Marianne van den Bree
Professor, Division of Psychological Medicine and Clinical Neurosciences
- vandenbreemb@cardiff.ac.uk
- +44 (0)29 2068 8433
- 2.16, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
- Available for postgraduate supervision
Overview
I am a Professor of Psychological Medicine within the Division of Psychological Medicine and Clinical Neurosciences, the MRC Centre for Neuropsychiatric Genetics and Genomics and the Neuroscience and Mental Health Research Institute at Cardiff University.
My research focuses on the characterisation of the genetic and environmental factors that play a role in the development of mental health disorders. This includes understanding the complex developmental relationships across the lifespan between mental health disorders and other health-related conditions.
My background is in psychology, human genetics and epidemiology/methodology.
I am interested in the wide-ranging developmental, behavioural, cognitive and mental health manifestations that can be experienced by people with chromosomal microdeletions and duplications known as Copy Number Variants (CNVs).
I have extensive experience playing lead roles in international consortia studying CNV and mental health.
A key aim is also to communicate mental health research findings widely and strive for societal benefit.
Biography
Education:
- BSc Psychology, Vrije Universiteit, Netherlands
- MSc Experimental Psychology, Vrije Universiteit, Netherlands
- PhD, Human Genetics, Medical College of Virginia - Virginia Commonwealth University, Richmond, VA.
Awards:
- RCUK Societal Impact Award, KTP 40th Anniversary Awards (2015)
- Cardiff University Social Innovation Award (2015)
- Research project ‘Improving mental health services for homeless people’ received highest grade of "Outstanding" by the KTP Grading Panel for achievement in meeting KTP's Objectives (2014)
- European Research Advisory Board Publication Award (2013)
Academic positions:
- Impact Lead Institute of Psychological Medicine and Clinical Neurosciences
- School of Medicine REF Management Group Member
Publications
2023
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Lin, J. et al. 2023. Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia. Molecular Psychiatry (10.1038/s41380-023-02009-y)
- Moreau, C. A. et al. 2023. Genetic heterogeneity shapes brain connectivity in psychiatry. Biological Psychiatry 93(1), pp. 45-58. (10.1016/j.biopsych.2022.08.024)
- Wolstencroft, J. et al. 2023. Mental health impact of autism on families of children with intellectual and developmental disabilities of genetic origin. JCPP Advances, article number: e12128. (10.1002/jcv2.12128)
- Chawner, S. J. R. A., Evans, A., IMAGINE-ID consortium, ., Williams, N., Owen, M. J., Hall, J. and van den Bree, M. B. M. 2023. Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions. Translational Psychiatry 13, article number: 7. (10.1038/s41398-022-02296-z)
2022
- Niarchou, M. et al. 2022. Psychopathology in mothers of children with pathogenic copy number variants. Journal of Medical Genetics (10.1136/jmg-2022-108752)
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12, article number: 438. (10.1038/s41398-022-02199-z)
- Moreau, C. A. et al. 2022. Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions. Brain (10.1093/brain/awac315)
- Egger, J. et al. 2022. Editorial: Treatment of psychopathological and neurocognitive disorders in genetic syndromes: In need of multidisciplinary phenotyping and treatment design. Frontiers in Psychiatry 13, article number: 1009376. (10.3389/fpsyt.2022.1009376)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE, a UK national cohort study. The Lancet Psychiatry 9(9), pp. 715-724. (10.1016/S2215-0366(22)00207-3)
- Donnelly, N. A. et al. 2022. Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms. eLife 11, article number: e75482. (10.7554/elife.75482)
- Fiksinski, A. M. et al. 2022. A normative chart for cognitive development in a genetically selected population. Neuropsychopharmacology 47(7), pp. 1379–1386. (10.1038/s41386-021-00988-6)
- Jones, R., van Den Bree, M., Zammit, S. and Taylor, P. 2022. The relationship between the Big Five personality factors, anger-hostility, and alcohol and violence in men and women: A nationally representative cohort of 15,701 young adults. Journal of Interpersonal Violence 37, pp. 11-12. (10.1177/0886260520978178)
- White, L. K. et al. 2022. The COVID-19 pandemic's impact on worry and medical disruptions reported by individuals with chromosome 22q11.2 copy number variants and their caregivers. Journal of Intellectual Disability Research 66(4), pp. 313-322. (10.1111/jir.12918)
- Jacquemont, S. et al. 2022. Genes To Mental Health (G2MH): A framework to map the combined effects of rare and common variants on dimensions of cognition and psychopathology. American Journal of Psychiatry 179(3), pp. 189-203. (10.1176/appi.ajp.2021.21040432)
- Cunningham, A. C., Hall, J., Owen, M. and van den Bree, M. B. M. 2022. Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs. Psychological Medicine 52(3), pp. 574-586. (10.1017/S0033291720002330)
- Chapman, G. et al. 2022. Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome. Molecular Psychiatry 27, pp. 819-830. (10.1038/s41380-021-01182-2)
