentistry, Cardiff University, UK.
    • 2014-15:  Member of the Programme Advisory Panel for the MRes Programme in 'Medical Research and Innovation'.  School of Medicine, Cardiff University, UK.
    • 2010-present:  Member of the Staff-Student Panel for Undergraduate Programmes.  School of Dentistry, Cardiff University, UK.
    • 2009-18:  Member of the Admissions and Monitoring Committee for Taught Programmes.  School of Dentistry, Cardiff University, UK.
    • 2008-18:  Director for the Cardiff Institute for Tissue Engineering and Repair (CITER) MSc Programme in Tissue Engineering.  Cardiff University, UK.
    • 2008-16:  Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) Learning, Teaching and Engagement Committee.  Cardiff University, UK.
    • 2008-13:  Member of the Postgraduate Board of Studies Committee.  School of Dentistry, Cardiff University, UK.
    • 2008-11:  Member of the Staff-Student Panel Committee for Taught Programmes.  School of Dentistry, Cardiff University, UK.
    • 2008-09:  Member of the Postgraduate Suite Task Group Committee.  School of Dentistry, Cardiff University, UK.
    • 2007-08:  Deputy Radiation Protection Supervisor.  School of Dentistry, Cardiff University, UK.
    • 2004-18:  Member of the Cardiff Institute for Tissue Engineering and Repair (CITER) MSc Programme in Tissue Engineering Board of Studies Committee.  Cardiff University, UK.
    • 2001-04:  Member of the Year 4 BDS Dental Undergraduate Elective Committee.  School of Dentistry, Cardiff University, UK.
    • 1993-95:  Secretary of the Postgraduate Society.  University of Wales College of Medicine, Cardiff, UK.

    Publications

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    Teaching

    Undergraduate Teaching

    BDS Dental Undergraduates

    • Lecture and provide revision tutorials to Year 2 BDS students as part of the ‘Oral Ecosystems’ Theme, including (i) dental-pulp complex, (ii) prenatal jaw development, (iii) alveolar bone and cementum, (iv) osseointegration; and (v) soft tissue wound repair mechanisms around implants.
    • Provide practical sessions to Year 2 BDS on (i) dentinogenesis, (ii) dental-pulp complex; and (iii) prenatal jaw development.
    • Organize all Year 2 BDS revision tutorial sessions.
    • Setting/assessment of Year 2 BDS Teaching-Based Learning (TBL) Exercises.
    • Setting/marking of in-course assessments and examination papers for Year 2 BDS.
    • Supervision of Year 5 BDS final year research projects.
    • Academic and personal tutor to a number of year 2 BDS students.

    BSc Dental Therapy and Hygiene Undergraduates

    • Lecture to Year 1 BSc students as part of the ‘Biomedical Sciences’ Module, including (i) tissues and organs; and (ii) dental-pulp complex and dentine sensitivity.

    MPharm Pharmacy Undergraduates

    • Lecture to Year 3 MPharm students as part of the 'Diseases and Drugs, 2' Module, on (i) mechanisms of dermal wound healing.
    • Setting/marking of examination papers for MPharm Programme.

    Postgraduate Teaching

    MSc in Tissue Engineering

    • Provide lectures on (i) impaired dermal wound healing, (ii) modelling of cell-extracellular matrix interactions in vitro; and (iii) large-scale tissue/organ engineering in vitro, for the ‘Tissue Engineering: Concept-Clinical Practice’ Module.
    • Setting/marking of in-course assessments and examination papers.
    • Supervision of laboratory-based, MSc research projects.

    MSc in Implantology

    • Provide lectures and revision tutorials on (i) the principles of osseointegration; (ii) cytokines and growth factors in bone repair; and (iii) proteinase and bone repair; for the ‘Implantology’ and ‘Cellular and Molecular Biology’ Modules.
    • Setting/marking of in-course assessments and examination papers.

