Professor Robert Sewell
Honorary Professor
Biography
Career profile
Robert Sewell graduated in pharmacy at the University of Bradford (B.Pharm) and became a registered pharmacist (M.R.Pharm.S). After a period in clinical pharmacy practice, Professor Sewell undertook research training in experimental applied pharmacology at the University of Wales Institute of Science and Technology (UWIST). His research was carried out in the laboratory of Prof. Paul Spencer on a Scholarship awarded by C. H. Boehringer Sohn and he was awarded Ph.D in 1976 for studies on Opioid Receptor Classification and Modified Neurotransmitter Function.
Professor Sewell was appointed as a lecturer in Pharmacology at UWIST in 1976 and spent a sabbatical period as a Heritage funded research scientist (1982 -1984) with Prof. Sheldon Roth in the Department of Pharmacology and Prof. Leo Strunin, Department of Anaesthesiology at the University of Calgary Medical School. Subsequently, he also spent collaborative periods with Prof. Bernard Roques from the Université René Descartes, Paris and Prof. Juan Mico from the Department of Pharmacology and Psychiatry at the School of Medicine, University of Cadiz.
Professor Sewell was appointed Senior Lecturer in Pharmacology at the School of Pharmacy and Pharmaceutical Sciences, Cardiff University in 1987 and then became Director of Postgraduate Studies (Clinical Research) in 1996. More recently, he has had research collaborations with Dr Marina Gruden at the P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow and with Prof Ludmilla Morozova-Roche at the Department of Medical Biochemistry and Biophysics, Umeå University, Sweden.
He was promoted to Reader in Pharmacology in 2010, and promoted again to Professor of Pharmacology in 2013.
He was designated a Fellow of the Royal Pharmaceutical Society of Great Britain in June 2009.
Scientific and professional service
Professor Sewell has acted as reviewer for over thirty international scientific and educational journals. He has served on the editorial board of the Journal of Pharmacological Methods and is currently on the editorial boards of the Journal of Psychopharmacology, Journal of Phytotherapy Research and the Journal of Enzyme Inhibition and Medicinal Chemistry. He was awarded an Alberta Heritage visiting scientist scholarship in 1982 and was the recipient of the British Telecom partnership award for Teaching and Learning in Science in 1994.
He also won the Association of British Pharmaceutical Industry (ABPI) Award for Pharmacy in 2007 for a project on the evaluation of a novel iris scanning and methadone dispensing system for drug abusers. More recently, he received the Anokhin Centennial Medal and Citation in 2008 for neuroscientific collaboration and his contribution to the development of the theory of functional systems by the P. K. Anokhin Institute for Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Professional memberships
- Royal Pharmaceutical Society of Great Britain
- British Neuroscience Association
- British Pharmacological Society
- British Association of Psychopharmacology
- Institute of Biology
- International Brain Research Organisation
- International Narcotics Research (INRC)
- European Opioid Colloquium
- Federation of European Neuroscience Societies
Academic positions
Professor in Pharmacology
Publications
2022
- Shah, D. et al. 2022. The neuroprotective propensity of organic extracts of Acacia Stenophylla Bark and their effectiveness against scopolamine-/diazepam-induced amnesia in mice. Journal of Inflammation Research 15, pp. 4785-4802. (10.2147/JIR.S376242)
- Arif, M., Rauf, K., Rehman, N. U., Tokhi, A., Ikram, M. and Sewell, R. D. 2022. 6-Methoxyflavone and donepezil behavioral plus neurochemical correlates in reversing chronic ethanol and withdrawal induced cognitive impairment. Drug Design, Development and Therapy 16, pp. 1573-1593. (10.2147/DDDT.S360677)
2021