- Adams, R. L. et al. 2022. Psychopathology in adults with copy number variants. Psychological Medicine (10.1017/S0033291721005201)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE - The UK National Cohort Study. [Online]. papers.SSRN.com: Elsevier. (10.2139/ssrn.4028542) Available at: http://dx.doi.org/10.2139/ssrn.4028542
- Sønderby, I. et al. 2022. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA Working Groups on CNVs. Human Brain Mapping 43(1), pp. 300-328. (10.1002/hbm.25354)
2021
- Chamberland, M. et al. 2021. Detecting microstructural deviations in individuals with deep diffusion MRI tractometry. Nature Computational Science 1, pp. 598-606. (10.1038/s43588-021-00126-8)
- Cleynen, I. et al. 2021. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Molecular Psychiatry, pp. 4496-4510. (10.1038/s41380-020-0654-3)
- Forsyth, J. K. et al. 2021. Prioritizing genetic contributors to cortical alterations in 22q11.2 deletion syndrome using imaging transcriptomics. Cerebral Cortex 31(7), pp. 3285-3298. (10.1093/cercor/bhab008)
- Modenato, C. et al. 2021. Effects of eight neuropsychiatric copy number variants on human brain structure. Translational Psychiatry 11(1), article number: 399. (10.1038/s41398-021-01490-9)
- Rogdaki, M. et al. 2021. Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study. Molecular Psychiatry (10.1038/s41380-021-01108-y)
- Linden, S. C. et al. 2021. The psychiatric phenotypes of 1q21 distal deletion and duplication. Translational Psychiatry 11, article number: 105. (10.1038/s41398-021-01226-9)
- Cunningham, A., Hall, J., Owen, M. and Van den Bree, M. 2021. Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants. Psychological Medicine 51(2), pp. 290-299. (10.1017/S0033291719003210)
- Chawner, S. et al. 2021. A genetics-first approach to dissecting the heterogeneity of autism: phenotypic comparison of autism risk copy number variants. American Journal of Psychiatry 178(1), pp. 77-86. (10.1176/appi.ajp.2020.20010015)
- Sønderby, I. E., Hall, J., Owen, M., Van Den Bree, M., Linden, D., Silva, A. and Doherty, J. 2021. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry 11, article number: 182. (10.1038/s41398-021-01213-0)
2020
- Davies, R. et al. 2020. Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 Deletion Syndrome. Nature Medicine 26, pp. 1912-1918. (10.1038/s41591-020-1103-1)
- Chawner, S. J. R. A. et al. 2020. Pan-European landscape of research into neurodevelopmental copy number variants: a survey by the MINDDS consortium. European Journal of Medical Genetics 63(12), article number: 104093. (10.1016/j.ejmg.2020.104093)
- Villalon-Reina, J. et al. 2020. Altered white matter microstructure in 22q11.2 deletion syndrome: a multi-site diffusion tensor imaging study. Molecular Psychiatry 25, pp. 2818-2831. (10.1038/s41380-019-0450-0)
- Dima, D. C. et al. 2020. Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk. Translational Psychiatry 10, article number: 324. (10.1038/s41398-020-00998-w)
- Sun, D. et al. 2020. Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry 25, pp. 1822-1834. (10.1038/s41380-018-0078-5)
- Jones, R., Van Den Bree, M., Zammit, S. and Taylor, P. 2020. Change in the relationship between drinking alcohol and risk of violence among adolescents and young adults: a nationally representative longitudinal study. Alcohol and Alcoholism 55(4), pp. 439-447. (10.1093/alcalc/agaa020)
- Cunningham, A., Fung, W., Massey, T., Hall, J., Owen, M., Van Den Bree, M. and Peall, K. 2020. Movement disorder phenotypes in children with 22q11.2 deletion syndrome. Movement Disorders 35(7), pp. 1272-1274. (10.1002/mds.28078)
- Ching, C. R. et al. 2020. Mapping subcortical brain alterations in 22q11.2 deletion syndrome: effects of seletion size and convergence with idiopathic neuropsychiatric illness. American Journal of Psychiatry 177(7), pp. 589-600. (10.1176/appi.ajp.2019.19060583)
- Drakulic, D. et al. 2020. Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD. Molecular Autism 11(1), article number: 42. (10.1186/s13229-020-00343-4)
- Moulding, H., Bartsch, U., Hall, J., Jones, M., Linden, D., Owen, M. and Van Den Bree, M. 2020. Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS). Psychological Medicine 50, pp. 1191-1202. (10.1017/S0033291719001119)
- van der Meer, D. et al. 2020. Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA Psychiatry 77(4), pp. 420-430. (10.1001/jamapsychiatry.2019.3779)
- Eaton, C. B. et al. 2020. Response to letter to editor: 'Knowing when and how to use epilepsy screening questionnaires'. Epilepsia 61(4), pp. 826-827. (10.1111/epi.16463)
- Morrison, S. et al. 2020. Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology. Translational Psychiatry 10, article number: 53. (10.1038/s41398-020-0736-7)
- Rizzo, R., Van Den Bree, M., Challenger, A., Cuthbert, A., Arribas-Ayllon, M., Clarke, A. and Thompson, R. 2020. Co-creating a knowledge base in the “22q11.2 deletion syndrome” community. Journal of Community Genetics 11(1), pp. 101-111. (10.1007/s12687-019-00425-8)
- Zhao, Y. et al. 2020. Complete sequence of the 22q11.2 allele in 1,053 subjects with 22q11.2 deletion syndrome reveals modifiers of conotruncal heart defects. American Journal of Human Genetics 106(1), pp. 26-40. (10.1016/j.ajhg.2019.11.010)
- Chamberland, M. et al. 2020. Tractometry-based anomaly detection for single-subject white matter analysis. Presented at: Medical Imaging with Deep Learning (MIDL 2020), Montréal, Canada, 6-9 July 2020.
