![Georgina Gardner](https://profiles-cardiff.imgix.net/attachments/3568?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Mrs Georgina Gardner
(she/her)
Clinical Trials Manager
- GardnerG@cardiff.ac.uk
- Neuadd Meirionnydd, Room Floor 6, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
Overview
With 25 years of experience in Oncology, my professional journey began within the Clinical Trials Unit at Velindre Cancer Centre, where I dedicated a decade to setting up various oncology studies alongside the Research Team. This equipped me with a wealth of knowledge which transferred to my 15-year tenure at CTR, initially as a Data Manager and subsequently promoted to the role of Trial Manager in 2014.
Over the years, I have actively contributed to a spectrum of studies, spanning lung, gynecological, and colorectal cancer, on both CTIMP and non-CTIMP studies such as RT3VIN, SCOPE, CONSCOP, CONSCOP2, VIM, PIN, and QuicDNA.
My primary focus revolves around early detection, screening, and prevention strategies. Currently, I am managing the CONSCOP2, where my efforts are dedicated to enhancing the efficacy of bowel cancer screening programs. This involves a meticulous comparison between standard colonoscopies and chromocolonoscopy to reduce the incidence and mortality of proximal colon cancer. I am also setting up the QuicDNA study which is looking at shortening the time to receive treatment for stage IV lung cancer patients.
Drawing from my extensive background, which includes setting up clinical trials in both hospital and university settings, I possess a broad understanding of the optimal approaches to engage sites, collaborate with research nurses, and maintant positive relationships across diverse professions.
Publication
2022
- Fennell, D. A. et al. 2022. Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial. EClinicalMedicine 52, article number: 101595. (10.1016/j.eclinm.2022.101595)
- Fennell, D. A. et al. 2022. Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine 48, article number: 101432. (10.1016/j.eclinm.2022.101432)
2019
- Hurt, C. et al. 2019. Feasibility and economic assessment of chromocolonoscopy for detection of proximal serrated neoplasia within a population-based colorectal cancer screening programme (CONSCOP): an open-label, randomised controlled non-inferiority trial. Lancet Gastroenterology and Hepatology 4(5), pp. 364-375. (10.1016/S2468-1253(19)30035-4)
Articles
- Fennell, D. A. et al. 2022. Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial. EClinicalMedicine 52, article number: 101595. (10.1016/j.eclinm.2022.101595)
- Fennell, D. A. et al. 2022. Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial. eClinicalMedicine 48, article number: 101432. (10.1016/j.eclinm.2022.101432)
- Hurt, C. et al. 2019. Feasibility and economic assessment of chromocolonoscopy for detection of proximal serrated neoplasia within a population-based colorectal cancer screening programme (CONSCOP): an open-label, randomised controlled non-inferiority trial. Lancet Gastroenterology and Hepatology 4(5), pp. 364-375. (10.1016/S2468-1253(19)30035-4)
Research
I have managed the following studies which are now closed.
VIM - A randomised controlled phase II trial of oral vinorelbine as second line therapy for patients with malignant pleural mesothelioma
PIN - A randomised phase II trial of Olaparib maintenance versus placebo monotherapy in patients with chemosensitive advanced non-small cell lung cancer
CONSCOP - Feasability study in reduction of right sided bowel cancer through contrast enhanced colnonoscopy
I currently manage the following clinical study within the Centre for Trials Research:
CONSCOP2 - Randomised controlled trial of contrast enhanced colonoscopy in the reduction of right sided bowel cancer
Papers and Abstracts
THELANCETGASTROHEP-D-19-00011R2, Feasibility and economic evaluation of chromocolonoscopy for detection of proximal serrated neoplasia: a randomised controlled trial within a population based colorectal cancer screening programme (the CONSCOP study)
ASCO Abstract #305579
PIN - A randomised phase II trial of olaparib maintenance versus placebo monotherapy in patients with chemosensitive advanced non-small cell lung cancer.
ASCO Annual Meeting (June 4 - June 8, 2021):
Abstract ID #: 333139 Title: VIM - A randomised phase II trial of oral vinorelbine as second line therapy for patients with malignant pleural mesothelioma.
Biography
Clinical Trials Manager, WCTU November 2014 to date
Solid Tumour Portfolio developer, NISCHR, WCTU July 2013 – November 2014
Data Manager, Wales Cancer Trials Unit December 2008 – July 2013
Research administrator, Velindre NHS Trust 1998 - 2008
Research themes
Specialisms
- Cancer screening, prevention and early diagnosis