- Qureshi, S. et al. 2021. Selected thiadiazine-thione derivatives attenuate neuroinflammation in chronic constriction injury induced neuropathy. Frontiers in Molecular Neuroscience 14, article number: 728128. (10.3389/fnmol.2021.728128)
- Gruden, M. A., Davydova, T. V., Ratmirov, A. M. and Sewell, R. D. E. 2021. Effects of antibodies to glutamate on cerebral expression of the Tnfrsf1A gene under conditions of spatial amnesia induced by proinflammatory protein S100A9 fibrils in aging mice. Bulletin of Experimental Biology and Medicine 172(1), pp. 18–21. (10.1007/s10517-021-05322-0)
- Khan, J. et al. 2021. Mechanistic evaluation of a novel cyclohexenone derivative?s functionality against nociception and inflammation: An in-vitro, in-vivo and in-silico approach. European Journal of Pharmacology 902, article number: 174091. (10.1016/j.ejphar.2021.174091)
- Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L. A., Zakharova, I. A. and Sewell, R. D. E. 2021. Delayed behavioral and neurochemical effects of anti-glutamate antibodies in aging C57BL/6 mice. Bulletin of Experimental Biology and Medicine 171(1), pp. 19–22. (10.1007/s10517-021-05163-x)
- Ahmad, N. et al. 2021. A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats. Behavioural Brain Research 405, article number: 113190. (10.1016/j.bbr.2021.113190)
- Shahrahmani, H., Ghazanfarpour, M., Shahrahmani, N., Abdi, F., Sewell, R. D. E. and Rafieian-Kopaei, M. 2021. Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis. Journal of Complementary and Integrative Medicine 18(2), pp. 261-269. (10.1515/jcim-2019-0212)
- Malekmohammad, K., Rafieian-Kopaei, M., Sardari, S. and Sewell, R. 2021. Toxicological effects of Mentha x piperita (Peppermint): A review. Toxin Reviews 40(4), pp. 445-459. (10.1080/15569543.2019.1647545)
2020
- Malekmohammad, K., Rafieian-Kopaei, M., Sardari, S. and Sewell, R. D. 2020. Effective antiviral medicinal plants and biological compounds against central nervous system infections: A mechanistic review. Current Drug Discovery Technologies 17(4), pp. 469-483. (10.2174/1570163816666190715114741)
- Sardari, S., Rafieian-Kopaei, M., Malekmohammad, K. and Sewell, R. D. E. 2020. Review of phytochemical compounds as antiviral agents against arboviruses from the genera flavivirus and alphavirus. Current Drug Discovery Technologies 17(4), pp. 484-497. (10.2174/1570163817666200122102443)
- Nazarian Samani, Z., Sewell, R. and Rafieian Kopaei, M. 2020. Inflammasome signaling and other factors implicated in atherosclerosis development and progression. Current Pharmaceutical Design 26(22), pp. 2583-2590., article number: 3. (10.2174/1381612826666200504115045)
- Malekmohammad, K., Sewell, R. and Rafieian-Kopaei, M. 2020. Mechanisms of medicinal plant activity on nitric oxide (NO) bioavailability as prospective treatments for atherosclerosis. Current Pharmaceutical Design 26(22), pp. 2591 - 2601. (10.2174/1381612826666200318152049)
- Asgharzade, S., Sewell, R., Rabiei, Z., Forouzanfar, F., Sheikhshabani, S. and Rafieian-Kopaei, M. 2020. Hydroalcoholic extract of anchusa italica protects global cerebral ischemia-reperfusion injury via a nitrergic mechanism. Basic and Clinical Neuroscience 11(3), pp. 323-332. (10.32598/bcn.11.2.1665.2)
- Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L., Zakharova, I. A. and Sewell, R. D. E. 2020. Antibodies to glutamate facilitate spatial memory formation in the Morris maze in aging C57BL/6 mice. Bulletin of Experimental Biology and Medicine 169(1), pp. 5-8. (10.1007/s10517-020-04812-x)
2019
- Kardani, A., Soltani, A., Sewell, R. D., Shahrani, M. and Rafieian-Kopaei, M. 2019. Neurotransmitter, antioxidant and anti-neuroinflammatory mechanistic potentials of herbal medicines in ameliorating autism spectrum disorder. Current Pharmaceutical Design 25(41), pp. 4421-4429. (10.2174/1381612825666191112143940)