    MSc in Clinical Dentistry

    • Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) proteinase and bone repair; as part of the Year 1 ‘Bone Biology’ Symposium.

    MSc in Orthodontics

    • Provide lectures on (i) cytokines and growth factors in bone repair, as part of the Year 1 ‘Bone Biology’ Symposium.

    MSc in Oral Biology

    • Provide lectures on (i) histology of healthy tissues, for the 'Cell Biology of Oral Tissues' Module.
    • Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) fibroblast heterogeneity and wound healing, for the 'Tissue Repair, Regeneration and Scientific Methods’ Module.
    • Setting/marking of in-course assessments and examination papers.
    • Supervision of laboratory-based, MSc research projects.

    Recent Research Grant Awards

    • Wellcome Trust (2017-18).  Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis. £49,995.  Principle Investigator.
    • Medical Research Council (MRC) (2017-18).  Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts. £49,993.  Principle Investigator.
    • Royal Botanical Gardens Kew (2018-19).  Evaluation of the modulatory effects of plant-derived saps on neutrophil and macrophage responses associated with impaired healing, tropical ulcers.  £6,600.  Principle Investigator.
    • QBiotics Group (2018-19).  Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts.  £127,762.  Principle Investigator.
    • Cardiff University Vice-Chancellor’s International Scholarship for Research Excellence & the School of Dentistry, Cardiff University (2018-21).  Novel cancer drugs, EBC-46 and IngM, regulate disintegrin and metaplloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer. £129,973.  Co-Investigator.
    • QBiotics Group (2019-21).  Elucidation of the downstream signalling mechanisms by which epoxy-tiglianes promote preferential dermal wound healing responses.  £165,925.  Principle Investigator.
    • Kingdom of Saudi Arabia Government, PhD Studentship (2019-21).  Ophthalmic applications of pomegranate extracts.  £105,970.  Co-Investigator.
    • Kingdom of Saudi Arabia Government, PhD Studentship (2019-22).  Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana).  £107,850.  Co-Investigator.
    • Phillips Research (2020-23).  Investigating the effects of blue light on cells of the periodontium.  £112,211.  Co-Investigator.
    • Dunhill Medical Trust (2021-23).  Development of epoxy-tiglianes as novel small molecule therapeutics for impaired re-epithelialisation associated with non-healing, chronic skin wounds in the aged.  £298,338.  Principle Investigator.
    • QBiotics Group (2021-23).  Elucidation of the mechanisms by which epoxy-tiglianes promote preferential wound healing responses in dermal fibroblasts.  £272,205.  Principle Investigator.

