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Cancer Immunology Group

Whilst seminal observations using immunocompromised mice have provided compelling evidence for tumour immunosurveillance, many fundamental questions remain unanswered in the field of tumour immunology.

The types of immune effector cells/molecules capable of controlling tumour growth in vivo have not yet been definitively identified. Furthermore, although many pathways of tumour-induced immunosuppression are thought to contribute to the overall paucity of anti-tumour immunity, these pathways remain poorly characterised.

Aims

  • To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity. This information is essential to inform the design of successful cancer therapy.

Central to this aim, our grouping in Cardiff, through studies of prostate cancer, breast cancer, cervical cancer, colorectal cancer, mesothelioma, and leukaemia, focuses on:

  • Engineering T cell receptors to enhance tumour recognition.
  • Evaluating the impact of regulatory T cells on tumour progression.
  • Exosomes in cancer immunology.
  • Gamma/delta T cells for cellular immunotherapy.
  • Therapies for chronic lymphocytic leukaemia.
  • Immune recognition and evasion in cancer.

We use in vivo and in vitro models, including direct analyses of samples from cancer patients and clinical trials to test novel approaches for therapeutic intervention.

Academic staff

Dr Paul Brennan

Dr Paul Brennan

Reader

Email:
brennanp@cardiff.ac.uk
Telephone:
+44 29 2068 7087
Professor Aled Clayton

Professor Aled Clayton

Email:
claytona@cardiff.ac.uk
Telephone:
+44 (0)29 2251 0589
Professor Matthias Eberl

Professor Matthias Eberl

Personal Chair, Division of Infection and Immunity. Engagement Lead, Systems Immunity Research Institute.

Email:
eberlm@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7011
Professor Awen Gallimore

Professor Awen Gallimore

Professor

Email:
gallimoream@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7018
Professor Andrew Godkin

Professor Andrew Godkin

Chair

Email:
godkinaj@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7003
Dr Stephen Man

Dr Stephen Man

Reader

Email:
mans@cardiff.ac.uk
Telephone:
+44 29206 87056
Professor Bernhard Moser

Professor Bernhard Moser

Professor

Email:
moserb@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7058
Professor Ann Ager

Professor Ann Ager

Theme Lead for Inflammation, Division of Infection and Immunity. Theme Lead for Chronic Inflammation, Systems Immunity Research Institute.

Email:
agera@cardiff.ac.uk
Telephone:
+44 (0)29 2068 8872
Professor Andrew Sewell

Professor Andrew Sewell

Professor, Division of Infection and Immunity. Mechanisms of Immunity Theme Lead, Systems Immunity Research Institute.

Email:
sewellak@cardiff.ac.uk
Telephone:
+44 (0)29 2068 7055
Dr Zsuzsanna Tabi

Dr Zsuzsanna Tabi

Reader

Email:
tabiz@cardiff.ac.uk
Telephone:
+44 (0)29 2251 0550