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Dr Alexandra Shephard

Research Assistant

School of Medicine

Email:
shepharda@cardiff.ac.uk
Telephone:
+44 (0)29 2061 5888 (ext 6373)
Location:
Velindre Hospital

Education and qualifications:

2014: PhD (Cellular and Molecular Medicine), University of Bristol, Bristol, UK

2010: MBiochem (Molecular and Cellular Biochemistry), University of Oxford, Oxford, UK

Career overview:

2015 - present: Post doctoral researcher, Cardiff University, Division of Cancer and Genetics

Honours and awards

2014: BACR/CRUK Travel Award to attend Keystone Symposium in Banff, Canada

Professional memberships

International Society of Extracellular Vesicles

British Association of Cancer Research

European Association of Cancer Research

Academic positions

2015 - present: Post doctoral researcher, Cardiff University

2010 - 2014: PhD student, Univeristy of Bristol

2019

I am currently funded by a PCUK research fellowship grant held by Dr Jason Webber. My research focuses on the role of extracellular vesicles, specifically exosomes, in the induction of fibroblast differentiation in prostate cancer. Conversion of prostate stroma fibroblasts to a more myofibroblastic phenotype is an important step in the carcinogenesis of aggressive prostate cancer. We have identified heparan sulphate proteoglycans (HSPGs) as the exosomal surface proteins responsible for driving this differentiation process. Current work involves elucidating the specific HSPGs responsible for exosome driven fibroblast differentation and development of an assay to detect these proteins in serum samples from prostate cancer patients.