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Name Qualification Mode Type

Biosciences

Our research ranges across the biological sciences, from the understanding of precisely how neurons grow, to the mechanisms of cancer and other diseases, the molecular basis of animal and plant development and exploring the genetics of orang-utans, elephants, pandas and other endangered species.

PhD, MPhil, MD Full-time, Part-time Programme

Structural analysis of receptors for insecticidal toxins

Insecticidal toxins produced by bacteria such as Bacillus thuringiensis and Lysinibacillus sphaericus are the active agents in these important biological pesticides and can also be exploited in the production of insect-resistant transgenic plants.

Project

Developing a 3rd generation sequencing based method for identification of bacteria without culturing

There are many instances in which we need to identify bacteria, but are unable to grow them in the laboratory, for example, urinary tract infections, wound infections and bacterial vaginosis.

Project

Molecular mechanisms of phenotype determination in BNST forebrain neurons

The complexity of adult brain function is largely met by the networking of a multitude of neurons, but there is also a requirement for different types of neuron.

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Cytoplasmic RNA regulation in cell motility

This project will investigate how cytoplasmic RNA regulation impacts on cell motility and immune function, by studying conserved RNA-binding proteins and their interactions with candidate mRNAs.

Project

The functional proteome of the microbiome and its role in endotoxin modulation

Inflammatory disease such as Inflammatory Bowel Disease and Non-alcoholic fatty liver disease, are all increasing in the global population, as are many other non-communicable diseases.

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Detection of outer membrane vesicles (OMVs) in common gut bacteria and fecal samples

The role of bacteria and microbes in cancer has received considerable attention due to the involvement of Helicobacter pylori and viruses such as HPV, EBV and Hep B and C.

Project

Protein interactions in the regulation of a model cell differentiation program

Cell differentiation programs drive the production of specialised tissues from progenitor cells during animal development.

Project

Role of the lysosome, and the lysosomal protein NPC1 in the pathogenesis and treatment of Mycobacteriumtuberculosis

Tuberculosis (TB) is a chronic disease that in it’s latent form affects approximately one third of the worlds population with an estimated 10 million new cases and 1.5 million deaths per year.

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Firing dynamics of thalamic and cortical neural networks during absence epilepsy

Epilepsy is one of the most serious and widespread neurological diseases, which affect about 1% of the population.

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A Synthetic Reaction-Diffusion System for Engineering Patterning and Self-Organisation in Plant Stem Cells

Reaction-diffusion systems are employed in biology to establish patterns associated with the formation of distinct tissues and organs at the multicellular scale.

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Developmental and molecular analysis of sperm production in Drosophila

This project links developmental biology and determination of cell fate, through transcriptional controls that interpret that cell fate decision and control differentiation to evolution and optimisation of reproductive function.

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Characterisation of microRNAs regulated by dihomo-gamma-linolenic acid in macrophages in relation to atherosclerosis

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for more deaths in the western world than any other disease with mortality increasing at a marked rate in developing countries.

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Examining the programming of offspring behaviour by maternal diet and abnormal maternal care

There is a well-defined association between early life adversity (either prenatally or in early childhood) and significantly poorer outcomes for children.

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Towards the clinical development of calcium-sensing receptor antagonists as novel therapeutics for inflammatory lung diseases

G protein-coupled receptors (GPCRs) have crucial roles in almost every physiological process from cardiac function, immune responses and neurotransmission to sensory functions comprising sight, taste and smell.

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The smell of infection – detecting infectious disease and determining mechanisms underlying the spread of disease on social networks

Social organization facilitates contacts between individuals altering the probability of parasite transmission (Perkins et al., 2009).

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