- Shahid, M., Subhan, F., Ahmad, N. and Sewell, R. 2019. Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy induced peripheral neuropathy. BMC Pharmacology and Toxicology 20(1), article number: 51. (10.1186/s40360-019-0329-3)
- Malekmohammad, K., Sewell, R. and Rafieian-Kopaei, M. 2019. Antioxidants and atherosclerosis: mechanistic aspects. Biomolecules 9(8), article number: 301. (10.3390/biom9080301)
- Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L. A., Zakharova, I. A. and Sewell, R. 2019. Effect of antibodies to glutamate on age-related memory changes in C57Bl/6 mice. Bulletin of Experimental Biology and Medicine 166(3), pp. 326-329. (10.1007/s10517-019-04343-0)
- Sedighi, M. et al. 2019. A review of the most important medicinal plants effective on cardiac ischemia-reperfusion injury. Current Pharmaceutical Design 25(3), pp. 352-358. (10.2174/1381612825666190329144016)
- Fathinezhad, Z., Sewell, R., Lorigooini, Z. and Rafieian-Kopaei, M. 2019. Depression and treatment with effective herbs. Current Pharmaceutical Design 25(6), pp. 738-745. (10.2174/1381612825666190402105803)
2018
- Sewell, R. D. E. 2018. Neuropathic pain models and outcome measures: a dual translational challenge. Annals of Translational Medicine 6(S1), article number: S42. (10.21037/atm.2018.09.58)
- Gholipour, S., Sewell, R. D. E., Lorigooini, Z. and Rafieian-Kopaei, M. 2018. Medicinal plants and atherosclerosis: A review on molecular aspects. Current Pharmaceutical Design 24(26), pp. 3123-3131. (10.2174/1381612824666180911121525)
- Nazarian-Samani, Z., Sewell, R., Lorigooini, Z. and Rafieian-Kopaei, M. 2018. Medicinal plants with multiple effects on Diabetes Mellitus and its complications: A systematic review. Current Diabetes Reports 18(10), pp. 72. (10.1007/s11892-018-1042-0)
- Kirenskaya, A. V., Storozheva, Z. I., Gruden, M. A. and Sewell, R. D. E. 2018. COMT and GAD1 gene polymorphisms are associated with impaired antisaccade task performance in schizophrenic patients. European Archives of Psychiatry and Clinical Neuroscience 268(6), pp. 571-584. (10.1007/s00406-018-0881-7)
- Iashchishyn, I. A., Gruden, M., Moskalenko, R., Davydova, T., Wang, C., Sewell, R. D. and Morozova-Roche, L. A. 2018. Intranasally administered S100A9 amyloids induced cellular stress, amyloid seeding and behavioral impairment in aged mice. ACS Chemical Neuroscience 9(6), pp. 1338-1348. (10.1021/acschemneuro.7b00512)
- Gruden, M. A., Ratmirov, A. M., Storozheva, Z. I., Solovieva, O. A., Sherstnev, V. V. and Sewell, R. D. E. 2018. The Neurogenesis Actuator and NR2B/NMDA Receptor Antagonist Ro25-6981 Consistently Improves Spatial Memory Retraining Via Brain Region-Specific Gene Expression. Journal of Molecular Neuroscience 65(2), pp. 167-178. (10.1007/s12031-018-1083-5)
- Deslandes, P., Ward, E., Norris, K. and Sewell, R. D. E. 2018. Effectiveness of paliperidone long-acting injection in clinical practice. Therapeutic Advances in Psychopharmacology 8(5), pp. 139-145. (10.1177/2045125317753332)
- Gruden, M. A., Davydova, T. V., Kudrin, V. S., Wang, C., Narkevich, V. B., Morozova-Roche, L. A. and Sewell, R. 2018. S100A9 protein aggregates boost hippocampal glutamate modifying monoaminergic neurochemistry: A glutamate antibody sensitive outcome on Alzheimer-like memory decline. ACS Chemical Neuroscience 9(3), pp. 568-577. (10.1021/acschemneuro.7b00379)
- Moradi, F., Sewell, R., Lorigooini, Z. and Rafieian-Kopaei, M. 2018. Immunosuppression-lipid metabolism interplay and medicinal plants in atherosclerosis: a review. Current Pharmaceutical Design 24(24), pp. 2789-2793. (10.2174/1381612824666180829105309)
2017
- Ahmad, N., Subhan, F., Islam, N. U., Shahid, M., Rahman, F. U. and Sewell, R. D. E. 2017. Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model. European Journal of Pharmacology 814, pp. 302-312. (10.1016/j.ejphar.2017.08.040)
- Shahid, M., Subhan, F., Ahmad, N. and Sewell, R. D. E. 2017. The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia. Biomedicine & Pharmacotherapy 95, pp. 1725-1733. (10.1016/j.biopha.2017.09.108)