    Filed Patents

    • Convatec Wound Care Ltd.  EP1245239A1 and US2003040690A1, relating to the antioxidant properties of wound dressing-based, biomaterials.
    • Johnson and Johnson Wound Management Ltd. (Systagenix Wound Management Ltd.).  EP1889069A1, EP1889069B1, GB2426335A, US8491852B2, US2009299161A1 and WO2006123091A1, relating to the use of total antioxidant capacity as a prognostic/diagnostic biomarker of chronic wound infection and healing.
    • Johnson and Johnson Wound Management Ltd. (Systagenix Wound Management Ltd.).  GB2447865A, US2010166694, US2012010099A1, US8012698B2 and WO2008119974A1, relating to the quantification of various cytokines and growth factors as prognostic/diagnostic biomarkers of diabetic foot ulcer wound infection and healing.
    • Peplin Inc. (LEO Pharma A/S).  AU20050906601, AU2006317523A1, AU20100213362A1, AU20100213362B2, BRPI0618926A2, CA2629899A1, CA2752389A1, CA2752389C, CN101360506A, CN102316866A, DK2395993T3, EP1965818A1, EP1965818A4, EP2395993A1, EP2395993A4, EP2395993B1, ES2633755T3, IL214133A, JP2009517345A, JP2012517450A, JP5638008B2, KR20080077625A, NZ568168A, NZ594184A, PL2395993T3, PT2395993T, RU2011137530A, RU2491050C2, US10143638B2, US2009215884A1, US2012041064A1, US2016317486A1, WO2007059584A1 and WO2010091472A1, relating to the application of ingenol mebutate and related compounds in the promotion of dermal wound healing and reduced scarring.
    • QBiotics Group.  AU2014253608A1, AU2014253608B2, BR112015026388A2,  BR112015026388A8, CA2909653A1, CN105308052A, CN105308052B, CY1121515T1, DK2986615T3, EA032501B1, EA032501B9, EA201591996A1, EP2986615A1, EP2986615A4, EP2986615B1, ES2715105T3, HK1214256A1, HRP20190435T1, HUE043272T2, IL242137A, JP2016522801A, JP6415538B2, KR102147796B1, KR20160023651A, LT2986615T, MX2015014607A, MX365255B, NZ713954A, PH12015502405A1,  PH12015502405B1, PL2986615T3, PT2986615T, RS58532B1, SG11201508588XA, SI2986615T1, TR201903565T4, UA118670C2, US10183921B2, US10183922B2, US10822317B2, US2016068499A1, US2017144981A1, US2019161462A1, WO2014169356A1; and ZA201508186B, relating to the application of epoxy-tigliane compounds, such as EBC-46, in the promotion of dermal wound healing and reduced scarring.

    External Collaborators

    • Professor Glen Boyle. QIMR Berghofer Medical Research Institute, Australia.
    • Professor Alastair Sloan.  University of Melbourne, Australia.
    • Dr Paul Reddell.  QBiotics Group, Australia.
    • Dr Steven Ogbourne, Dr Fraser Russell.  University of the Sunshine Coast, Australia.
    • Professor Matthias Born, Dr Monique Stoffels, Pieter Horstman.  Phillips Research, The Netherlands.
    • Dr Tom Prescott.  Royal Botanical Gardens Kew, UK.
    • Dr Daryn Michael, Dr Susan Plummer.  Cultech Ltd., UK.

    Cardiff University Collaborators

    • School of Biosciences:  Dr Ahmed Ali.
    • School of Dentistry:  Professor Rachel Waddington, Dr Vera Knäuper, Dr Sharon Dewitt.
    • School of Medicine:  Dr Robert Steadman.
    • School of Pharmacy and Pharmaceutical Sciences:  Dr Charles Heard.

    Current Postgraduate Students

    Co-Supervisor

    • Vildan Celiksoy (PhD student, Year 3).  Punica granatum extract applications (in collaboration with the School of Pharmacy & Pharmaceutical Sciences, Cardiff University).
    • Kasope Olukogbon (PhD student, Year 3).  Calcilytics for treating pulmonary remodelling associated with inflammatory lung diseases:  Gene and protein expression studies of human lung fibroblasts (in collaboration with the School of Biosciences, Cardiff University).
    • Frank Antwi (PhD student, Year 3).  Novel cancer drugs, EBC-46 and IngM, regulate disintegrin and metaplloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer.
    • Ahmed Asiri (PhD student, Year 2).  Ophthalmic applications of pomegranate extracts (in collaboration with the School of Pharmacy & Pharmaceutical Sciences and the School of Optometry & Vision Sciences, Cardiff University).
    • Abdulaziz Alqarni (PhD student, Year 2).  Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana) (in collaboration with the School of Pharmacy & Pharmaceutical Sciences and the School of Biosciences, Cardiff University).
    • Edward Gait-Carr (PhD student, Year 2).  Investigating the effects of blue light on cells of the periodontium.

    Current Postdoctoral Research Staff

    • Dr Jordanna Dally.  Development of epoxy-tiglianes as novel small molecule therapeutics for impaired re-epithelialisation associated with non-healing, chronic skin wounds in the aged (in collaboration with the School of Medicine, Cardiff University).
    • Dr Emma Woods.  Elucidation of the mechanisms by which epoxy-tiglianes promote preferential wound healing responses in dermal fibroblasts (in collaboration with the School of Medicine, Cardiff University).

