Dr You Zhou
Lecturer
- zhouy58@cardiff.ac.uk
- +44 (0)29 2068 7076
- Tenovus Building, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
- Available for postgraduate supervision
Overview
I am a Lecturer at the Systems Immunity University Research Institute and the Division of Infection & Immunity, Cardiff University. Over the course of my career, I have worked for, the World Health Organization, the Finnish National Institute for Health and Welfare, and the Chinese State Key Laboratory of Virology. These positions have led to impactful presentations at major conferences (e.g., WHO meeting in Nutrition, Physical Activity and Obesity; EU Framework 7 project meeting) and several scientific awards including a Young Scientist Award from a biennial international forum, Nordic Lipid Forum. My research interest is using data-driven informatics to understand metabolic inflammation, focusing on, but not limited to, fatty liver disease.
Biography
Career overview
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Systems Immunity University Research Institute and Division of Infection & Immunity, Cardiff University: Lecturer (2016-Present)
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Faculty of Medicine, University of Helsinki: Adjunct Professor/Docent in Molecular Medicine (Honorary title granted for lifetime, May 2015-Present)
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Minerva Foundation Institute for Medical Research. Postdoctor fellow in Bioinformatics. Supervisor: Prof. Hannele Yki-Järvinen (2013-2016)
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Minerva Foundation Institute for Medical Research, Finland. Researcher. Supervisor: Director & Prof. Vesa Olkkonen (2012-2013)
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Division of Noncommunicable Diseases and Health Promotion, World Health Organization, European headquarter, Denmark. Supervisor: Dr. João Breda. (2012)
- National Institute for Health and Welfare, Finland. Researcher. Supervisor: Prof. Vesa Olkkonen (2007-2011)
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State key laboratory of Virology, China. Research assistant. Supervisor: Dean & Prof. Deyin Guo (2005-2007).
Education and qualifications
- PhD in Medical Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Finland (Nov. 2007-Apr. 2013).
- Minor in Mathematics and Statistics, Faculty of Science, University of Helsinki, Finland (obtained 60 ECTs, Nov. 2007-Apr. 2013).
- Master of Science in Microbiology, College of Life Sciences, Wuhan University, China.GPA: A level, 93/100 (equals to 3.8/4.0). (Sep 2005-Aug 2007)
Honours and awards
- Young Scientist Award, Nordic Lipid Forum, biennial international forum, June 2011.
- University of Helsinki Medicine Fund Award for 2 years (2011-2013)
- Finnish Atherosclerosis Society travel grant award for 6 continuous years (2008-2014).
- University of Helsinki Chancellor’s Grant for 5 continuous years (2008-2013)
- Third Prize, Chinese National Mathematical Olympiad (2000).
Professional memberships
Chair, BSI South Wales Immunology Group (April 2018 - present)
Publications
2023
- Wang, H. et al. 2023. Modelling hybrid acoustofluidic devices for enhancing nano- and micro-particle manipulation in microfluidics. Applied Acoustics 205, article number: 109258. (10.1016/j.apacoust.2023.109258)
2022
- Asghar, M. Y., Knuutinen, T., Holm, E., Nordström, T., Nguyen, V. D., Zhou, Y. and Törnquist, K. 2022. Suppression of calcium entry modulates the expression of TRβ1 and Runx2 in thyroid cancer cells, two transcription factors that regulate invasion, proliferation and thyroid-specific protein levels. Cancers 14(23), article number: 5838. (10.3390/cancers14235838)
- Sun, C. et al. 2022. Acoustically accelerated neural differentiation of human embryonic stem cells. Acta Biomaterialia 151, pp. 333-345. (10.1016/j.actbio.2022.07.041)
- Robb, C. T. et al. 2022. Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses. Allergy (10.1111/all.15541)
- Nagaraj, M. et al. 2022. GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth. Journal of Lipid Research 63(9), article number: 100259. (10.1016/j.jlr.2022.100259)
- Lluch, A. et al. 2022. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis. JCI Insight 7(14), article number: e150461. (10.1172/jci.insight.150461)