- Akbar, s. et al. 2017. Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach.. European Journal of Pharmacology 801, pp. 19-27. (10.1016/j.ejphar.2017.02.047)
- Shahid, M., Subhan, F., Ahmad, N., Ali, G., Akbar, S., Fawad, K. and Sewell, R. D. E. 2017. Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. European Journal of Pain 21(4), pp. 668-680. (10.1002/ejp.971)
- Gruden, M. A., Davydova, T. V., Fomina, V. G., Vetrile, L. A., Morozova-Roche, L. A. and Sewell, R. 2017. Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice. Bulletin of Experimental Biology and Medicine 162(4), pp. 430-432. (10.1007/s10517-017-3632-2)
- Alam, J., Subhan, F., Ullah, I., Shahid, M., Ali, G. and Sewell, R. D. E. 2017. Synthetic and natural antioxidants attenuate cisplatin-induced vomiting. BMC Pharmacology and Toxicology 18(4) (10.1186/s40360-016-0110-9)
- Ayaz, M., Subhan, F., Sadiq, A., Ullah, F., Ahmed, J. and Sewell, R. D. E. 2017. Cellular efflux transporters and the potential role of natural products in combating efflux mediated drug resistance. Frontiers in Bioscience 22(4), pp. 732-756. (10.2741/4513)
2016
- Gruden, M. A. et al. 2016. The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit. Behavioural Brain Research 306, pp. 106-116. (10.1016/j.bbr.2016.03.016)
- Aman, U. et al. 2016. Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. BMC Complementary and Alternative Medicine 16(1), article number: 77. (10.1186/s12906-016-1048-6)
2015
- Khan, M. S., Gohar, A., Abbas, G., Mahmood, W., Rauf, K. and Sewell, R. D. E. 2015. Thymoquinone inhibition of acquisition and expression of alcohol-induced behavioral sensitization. Phytotherapy Research 29(10), pp. 1610-1615. (10.1002/ptr.5409)
- Ali, G., Subhan, F., Abbas, M., Zeb, J., Shahid, M. and Sewell, R. D. E. 2015. A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. Naunyn Schmiedeburgs Archives of Pharmacology, pp. 1-12. (10.1007/s00210-015-1145-y)
- Deslandes, P., Dwivedi, M. and Sewell, R. D. E. 2015. Five-year patient outcomes with risperidone long-acting injection or oral aripiprazole. Therapeutic Advances in Psychopharmacology 5(3), pp. 151-157. (10.1177/2045125315581997)
- Storozheva, Z. I., Gruden, M. A., Proshin, A. T. and Sewell, R. D. E. 2015. Learning ability is a key outcome determinant of GSK-3 inhibition on visuospatial memory in rats. Journal of Psychopharmacology 29(7), pp. 822-835. (10.1177/0269881115573805)
- Akintomide, H., Brima, N., Sewell, R. D. E. and Stephenson, J. M. 2015. Patients' experiences and providers' observations on pain during intrauterine device insertion. The European Journal of Contraception and Reproductive Health Care 20(4), pp. 319-326. (10.3109/13625187.2015.1031885)
- Gruden, M. A. et al. 2015. Noradrenergic and serotonergic neurochemistry arising from intranasal inoculation with α-synuclein aggregates which incite parkinsonian-like symptoms. Behavioural Brain Research 279, pp. 191-201. (10.1016/j.bbr.2014.11.001)
2014
- Ullah, I., Subhan, F., Rudd, J. A., Rauf, K., Alam, J., Shahid, M. and Sewell, R. D. E. 2014. Attenuation of cisplatin-induced emetogenesis by standardized Bacopa monnieri extracts in the pigeon: behavioral and neurochemical correlations. Planta Medica 80(17), pp. 1569-1579. (10.1055/s-0034-1383121)
- Gruden, M. A. et al. 2014. Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates. Behavioural Brain Research 263, pp. 158-168. (10.1016/j.bbr.2014.01.017)
- Ali, G., Subhan, F., Ul Islam, N., Ullah, N., Sewell, R. D. E., Shahid, M. and Khan, I. 2014. Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates. Naunyn-Schmiedeberg's Archives of Pharmacology 387(3), pp. 281-290. (10.1007/s00210-013-0941-5)
- Gruden, M. A. et al. 2014. Corrigendum to 'Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression?' [Journal of Neuroimmunology, 233 (2011) 221-227]. Journal of Neuroimmunology 268(1-2), pp. 99. (10.1016/j.jneuroim.2014.01.001)
2013
