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Dr Ryan Moseley

Dr Ryan Moseley

Reader in Tissue Repair

School of Dentistry

Email
moseleyr@cardiff.ac.uk
Telephone
+44 (0) 29 2251 0649 (Ext. 10649).
Campuses
Room 413, 4th Floor, University Dental Hospital, Heath Park, Cardiff, CF14 4XY
Comment
Media commentator
Users
Available for postgraduate supervision

Research Group

Stem Cells, Wound Repair and Regeneration Group

Professional Memberships

Association of Science Educators in Dentistry (ASEiD); British Society for Oral and Dental Research (BSODR); Cardiff Institute for Tissue Engineering and Repair (CITER); European Tissue Repair Society (ETRS); Higher Education Academy (HEA, Fellow Status); International Association for Dental Research (IADR); MediWales, Natural Compounds Special Interest Group; STEM Learning.

Previous Academic Positions

2012-2017: Senior Lecturer in Tissue Repair & Programme Director, CITER MSc in Tissue Engineering. Stem Cells, Wound Repair and Regeneration, Oral and Biomedical Sciences, School of Dentistry, Cardiff University.

2008-2012: Lecturer in Tissue Repair & Programme Director, CITER MSc in Tissue Engineering. Wound Biology Group, Tissue Engineering & Reparative Dentistry, School of Dentistry, Cardiff University.

2002-2008: Senior Postdoctoral Research Officer. Wound Biology Group, Tissue Engineering & Reparative Dentistry, School of Dentistry, Cardiff University.

2000-2002: Locum Lecturer in Oral Biochemistry. Matrix Biology & Tissue Repair Research Unit, Department of Dental Health & Biological Sciences, School of Dentistry, University of Wales College of Medicine, Cardiff.

1998-2000: Postdoctoral Research Fellow, funded by The Wellcome Trust. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, Cardiff.

1996-1998: Postdoctoral Research Fellow, funded by The British Heart Foundation. Department of Cardiology & Institute of Nephrology, University of Wales College of Medicine, Cardiff.

Qualifications

2010: Postgraduate Certificate in University Teaching and Learning (PCUTL). Human Resource Directorate, Cardiff University.

1996: PhD in Oral Biochemistry, funded by the Medical Research Council. Department of Basic Dental Science, School of Dentistry, University of Wales College of Medicine, Cardiff.  PhD Thesis entitled ‘Structural Changes in Periodontal Proteoglycans by Reactive Oxygen Species’.

1993: Diploma in Biomedical Methods. University of Wales College of Medicine, Cardiff.

1991: Upper Second Class BSc (Honours) Degree in Biochemistry. Department of Biochemistry, Swansea University.

Dr Moseley is currently Reader in Tissue Repair.  He obtained his BSc in Biochemistry at Swansea University in 1991, before commencing his MRC-funded, PhD at the School of Dentistry, University of Wales College of Medicine (UWCM) in 1992.  He obtained his PhD in 1996, before embarking on Postdoctoral Researcher positions at UWCM / Cardiff University (funded by the British Heart Foundation, Wellcome Trust and Johnson & Johnson Wound Management).  In 2008, Dr Moseley was appointed Lecturer in Tissue Repair within the School of Dentistry and as Director of the CITER MSc Programme in Tissue Engineering (2008-2018), being promoted to Senior Lecturer in 2012 and to Reader in 2017.

Dr Moseley’s research focus on the mechanisms underlying cellular wound healing responses in oral (bone, oral mucosa, dental pulp) and dermal (normal skin, chronic wound) tissues during health and disease.  By understanding these mechanisms, his Research Group aims to develop cellular, biomaterial and pharmaceutical strategies to promote repair in these tissues.