2019
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Eaton, C. B. et al. 2019. Prevalence and aetiology of epileptic seizures in young people with 22Q11.2 Deletion syndrome and relationships with other neurodevelopmental disorders. Presented at: SSBP 22nd Educational Day and Research Symposium 2019, Birmingham, England, 4-6 September 2019, Vol. 63. Vol. 9. Wiley pp. 1080., (10.1111/jir.12676)
- Cunningham, A. et al. 2019. Using kinematic analyses to explore sensorimotor control impairments in children with 22q11.2 deletion Syndrome. Journal of Neurodevelopmental Disorders 11, article number: 8. (10.1186/s11689-019-9271-3)
- Chawner, S. J. R. A. et al. 2019. Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study. Lancet Psychiatry 6(6), pp. 493 - 505. (10.1016/S2215-0366(19)30123-3)
- Srinivasan, R., Wolstencroft, J., Erwood, M., Raymond, F. L., Van Den Bree, M., Hall, J. and Skuse, D. 2019. Mental health and behavioural problems in children with XXYY: a comparison with intellectual disabilities. Journal of Intellectual Disability Research 63(5), pp. 477-488. (10.1111/jir.12607)
- Eaton, C. et al. 2019. Epilepsy and seizures in young people with 22q11.2 deletion syndrome: prevalence and links with other neurodevelopmental disorders. Epilepsia 60(5), pp. 818-829. (10.1111/epi.14722)
- Chawner, S., Owen, M. J., Holmans, P., Raymond, L., Skuse, D., Hall, J. and van den Bree, M. 2019. Genotype-phenotype relationships in children with copy number variants associated with high neuropsychiatric risk: Findings from the Intellectual Disability & Mental Health: Assessing the Genomic Impact on Neurodevelopment (IMAGINE-ID) study.. [Online]. BioRxiv. (10.1101/535708) Available at: https://doi.org/10.1101/535708
- Drakesmith, M. et al. 2019. Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures. Translational Psychiatry 9(1), article number: 102. (10.1038/s41398-019-0440-7)
- Niarchou, M. et al. 2019. Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome. Schizophrenia Research 204, pp. 320-325. (10.1016/j.schres.2018.07.044)
- Niarchou, M. et al. 2019. Psychiatric disorders in children with 16p11.2 deletion and duplication. Translational Psychiatry (10.1038/s41398-018-0339-8)
2018
- Brieva, J. et al. 2018. Alternative diffusion anisotropy measures for the investigation of white matter alterations in 22q11.2 deletion syndrome. Presented at: 14th International Symposium on Medical Information Processing and Analysis,, Mazatlán, Mexico, 24-26 October 2018 Presented at Romero, E., Lepore, N. and Brieva, J. eds.14th International Symposium on Medical Information Processing and Analysis, Vol. 10975. Proceedings of SPIE Bellingham, Washington: SPIE pp. 51., (10.1117/12.2513788)
- Chawner, S. J., Niarchou, M., Doherty, J. L., Moss, H., Owen, M. J. and Van Den Bree, M. 2018. The emergence of psychotic experiences in the early adolescence of 22q11.2 Deletion Syndrome. Journal of Psychiatric Research 109, pp. 10-17. (10.1016/j.jpsychires.2018.11.002)
- Zhao, Y. et al. 2018. Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects. American Journal of Medical Genetics Part A 176(10), pp. 2172-2181. (10.1002/ajmg.a.40359)
- Morrison, S., Chawner, S., van Amelsvoort, T., Swillen, A., Vergaelen, E., Owen, M. and Van Den Bree, M. 2018. Vulnerable periods for cognitive development in individuals at high genomic risk of schizophrenia [Conference Abstract]. Schizophrenia Bulletin 44(suppl), pp. S86. (10.1093/schbul/sby015.214)
- Cunningham, A. C. et al. 2018. Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome. British Journal of Psychiatry 212(1), pp. 27-33. (10.1192/bjp.2017.6)
2017
- Bassett, A. S. et al. 2017. Rare genome-wide copy number variation and expression of schizophrenia in 22q11.2 deletion syndrome. American Journal of Psychiatry 174(11), pp. 1054-1063. (10.1176/appi.ajp.2017.16121417)
- Demaerel, W. et al. 2017. Nested inversion polymorphisms predispose chromosome 22q11.2 to meiotic rearrangements [RETRACTED]. American Journal of Human Genetics 101(4), pp. 616-622. (10.1016/j.ajhg.2017.09.002)
- Chawner, S., Doherty, J. L., Moss, H., Niarchou, M., Walters, J., Owen, M. J. and Van Den Bree, M. B. 2017. Childhood cognitive development in 22q11.2 deletion syndrome: case–control study. British Journal of Psychiatry 211(4), pp. 223-230. (10.1192/bjp.bp.116.195651)
- Weisman, O. et al. 2017. Subthreshold psychosis in 22q11.2 deletion syndrome: multisite naturalistic study. Schizophrenia Bulletin 43(5), pp. 1079-1089. (10.1093/schbul/sbx005)
- Weisman, O., Guri, Y., Gur, R., McDonald-McGinn, D., Calkins, M. and Van Den Bree, M. 2017. Lithium use in pregnancy and the risk of cardiac malformations. New England Journal of Medicine 377(9), pp. 893-894. (10.1056/NEJMc1708919)
- Gur, R. et al. 2017. A neurogenetic model for the study of schizophrenia spectrum disorders: The International 22q11.2 Deletion Syndrome Brain Behavior Consortium. Molecular Psychiatry 22, pp. 1664-1672.
- Johnston, H. R. et al. 2017. PEMapper and PECaller provide a simplified approach to whole-genome sequencing. Proceedings of the National Academy of Sciences of the United States of America 114(10), pp. E1923-E1932. (10.1073/pnas.1618065114)
2016
- Johnston, J., Linden, D. E. J. and Van Den Bree, M. B. 2016. Combining stress and dopamine based models of addiction: towards a psycho-neuro-endocrinological theory of addiction. Current Drug Abuse Reviews 9(1), pp. 61-74. (10.2174/1874473709666151209113913)
- D'Angelo, D. et al. 2016. Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities. JAMA Psychiatry 73(1), pp. 20-30. (10.1001/jamapsychiatry.2015.2123)
2015
- Maillard, A. M. et al. 2015. 16p11.2 Locus modulates response to satiety before the onset of obesity. International Journal of Obesity 40(5), pp. 870-876. (10.1038/ijo.2015.247)
- Niarchou, M., Martin, J., Thapar, A., Owen, M. J. and van den Bree, M. B. 2015. The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168(8), pp. 730-738. (10.1002/ajmg.b.32378)
- Hodgson, K., Shelton, K. H. and van den Bree, M. B. 2015. Psychopathology among young homeless people: Longitudinal mental health outcomes for different subgroups. British Journal of Clinical Psychology 54(3), pp. 307-325. (10.1111/bjc.12075)
