Skip to content

Oncolytic Adenovirus Virology

Research within the Oncolytic Adenovirus Virology lab is focused on developing bespoke oncolytic adenoviral vectors for translational cancer applications.

To achieve this, we are developing tumour selective virotherapies that selectively infect cancer cells, leaving normal cells uninfected. To achieve this, we take two approaches. Our first approach is a “bottom up” approach involving the use of Ad5, a well described, well understood and clinically well studied virus. Although safe, Ad5 has a number of features which limits efficacy as a tumour selective virotherapy.

Firstly, the primary Ad5 receptor, hCAR (human coxsackie and adenovirus receptor) is ubiquitously expressed on red blood cells and in all tissues, located at tight junctions, but is commonly downregulated or even absent in advanced cancers, and therefore represents a poor target for tumour targeting strategies.

Secondly, uptake into immune cells, mediated by the interaction between αvβ3/5 integrin and the Ad5 penton base protein can promote significant dose limiting toxicities. Finally, intravascular delivery of Ad5, a pre-requisite for therapy of metastatic disease, is compromised for Ad5 due to the high affinity interaction with the blood clotting factor, FX, which bridges the virus: FX complex to HSPGs and is responsible for the significant levels of hepatic uptake of Ad5 based virotherapies (overviewed in Figure.1).

To target the refined, basal vector to tumour cells, we further modulate the vector to incorporate peptide ligands binding to tumour specific markers, such as αvβ6 integrin (Figure.2).

Discover more about the research carried out into Infection and Immunity.

External activities

Dr Alan Parker is a BSGCT Board member. In this role he chairs the Professional Collaboration sub-committee, and vice chair of the communication and promotion sub-committee, and chaired the 2017 annual meeting in Cardiff.  Alan is actively involved in a wide range of public engagement activities, both within his role with BSGCT and in promoting the work of the lab locally, and is a registered STEM ambassador.

Key collaborators

Area of researchMembers
VectorologyRichard Stanton (Cardiff University)
Gavin Wilkinson (Cardiff University)
Lynda Coughlan (Icahn School of Medicine, New York)
Oncolytic adenovirusesGunnel Hallden (Barts Cancer Institute)
Robert Carlisle (Oxford University)
Len Seymour (Oxford University)
Richard Vile (Mayo Institute, Rochester, USA)
αvβ6 biologyJohn Marshall (Bart’s Cancer Institute)
Structural studies of viral proteinsPierre Rizkallah (Cardiff University)
Alex Greenshields-Watson (Cardiff University)
Translational immunologyAwen Gallimore (Cardiff University)
Andy Godkin (Cardiff University)
Advanced therapeutics for breast cancerRichard Clarkson (Cardiff University)
Luke Piggott (Cardiff University)
Advanced therapeutics for pancreatic cancerGunnel Hallden (Bart’s Cancer Institute)
Catherine Hogan (Cardiff University)
Translational studiesJohn Chester (Cardiff University)
Ovarian cancer collaboratorsRachel Jones (Cardiff University)
Emma Hudson (Cardiff University)
Louise Hanna (Cardiff University)
James Cronin (Cardiff University)
Steve Conlan (Swansea)
Viral proteins as drug delivery agentsAngela Casini (Cardiff University)
Steven Paisey (Cardiff University)

Lead researcher

Dr Alan Parker

Dr Alan Parker

Reader

Email:
parkeral@cardiff.ac.uk
Telephone:
+44 (0)29 22 510 231

Academic staff

Dr Sarah Curtis

Dr Sarah Curtis

Research Associate

Email:
curtiss5@cardiff.ac.uk
Dr James Davies

Dr James Davies

Senior Technician

Email:
daviesja9@cardiff.ac.uk
Telephone:
+44 29206 87319

Postgraduate students

No profile image

Mr Alexander Baker

Research student

Email:
bakerat@cardiff.ac.uk