    Supervision

    I am currently interested in supervising PhD students in the following areas:

    • Mechanisms underlying oral mucosal and dermal wound healing responses.
    • Drug development for enhanced wound healing outcomes in skin.
    • Dental pulp stem cell (DPSC) heterogeneity.
    • Oxidative stress and impaired diabetic bone healing.

    Past projects

    Completed Postgraduate Research Students and Year of Award

    PhD Students

    • 2020:  Dr Nadia Alaidaroos.  Role of oxidative stress responses in clonal variations in dental pulp progenitor cell ageing and regenerative potentialLead Supervisor.
    • 2017:  Dr Jordanna Dally.  Pharmaceutical evaluation of novel tigliane compounds as modulators of dermal fibroblast-myofibroblast differentiation, scar tissue resolution and fibrosis; and elucidation of their underlying mechanisms of actionLead Supervisor.
    • 2017:  Dr Glyn Morris.  Role of microRNA-7 in the age-related impairment of TGF-β1-driven differentiation in chronic wound fibroblastsCo-Supervisor.
    • 2017:  Dr Ahmed Al-Qarakhli.  Altered bone cell biology associated with type 2 diabetes mellitus – Consequences for periodontal diseaseCo-Supervisor.
    • 2015:  Dr Rachael Moses.  Evaluation of the stimulatory effects of EBC-46 on dermal fibroblast and keratinocyte wound healing responses in vitroLead Supervisor.
    • 2014:  Dr Karina Hamilton.  Evaluation of the wound-healing properties of cerumen from the Australian native stingless bee (Tetragonula carbonaria) for the treatment of chronic wounds, and the effects of bee foraging behaviours on cerumen bioactivityCo-Supervisor.
    • 2014:  Dr Norayati Yusop.  Growth factor responsiveness of mesenchymal progenitor cells during bone repair associated with type 2 diabetesCo-Supervisor.
    • 2012:  Dr Amr Alraies.  Exploiting dental pulp stem cells for dental tissue regenerationCo-Supervisor.
    • 2009:  Dr Nicole Kane-Maguire.  An in vitro study on the potential effects of PEP005 on the wound healing responses of fibroblasts and keratinocytesLead Supervisor.
    • 2009:  Dr Joseph Hardwicke.  Polymer therapeutics to modify cellular responses in impaired human wound healingCo-Supervisor.
    • 2005:  Dr Rachael McInnes.  Prognostic and diagnostic markers of infection in chronic woundsLead Supervisor.

    MD, MPhil and MScD Students

    • 2009:  Dr Arshad Kazi (MScD student).  Influence of the hydrogen peroxide pre-treatment of titanium surfaces on the induction of osteoblast differentiation in vitroLead Supervisor.
    • 2007:  Dr Parkash Lohana (MPhil student).  Oxidative stress mediation of cellular ageing in patient-matched, oral mucosal and skin fibroblastsLead Supervisor.
    • 2006:  Dr Abdulaziz Daw (MPhil student).  An investigation of the potential enhancement of osseointegration at titanium implant surfaces, via the pre-application of hydrogen peroxideLead Supervisor.
    • 2006:  Dr Mariam Nagassa (MScD student).  Influence of hydrogen peroxide pre-treatment on protein interaction and the topography of titanium implant surfacesLead Supervisor.
    • 2005:  Dr Albert Suryaprawira (MScD student).  Immunohistochemical comparison of oxidative stress biomarker and antioxidant enzyme profiles between oral mucosal and dermal tissuesLead Supervisor.
    • 2003:  Dr Joanna Hilton (MD student).  A study of cellular and molecular ageing in the tissues of patients with chronic venous leg ulceration.  Co-Supervisor.