- Akintomide, H., Sewell, R. D. E. and Stephenson, J. M. 2013. The use of local anaesthesia for intrauterine device insertion by health professionals in the UK. Journal of Family Planning and Reproductive Health Care 39(4), pp. 276-280. (10.1136/jfprhc-2012-100486)
- Gruden, M. A., Storozheva, Z. I., Sewell, R. D. E., Kolobov, V. V. and Sherstnev, V. V. 2013. Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory. Behavioural Brain Research 252, pp. 230-238. (10.1016/j.bbr.2013.06.024)
- Gruden, M. A., Davidova, T. V., Yanamandra, K., Kucheryanu, V. G., Morozova-Roche, L. A., Sherstnev, V. V. and Sewell, R. D. E. 2013. Nasal inoculation with α-synuclein aggregates evokes rigidity, locomotor deficits and immunity to such misfolded species as well as dopamine. Behavioural Brain Research 243, pp. 205-212. (10.1016/j.bbr.2013.01.011)
- Ali, G. et al. 2013. Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study. Archives of Pharmacal Research 37(7), pp. 916-926. (10.1007/s12272-013-0245-9)
2012
- Gruden, M. A., Yanamandra, K., Kucheryanu, V. G., Bocharova, O. R., Sherstnev, V. V., Morozova-Roche, L. A. and Sewell, R. D. E. 2012. Correlation between protective immunity to alpha-synuclein aggregates, oxidative stress and inflammation. Neuroimmunomodulation 19(6), pp. 334-342. (10.1159/000341400)
- Rauf, K., Subhan, F. and Sewell, R. D. E. 2012. A Bacoside containing Bacopa monnieri extract reduces both morphine hyperactivity plus the elevated striatal dopamine and serotonin turnover. Phytotherapy Research 26(5), pp. 758-763. (10.1002/ptr.3631)
2011
- Deslandes, P. N., Xiao, X., Thomas, A., Jones, N. and Sewell, R. D. E. 2011. Reduction education in illicit opiate usage during a supervised methadone treatment programme. Journal of Psychopharmacology 25(8), pp. A38-A38.
- Gruden, M. A. et al. 2011. Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression. Journal of Neuroimmunology 233(1-2), pp. 221-227. (10.1016/j.jneuroim.2010.12.001)
2010
- Subhan, F., Karim, N., Gilani, A. H. and Sewell, R. D. E. 2010. Terpenoid content of Valeriana wallichii extracts and antidepressant-like response profiles. Phytotherapy Research 24(5), pp. 686-691. (10.1002/ptr.2980)
2009
- Deslandes, P. N., Lewis, A., Thomas, A. and Sewell, R. D. E. 2009. Risperidone long acting injection: Findings of a 2-year retrospective follow-up study. International Journal of Psychiatry in Clinical Practice 13(4), pp. 298-302. (10.3109/13651500903046286)
- Hodson, K. et al. 2009. Community pharmacies in south wales: misuse of over-the-counter medicines [Abstract]. Pharmacy World & Science 31(1), pp. 87. (10.1007/s11096-008-9262-z)
- Subhan, F., Khan, N. and Sewell, R. D. E. 2009. Adulterant Profile of Illicit Street Heroin and Reduction of its Precipitated Physical Dependence Withdrawal Syndrome by Extracts of St John's Wort (Hypericum perforatum). Phytotherapy Research 23(4), pp. 564-571. (10.1002/ptr.2692)
2008
- Gruden, M., Sewell, R. D. E., Sherstnev, V. and Morozova-Roche, L. 2008. Correlation between protein misfolding, immunity and neurodegeneration [Abstract]. FEBS Journal 275(S1), pp. 190. (10.1111/j.1742-4658.2008.06448.x)
- Deslandes, P., Thomas, A., Blackmore, E. E. and Sewell, R. D. E. 2008. Aripiprazole: 6-month outcomes in a retrospective naturalistic study. International Journal of Psychiatry in Clinical Practice 12(4), pp. 243-246. (10.1080/13651500801993241)
- Deslandes, P., Thomas, A., Lewis, A. and Sewell, R. D. E. 2008. Risperidone long acting injection: 2 year outcomes in a naturalistic study. European Neuropsychopharmacology 18(S4), pp. S411-S412.
- Urasov, V., Gruden, M., Storogeva, Z., Sewell, R. D. E. and Sherstnev, V. 2008. Linked mechanisms of neurogliogenesis and apoptosis in adult rat brain. Febs Journal 275, pp. 298-299.
2007
- Deslandes, P. N., Thomas, A., Blackmore, E. E. and Sewell, R. D. E. 2007. Early patient outcomes with two novel antipsychotic preparations. European Neuropsychopharmacology 17, pp. S429-S429.
