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Dr Matthew Tredwell

Dr Matthew Tredwell

Lecturer in Medicinal Chemistry, Research Radiochemist - Wales Research and Diagnostic PET Imaging Centre

School of Chemistry

Users
Available for postgraduate supervision

Overview

Tredwell Group – core research areas

  • organofluorine chemistry
  • transition-metal catalysis
  • radiochemical synthesis
  • radiotracer development
  • automated synthesis
  • clinical translation

Biography

  • Lecturer in Medicinal Chemistry 2020-current
  • Research Fellow, Cardiff University, 2019-current
  • Group Leader, Max-Planck-Institut für Kohlenforschung, 2015-2019
  • Postdoctoral Researcher, University of Oxford, 2009-2015
  • Postdoctoral Researcher, University of Cambridge, 2007-2009
  • DPhil, University of Oxford, 2003-2007
  • MChem University of Oxford, 1999-2003

Publications

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2008

2007

2006

2005

Research in the Tredwell Group has two main directions, organofluorine chemistry and fluorine-18 radiochemistry. We have fully equipped laboratories that allows us to perform both synthetic chemistry and radiochemistry in-house.

Fluorinated molecules have found widespread applications in agrochemistry, pharmaceuticals, through to fields such as materials science. Our research looks to develop novel methods for the selective and efficient synthesis of complex fluorinated compounds. Our current research programmes in this area includes

  • Transition metal-catalysed synthesis of C-CFstereogenic centres
  • Electrochemical fluorination
  • Development of novel fluorinated motifs

Positron emission tomography (PET) imaging is a medicial imaging technique that is used both for clinical diagnosis of disease and to support drug discovery. This technique relies on the use of PET radiotracers, molecules containing positron-emitting radionuclides, designed to probe specific biochemical interactions. Fluorine-18 is positron-emitting radionuclide (t1/2 = 109.7 minutes) that is ideally suited for the radiolabelling of small molecules. Many of our synthetic chemistry programmes are intergrated in our radiochemistry research. Our current research in this area includes

  • synthesis of 18F-perfluorinated motifs
  • radiotracer development
  • clinical translation of radiochemical technologies