Infection and Immunity

You can conduct your research degree within the Division of Infection & Immunity. Research extends from basic mechanisms of infection and immunology to translation directly impacting diagnosis, management and prevention of disease.

The aim is to offer a broad knowledge and expertise in in all aspects of immunological-based disease processes at the molecular and cellular level, with strengths in innate immunity, cancer immunology, T-cell biology and viral and bacterial infection. Centrally supported state of-the-art technology platforms, genomics, Medicine courses continue over proteomics, lipidomics, imaging and flow cytometry with expertise in cell and molecular biology.

Distinctive features

New and refurbished lab space in the Henry Wellcome and Tenovus Buildings combines state-of-the-art laboratories with shared core facilities for proteomics, genomics, transgenics, flow cytometry, histology and imaging.

Contacts

Administrative contact(s)

School of Medicine Research Degrees Office

Administrative contact

Academic contact(s)

Philip Taylor

Professor Philip Taylor

Professor of Translational Immunology, Division of Infection and Immunity. PGR Lead, Systems Immunity Research Institute.

Email:
taylorpr@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7328

The Division of Infection and Immunity conducts internationally recognised research in the areas of infection, immunity and inflammation. The long-term objective of this research is to develop or redefine treatment strategies for use in inflammatory disorders, infectious diseases and cancer. Further details can be found on the Division webpages.

The Division is comprised of a team of 40 principal investigators from different fields of expertise. Our researchers include laboratory scientists, clinical academics and hospital doctors, who share knowledge through regular seminars and workshops. Our Division includes 12 professors, and we are currently training 60 PhD students.

The following research areas are of particular strength:

  • Complement Biology
  • Inflammation and leukocyte trafficking
  • Biology of leukocytes sub-sets
  • Cytokines and Chemokines
  • T lymphocyte subsets and immune regulation
  • Immunotherapy
  • Arthritis
  • Innate and acquired immunity
  • Viruses and viral immunity
  • Cancer Immunology
  • Lipid Mediators
  • Antibiotic resistance and bacterial infection.

Chromatin dynamics in Huntington's disease

The aim of this project is to investigate whether chromatin structure influences CAG repeat expansion in Huntingtin, and whether repeat expansion in turn alters chromatin structure.

Advanced virotherapies for immuno-oncolytic applications

This project will develop refined virotherapies for the delivery immunotherapies in vivo.

Optimising expansion of CD8+ T cells for immunotherapy

This study aims to generate new understanding/reagents that will enable the expansion of highly functional T-cells for immunotherapy.

Ehmt1 and the epigenetic control of genomic imprinting in neurodevelopmental disorders

This project will explore whether haploinsuffficiency of Ehmt1 leads to abnormal genomic imprinting during neurodevelopment.

Control of CD4+ T cell responses by human gamma/delta T cells

The objective of this project is to define the molecular mechanisms underlying CD4+ T-cell polarisation by γ5 T-cells and identify ways to manipulate them for future interventions.

Understanding how C-type lectin-like receptors collaborate to clear fungal infections

The aim of this project is to determine whether CLR targeting/co-engagement could have therapeutic benefits.

Dissecting the impact of L-selectin proteolysis on T lymphocyte dependent virus immunity

This project will determine how fragments of digested L-selectin control the ability of killer T cells to detect and kill virus.

Mechanisms controlling the switch between the pro- and anti-fibrotic functions of the long non-coding natural anti-sense to hyaluronan synthase 2

This project will dissect, at the molecular level, the mechanisms that regulate HAS2-AS1 expression/function leading to a HA-dependent pro-fibrotic cell-phenotype and which can be used as potential novel therapeutic targets.

Funding

There are currently no funding opportunities available.

Tuition fees

UK and EU students (2017/18)

Get the latest information on postgraduate fees.

Students from outside the EU (2017/18)

Get the latest information on postgraduate fees.

Programme information

For programme structure, entry requirements and how to apply, visit the Medicine programme.

View programme
Postgraduate students on campus

Open Day

Meet us at our Postgraduate Open Day on 22 November 2017.

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