Cancer Immunology Group
To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity.
Whilst seminal observations using immunocompromised mice have provided compelling evidence for tumour immunosurveillance, many fundamental questions remain unanswered in the field of tumour immunology.
The types of immune effector cells/molecules capable of controlling tumour growth in vivo have not yet been definitively identified. Furthermore, although many pathways of tumour-induced immunosuppression are thought to contribute to the overall paucity of anti-tumour immunity, these pathways remain poorly characterised.
- To identify pathways that limit tumour growth and those that impede effective anti-tumour immunity. This information is essential to inform the design of successful cancer therapy.
Central to this aim, our grouping in Cardiff, through studies of prostate cancer, breast cancer, cervical cancer, colorectal cancer, mesothelioma, and leukaemia, focuses on:
- Engineering T cell receptors to enhance tumour recognition.
- Evaluating the impact of regulatory T cells on tumour progression.
- Exosomes in cancer immunology.
- Gamma/delta T cells for cellular immunotherapy.
- Therapies for chronic lymphocytic leukaemia.
- Immune recognition and evasion in cancer.
We use in vivo and in vitro models, including direct analyses of samples from cancer patients and clinical trials to test novel approaches for therapeutic intervention.
Professor Paul Brennan
- +44 29 2068 7087
Professor Aled Clayton
Director of Research
- Welsh speaking
- +44 (0)29 2251 0589
Professor Matthias Eberl
Professor of Translational Immunology, Division of Infection and Immunity. Joint Academic Lead for Public Involvement and Engagement, School of Medicine.
- +44 (0)29 2068 7011
Professor Awen Gallimore
Co-Director of Systems Immunity Research Institute
- Welsh speaking
- +44 (0)29 2068 7012
Professor Andrew Godkin
- +44 (0)29 2068 7003
Dr Stephen Man
- +44 29206 87056
Professor Bernhard Moser
- +44 (0)29 2068 7058
Professor Ann Ager
Professor of Cellular Immunity and Immunotherapy, Division of Infection and Immunity and Systems Immunity Research Institute
- +44 (0)29 2068 8872
Professor Andrew Sewell
Professor, Division of Infection and Immunity. Mechanisms of Immunity Theme Lead, Systems Immunity Research Institute.
Dr Zsuzsanna Tabi
- +44 (0)29 2251 0550
A large amount of our research has been generously funded by grants provided by: