Dr Irina Erchova
Research Associate
Overview
I have a long-standing interest in brain’s ability to adapt and repair. My current research is into early functional deficits in eye condition caused by progressive retinal neurodegeneration. This focus stems from our knowledge that cell’s functional abnormalities precede cell death and further deterioration can be delayed or even prevented. This early diagnostics opens a window for successful medical intervention for many conditions that deemed incurable and current treatment is largely supportive (like macular degeneration, diabetic retinopathy, glaucoma and even Alzheimer’s Dementia (AD). My current work is focused on in vivo tests and electrophysiological characterisation of murine retina and brain.
I have a dual background in engineering (MSc in Computer science) and life sciences (PhD in Neuroscience) and I am particularly interested in integrated multidisciplinary approach to bio scientific research. I am also a STEM ambassador and enjoy disseminating our cutting-edge science to an interested audience.
Biography
Publications
2021
- Erchova, I., Sun, S. and Votruba, M. 2021. A perspective on accelerated ageing caused by genetic deficiency of the metabolic protein, OPA1. Frontiers in Neurology
2020
- Bevan, R. J.et al. 2020. OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory. Brain Communications 2(2), article number: fcaa101. (10.1093/braincomms/fcaa101)
- Sun, S.et al. 2020. Opa1 deficiency leads to diminished mitochondrial bioenergetics with compensatory increased mitochondrial motility. Investigative Ophthalmology & Visual Science 61(6), article number: 42. (10.1167/iovs.61.6.42)
2018
- Erchova, I.et al. 2018. Optophysiological characterisation of inner retina responses with high-resolution optical coherence tomography. Scientific Reports 8, article number: 1813. (10.1038/s41598-018-19975-x)
2017
- Erchova, I.et al. 2017. Enhancement of visual cortex plasticity by dark exposure. Philosophical Transactions B: Biological Sciences 372(1715), article number: 20160159. (10.1098/rstb.2016.0159)
- Morgan, J.et al. 2017. The optical detection of retinal ganglion cell damage. Eye 31(2), pp. 199-205. (10.1038/eye.2016.290)
2014
- Anantrasirichai, N.et al. 2014. Adaptive-weighted bilateral filtering and other pre-processing techniques for optical coherence tomography. Computerized Medical Imaging and Graphics 38(6), pp. 526-539. (10.1016/j.compmedimag.2014.06.012)
- Tudor, D.et al. 2014. Non-invasive detection of early retinal neuronal degeneration by ultrahigh resolution optical coherence tomography. PLoS ONE 9(4), article number: e93916. (10.1371/journal.pone.0093916)
Recent publications:
Erchova I, Vasalauskaite A, Longo V, Sengpiel F.(2017) Enhancement of visual cortex plasticity by dark exposure. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715).
Morgan JE, Tribble J, Fergusson J, White N, Erchova I.(2017) The optical detection of retinal ganglion cell damage. Eye (Lond). 2017 Feb;31(2):199-205
Tudor D, Kajić V, Rey S, Erchova I, Považay B, Hofer B, Powell KA, Marshall D, Rosin PL, Drexler W, Morgan JE.(2014) Non-invasive detection of early retinal neuronal degeneration by ultrahigh resolution optical coherence tomography. PLoS One. 28;9(4):e93916.
Anantrasirichai N, Nicholson L, Morgan JE, Erchova I, Mortlock K,
North RV, Albon J, Achim A.(2014) Adaptive-weighted bilateral filtering and other pre-processing techniques for optical coherence tomography. Comput Med Imaging Graph. 38(6):526-39.
Anantrasirichai N, Achim A, Morgan JE, Erchova I, Nicholson L (2013) Svm-Based Texture Classification in Optical Coherence Tomography IEEE International Symposium on Biomedical Imaging (ISBI) proc.
Pappas O, Anantrasirichai N, Nicholson L, Morgan JE, Erchova I, Achim A (2013) Curvelet domain image fusion of OCT and fundus imagery using convolution of meridian distributions IEEE International Conferenference on Image Processing
Boehlen A, Henneberger C , Heinemann U, Erchova I.(2013) Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells J Neurophysiol. 109(2):445-63