Skip to content
Dr Liam Morgan

Dr Liam Morgan

Research Associate

School of Medicine

Email:
morganld1@cardiff.ac.uk
Telephone:
+44 (0)29 2087 9245
Location:
Henry Wellcome Building

Overview

I am currently the Organisational & Staff Development Officer for Research at Cardiff University, and Programme Manager for the 'Welsh Crucible' programme of personal, professional and leadership development for future research leaders in Wales.

Previously, I have worked as a Research Associate in the Cardiff CLL Research Group and in the Cardiff-China Medical Research Collaborative (CCMRC), both part of the Division of Cancer & Genetics at Cardiff University School of Medicine.

My research has most recently focused on the metastasis of prostate cancer to bone, looking specifically at the factors involved in the osteoblastic phenotype exhibited by prostate cancer, in addition to the interactions between prostate cancer cells and the permissive bone microenvironment that allow secondary tumours to develop and progress at these sites. My research was funded by Cancer Research Wales.

Education and Qualifications

2008: PhD (Cancer Pharmacology) Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff UK

  • Thesis: “Elevated Src Kinase activity accompanies endocrine-resistance in breast cancer and promotes an aggressive cell phenotype”

1996: Biochemistry BSc (Hons) Warwick University, Coventry, Warwickshire, UK

Career Overview

  • 2017 - Present Organisational and Staff Development Officer (Research), Cardiff University, Cardiff, UK
  • 2017 - Present Welsh Crucible Programme Manager, Cardiff University, Cardiff, UK
  • 2015 – 2016: Research Associate, CCMRC, Cardiff University School of Medicine, Cardiff, UK
  • 2008 – 2015: Research Associate, Cardiff CLL Research Group, Cardiff University School of Medicine, Cardiff, UK
  • 2007 – 2008: Research Technician, Dept. of Child Health, Cardiff University School of Medicine, Cardiff, UK
  • 2003 – 2007: PhD Studentship, Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff UK

Honours and Awards

CUKC Poster Scholar 2015 - China-UK Cancer Conference, Cardiff, UK (July 2015)

  • “Identification of an NF-kB-Dependent CD38 Positive Feedback Loop in Chronic Lymphocytic Leukaemia (CLL)”

Postgraduate Researcher Poster Prize - Cardiff School of Pharmacy and Pharmaceutical Sciences Postgraduate Research Day, Cardiff, UK (March 2005)

  • “Elevated Src kinase activity promotes an aggressive tumour cell phenotype in endocrine-resistant breast cancer”

Speaking Engagements

  • 2016 – Invited speaker at China-UK Cancer Conference 2016 (Beijing, China)
  • 2016 – CCMRC Winter Academic Meeting (Cardiff, UK)
  • 2014 – European NF-kB Workshop (Pitlochry, Scotland, UK)
  • 2012 – Site visit for Bloodwise (formerly LLR) grant application (Cardiff University School of Medicine, Cardiff, UK)
  • 2011 – Division of Cancer & Genetics Seminar (Cardiff University School of Medicine, Cardiff, UK)
  • 2010 – Division of Infection & Immunity Seminar (Cardiff University School of Medicine, Cardiff, UK)
  • 2009 – Division of Cancer & Genetics (Haematology) Seminar (Cardiff University School of Medicine, Cardiff, UK)

2019

2017

2016

2012

2011

2010

2009

2008

2007

2006

2004

2002

Teaching

  • Supervision of Lab based Intercalated Project students for the Intercalated Degree Programme.
  • Coaching, mentoring and lab-based supervision of postgraduate (MRes, MD, PhD) and SSC students.
  • Academic Mentor to MB BCh undergraduate medical students.

Public Engagement

  • Frequent participant in the ‘Science in Health Live’ programme run by Cardiff University School of Medicine.
  • Active contributor to research open days held for members of the public by charities such as CRUK.

Research

After graduating with a BSc in Biochemistry from the University of Warwick I joined the Department of Child Health in Cardiff University’s School of Medicine where I investigated the protective qualities of phytoestrogens in the development of breast cancer. From here I moved to a more industrial setting, gaining valuable experience working as a senior member of the Chromatography department in BioClinical Services, a local CRO based in Cardiff.

I returned to academia in 2002 when I joined the team at the Tenovus Centre for Cancer Research (now the Breast Cancer Molecular Pharmacology Group) based at the Cardiff School of Pharmacy and Pharmaceutical Sciences. My work explored the role of Src family kinases in the increased metastatic potential associated with Tamoxifen-resistant breast cancer. This subject later became the focus of my studies after I decided to undertake a PhD with the group; the data I generated suggested a potential role for Src not only in the development of a metastatic phenotype but also in the acquisition and maintenance of Tamoxifen resistance itself.

On completion of my PhD I returned to Cardiff University’s School of Medicine where I joined the Cardiff Chronic Lymphocytic Leukaemia (CLL) Research Group. Here, my project explored the causative factors involved in the development of aggressive CLL, focussing on the potential role of the prognostic marker CD38. The project gradually evolved over time and my interests shifted towards the regulation of CD38 expression in primary CLL cells, concentrating on the involvement of extracellular signals received from the lymphoid microenvironment and the role of NF-kB signalling pathways.

In 2015 I joined the Cardiff-China Medical Research Collaborative (CCMRC) in the School of Medicine in order to return to my primary research interest, namely the metastasis of solid tumours. My current research focuses on the metastasis of prostate cancer to bone, looking specifically at the factors involved in the osteoblastic phenotype exhibited by prostate cancer, in addition to the interactions between prostate cancer cells and the permissive bone microenvironment that allow secondary tumours to develop and progress at these sites.

Areas of Technical Expertise

  • Cell behaviour assays (adhesion, migration, invasion and proliferation)
  • Chromatin immunoprecipitation (ChIP)
  • Flow cytometry
  • Gene up-regulation/knock-out
  • Immunocytochemistry
  • In vitro cell culture (primary and cell-lines)
  • PCR/qPCR
  • SDS PAGE/Western blotting