- Gruden, M. A. et al. 2007. Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: Autoantibodies to A beta((25-35)) oligomers, S100b and neurotransmitters. Journal of Neuroimmunology 186(1-2), pp. 181-192. (10.1016/j.jneuroim.2007.03.023)
- Lane, S. R. and Sewell, R. D. E. 2007. The bacterial profile of cotton lint from worldwide origins, and links with occupational lung disease. American Journal of Industrial Medicine 50(1), pp. 42-47. (10.1002/ajim.20412)
- Ostrovskaya, R. U. et al. 2007. The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model. Journal of Psychopharmacology 21(6), pp. 611-619. (10.1177/0269881106071335)
2006
- Lane, S. R. and Sewell, R. D. E. 2006. The fungal profile of cotton lint from diverse sources and implications for occupational health. Journal of Occupational and Environmental Hygiene 3(9), pp. 508-512. (10.1080/15459620600872567)
- Lane, S. R. and Sewell, R. D. E. 2006. Correlative measurement of four biological contaminants on cotton lint, and their implications for occupational health. International Journal of Occupational and Environmental Health 12(2), pp. 120-125. (10.1179/oeh.2006.12.2.120)
- Lane, S. R., Sewell, R. D. E. and Jiang, R. 2006. Biological contamination parameters of cotton lint as biomarkers for fibre quality; A preliminary study. Fibers and Polymers 7(1), pp. 8-11. (10.1007/BF02933595)
2005
- Sewell, R. D. E. et al. 2005. Does the human leukaemia differentiation factor fragment HLDF6 improve memory via brain DNA and protein synthesis?. Journal of Psychopharmacology 19(6), pp. 602-608. (10.1177/0269881105056645)
- Fernandez-Perez, S., Pache, D. M. and Sewell, R. D. E. 2005. Co-administration of fluoxetine and WAY100635 improves short-term memory function. European Journal of Pharmacology 522(1-3), pp. 78-83. (10.1016/j.ejphar.2005.08.039)
- Lane, S. R., Sewell, R. D. E. and Nicholls, P. J. 2005. The fungal profile of cotton fibres, associated toxins and wider implications for indoor health. African Journal of Pharmacy and Pharmacology 57(S1), pp. S105-S106. (10.1211/002235705778248622)
- Raitt, L. J., Deslandes, P. N., Thomas, A. and Sewell, R. D. E. 2005. Effectiveness and tolerability of selective and non-selective antimuscarinic agents in the treatment of clozapine induced hypersalivation. Journal of Psychopharmacology 57, pp. S78-S79.
- Lane, S. R., Sewell, R. D. E. and Nicholls, P. J. 2005. The Gram-negative bacterial flora of the cotton production environment and relevance to occupational lung disease. Journal of Pharmacy and Pharmacology 57(S1), pp. S105-S105. (10.1211/002235705778248622)
- Raitt, L. J., Deslandes, P. N. and Sewell, R. D. E. 2005. Comparison of hyoscine and pirenzepine in the treatment of clozapine induced sialorrhoea. Journal of Psychopharmacology 19(5), pp. A15-A15.
- Angotti, M., Hartmann, R. W., Kirby, A. J., Simons, C., Nicholls, P. J., Sewell, R. D. E. and Smith, H. J. 2005. Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3, 4-dihydronaphthalen-1 (2H)-one on all-trans and 13-cis-retinoic acid levels in plasma quantified by high perfomance liquid chromatography coupled to tandem mass spectrometry. Journal Of Enzyme Inhibition And Medicinal Chemistry 20(3), pp. 219-226.