Dr Moseley has successfully managed numerous projects in these research areas, supported by non-commercial and commercial funding sources worldwide (>£2.8M to date), including the MRC, NHMRC (Australia), Wellcome Trust, NISCHR, Life Sciences Research Network Wales (Sêr Cymru), Malaysian Government, Iraqi Government, Kingdom of Saudi Arabian Government, Convatec Wound Care Ltd., Systagenix Wound Management Ltd., Peplin Inc. (now owned by LEO Pharma A/S), QBiotics Group and Phillips Research.

Such research has culminated in numerous peer-reviewed papers, filed patents with industrial partners in the dermal wound healing sector; and many local, national and international conference prizes for staff and students under his supervision.  He also acts as an ad hoc reviewer for national and international grant funding bodies, journals and as an examiner of a number of Postgraduate (MSc, MD, PhD) research degree theses.  In addition, Dr Moseley is a member of the Editorial Boards for the Journal of Dentistry and Oral Biology, Journal of Oral Biology, Current Research in Regenerative Medicine; and Review Editor for the Regenerative Dentistry Editorial Board of Frontiers in Dentistry.

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Undergraduate Teaching

BDS Dental Undergraduates

  • Lecture and provide revision tutorials to Year 2 BDS students as part of the ‘Oral Ecosystems’ Theme, including (i) dental-pulp complex, (ii) prenatal jaw development, (iii) alveolar bone and cementum, (iv) osseointegration; and (v) soft tissue wound repair mechanisms around implants.
  • Provide practical sessions to Year 2 BDS on (i) dentinogenesis, (ii) dental-pulp complex; and (iii) prenatal jaw development.
  • Organize all Year 2 BDS revision tutorial sessions.
  • Setting/assessment of Year 2 BDS Problem Based Learning (PBL) Exercises.
  • Setting/marking of in-course assessments and examination papers for Year 2 BDS.
  • Supervision of Year 5 BDS final year research projects.
  • Academic and personal tutor to a number of year 2 BDS students.

MPharm Pharmacy Undergraduates

  • Lecture to Year 3 MPharm as part of the 'Diseases and Drugs, 2' Module, on (i) mechanisms of dermal wound healing.
  • Setting/marking of examination papers for MPharm Programme.

Postgraduate Teaching

MSc in Tissue Engineering

  • Provide lectures on (i) impaired dermal wound healing, (ii) modelling of cell-extracellular matrix interactions in vitro; and (iii) large-scale tissue/organ engineering in vitro, for the ‘Tissue Engineering: Concept-Clinical Practice’ Module.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

MSc in Implantology

  • Provide lectures and revision tutorials on (i) the principles of osseointegration; (ii) cytokines and growth factors in bone repair; and (iii) proteinase and bone repair; for the ‘Implantology’ and ‘Cellular and Molecular Biology’ Modules.
  • Setting/marking of in-course assessments and examination papers.

MSc in Clinical Dentistry

  • Provide lectures on (i) cytokines and growth factors in bone repair; and (ii) proteinase and bone repair; as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Orthodontics

  • Provide lectures on (i) cytokines and growth factors in bone repair, as part of the Year 1 ‘Bone Biology’ Symposium.

MSc in Oral Biology

  • Provide lectures on (i) Fibroblast heterogeneity and wound healing, for the 'Tissue Repair, Regeneration and Scientific Methods’ Module.
  • Setting/marking of in-course assessments and examination papers.
  • Supervision of laboratory-based, MSc research projects.

My research focusses on various aspects of basic and translational research, related to the mechanism underlying contrasting wound healing responses in oral (e.g. bone, oral mucosa, dental pulp) and dermal (e.g. normal skin, chronic wound) tissues, during health and disease.  Such studies have furthered our understanding of oral and dermal tissues, enabling my research to also develop cellular, biomaterial and pharmaceutical strategies to promote tissue repair and disease management in patients.

Recent Grant Awards

Sêr Cymru (Life Sciences Research Network Wales) & QBiotics Group. (2014-2017).  Pharmaceutical evaluation of novel tigliane compounds as modulators of dermal fibroblast-myofibroblast differentiation, scar tissue resolution and fibrosis; and elucidation of their underlying mechanisms of action. £105,190.