- Ahonen, M. A. et al. 2022. Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. Molecular Medicine 28(1), article number: 68. (10.1186/s10020-022-00496-3)
- Takala, R. et al. 2022. Pinolenic acid exhibits Anti-inflammatory and Anti-atherogenic effects in Peripheral blood- derived Monocytes from patients with Rheumatoid Arthritis. Scientific Reports 12, article number: 8807. (10.1038/s41598-022-12763-8)
- Arora, A. et al. 2022. Protrudin regulates FAK activation, endothelial cell migration and angiogenesis. Cellular and Molecular Life Sciences 79(4), article number: 220. (10.1007/s00018-022-04251-z)
- Takala, R., Ramji, D. P., Andrews, R., Zhou, Y., Burston, J. and Choy, E. 2022. Anti-inflammatory and immunoregulatory effects of pinolenic acid in rheumatoid arthritis. Rheumatology 61(3), pp. 992-1004. (10.1093/rheumatology/keab467)
2021
- Goepp, M., Crittenden, S., Zhou, Y., Rossi, A. G., Narumiya, S. and Yao, C. 2021. Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF-β signalling. Immunology 164(4), pp. 777-791. (10.1111/imm.13417)
- Asghar, M. Y. et al. 2021. Stromal interaction molecule 1 (STIM1) knock down attenuates invasion and proliferation and enhances the expression of thyroid-specific proteins in human follicular thyroid cancer cells. Cellular and Molecular Life Sciences 78, pp. 5827-5846. (10.1007/s00018-021-03880-0)
- Crittenden, S. et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
- Abdul-Jawad, S. et al. 2021. Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients. Cancer Cell 39(2), pp. 257-275., article number: E6. (10.1016/j.ccell.2021.01.001)
- Bai, X. et al. 2021. Integrated metabolomics and lipidomics analysis reveal remodeling of lipid metabolism and amino acid metabolism in glucagon receptor–deficient zebrafish. Frontiers in Cell and Developmental Biology 8, article number: 605979. (10.3389/fcell.2020.605979)
2020
- Qadri, S. et al. 2020. The PNPLA3‐I148M variant increases polyunsaturated triglycerides in human adipose tissue. Liver International 40(9), pp. 2128-2138. (10.1111/liv.14507)
- Sun, C. et al. 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67(8), pp. 3355-3361. (10.1109/TED.2020.3002498)
- Ruhanen, H. et al. 2020. ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1865(7), article number: 158679. (10.1016/j.bbalip.2020.158679)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- Latorre, J. et al. 2020. Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes. EBioMedicine 53, article number: 102697. (10.1016/j.ebiom.2020.102697)
- Liang, G. et al. 2020. Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression. Molecular Cancer 19(1), article number: 65. (10.1186/s12943-020-01152-2)
2019
- Luukkonen, P. K. et al. 2019. Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight 4(16), article number: e127902. (10.1172/jci.insight.127902)
- Liu, Z. et al. 2019. Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p. Cell Death and Disease 10, article number: 55. (10.1038/s41419-018-1287-1)
2018
- Kentala, H. et al. 2018. OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism. Cellular and Molecular Life Sciences 75(21), pp. 4041-4057.
- Luukkonen, P. K. et al. 2018. Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars. Diabetes Care 41(8), pp. 1732-1739. (10.2337/dc18-0071)
- Hua, B., Hakkarainen, A., Zhou, Y., Lundbom, N. and Yki-Järvinen, H. 2018. Fat accumulates preferentially in the right rather than the left liver lobe in non-diabetic subjects. Digestive and Liver Disease 50(2), pp. 168-174. (10.1016/j.dld.2017.08.030)
- Aldrovandi, M., Banthiya, S., Meckelmann, S., Zhou, Y., Heydeck, D., O'Donnell, V. B. and Kuhn, H. 2018. Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863(2), pp. 152-164. (10.1016/j.bbalip.2017.11.005)
- Kentala, H., Koponen, A., Kivelä, A. M., Andrews, R., Li, C., Zhou, Y. and Olkkonen, V. M. 2018. Analysis of ORP2 knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation. FASEB Journal (10.1096/fj.201700604R)
2017
- Liu, X., Jiang, H., Chen, J., Zhou, Y., Huang, Z. and Song, B. 2017. Gadoxetic acid-enhanced MRI outperformed MDCT in diagnosing small hepatocellular carcinoma: A meta-analysis. Liver Transplantation 23(12), pp. 1505-1518. (10.1002/lt.24867)
