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Name Qualification Mode Type

Biosciences

Our research ranges across the biological sciences, from the understanding of precisely how neurons grow, to the mechanisms of cancer and other diseases, the molecular basis of animal and plant development and exploring the genetics of orang-utans, elephants, pandas and other endangered species.

PhD, MPhil, MD Full-time, Part-time Programme

Structural analysis of receptors for insecticidal toxins

Insecticidal toxins produced by bacteria such as Bacillus thuringiensis and Lysinibacillus sphaericus are the active agents in these important biological pesticides and can also be exploited in the production of insect-resistant transgenic plants.

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The gut microbiota continuum - what does it mean for the host?

This project will explore and measure basic parameters of three groups of individuals, which fall at the extremes of this continuum and in the middle.

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Molecular mechanisms of phenotype determination in BNST forebrain neurons

The complexity of adult brain function is largely met by the networking of a multitude of neurons, but there is also a requirement for different types of neuron.

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Cytoplasmic RNA regulation in cell motility

This project will investigate how cytoplasmic RNA regulation impacts on cell motility and immune function, by studying conserved RNA-binding proteins and their interactions with candidate mRNAs.

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Developing a 3rd generation sequencing based method for identification of bacteria without culturing

There are many instances in which we need to identify bacteria, but are unable to grow them in the laboratory, for example, urinary tract infections, wound infections and bacterial vaginosis.

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The functional proteome of the microbiome and its role in endotoxin modulation

Inflammatory disease such as Inflammatory Bowel Disease and Non-alcoholic fatty liver disease, are all increasing in the global population, as are many other non-communicable diseases.

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Detection of outer membrane vesicles (OMVs) in common gut bacteria and fecal samples

The role of bacteria and microbes in cancer has received considerable attention due to the involvement of Helicobacter pylori and viruses such as HPV, EBV and Hep B and C.

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Protein interactions in the regulation of a model cell differentiation program

Cell differentiation programs drive the production of specialised tissues from progenitor cells during animal development.

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Role of the lysosome, and the lysosomal protein NPC1 in the pathogenesis and treatment of Mycobacteriumtuberculosis

Tuberculosis (TB) is a chronic disease that in it’s latent form affects approximately one third of the worlds population with an estimated 10 million new cases and 1.5 million deaths per year.

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Firing dynamics of thalamic and cortical neural networks during absence epilepsy

Epilepsy is one of the most serious and widespread neurological diseases, which affect about 1% of the population.

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Transcriptional landscaping in plant stem cells: from chromatin to gene regulatory networks

Agriculture depends on the activity of meristems – small populations of pluripotent stem cells from which all major plant tissues and organs are produced.

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A Synthetic Reaction-Diffusion System for Engineering Patterning and Self-Organisation in Plant Stem Cells

Reaction-diffusion systems are employed in biology to establish patterns associated with the formation of distinct tissues and organs at the multicellular scale.

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Plasticity of visual information processing and the consequences of neurodevelopmental disorders

The aim of this project is to identify specific cellular mechanisms by which developmental or genetic defects translate into visual or neurological condition.

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Novel water treatments for zoonotic pathogen Cryptosporidium

This interdisciplinary project will combine the novel method of water treatment using microwaves with state-of-art Cryptospordium culturing.

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Developmental and molecular analysis of sperm production in Drosophila

This project links developmental biology and determination of cell fate, through transcriptional controls that interpret that cell fate decision and control differentiation to evolution and optimisation of reproductive function.

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Characterisation of microRNAs regulated by dihomo-gamma-linolenic acid in macrophages in relation to atherosclerosis

Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for more deaths in the western world than any other disease with mortality increasing at a marked rate in developing countries.

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Examining the programming of offspring behaviour by maternal diet and abnormal maternal care

There is a well-defined association between early life adversity (either prenatally or in early childhood) and significantly poorer outcomes for children.

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Developing plants as an expression system for mammalian ion channels

The aim of this project is to develop plant expression systems for eukaryotic membrane proteins, focusing on the P2X receptor family of ATP-gated ion channels.

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Tackling antibiotic resistance by combining synthetic biology and nanotechnology: development of new biosensing systems

This project will bridge the areas of synthetic biology and nanotechnology to address the growing problem of antimicrobial resistance (AMR).

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Olfactory perception and prey choice behaviour by generalist predators (Carabidae)

This project combines fundamental work on a major mechanism for prey choice by predators of pests in crops with work of much wider significance for our understanding of basic perception.

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Gene expression regulation by RNA-binding proteins during fly development

This project will employ complementary in vivo and in vitro approaches to functionally characterize nuclear and cytoplasmic PTB-containing complexes.

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New approaches antimicrobial resistance detection and treatment

This project aims to develop a set of proteins that can bind across a broad set of BLs for the purpose of detection and potential treatment.

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Using human genetics to reveal novel molecular pathways involved in mediating protective skeletal responses to exercise and mechanical loading

This project is intended to identify further pathways involved in mechanical loading responses of bone, which could act as additional targets for bone-forming drugs.

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How can we engineer more robust plants? Smart genetic screens and advanced imaging strategies to understand the cellular basis of plant growth under normal and stress conditions

This project aims to study and understand molecular mechanisms that link stress to the stopping of cell division and attempt to identify mutants that can uncouple these processes.

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Building the molecular tool kits to exploit Burkholderia bacteria as biotechnological agents

This PhD project aims to express silent gene clusters, optimally produce novel antibiotics and genetically engineer pathways to create novel products.

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Towards the clinical development of calcium-sensing receptor antagonists as novel therapeutics for inflammatory lung diseases

G protein-coupled receptors (GPCRs) have crucial roles in almost every physiological process from cardiac function, immune responses and neurotransmission to sensory functions comprising sight, taste and smell.

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Understanding the dynamics and determinants of recovery of a regionally iconic wild food resource following its near-extinction due to infectious disease

This is a multidisciplinary project focused on recovering regionally iconic wild food resource following its near-extinction due to infectious disease.

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Probing 'kiss and go'; in vivo detection of interactions with RBR in the Arabidopsis root meristem

This project will develop molecular tools based on fluorescent tags to investigate the levels of bound and unbound retinoblastoma in living cells with different kinase levels by advanced imaging.

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The regulation of flower opening in lilies and how to control it to improve post-harvest quality

This project will use a combination of confocal microscopy, analytical techniques and transcriptome analyses to build up a model of the changes occurring during flower opening.

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