Iraqi Government, Ministry for Higher Education and Scientific Research (2014-17).  Altered bone cell biology associated with type 2 diabetes mellitus:  Consequences for periodontal disease. £90,000.

National Institute for Social Care and Health Research (NISCHR) (2014-17).  Role of microRNA-7 in impaired TGF-β1-driven differentiation in chronic wound fibroblasts. £66,000.

Australian National Health & Medical Research Council (NHMRC) (2015-18).  Development of a novel drug for chronic and infected wounds. AU$467,975.

Kingdom of Saudi Arabia Government, PhD Studentship (2015-18).  Role of oxidative stress responses in clonal variations in dental pulp progenitor cell ageing and regenerative potential. £88,500.

Medical Research Council (MRC) (2016-17).  Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis. £49,988.

QBiotics Group (2016-18).  Elucidation of the underlying mechanisms of action by which novel epoxy-tigliane pharmaceuticals promote preferential wound healing. £251,706.

Wellcome Trust (2017-18).  Repurposing ingenol mebutate as a novel pharmaceutical therapy for dermal fibrosis. £49,995.

Medical Research Council (MRC) (2017-18).  Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts. £49,993.

Royal Botanical Gardens Kew (2018-19).  Evaluation of the modulatory effects of plant-derived saps on neutrophil and macrophage responses associated with impaired healing, tropical ulcers.  £6,600.

QBiotics Group (2018-19).  Evaluation of novel epoxy-tigliane pharmaceuticals as modulators of impaired wound healing responses in chronic wound fibroblasts.  £127,762.

Cardiff University Vice-Chancellor’s International Scholarship for Research Excellence & the School of Dentistry, Cardiff University (2018-21).  Novel cancer drugs, EBC-46 and IngM, regulate disintegrin and metaplloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer. £129,973.

QBiotics Group (2019-20).  Elucidation of the downstream signalling mechanisms by which epoxy-tiglianes promote preferential dermal wound healing responses.  £165,925.

Kingdom of Saudi Arabia Government, PhD Studentship (2019-21).  Ophthalmic applications of pomegranate extracts.  £105,970.

Kingdom of Saudi Arabia Government, PhD Studentship (2019-22).  Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana).  £107,850.

Phillips Research (2020-23).  Investigating the effects of blue light on cells of the periodontium.  £112,211.

Recent Awards

2015:  Cardiff University, Postgraduate Research Day Poster Prize (Jordanna Dally).

2015:  Sêr Cymru (Life Sciences Research Network Wales) PhD Student Oral Presentation Prize (Jordanna Dally).

2017:  ETRS Poster Prize (Glyn Morris).

2017:  CITER Oral Presentation Prize (Glyn Morris).

2018:  Cardiff University, Postgraduate Research Day Poster Prize (Nadia Alaidaroos).

2019:  Cardiff University, School of Dentistry Annual Research Day Poster Prize (Jordanna Dally).

2020:  Cardiff University, Postgraduate Research Day Poster Prize (Vildan Celiksoy).

Filed Patents

Convatec Wound Care Ltd. EP1245239A1 and US2003040690A1, relating to the antioxidant properties of wound dressing-based, biomaterials.

Systagenic Wound Management Ltd. EP1889069A1, EP1889069B1, GB2426335A, US8491852B2, US2009299161A1 and WO2006123091A1, relating to the use of total antioxidant capacity as a prognostic/diagnostic biomarker of chronic wound infection and healing.

Systagenic Wound Management Ltd. GB2447865A, US2010166694, US2012010099A1, US8012698B2 and WO2008119974A1, relating to the quantification of various cytokines and growth factors as prognostic/diagnostic biomarkers of diabetic foot ulcer wound infection and healing.