- Pesola, F., Shelton, K. H., Heron, J., Munafò, M., Hickman, M. and van den Bree, M. B. 2015. The developmental relationship between depressive symptoms in adolescence and harmful drinking in emerging adulthood: the role of peers and parents. Journal of Youth and Adolescence 44(9), pp. 1752-66. (10.1007/s10964-015-0295-z)
- Vorstman, J. A. S. et al. 2015. Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome. JAMA Psychiatry 72(4), pp. 377-385. (10.1001/jamapsychiatry.2014.2671)
- Pesola, F., Shelton, K. H., Heron, J., Munafo, M., Maughan, B., Hickman, M. and Van Den Bree, M. B. 2015. The mediating role of deviant peers on the link between depressed mood and harmful drinking. Journal of Adolescent Health 56(2), pp. 153-159. (10.1016/j.jadohealth.2014.10.268)
2014
- Pesola, F., Shelton, K. H. and van den Bree, M. B. M. 2014. Sexual orientation and alcohol problem use among UK adolescents: an indirect link through depressed mood. Addiction 109(7), pp. 1072-1080. (10.1111/add.12528)
- Hodgson, K., Shelton, K. and Van Den Bree, M. 2014. Mental health problems in young people with experiences of homelessness and the relationship with health service use: a follow-up study. Evidence-Based Mental Health 17(3), pp. 76-80. (10.1136/eb-2014-101810)
- Niarchou, M., Zammit, S., Escott-Price, V., Owen, M. J. and van den Bree, M. B. 2014. Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165(5), pp. 410-420. (10.1002/ajmg.b.32245)
- Hodgson, K., Shelton, K. H. and van den Bree, M. B. 2014. Mental health problems in young people with experiences of homelessness and the relationship with health service use: a follow-up study [Correction]. Evidence-Based Mental Health 18(1), pp. 26. (10.1136/ebmental-2014-101810)
- Schneider, M. et al. 2014. Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: Results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome. American Journal of Psychiatry 171(6), pp. 627-639. (10.1176/appi.ajp.2013.13070864)
- Monks, S. et al. 2014. Further evidence for high rates of schizophrenia in 22q11.2 deletion syndrome. Schizophrenia Research 153(1-3), pp. 231-236. (10.1016/j.schres.2014.01.020)
- Di Florio, A., Craddock, N. J. and van den Bree, M. B. 2014. Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates. European Psychiatry 29(3), pp. 117-24. (10.1016/j.eurpsy.2013.07.004)
- Niarchou, M., Zammit, S., van Goozen, S. H. M., Thapar, A., Tierling, H. M., Owen, M. J. and van den Bree, M. B. M. 2014. Psychopathology and cognition in children with 22q11.2 deletion syndrome. British Journal of Psychiatry 204(1), pp. 46-54. (10.1192/bjp.bp.113.132324)
2013
- Moore, S. C., Crompton, K., van Goozen, S. H. M., van den Bree, M. B., Bunney, J. and Lydall, E. S. 2013. A feasibility study of short message service text messaging as a surveillance tool for alcohol consumption and vehicle for interventions in University students. BMC Public Health 13, article number: 1011. (10.1186/1471-2458-13-1011)
- van den Bree, M. B., Miller, G., Mansell, E., Thapar, A., Flinter, F. and Owen, M. J. 2013. The internet is parents' main source of information about psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS). European Journal of Medical Genetics 56(8), pp. 439-441. (10.1016/j.ejmg.2013.05.001)
- Niarchou, M., Zammit, S., Walters, J. T. R., Lewis, G., Owen, M. J. and van den Bree, M. B. 2013. Defective processing speed and nonclinical psychotic experiences in children: longitudinal analyses in a large birth cohort. American Journal of Psychiatry 170(5), pp. 550-557. (10.1176/appi.ajp.2012.12060792)
- Delio, M. et al. 2013. Enhanced maternal origin of the 22q11.2 deletion in velocardiofacial and DiGeorge syndromes. American Journal of Human Genetics 92(3), pp. 439-447. (10.1016/j.ajhg.2013.01.018)
- Hodgson, K., Shelton, K. H., van den Bree, M. B. and Los, F. J. 2013. Psychopathology in young people experiencing homelessness: A systematic review. American Journal of Public Health 103(6), pp. e24-e37. (10.2105/AJPH.2013.301318)
- Hummel, A., Shelton, K. H., Heron, J., Moore, L. A. R. and van den Bree, M. B. 2013. A systematic review of the relationships between family functioning, pubertal timing and adolescent substance use. Addiction 108(3), pp. 487-496. (10.1111/add.12055)
2012
- Taberner, J., Fullana, M. A., Caseras, X., Pertusa, A., Bados, A., van den Bree, M. B. and Torrubia, R. 2012. Familial predictors of obsessive-compulsive symptom dimensions (contamination/cleaning and symmetry/ordering) in a nonclinical sample. Journal of Clinical Psychology 68(12), pp. 1266-1275. (10.1002/jclp.21861)
- Ware, J. J., van den Bree, M. B. and Munafo, M. R. 2012. From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. Nicotine & Tobacco Research 14(11), pp. 1291-1299. (10.1093/ntr/nts106)
- Saraceno, L., Heron, J., Munafò, M., Craddock, N. J. and van den Bree, M. B. 2012. The relationship between childhood depressive symptoms and problem alcohol use in early adolescence: findings from a large longitudinal population-based study. Addiction 107(3), pp. 567-577. (10.1111/j.1360-0443.2011.03662.x)
- Shelton, K. H., Mackie, P. K., van den Bree, M. B., Taylor, P. J. and Evans, S. L. 2012. Opening doors for all American youth? Evidence for Federal homelessness policy. Housing Policy Debate 22(3), pp. 483-504. (10.1080/10511482.2012.683034)
2011
- Harold, G. T., Rice, F., Hay, D. F., Boivin, J., van den Bree, M. B. and Thapar, A. 2011. Familial transmission of depression and antisocial behavior symptoms: Disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting. Psychological Medicine 41(6), pp. 1175-1185. (10.1017/S0033291710001753)
- Ware, J. J., van den Bree, M. B. and Munafo, M. R. 2011. Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. Nicotine & Tobacco Research 13(12), pp. 1167-1175. (10.1093/ntr/ntr118)
- Jones, R. M., Arlidge, J. W., Gillham, R., Reagu, S. M., van den Bree, M. B. and Taylor, P. J. 2011. Efficacy of mood stabilisers in the treatment of impulsive or repetitive aggression: systematic review and meta-analysis. British Journal of Psychiatry 198(2), pp. 93-98. (10.1192/bjp.bp.110.083030)
2010
- Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
- Glaser, B., Shelton, K. H. and van den Bree, M. B. 2010. The moderating role of close friends in the relationship between conduct problems and adolescent substance use. Journal of Adolescent Health 47(1), pp. 35-42. (10.1016/j.jadohealth.2009.12.022)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Rice, F., Harold, G. T., Boivin, J., van den Bree, M. B., Hay, D. F. and Thapar, A. 2010. The links between prenatal stress and offspring development and psychopathology: Disentangling environmental and inherited influences. Psychological Medicine 40(2), pp. 335-345. (10.1017/S0033291709005911)
