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 Hazel Hall-Roberts

Hazel Hall-Roberts

Research Associate, Dementia Research Institute

School of Medicine

Email
hall-robertsh@cardiff.ac.uk
Campuses
Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

Overview

I am a postdoctoral research associate in the UK Dementia Research Institute at Cardiff, and I manage their Stem Cell facility. I received my undergraduate BSc Biochemistry with Year in Industry degree from University of Bristol (2012), and a PhD from the University of Bath, UK.

My research focusses on the role of microglia in neurodegenerative diseases, specifically Alzheimer's disease, using in vitro models. As a postdoctoral researcher in the lab of Dr Sally Cowley/Prof William James in the University of Oxford (2016-2020), I was trained in induced pluripotent stem cell (iPSC) culture and differentiation to macrophages and microglia. In collaboration with the Alzheimer's Research UK Oxford Drug Discovery Institute, I studied the impact of late-onset Alzheimer's disease genetic risk factors upon microglia cell phenotype, using iPSC-macrophages as an in vitro microglia model. I then moved to the UK Dementia Research Institute at Cardiff University to head an ambitious project under Prof Julie Williams, generating new iPSC lines from Alzheimer's disease patients with high levels of polygenic risk, and studying their phenotypes when differentiated to iPSC-microglia-like cells.

Biography

Publications

2021