- Angotti, M., Hartmann, R. W., Kirby, A. J., Simons, C., Nicholls, P. J., Sewell, R. D. E. and Smith, H. J. 2005. Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3,4-dihydronaphthalen-1(2H)-one on all-transand 13-cis-retinoic acid levels in plasma quantified by high perfomance liquid chromatography coupled to tandem mass spectrometry. Journal of Enzyme Inhibition and Medicinal Chemistry 20(3), pp. 219-226. (10.1080/14756360400008889)
2004
- Lane, S. R., Cain, A. M., Sewell, R. D. E. and Nicholls, P. J. 2004. The measurement of endotoxin on cotton fibres and implications for industrial health. Journal of Pharmacy and Pharmacology 56(S1), pp. S85-S85. (10.1211/002235704777489348)
- Lane, S. R., Thomas, F. J. L., Sewell, R. D. E. and Nicholls, P. J. 2004. The applicability of a glucan-specific enzyme assay for the measurement of (1-3)-beta-D-glucan on cotton fibres and implications for occupational health. Journal of Pharmacy and Pharmacology 56, pp. S85-S85. (10.1211/002235704777489348)
- Lane, S. R., Nicholls, P. J. and Sewell, R. D. E. 2004. The measurement and health impact of endotoxin contamination in organic dusts from multiple sources: Focus on the cotton industry. Inhalation Toxicology 16(4), pp. 217-229. (10.1080/08958370490277164)
- Grudena, M. A. et al. 2004. Autoimmune responses to amyloid structures of A beta(25-35) peptide and human lysozyme in the serum of patients with progressive Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 18(2), pp. 165-171. (10.1159/000079197)
2003
- Pache, D. M., Fernandez-Perez, S. and Sewell, R. D. E. 2003. Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. European Journal of Pharmacology 477(3), pp. 205-211. (10.1016/j.ejphar.2003.08.029)
2002
- Deslandes, P. N., Pache, D. M. and Sewell, R. D. E. 2002. Drug dependence: neuropharmacology and management. Journal of Pharmacy and Pharmacology 54(7), pp. 885-895. (10.1211/002235702760088992)
- Deslandes, P., Pache, D. M., Buckland, P. R. and Sewell, R. D. E. 2002. Morphine, cocaine and antidepressant induced motivational activity and midbrain dopaminergic neurotransmission. European Journal of Pharmacology 453(2-3), pp. 223-229. (10.1016/S0014-2999(02)02451-2)
2000
- Subhan, F., Deslandes, P. N., Pache, D. M. and Sewell, R. D. E. 2000. Do antidepressants affect motivation in conditioned place preference?. European Journal of Pharmacology 408(3), pp. 257-263. (10.1016/S0014-2999(00)00771-8)
- Deslandes, P. N., Pache, D. M. and Sewell, R. D. E. 2000. Does naloxone have differing actions on reward?. British Journal of Pharmacology 131, pp. U33-U33.
- Fernandez-Perez, S., Pache, D. M., Spenser, P. S. J. and Sewell, R. D. E. 2000. Differential effects of 5-HT1A receptor activation in a combined delayed-matching/non-matching-to-position task. British Journal of Pharmacology 131, pp. U32-U32.
- Hutcheson, D. M., Subhan, F., Pache, D. M., Maldonado, R., Fournie-Zaluski, M. C., Roques, B. P. and Sewell, R. D. E. 2000. Analgesic doses of the enkephalin degrading enzyme inhibitor RB 120 do not have discriminative stimulus properties. European Journal of Pharmacology 401(2), pp. 197-204. (10.1016/S0014-2999(00)00441-6)
- Subhan, F., Pache, D. M. and Sewell, R. D. E. 2000. Potentiation of opioid-induced conditioned place preference by the selective serotonin reuptake inhibitor fluoxetine. European Journal of Pharmacology 390(1-2), pp. 137-143. (10.1016/S0014-2999(99)00909-7)
1999
- Gray, A. M., Pache, D. M. and Sewell, R. D. E. 1999. Do alpha(2)-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?. European Journal of Pharmacology 378(2), pp. 161-168. (10.1016/S0014-2999(99)00464-1)
- Pache, D. M., Sewell, R. D. E. and Spencer, P. S. J. 1999. Detecting drug effects on short-term memory function using a combined delayed matching and non-matching to position task. Journal of Pharmacological and Toxicological Methods 41(4), pp. 135-141. (10.1016/S1056-8719(99)00032-5)
- Gray, A. M., Nevinson, M. J. and Sewell, R. D. E. 1999. The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception. European Journal of Pharmacology 365(2-3), pp. 149-157. (10.1016/S0014-2999(98)00837-1)
1998
- Gray, A. M., Spencer, P. S. J. and Sewell, R. D. E. 1998. The involvement of the opioidergic system in the antinociceptive mechanism of action of antidepressant compounds. British Journal of Pharmacology 124(4), pp. 669-674. (10.1038/sj.bjp.0701882)
1996
- Hutchings, R., Pache, D. M., Sewell, R. D. E. and Spencer, P. S. J. 1996. The effect of the endopeptidase inhibitor RB38A on hippocampal expression of APP mRNA isoforms. British Journal of Pharmacology 119, pp. P367-P367. (10.1111/j.1476-5381.1996.tb17247.x)
- Dobson, M. Y., Sewell, R. D. E. and Spencer, P. S. J. 1996. Analgesic activity of the 5-HT1A agonists buspirone and 8-hydroxy-2-(di-N-propyl-amino)tetralin(8-OH-DPAT) and their differing antagonist interactions. British Journal of Pharmacology 119, pp. P348-P348.