- Shelton, K. H. and van den Bree, M. B. 2010. The Moderating Effects of Pubertal Timing on the Longitudinal Associations Between Parent-Child Relationship Quality and Adolescent Substance Use. Journal of Research on Adolescence 20(4), pp. 1044-1064. (10.1111/j.1532-7795.2010.00643.x)
2009
- van den Bree, M. B., Shelton, K. H., Bonner, A., Moss, S., Thomas, H. V. and Taylor, P. J. 2009. A longitudinal population-based study of factors in adolescence predicting homelessness in young adulthood. Journal of Adolescent Health 45(6), pp. 571-578. (10.1016/j.jadohealth.2009.03.027)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Taberner, J. et al. 2009. Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?. Depression and Anxiety 26(10), pp. 902-908. (10.1002/da.20606)
- Shelton, K. H., Boivin, J., Hay, D. F., van den Bree, M. B., Rice, F., Harold, G. T. and Thapar, A. 2009. Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies. International Journal of Behavioral Development 33(5), pp. 385-392. (10.1177/0165025409338444)
- Saraceno, L., Munafó, M., Heron, J., Craddock, N. J. and van den Bree, M. B. 2009. Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. Addiction 104(7), pp. 1100-1121. (10.1111/j.1360-0443.2009.02571.x)
- Boivin, J., Rice, F., Hay, D. F., Harold, G. T., Lewis, A., van den Bree, M. B. and Thapar, A. 2009. Associations between maternal older age, family environment and parent and child wellbeing in families using assisted reproductive techniques to conceive. Social Science & Medicine 68(11), pp. 1948-1955. (10.1016/j.socscimed.2009.02.036)
- Shelton, K. H., Taylor, P. J., Bonner, A. and van den Bree, M. B. 2009. Risk Factors for Homelessness: Evidence From a Population-Based Study. Psychiatric Services 60(4), pp. 465-472. (10.1176/appi.ps.60.4.465)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Jones, R. M., van den Bree, M. B., Ferriter, M. and Taylor, P. J. 2009. Childhood risk factors for offending before first psychiatric admission for people with schizophrenia: a case-control study of high security hospital admissions. Behavioral Sciences & the Law 28(3), pp. 351-365. (10.1002/bsl.885)
- Rice, F., Harold, G. T., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2009. Disentangling prenatal and inherited influences in humans with an experimental design. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2464-2467. (10.1073/pnas.0808798106)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
2008
- Shelton, K. H., Harold, G. T., Fowler, T. A., Rice, F., Neale, M. C., Thapar, A. and van den Bree, M. B. 2008. Parent-Child Relations, Conduct Problems and Cigarette Use in Adolescence: Examining the Role of Genetic and Environmental Factors on Patterns of Behavior. Journal of Youth and Adolescence 37(10), pp. 1216-1228. (10.1007/s10964-007-9254-7)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
- Harold, G. T., Shelton, K. H., Rice, F., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2008. Disentangling genetic and environmental influences on children’s development: introducing a novel methodology. Acta Psychologica Sinica 40(10), pp. 1124-1134.
2007
- Rice, F. et al. 2007. Genetic and environmental transmission of anxiety and depression in families using a novel design [Abstract]. Behavior Genetics 37(6), pp. 788-788. (10.1007/s10519-007-9169-9)
- van den Bree, M. B. 2007. Genes, Environment, and Psychopathology: Understanding the Causes of Psychiatric and Substance Use Disorders [Book Review]. Psychological Medicine 37(7), pp. 1061-1061. (10.1017/S0033291707000037)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Fowler, T. A. et al. 2007. Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction 102(3), pp. 413-422. (10.1111/j.1360-0443.2006.01694.x)
- Shelton, K. H., Lifford, K., Fowler, T., Rice, F., Harold, G. T., Thapar, A. and van den Bree, M. B. 2007. The association between conduct problems and the initiation and progression of marijuana use during adolescence: A genetic analysis across time. Behavior Genetics 37(2), pp. 314-325. (10.1007/s10519-006-9124-1)
- van den Bree, M. B. et al. 2007. The Cardiff Study of All Wales and North West of England Twins (CaStANET): A longitudinal research program of child and adolescent development. Twin Research and Human Genetics 10(1), pp. 13-23. (10.1375/twin.10.1.13)
- Thapar, A. et al. 2007. Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects. BMC Medical Research Methodology 7(1), pp. 25-32. (10.1186/1471-2288-7-25)
- Fowler, T. et al. 2007. Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents. Addiction 102(6), pp. 894-903. (10.1111/j.1360-0443.2007.01824.x)
- Rice, F. et al. 2007. Agreement between maternal report and antenatal records for a range of pre and peri-natal factors: The influence of maternal and child characteristics. Early Human Development 83(8), pp. 497-504. (10.1016/j.earlhumdev.2006.09.015)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
2006
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- McMurran, M., Egan, V., Cusens, B., van den Bree, M. B., Austin, E. and Charlesworth, P. 2006. The Alcohol-related Aggression Questionnaire. Addiction Research and Theory 14(3), pp. 323-343. (10.1080/16066353600608646)
- van den Bree, M. B., Przybeck, T. R. and Robert Cloninger, C. 2006. Diet and personality: Associations in a population-based sample. Appetite 46(2), pp. 177-188. (10.1016/j.appet.2005.12.004)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
2005
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Bergen, A. W. et al. 2005. Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology 30(9), pp. 1703-1710. (10.1038/sj.npp.1300719)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- van den Bree, M. B. 2005. Combining research approaches to advance our understanding of drug addiction. Current Psychiatry Reports 7(2), pp. 125-132. (10.1007/s11920-005-0009-4)
- van den Bree, M. B. and Pickworth, W. B. 2005. Risk factors predicting changes in marijuana involvement in teenagers. Archives of General Psychiatry 62(3), pp. 311-319. (10.1001/archpsyc.62.3.311)
- Cope, N. A. et al. 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10(3), pp. 237-238. (10.1038/sj.mp.4001596)