Peplin Inc. (LEO Pharma A/S). AU20050906601, AU2006317523A1, AU20100213362A1, AU20100213362B2, BRPI0618926A2, CA2629899A1, CA2752389A1, CA2752389C, CN101360506A, CN102316866A, DK2395993T3, EP1965818A1, EP1965818A4, EP2395993A1, EP2395993A4, EP2395993B1, ES2633755T3, IL214133A, JP2009517345A, JP2012517450A, JP5638008B2, KR20080077625A, NZ568168A, NZ594184A, PL2395993T3, PT2395993T, RU2011137530A, RU2491050C2, US10143638B2, US2009215884A1, US2012041064A1, US2016317486A1, WO2007059584A1 and WO2010091472A1, relating to the application of ingenol mebutate and related compounds, in the promotion of dermal wound healing and reduced scarring.

QBiotics Group. AU2014253608A1, AU2014253608B2, BR112015026388A2, CA2909653A1, CN105308052A, CN105308052B, DK2986615T3, EA201591996A1, EA032501B1, EA032501B9, EP2986615A1, EP2986615A4, EP2986615B1, ES2715105T3, HK1214256A1, HRP20190435T1, HUE043272T2, IL242137A, JP2016522801A, JP6415538B2, KR20160023651A, LT2986615T, MX2015014607A, MX365255B, PH12015502405A1, PL2986615T3, PT2986615T, RS58532B1, SG11201508588XA, SI2986615T1, TR201903565T4, UA118670C2, US2016068499A1, US10183921B2, US2017144981A1, US10183922B2, US2019161462A1, WO2014169356A1 and ZA201508186B, relating to the application of epoxy-tigliane compounds, such as EBC-46 and EBC-211, in the promotion of dermal wound healing and reduced scarring.

External Collaborators

Professor Glen Boyle, QIMR Berghofer Medical Research Institute, Australia.

Dr Steven Ogbourne & Dr Fraser Russell, University of the Sunshine Coast, Australia.

Dr Paul Reddell, QBiotics Group, Australia.

Dr Tom Prescott, Royal Botanical Gardens Kew, UK.

Professor M Born, Dr P Horstman and Dr J Liebmann, Phillips Research, The Netherlands.

Current Postgraduate Students

Lead Supervisor

  • Nadia Alaidaroos (PhD student, Year 3).  Role of oxidative stress responses in clonal variations in dental pulp progenitor cell ageing and regenerative potential.

Co-Supervisor

  • Vildan Celiksoy (PhD student, Year 3).  Punica granatum extract applications (in collaboration with the School of Pharmacy & Pharmaceutical Sciences, Cardiff University).
  • Kasope Olukogbon (PhD student, Year 2).  Calcilytics for treating pulmonary remodelling associated with inflammatory lung diseases:  Gene and protein expression studies of human lung fibroblasts (in collaboration with the School of Biosciences, Cardiff University).
  • Frank Antwi (PhD student, Year 2).  Novel cancer drugs, EBC-46 and IngM, regulate disintegrin and metaplloproteinase (ADAM) activity - Impact on tyrosine kinase signalling in head and neck cancer.
  • Ahmed Asiri (PhD student, Year 2).  Ophthalmic applications of pomegranate extracts (in collaboration with the School of Pharmacy & Pharmaceutical Sciences and the School of Optometry & Vision Sciences, Cardiff University).
  • Abdulaziz Alqarni (PhD student, Year 1).  Evaluation of the antibacterial, anti-inflammatory and wound healing properties of frankincense (Boswellia frereana) (in collaboration with the School of Pharmacy & Pharmaceutical Sciences and the School of Biosciences, Cardiff University).
  • Edward Gait-Carr (PhD student, Year 1).  Investigating the effects of blue light on cells of the periodontium.

Current Postdoctoral Staff

  • Dr Rachael Moses. Elucidation of the downstream signalling mechanisms by which epoxy-tiglianes promote preferential dermal wound healing responses. (in collaboration with the School of Medicine, Cardiff University).