- Lallukka, S. et al. 2017. Predictors of liver fat and stiffness in non-alcoholic fatty liver disease (NAFLD) - an 11-Year prospective study. Scientific Reports 7(1), article number: 14561. (10.1038/s41598-017-14706-0)
- Mysore, R., Liebisch, G., Zhou, Y., Olkkonen, V. M. and Nidhina Haridas, P. 2017. Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition. Chemistry and Physics of Lipids 207(B), pp. 246-252. (10.1016/j.chemphyslip.2017.05.002)
- Isokuortti, E. et al. 2017. Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study. Diabetologia 60(10), pp. 1873-1882. (10.1007/s00125-017-4340-1)
- Luukkonen, P. K. et al. 2017. Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology 67(1), pp. 128-136. (10.1016/j.jhep.2017.02.014)
- Kara, B. et al. 2017. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. European Journal of Human Genetics 25(3), pp. 315-323. (10.1038/ejhg.2016.183)
- Lallukka, S. et al. 2017. Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans. Thrombosis and Haemostasis 2017(2), pp. 207-428. (10.1160/TH16-09-0716)
2016
- Luukkonen, P. K. et al. 2016. The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology 65(6), pp. 1263-1265. (10.1016/j.jhep.2016.07.045)
- Hu, B. et al. 2016. Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin. Scientific Reports 6, article number: 36436. (10.1038/srep36436)
- Zhou, Y. et al. 2016. Non-invasive detection of non-alcoholic Steatohepatitis using clinical markers and circulating levels of lipids and metabolites. Clinical Gastroenterology and Hepatology 14(10), pp. 1463-1472. (10.1016/j.cgh.2016.05.046)
- Petäjä, E. et al. 2016. Determination of a Normal value for HOMA-IR and cut-off Value for Non-Alcoholic Fatty Liver Disease. Journal of Hepatology 64(2), pp. S481. (10.1016/S0168-8278(16)00817-5)
- Xia, M. et al. 2016. Influence of ethnicity on the accuracy of non-invasive scores predicting non-alcoholic fatty liver disease. PLoS ONE 11(8), pp. e0160526. (10.1371/journal.pone.0160526)
- Luukkonen, P. K. et al. 2016. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. Journal of Hepatology 64(5), pp. 1167-1175. (10.1016/j.jhep.2016.01.002)
- Petäjä, E. M., Zhou, Y., Havana, M., Hakkarainen, A., Lundbom, N., Ihalainen, J. and Yki-Järvinen, H. 2016. Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD. Scientific Reports 6, article number: 24740. (10.1038/srep24740)
- Mysore, R. et al. 2016. MicroRNA-192* impairs adipocyte triglyceride storage. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861(4), pp. 342-351. (10.1016/j.bbalip.2015.12.019)
- Qin, S. et al. 2016. A deleterious role for Th9/IL-9 in hepatic fibrogenesis. Scientific Reports 6, article number: 18694. (10.1038/srep18694)
- Soronen, J. et al. 2016. Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease. Physiological Reports 4(1), article number: e12661. (10.14814/phy2.12661)
2015
- Hu, B., Luo, W., Hu, R., Zhou, Y., Qin, S. and Jiang, H. 2015. Meta-analysis of prognostic and clinical significance of CD44v6 in esophageal cancer. Medicine 94(31), article number: e1238. (10.1097/MD.0000000000001238)
- Zhou, Y., Llauradó, G., Oresic, M., Hyötyläinen, T., Orho-Melander, M. and Yki-Järvinen, H. 2015. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. Journal of Hepatology 62(3), pp. 657-663. (10.1016/j.jhep.2014.10.010)
- Weber-Boyvat, M. et al. 2015. OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Experimental Cell Research 331(2), pp. 278-291. (10.1016/j.yexcr.2014.10.019)
- Bian, H., Hakkarainen, A., Zhou, Y., Lundbom, N., Olkkonen, V. M. and Yki-Järvinen, H. 2015. Impact of non-alcoholic fatty liver disease on liver volume in humans. Hepatology Research 45(2), pp. 210-219. (10.1111/hepr.12338)
- Wei, B. et al. 2015. Cripto-1 expression and its prognostic value in human bladder cancer patients. Tumor Biology 36(2), pp. 1105-1113. (10.1007/s13277-014-2695-1)
2014
- Lu, J., Zhou, Y., Huang, G., Jiang, H., Hu, B. and Qin, S. 2014. Association of ADIPOQ polymorphisms with obesity risk: a meta-analysis. Human Immunology 75(10), pp. 1062-1068. (10.1016/j.humimm.2014.09.004)
- Qin, S., Zhou, Y., Li, P. and Jiang, H. 2014. Diagnostic efficacy of cell block immunohistochemistry, smear cytology, and liquid-based cytology in endoscopic ultrasound-guided fine-needle aspiration of pancreatic lesions: a single-institution experience. PLoS ONE 9(9), article number: e108762. (10.1371/journal.pone.0108762)