2004
- Rice, F., van den Bree, M. B. and Thapar, A. 2004. A population-based study of anxiety as a precursor for depression in childhood and adolescence. BMC Psychiatry 4, article number: 43. (10.1186/1471-244X-4-43)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- van den Bree, M. B., Whitmer, M. D. and Pickworth, W. B. 2004. Predictors of smoking development in a population-based sample of adolescents: A prospective study. Journal of Adolescent Health 35(3), pp. 172-181. (10.1016/j.jadohealth.2003.09.021)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Scourfield, J., van den Bree, M. B., Martin, N. and McGuffin, P. 2004. Conduct problems in children and adolescents: a twin study. Archives of General Psychiatry 61(5), pp. 489-496. (10.1001/archpsyc.61.5.489)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
2003
- Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
- Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Thapar, A. et al. 2003. Maternal smoking in pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Behavior Genetics 33(6), pp. 720-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Bergen, A. et al. 2003. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: Serotonin 1D and delta opioid receptors display significant association to anorexia nervosa [Conference Abstract]. Biological Psychiatry 53(8), pp. 165S-165S. (10.1016/S0006-3223(03)00164-1)
- Bergen, A. W. et al. 2003. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Molecular Psychiatry 8(4), pp. 397-406. (10.1038/sj.mp.4001318)
- Bergen, A. et al. 2003. Candidate Gene Analysis of the Price Foundation Anorexia Nervosa Affected Relative Pair Dataset. Current Drug Target -CNS & Neurological Disorders 2(1), pp. 41-51. (10.2174/1568007033338760)
- Turic, D. et al. 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8(2), pp. 176-185. (10.1038/sj.mp.4001216)
- van den Bree, M. B. and Owen, M. J. 2003. The future of psychiatric genetics. Annals of Medicine 35(2), pp. 122-134. (10.1080/07853890310010023)
2002
- Miles, D. R., van den Bree, M. B. and Pickens, R. W. 2002. Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents. American Journal of Medical Genetics 114(2), pp. 159-168. (10.1002/ajmg.10178)
2001
- Miles, D. R., van den Bree, M. B., Gupman, A. E., Newlin, D. B., Glantz, M. D. and Pickens, R. W. 2001. A twin study on sensation seeking, risk taking behavior and marijuana use. Drug and Alcohol Dependence 62(1), pp. 57-68. (10.1002/ajmg.b.32352)
- Pickens, R. W. et al. 2001. Family history influence on drug abuse severity and treatment outcome. Drug and Alcohol Dependence 61(3), pp. 261-270. (10.1016/S0376-8716(00)00146-0)
2000
- Newlin, D. B., Miles, D. R., van den Bree, M. B., Gupman, A. E. and Pickens, R. W. 2000. Environmental transmission of DSM-IV substance use disdorders in adoptive and step families. Alcoholism-Clinical and Experimental Research 24(12), pp. 1785-1794. (10.1111/j.1530-0277.2000.tb01982.x)
1999
- van den Bree, M. B., Eaves, L. J. and Dwyer, J. T. 1999. Genetic and environmental influences on eating patterns of twins aged >/=50 y. American Journal of Clinical Nutrition 70(4), pp. 456-465.
1998
- van den Bree, M. B., Johnson, E. O., Neale, M. C. and Pickens, R. W. 1998. Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug and Alcohol Dependence 52(3), pp. 231-241. (10.1016/S0376-8716(98)00101-X)
- Johnson, E. O., van den Bree, M. B., Gupman, A. E. and Pickens, R. W. 1998. Extension of a typology of alcohol dependence based on relative genetic and environmental loading. Alcoholism-Clinical and Experimental Research 22(7), pp. 1421-1429. (10.1111/j.1530-0277.1998.tb03930.x)
- van den Bree, M. B., Svikis, D. S. and Pickens, R. W. 1998. Genetic influences in antisocial personality and drug use disorders. Drug and Alcohol Dependence 49(3), pp. 177-187. (10.1016/S0376-8716(98)00012-X)
- van den Bree, M. B., Johnson, E. O., Neale, M. C., Svikis, D. S., McGue, M. and Pickens, R. W. 1998. Genetic analysis of diagnostic systems of alcoholism in males. Biological psychiatry 43(2), pp. 139-145. (10.1016/S0006-3223(97)00225-4)
1996
- Johnson, E. O., van den Bree, M. B. and Pickens, R. W. 1996. Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Alcoholism-Clinical and Experimental Research 20(8), pp. 1472-1480. (10.1111/j.1530-0277.1996.tb01151.x)
- van den Bree, M. B., Schieken, R. M., Moskowitz, W. M. and Eaves, L. J. 1996. Genetic regulation of hemodynamic variables during dynamic exercise. The MCV twin study. Circulation 94(8), pp. 1864-1869. (10.1161/01.CIR.94.8.1864)
- Johnson, E. O., van den Bree, M. B., Uhl, G. R. and Pickens, R. W. 1996. Indicators of genetic and environmental influences in drug abusing individuals. Drug and Alcohol Dependence 41(1), pp. 17-23. (10.1016/0376-8716(96)01223-9)
- Johnson, E. O., van den Bree, M. B. and Pickens, R. W. 1996. Indicators of genetic and environmental influence in alcohol-dependent individuals. Alcoholism-Clinical and Experimental Research 20(1), pp. 67-74. (10.1111/j.1530-0277.1996.tb01046.x)
1990
- Keuss, P., van der Zee, F. and van den Bree, M. B. 1990. Auditory accessory effects on visual processing. Acta Psychologica 75(1), pp. 41-54. (10.1016/0001-6918(90)90065-N)
- Passchier, J., van den Bree, M. B., Emmen, H., Osterhaus, S., Orlebeke, J. and Verhage, F. 1990. Relaxation Training in School Classes Does Not Reduce Headache Complaints. Headache 30(10), pp. 660-664. (10.1111/j.1526-4610.1990.hed3010660.x)
- van den Bree, M. B., Passchier, J. and Emmen, H. 1990. Influence of Quality of Life and Stress Coping Behaviour on Headaches in Adolescent Male Students: an Explorative Study. Headache 30(3), pp. 165-168. (10.1111/j.1526-4610.1990.hed3003165.x)
1989
- Boomsma, D. I., van den Bree, M. B., Orlebeke, J. F. and Molenaar, P. C. M. 1989. Resemblances of parents and twins in sports participation and heart rate. Behavior Genetics 19(1), pp. 123-141. (10.1007/BF01065888)
- Passchier, J., van den Bree, M. B., Leijdekkers, M. and Verhage, F. 1989. Development of a short instrument for the measurement of self-aggression. Preliminary results in female migraine patients. Psychotherapy and Psychosomatics 52(4), pp. 205-208.
Teaching
Teaching experiences include:
The epidemiology and biology of substance misuse (medical students).
CNVs and mental health risk (PhD students).
