PhD in Dentistry: Validation of a stem cell derived cartilage model for osteoarthritis research and drug screening

This funding opportunity has expired.

Key facts

Application deadline 18 June 2018
Start date 1 July or 1 October 2018
Duration 3 years
Level of study Postgraduate research
Award type PhD studentship
Number of studentships One

This is a collaborative PhD studentship funded by Cardiff University and Arthritis Research UK, and aligned to the research program of the Arthritis Research UK Biomechanics and Bioengineering Centre.

Osteoarthritis is a chronic, painful and progressive joint disorder characterised by loss of articular cartilage. Despite eight million sufferers in the UK alone, treatments are still limited to pain management strategies and ultimately joint replacement surgery. We urgently need to better understand the mechanisms underlying disease development and progression, and to develop diagnostic assays for early identification of patients at risk of developing osteoarthritis to develop 21st Century therapeutics.

Tissue engineering methods, developed at Cardiff University’s School of Dentistry, use human stem cells to produce tissue closely resembling articular cartilage. This PhD project will use cutting-edge biophysical and microscopic techniques developed by our collaborators at the University of Exeter to characterise our ‘engineered’ cartilage at microstructural levels. This project will refine, validate and further develop our joint-specific model of human cartilage, which will then be used to model osteoarthritis development and to identify disease biomarkers and screen therapeutic agents.

This is an interdisciplinary PhD opportunity based at Cardiff University, but working closely with our collaborators at the University of Exeter. It offers outstanding training opportunities and you will develop knowledge in tissue engineering and cartilage stem cell biology, and an unique set of skills including 3D cell culture, molecular biology, state of the art microscopy techniques and Raman microspectrometery.

Supervisors

This is an interdisciplinary PhD opportunity based in Cardiff University, but working closely with our collaborators in the University of Exeter.

Contact

Beverley Howell

Beverley Howell

Postgraduate Admissions Assistant

Email:
howellb@cardiff.ac.uk
Telephone:
+44 29207 44251

Dr Sharon Dewitt

Lecturer

Email:
dewitt@cardiff.ac.uk
Telephone:
+44 29207 44509

Funding details

Tuition fee support Full UK/EU tuition fees
Maintenance stipend Doctoral stipend matching UK Research Council National Minimum
Additional funding offered Funding is provided for research consumables and project costs.

Eligibility criteria

Residency Open to all students of any nationality without restrictions (UK/EU and International)
Academic criteria

You should have a 2:1 or 1st Class Honours Degree (or demonstrate excellence during previous degrees) in a Biological, Biomedical, Biochemical or Physical (Chemistry, Biophysics) Science subject area.

Given that this project employs various state-of-the-art biophysical approaches to address questions in biology, numerical skills are a requirement.

Favourable consideration will be given to applicants able to demonstrate previous research experience.

Full UK/EU tuition fees will be provided. Any eligible non-home fee paying candidate must fund the remainder of the overseas fee themselves, estimated at £15,666 for the 2018/19 academic year (based on current Cardiff University guidelines for Postgraduate Tuition Fees 2018/19). Fees are revised annually.

See detailed information on tuition fees.

Contact

Beverley Howell

Beverley Howell

Postgraduate Admissions Assistant

Email:
howellb@cardiff.ac.uk
Telephone:
+44 29207 44251

Dr Sharon Dewitt

Lecturer

Email:
dewitt@cardiff.ac.uk
Telephone:
+44 29207 44509

Consideration is automatic upon application for admission to the Doctor of Philosophy (Dentistry) with a 1 October 2018 start date.

In the “Research Proposal and Funding” section of your application, please specify the project title and supervisors of this project and copy the project description in the text box provided.

Please select “No, I am not self-funding my research” when asked whether you are self-funding your research.

Please add “PhD in Dentistry: Validation of a stem cell derived cartilage model for osteoarthritis research and drug screening" when asked "Please provide the name of the funding you are applying for."

We reserve the right to close applications early should sufficient applications be received.

Contact

Beverley Howell

Beverley Howell

Postgraduate Admissions Assistant

Email:
howellb@cardiff.ac.uk
Telephone:
+44 29207 44251

Dr Sharon Dewitt

Lecturer

Email:
dewitt@cardiff.ac.uk
Telephone:
+44 29207 44509

Funding opportunity provided by:

Tuition fee discount of £3,400 for eligible Welsh and EU students starting a master’s degree in September 2018.

Eligible research programmes