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Dr Sharmila Khot

Dr Sharmila Khot

Clinical Research Fellow (Drugs and Physiology)

School of Psychology

Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ


I am a Consultant in the Department of Anaesthesia, Intensive Care and Pain Medicine, Cardiff and Vale University Health Board. I work within the Division of Perioperative Medicine. I am currently Clinical Research Fellow (Drugs and Physiology) in the Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University. My associated research groups are the Imaging Cerebral Physiology and MEG group at CUBRIC.


Undergraduate Education: MBBS

Postgraduate Education: FRCA, FFPMRCA, MD Anaesthesia, Diploma in Anaesthesia, MSc Pain Management Cardiff University


2004-present: Consultant in Anaesthesia, Pain Medicine and Intensive Care, Cardiff and Vale University Health Board

April 2019-present: Clinical Research Fellow (Drugs & Physiology), CUBRIC, CU

2013-2018: Honorary Senior Lecturer, CUBRIC, School of Psychology, Cardiff University (research secondment)

2007-2013: Honorary Senior Lecturer in Medical Education, School of Medicine, Cardiff University (undergraduate and postgraduate teaching, simulation education, course development and training)

Professional memberships

  • Fellow of the Royal College of Anaesthetists of Great Britan and Ireland
  • Fellow of the Faculty of Pain Medicine, Royal College of Anaesthetists
  • British Pain Society













My teaching activity as Honorary Senior Lecturer, School of Medicine, CU (2008-2013), covered several aspects of teaching, from one-to-one sessions as personal tutor to developing innovative teaching techniques locally and at national courses. My audience includes medical students, clinical staff, and undergraduate and postgraduate students and colleagues from various specialities including psychiatry, physiotherapy, rehabilitation medicine, neurology and general practice.

Undergraduate teaching: I teach on the second-year medical school, case 14 low back pain module. This includes clinical skills teaching as well as lumbar puncture tutorial at the school of biosciences. I have previously taught on the Professionalism and Diversity module (old curriculum) including the interpreter led immersive learning sessions.  I have been an examiner for final MBBS and supervise Student Selected Projects most of which have been presented in local and National meetings.

Clinical specialist teaching: I was appointed Regional Advisor in Pain Management for Wales for the Royal College of Anaesthetists for two 3-year terms, and a member of the Anaesthesia Speciality Training Committee, as well as the Welsh Anaesthesia advisory group as representative for Pain Medicine. I developed the structured training in Pain Medicine in Wales.

I have been invited Lecturer at several national study courses for anaesthetists most notably on the Training the Trainers: Small Group Teaching techniques at the Association of Anaesthetists of Great Britain and Ireland.

I continue to teach an integrated biopsychosocial approach to pain management and pain physiology to all levels of anaesthesia and GP trainees.

My specialist clinical interests are in pain management, including acute postoperative pain, pain and fatigue in systemic inflammatory conditions such as Rheumatoid Arthritis (RA) and in other chronic persistent pain conditions including fibromyalgia.

My research interests cover clinical and physiological aspects of preclinical and clinical pain research using advanced imaging methods.

I am Wellcome Trust funded for pharmacological sedation workstream of the WTSA project evaluating brain mechanisms of sedation including electrical, metabolic and functional connectivity underlying GABAergic and non-GABAergic sedation. I am interested in both forward and reverse translational research.

Clinical: I am a Co-Investigator in a clinical neuroimaging pain study assessing the effect of Tofacitinib (JAK-STAT inhibitor) on Pain processing in rheumatoid arthritis. Abnormal pain processing in the brain is associated with severe pain and disability including fatigue and sleep disturbances in RA. Cytokines have been implicated in the pathophysiology of abnormal pain processing. Effective inhibition of cytokines may lead to rapid restoration of pain processing and more substantial reduction in pain as well as other symptoms. However specific neural mechanisms of pain or fatigue and response to biological treatments remain unknown. Our research utilises cutting edge brain imaging techniques in order to address this gap in our knowledge.

Drug research: Through a process of clinical audit, research and publications I have successfully led the development of a market for a ‘specials product’: topical Gabapentin cream, manufactured in a local NHS pharmaceutical unit. My group has validated the existing formulation and trademarked the product; Gabagel. 

Neuroscience: Pain is a complex bio-psycho-social phenomenon involving peripheral and central mechanisms. 

A human experimental model for chronic pain remains difficult to characterise due to the sensory, motivational and cognitive experiences that define pain. Chronic pain presents with an apparent shift towards greater affective and cognitive influences during individual pain experience. We aim to explore the cortical mechanisms of chronic pain utilising non-invasive magnetoencephalography (MEG). 

Fatigue is experienced by people suffering from several neurological and non-neurological conditions. I am interested in exploring the cerebral mechanisms that underpin fatigue experienced in several disease models utilising advanced neuroimaging techniques developed in CUBRIC.

Methodological: I am interested in the development of functional neuroimaging for clinical applications such as drug development, exploring mechanisms of drug activity with sedation, e.g. GABAergic/non-GABAergic and in clinical pain conditions. I have contributed to the development of advanced methods of functional and structural neuroimaging to characterise anatomical and functional changes in the development of neuroimaging markers of drug effects.