I have previously led the medical intercalated degree of Psychology and Medicine.
Lead roles
LIfespaN multimorbidity research Collaborative (LINC)
I lead a programme grant, bringing together reserchers from Cardiff, Bristol, Leeds, Queen Mary London, and Exeter Universities as well as Copenhagen University in Denmark and the Wellcone Sanger Institute aiming to study the development of physical and mental health multimorbidity across the lifespan. The programme involves analysis of five large longitudinal cohorts and evaluates the role of genetic and environmental factors on risk of multimorbidity development.
Cardiff ECHO study
I have initiated and lead a large longitudinal research programme of people with CNV linked with increased risk of neurodevelopmental disorder (ND-CNV) and their family members. This programme (the ExperienCes of people witH cOpy number variants (ECHO Study)) combines detailed phenotyping with genetic, pharmacological and brain imaging studies to investigate mental health risk.
IMAGINE-ID
Cardiff Lead Investigator of the Assessing Genomic Impact on Neurodevelopment (IMAGINE-ID) study (collaboration with D. Skuse (University College London)).
Medical Research Council (MRC)-funded.
Web page: https://imagine-id.org/
Genes to Mental Health (G2MH) Network
Principal Investigator of one of a cluster of nine NIMH RO1 grants studying the mental health profiles of individuals with 16p11.2 and 22q11.2 deletion or duplication (collaboration with R. Gur (University of Pennsylvania), C. Bearden (University of California, Los Angeles), S. Jacquemont (University of Montreal), D. McDonald-McGinn (Children’s Hospital of Philadelphia), J. Sebat (University of California, San Diego), A. Swillen (Katholieke Universiteit Leuven), T. van Amelsvoort (Maastricht University) and J. Vorstman (University of Toronto)).
National Institute of Mental Health USA (NIMH)-funded.
Website: genes2mentalhealth.com
Biomarkers for intellectual disability and autism spectrum disorder in deletion and duplication of 16p11.2
Phenotyping Work Package Lead of a research programme studying signalling pathways in individuals with 16p11.2 deletion or duplication (collaboration with R. Brambilla (Cardiff University)).
MRC-funded.
Knowledge Transfer Partnership
Partnership with support charity CEREBRA to improve mental health for children with neurodevelopmental disabilities linked with CNV.
Innovate UK and CEREBRA funded.
Website: https://cerebra.org.uk/what-we-do/research/our-research-partners/cardiff-university/
Experience playing lead roles in international consortia:
- International Genes to Mental Health Consortium (G2MH)(Site Lead)
- Physical and mental health multimobidity across the lifespan (LIfespaN multimorbidity research Collaborative (LINC))(Lead)
- Mental Health NIMH Rare Genetic Disease Network (MHRGDN) Steering Committee (Member)
- 22q11.2 Deletion Syndrome International Brain and Behavior Consortium (IBBC)(Coordinator of half of EU sites)
- Pan-EU MINDDS Consortium (Work Package Lead)
Other memberships:
- Board Member National Centre for Mental Health (NCMH)
- Academic Partner Cleft Collective Cohort, Bristol University.
Recent Funding:
MRC, ESRC, NIHR. Physical and mental health multimorbidity across the lifespan (LIfespaN multimorbidity research Collaborative: LINC). Role: PI. £3,631,451
MRC, ESCR, NIHR. Investigating five large population-based cohort studies to understand the precursors of multimorbidity risk. Role: PI. £74,363.78
MRC. IMAGINE-2: Stratifying Genomic Causes of Intellectual Disability by Mental Health Outcomes in Childhood and Adolescence. PI: Skuse. Role: Co-I, Lead of Work Package 2 (face-to-face phenotyping). £1,999,599.26
Wellcome Trust ISSF. Using genomics to understand the early developmental origins of psychiatric conditions. PI: Chawner. Role: Research sponsor. £69,443.
NIMH. Supplement to 7/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders. Subcontract to Children’s Hospital of Philadelphia (CHOP). Role: PI: $41,833.80
MRC. Targeting ERK signalling to ameliorate intellectual disability and autism spectrum disorder associated with chromosomal rearrangements at 16p11.2. PI: Brambilla. Role Co-I, Lead of Work Package 1 (face-to-face phenotyping). £1,181,767.
NIMH. RO1(7) is: 7/9 Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders. Role: PI. $6,000,000 ($1,477,560 to Cardiff directly).
Baily Thomas Charitable Trust. Pilot study to develop and instrument to capture broad-ranging neurodevelopmental problems in children with a genetic diagnosis of intellectual disability. Role: PI. £48,502.
Takeda. To establish a scalable set of assay platforms against which the phenotype consequences of manipulating the identified exclusive targets can be screened and effects the drug compounds assessed to develop therapeutics for schizophrenia. PI: Wilkinson. Role: Co-I. £2,960,749.
Innovate UK, CEREBRA. Knowledge Transfer Partnership (KTP). Improving mental health for children with neurodevelopmental disabilities: A Knowledge Transfer Partnership between Cerebra and Cardiff University. Role: PI. £216,320.
European Union Cooperation in Science and Technology (COST). Maximising Impact of research in Neuro-Developmental DisorderS (MINDDS). PI: Harwood. Role: Management Committee Member and Leader of Working Group 2.
Supervision
I have thus far successfully supervised 13 PhD students and clinical fellows.
You are welcome to contact me if you are looking to do a PhD in a vibrant research group and you are interested in:
- Genetics
- Mental Health
- Cognition
- Rare genetic syndromes
- Mental and physical health multimorbidity
- Epidemiology
- Longitudinal research
Current supervision
Past projects
Primary Supervisor:
2019-2022 Nabila Mohammed Hassan Ali (with Michael Owen, Cardiff University). The etiology of autism spectrum disorder traits in high-risk children with genomic deletions and duplications.
2019-2022 Lowri O’Donovan (with Jeremy Hall, Cardiff University and Tamsin Ford, Cambridge University). School experiences, including bullying, in children at high genetic risk of mental health problems.
2016-2019 Sinead Morrison (with Michael Owen, Cardiff University). Longitudinal study of neurocognitive development and risk for psychopathology in 22q11.2DS.
