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 Chris Hurt

Chris Hurt

Senior Research Fellow - Statistics

Email
hurtcn@cardiff.ac.uk
Telephone
+44 (0)29 2068 7471
Campuses
Room 504, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS

Senior Research Fellow (Statistics) at the Centre for Trials Research working on the design and analysis of clinical trials and other epidemiological studies primarily in maternal health, radiation oncology, and cancer prevention.

Education and qualifications

2018: PgD Autism and Related Conditions (with Distinction), Swansea

2004: MSc Applied Statistics (with Distinction), Sheffield

1998: MSc Computing Science (with Merit), Birkbeck College, London

1994: BSc Ecology (2i), University of Sheffield

Honours and awards

Honorary Member of the Royal College of Radiologists, 2016

Professional memberships

2012-2015: Member of the National Cancer Research Institute Upper GI CSG

2009-present: Member of the National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group 

2008-2011: Member of the National Cancer Research Institute Primary Care CSG

Academic positions

2007- present: Senior Statistician, Cardiff University

2006-7: Principal Researcher, Office for National Statistics (Civil Service Fast Stream)

2004-6: Statistician, London School of Hygiene and Tropical Medicine

2001-4: Research Fellow, Advanced Computation Laboratory, Cancer Research UK

2000-2001: Statistical Programmer, Imperial College London

1999-2000: Analyst Programmer, University of Oxford

Committees and reviewing

2011-present: Member of the Cancer Research UK Clinical Expert Review Panel

2015-present: Member of the Welsh Bowel Cancer Screening Research & Evaluation Group (Public Health Wales)

2018-present: Peer Reviewer for National Institute for Health Research grant applications

Chair of the Indepedent Data Monitoring Committe for the following trials:

ARISTOTLE: A phase III trial comparing standard versus novel CRT as pre-operative treatment for MRI defined locally advanced rectal cancer (run by University College London)

HYBRID: A multicentre randomised phase II study of HYpofractionated Bladder Radiotherapy with or without Image guided aDaptive planning (run by Institute of Cancer Research, London)

RAIDER: A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder (run by Institute of Cancer Research, London)

Member of the Indepedent Data Monitoring Committe for the following UK trials:

COSTAR - A Multicentre Randomised Study Of Cochlear Sparing Intensity Modulated Radiotherapy Versus Conventional Radiotherapy In Patients With Parotid Tumours (run by Institute of Cancer Research, London)

REALISTIC - A Phase I, Dose Escalation Trial Of Recombinant Listeria Monocytogenes (Lm)-Based Vaccine Encoding Human Papilloma Virus Serotype 16 Target Antigens (ADXS11-001) In Patients With HPV-16 +ve Oropharyngeal Carcinoma (University College London)

DARS – A phase III randomised multicentre study of dysphagia optimised intensity modulated radiotherapy (Do-IMRT) versus standard intensity modulated radiotherapy (S-IMRT) in head and neck cancer (run by Institute of Cancer Research, London)

E-PREDICT - A Phase I Study Of Everolimus Therapy Before Nephrectomy In Metastatic Renal Cell Cancer (run by Institute of Cancer Research, London)

ART-DECO: A Randomised Multicentre Accelerated Radiotherapy Study of Dose Escalated Intensity Modulated Radiotherapy vs Standard Dose Intensity Modulated Radiotherapy in Patients Receiving Treatment for Locally Advanced Laryngeal and Hypopharyngeal Cancers (run by Institute of Cancer Research, London)

NEPTUNES: Nivolumab and ipilimumab treatment in prostate cancer with an immunogenic signature (University College London)

LITEFORM: A Randomised Controlled Trial of the Clinical and Cost Effectiveness of Low Level Laser in the Management of Oral Mucositis in Head and Neck Cancer Irradiation (Newcastle University).

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Co-supervisor for research projects on the Intercalated BSc in Population Medicine at Cardiff University 

2007-present: Module Organiser (Statistics for Epidemiology) on the MSc Epidemiology at the London School of Hygiene and Tropical Medicine

2011-2014: Member of the exam board for Fellowship of the Royal College of Radiologists (FRCR)

2009-2011: Lecturer (Study Design) on the MSc Palliative care at Cardiff University 

I am interested in designing studies and analysing data to improve health outcomes.

Currently I am a co-investigator on the following funded projects and programme grants:

VALTIVE1: Validation of Tie2 as the first tumour vascular response biomarker for VEGF inhibitors: Optimising the design of a subsequent randomised discontinuation trial (CRUK; £1.00 million; 2010-2024)

CONSCOP2: Randomised controlled trial of contrast enhanced colonoscopy in the reduction of right sided bowel cancer (NIHR HTA; £2.20 million; 2019-2025)

Trials unit core funding: Cancer Division of the Centre for Trials Research (NIHR HTA; £5.50 million; 2018-2023)

PATHOS Phase III: Post-operative adjuvant treatment for HPV-positive tumours Phase 3 (CRUK; £2.10 million; 2018-2027)

Best-of: Phase III study assessing the “best of” radiotherapy compared to the “best of” surgery (trans-oral surgery (TOS)) in patients with T1-T2, N0 oropharyngeal carcinoma (CRUK; £0.32 million; 2017-2025)

SCOPE2: A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemo-radiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET) (CRUK; £1.68 million; 2015-2024)

I am interested in supervising PhD students in the areas of:

  • methodology involved in the design and analysis of oncology trials
  • colorectal cancer screening
  • radiation oncology

Past projects

Co-supervisor intercalated BSc project: “Impact of the bowel cancer screening programme on mortality from colorectal cancer in Wales” (2020)

Co-supervisor MSc Palliative Care project: “Quality of life in palliative care centres” (awarded 2011)