- Zhou, Y., Wohlfahrt, G., Paavola, J. and Olkkonen, V. M. 2014. A vertebrate model for the study of lipid binding/transfer protein function: Conservation of OSBP-related proteins between zebrafish and human. Biochemical and Biophysical Research Communications 446(3), pp. 675-680. (10.1016/j.bbrc.2013.12.002)
- Hyysalo, J. et al. 2014. A population-based study on the prevalence of NASH using scores validated against liver histology. Journal of Hepatology 60(4), pp. 839-846. (10.1016/j.jhep.2013.12.009)
- Ruhanen, H. et al. 2014. PNPLA3 mediates hepatocyte triacylglycerol remodeling. Journal of Lipid Research 55(4), pp. 739-746. (10.1194/jlr.M046607)
- Zhong, W. et al. 2014. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. Experimental Cell Research 322(2), pp. 227-235. (10.1016/j.yexcr.2014.01.002)
- Qin, S., Ma, S., Huang, X., Lu, D., Zhou, Y. and Jiang, H. 2014. Th22 cells are associated with hepatocellular carcinoma development and progression. Chinese Journal of Cancer Research 26(2), pp. 135-141. (10.3978/j.issn.1000-9604.2014.02.14)
- Wang, J., Nong, L., Wei, Y., Qin, S., Zhou, Y. and Tang, Y. 2014. Association of osteopontin polymorphisms with nasopharyngeal carcinoma risk. Human Immunology 75(1), pp. 76-80. (10.1016/j.humimm.2013.09.014)
2013
- Qin, S., Jiang, H., Lu, D. and Zhou, Y. 2013. Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: A meta-analysis. World Journal of Gastroenterology 19(48), pp. 9472-9480. (10.3748/wjg.v19.i48.9472)
- Wang, J., Nong, L., Wei, Y., Qin, S., Zhou, Y. and Tang, Y. 2013. Association of interleukin-12 polymorphisms and serum IL-12p40 levels with osteosarcoma risk. DNA and Cell Biology 32(10), pp. 605-610. (10.1089/dna.2013.2098)
- Qin, S., Liu, J., Jiang, H., Hu, B., Zhou, Y. and Olkkonen, V. M. 2013. Association between baseline lipoprotein (a) levels and restenosis after coronary stenting: meta-analysis of 9 cohort studies. Atherosclerosis 227(2), pp. 360-366. (10.1016/j.atherosclerosis.2013.01.014)
- Ruan, J. et al. 2013. Predictive value of Sox2 expression in transurethral resection specimens in patients with T1 bladder cancer. Medical Oncology 30(1), article number: 445. (10.1007/s12032-012-0445-z)
2012
- Li, F. et al. 2012. Identification of urinary Gc-globulin as a novel biomarker for bladder cancer by two-dimensional fluorescent differential gel electrophoresis (2D-DIGE). Journal of Proteomics 77, pp. 225-236. (10.1016/j.jprot.2012.09.002)
- Zhou, Y. et al. 2012. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: Evidence for impacts on the adipocyte phenotype. PLoS ONE 7(9), article number: e45352. (10.1371/journal.pone.0045352)
- Olkkonen, V. M., Zhou, Y., Yan, D. and Vihervaara, T. 2012. Oxysterol-binding proteins-emerging roles in cell regulation. European Journal of Lipid Science and Technology 114(6), pp. 634-643. (10.1002/ejlt.201200044)
2011
- Li, F. et al. 2011. Milk and dairy consumption and risk of bladder cancer: a Meta-analysis. Urology 78(6), pp. 1298-1305. (10.1016/j.urology.2011.09.002)
- Zhong, W. et al. 2011. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Experimental Cell Research 317(16), pp. 2353-2363. (10.1016/j.yexcr.2011.05.028)
- Wei, B. et al. 2011. XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis. Prostate Cancer and Prostatic Diseases 14(3), pp. 225-231. (10.1038/pcan.2011.26)
2010
- Zhou, Y., Li, S., Mäyränpää, M. I., Zhong, W., Bäck, N., Yan, D. and Olkkonen, V. M. 2010. OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface. Experimental Cell Research 316(19), pp. 3304-3316. (10.1016/j.yexcr.2010.06.008)
2008
- Wu, X., Zhou, Y., Zhang, K., Liu, Q. and Guo, D. 2008. Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Letters 582(15), pp. 2155-2160. (10.1016/j.febslet.2008.05.033)
Teaching
- MSc Bioinformatics courses: Metabolomics; Pathway and Network Analysis.
- Supervisor for SSC projects (Spring term, 2018: supervised three year-3 students' projects)
- Personal Tutor for 10 MBBCH students per year (2016 - present)
- Appraisal panelist for 8 PhD and MD students per year (2016 - present)
- Internal examiner of PhD theses at Cardiff University (e.g. Examinee: Dr Khalid)
- External examiner of PhD theses (e.g. http://jultika.oulu.fi/files/isbn9789526215082.pdf)