2015-2018 Christopher Eaton (with David Linden and Michael Owen, Cardiff University). Psychopathology, cognition, epilepsy and brain findings in children with Copy Number Variants (CNVs)
2015-2018 Hayley Moulding (with Jeremy Hall and Michael Owen, Cardiff University). Sleep disturbance in children/ adolescents with Copy Number Variants posing high risk for development of schizophrenia.
2014-2017 Adam Cunningham (with David Linden and Michael Owen, Cardiff University). Developmental coordination, fine motor skills and brain structure in children with 22q11.2 Deletion Syndrome.
2012-2015 Samuel Chawner (with Michael Owen, Cardiff University). Longitudinal follow-up of children with 22q11.2DS: A study of individuals at high risk of psychotic disorder.
2010-2013 Maria Niarchou (with Michael Owen, Cardiff University). Psychopathology in children with 22q11.2 Deletion Syndrome.
2010-2013 Alegra Hummel (with Katherine Shelton, Cardiff University, Jon Heron, ALSPAC study and Lawrence Moore, DECIPHer, Cardiff University). Psychosocial aspects of pubertal maturation, family functioning and substance use in adolescence.
2009-2012 Jennifer Ware (with Marcus Munafo, Bristol University): Exploring associations between the nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 and smoking-related behaviours.
2007-2010 Luca Saraceno (with Marcus Munafo, Bristol University, Nick Craddock, Cardiff University and Jon Heron, ALSPAC study). Temporal Association Between Childhood Depressive Symptoms and Alcohol Problem Use in Early Adolescence: Findings from a Large Longitudinal Population-based Study.
Co-supervisor:
2009-2015 Roland Jones, recipient of MRC Clinical Fellowship (with Pamela Taylor, Cardiff University). Predicting change in the relationship between alcohol abuse and violence in young people.
2011-2014 Kate Hodgson (with Katherine Shelton, Cardiff University). Longitudinal study of young homeless people.
2012-2015 Afnan Salaka (with Nigel Williams and Michael Owen, Cardiff University). Molecular genetic characterisation of the 22q11.2 region.
2012-2015 Joanne Doherty (with Michael Owen, David Linden, and Krish Singh). Excitatory-inhibitory balance in adolescents at high genetic risk of mental disorder: a study of cortical gamma oscillations and GABA concentrations in 22q11.2 deletion syndrome.
Engagement
Key Note Presentations:
- Lectio Magistralis at the Festival Della Scienza, Genoa, Italy (2020).
- CEREBRA lecture, Cardiff (2019)
- International Medical Advisory Group (IMAG) conference, Amsterdam (2014)
- Faculty of Addictions Psychiatry Annual Conference 2012, Cardiff (2012)
- International Medical Advisory Group (IMAG) conference, Frascati, Italy (2010)
- Inter Celtic Congress, St Malo, France (2007).
- Annual Meeting of the Royal College of Psychiatrists, Glasgow, Scotland (2006)
Selected Other Presentations:
- ‘What I know best’ congress, lectures Medical Geneticists, Rome, Italy (2020).
- Cleft Collective Cohort Studies, Bristol (2019)
- Panel Member at the 10-year celebration event of the MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff (2019)
- European Society for Child and Adolescent Psychiatry (ESCAP) congress, Vienna, Austria (2019)
- Waterloo Foundation "Changing Minds" symposium, Cardiff (2019)
- 22q Northern Ireland charity family and clinician day, Belfast (2019)
- Centre for Genomic Medicine clinical meeting, Manchester (2018).
- NMHRI Centre Neurodevelopmental Disorder Research Day at to celebrate the opening of the new Child Development Centre, Cardiff (2018)
- Presentation to Belgium Ambassador in the UK, Ambassador Rudolf Huygelen, Cardiff (2017)
- 16p11.2 family day, Cardiff (2016)
- MRC Centre for Neuropsychiatric Genetics and Genomics External Advisory Board, Cardiff (2016)
- Medical Genetics Regional Genetics Centres, London (2016).
- Royal College of Psychiatrists International Conference, London (2016)
- National Centre for Mental Health (NCMH), Cardiff (2016).
- 22q11.2 Deletion Syndrome family meeting. MaxAppeal! (2015)
- European College of Neuropsychopharmacology (ECNP), Amsterdam (2015)
- Waterloo Foundation - Neurodevelopmental Disorders and Therapies Event, Cardiff (2015)
- Genetics Update for Paediatricians meeting, Cardiff (2014)
- 22q11.2 Deletion Syndrome family meeting. MaxAppeal!, Stourbridge (2015)
- Guys Hospital, London (2014)
- South West of Britain Clinical Genetics Group meeting, Cardiff (2013)
- Fourth Cardiff Symposium on Clinical Cardiovascular Genetics “Current Trends in Diagnosis and Therapy of Inherited Cardiovascular Disorders”, Cardiff (2013)
- Open University Symposium on Psychosis. UK Research Highlights Session. Brain and Behavioural Sciences series, Milton Keynes (2013)
- South East Dysmorphology group (Kleefstra Syndrome Meeting), Guy’s Hospital, London (2013).
Selected Other Engagement:
- Contribution to children’s book "My experience: what has mental health got to do with the brain?" to the book "What is mental health? Where does it come from? And other big questions" by Lucy Maddox, Wayland (2019)(https://www.worldbookday.com/2020/05/best-books-for-8-12-year-olds-for-mental-health-awareness-week/).
- NCMH podcast about 22q11.2DS (https://www.ncmh.info/videos-and-podcasts/podcast/episode-6-22q11-2-deletion-syndrome/
- National Institute for Health Research (NIHR) Rare Disease interview: https://www.nihr.ac.uk/news-and-events/support-our-campaigns/rare-disease-day-2018/echo-study.htm
- BBC Wales radio (https://www.cardiff.ac.uk/news/view/1726668-sleep-problems-in-children-with-genetic-condition-linked-to-mental-health-issues,-clumsiness-and-impaired-planning-ability,-experts-say).
- Rare disease day (https://animoto.com/play/baR6a8NMV7Z6QiNbdlcrfg)
- The Conversation (https://www.spectrumnews.org/news/deletion-duplication-chromosome-16-segment-may-confer-autism-risk/)
- BBC breakfast show: (https://www.bbc.co.uk/news/uk-wales-46292480)(http://www.cardiff.ac.uk/news/view/1371274-awareness-of-22q)
- Youtube Film (https://www.youtube.com/watch?v=7k-Njq95yp0)