Research Collaborators

Prof Richard Wise, Head of MRI, CUBRIC, School of Psychology, CU

Prof Krishna Singh, Head of Human Electrophysiology, CUBRIC, School of Psychology, CU

Prof Ernest Choy, Head of Rheumatology and Translational Research-School of Medicine CU

Prof Kevin Murphy, School of Physics and Astronomy, CUBRIC, CU

Dr Girish Patel, Consultant Dermatologist, Cardiff and Vale UHB and Honorary Senior Lecturer, European Cancer Stem Cell Research Institute, Haydn Ellis Building, CU

Dr Sarah Hiom, All Wales Specialist Pharmacist, R and D, St Mary’s Pharmaceutical Unit, Cardiff and Vale UHB

Dr David Nunns, Consultant in Obstetrics and Gynaecology, Nottingham University Hospital NHS Trust.

Dr Neeraj Saxena, Consultant in Anaesthesia and Pain Medicine, Cwm Taf University Health Board, Clinical Senior Lecturer, CUBRIC, Visiting Professor University of South Wales.

Dr Kyle Pattinson, Senior Clinical Research Fellow, Wellcome Centre for Integrative Neuroimaging, Consultant Anaesthetist and Associate Professor, Nuffield Department of Clinical Neurosciences, Oxford


2018 ASPIRE Pfizer Rheumatology and Inflammatory Bowel Disease Research Awards

CUBRIC publications

Whittaker J, Khot S, Murphy K (2018) Magnetic Resonance Imaging to understand cerebral autoregulation. Comments on CrossTalk 34: Dynamic cerebral autoregulation should be quantified using spontaneous/induced blood pressure fluctuations On the choice of optimal stimulus type for assessing dynamic cerebral autoregulation. The Journal of Physiology 2018 0.0 pp 1-8

Whittaker J, Bright M, Driver I, Babic A, Khot S, Murphy K (2017) Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI. Neuroimage,

Merola A, Germuska MA, Warnert EAH, Richmond L, Helme D, Khot S, Murphy K, Rogers PJ, Hall JE, Wise RG (2017)Mapping the pharmacological modulation of brain oxygen metabolism: the effects of caffeine on absolute CMRO2 measured using dual calibrated fMRI, NeuroImage,

Germuska M, Merola A, Murphy K, Babic A, Richmond L, Khot S, Hall JE, Wise RG (2016) A forward modelling approach for the estimation of oxygen extraction fraction by caliberated fMRI, NeuroImage 139, pp. 313-323

Other publications

Jansen V, Hiom S, Khot S: 062 Evaluation of the Service provided to Neuropathic Pain Patients Treated with Gabapentin Gel, Gabagel™ British Journal of Pain 2016 10(2) Supplement1

Hiom S, Patel GK, Newcombe RG, Khot S (2015) Severe Postherpetic Neuralgia and Other Neuropathic Pain Syndromes Alleviated by Topical Gabapentin. Br J Dermatol. Jul;173(1):300-2.

Hiom S. Khot S, Mogford S, Hart C, Patel G, Roberts G, Martin C, Newcombe R (2015) Topical delivery of gabapentin (Gaba Gel ™) for neuropathic pain: A proof of concept study. International Journal of Pharmacy Practice, 23 (S2), p. 46

Khot S and Hopkins S (2015) Commissioning of Services Chronic Pain Wales, Core Standards for Pain Management Services in the UK, Faculty of Pain Medicine, Royal College of Anaesthetists 2.2, pg14-17

Khot S and Shortland G (2014) Appendix 2; Case studies: a How would prudent healthcare affect the treatment of ‘chronic pain’? pages 38-42 in Bradley P & Wilson A (2014) Achieving prudent healthcare in NHS Wales, Cardiff: Public Health Wales

Khot S, Morgan C Ll, Kadambande S, Poole CD (2014) Use of 5% lidocaine medicated plasters for the treatment of pain in routine hospital practice: patient reported pain, functioning and satisfaction. Current Medical Research & Opinion May, 1-6

Khot S, Lewis R (Autumn 2014) Pain in Wales: Past, Present and Future. Transmitter, Newsletter of the Faculty of Pain Medicine-Royal College of Anaesthetists, page5-6

Khot S, Flory S, Tahir T (June 2013) A simulation-based course for pain management: Improving skills in the utilisation of bio-psychosocial formulation in non-psychiatrists. Journal of Psychosomatic Research Volume 74, Issue 6, Pages A1-A2, Page 549

Khot S (Spring 2013) Pain In Wales, Transmitter, Newsletter of the Faculty of Pain Medicine, Royal College of Anaesthetists, page 10.

Khot S (2011) Synaptic Plasticity in Pain; Book Review, in Anaesthesia: Volume 66, Issue 5, pages 415–416, May 2011-Wiley Online Library Synaptic Plasticity in Pain M.Malcangio (Ed.) Springer-Verlag , New York ; July 2009

Ghei A, Khot S (2010) Pain Management in patients with head and neck carcinoma. Otorhinolaryngology Clinics January-April 2010 Volume 2 Number 1 pg 69-75 ISSN 0975-444X