- Pache, D. M., Hutchings, R., Sewell, R. D. E. and Spencer, P. S. J. 1996. Effect of scopolamine on delayed non-matching-to-position performance following central 5,7-dihydroxytryptamine treatment. British Journal of Pharmacology 119, pp. P349-P349.
- Sewell, R. D. E., Stevens, R. G. and Lewis, D. J. A. 1996. Pharmacology experimental benefits from the use of computer-assisted learning. American Journal of Pharmaceutical Education 60(3), pp. 303-307.
1995
- Gray, A. M., Callaghan, L. J., Spencer, P. S. J. and Sewell, R. D. E. 1995. Dothiepin prevents the acquisition of place aversion to Naloxone-precipitated opiate withdrawal. British Journal of Pharmacology 116, pp. P395-P395.
- Rafieiankopaei, M., Gray, A. M., Spencer, P. S. J. and Sewell, R. D. E. 1995. Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning. European Journal of Pharmacology 275(2), pp. 185-189. (10.1016/0014-2999(94)00770-8)
- Sewell, R. D. E., Stevens, R. G. and Lewis, D. J. A. 1995. Multimedia computer technology as a tool for teaching and assessment of biological science. Journal of Biological Education 29(1), pp. 27-32. (10.1080/00219266.1995.9655415)
1992
- Livingston, S. J., Smith, H. J., Sewell, R. D. E. and Ahmed, S. 1992. Novel inhibitors of enkephalin-degrading enzymes. IV: Structure-activity relationships within the penicillins as enkephalinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 6(2), pp. 165-173. (10.3109/14756369209040748)
1991
- Patel, A., Smith, H. J., Sewell, R. D. E. and Ahmadi, M. 1991. 3-substituted-2-tetrahydroquinoxalinones from reductive cyclodehydration of the hemi amides of 2-(2'-nitrophenylamino) butanoic acids. Chemistry and Industry(17), pp. 630-631.
- Darmani, N. A., Sewell, R. D. E. and Nicholls, P. J. 1991. Acute effects of beclamide on brain regional monoamine concentrations, their metabolites and radioligand binding studies. Journal of Pharmacy and Pharmacology 43(6), pp. 425-429. (10.1111/j.2042-7158.1991.tb03502.x)
- Rooney, K. F., Armstrong, R. A. and Sewell, R. D. E. 1991. Increased dopamine receptor sensitivity in the rat following acute administration of sufentanil, U50,488H and D-Ala2-D-Leu5-enkephalin. Naunyn Schmiedeburgs Archives of Pharmacology 343(5), pp. 458-462. (10.1007/BF00169546)
1990
- Gray, A. M., Sewell, R. D. E. and Spencer, P. S. J. 1990. Antidepressant inhibitory activity in the abdominal constriction assay is competitively blocked by opioid antagonists. British Journal of Pharmacology 101(S1), pp. P554-P554. (10.1111/j.1476-5381.1990.tb16273.x)
- Darmani, N. A., Sewell, R. D. E., Hasan, M. Y. and Nicholls, P. J. 1990. Comparison of the inhibitory action of aminobeclamide and beclamide on socially offensive behaviour. Journal of Pharmacy and Pharmacology 42(6), pp. 447-449.
- Yu, Z., Williams, P. S., Patel, A., Smith, H. J., Sewell, R. D. E. and Gonzalez, J. P. 1990. 2-substituted-N5-(2'-aminophenyl)-4-thiohydantoic acids as aminopeptidase inhibitors with pro-antinociceptive activity. Progress in Clinical and Biological Research 328, pp. 481-484.
- Livingston, S. J., Williams, P. S., Sewell, R. D. E. and Smith, H. J. 1990. Penicillins exhibit enkephalinase inhibitory activity in mice. International Narcotics Research Conference 328, pp. 413-416.
1989
- Rooney, K. F. and Sewell, R. D. E. 1989. Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception. European Journal of Pharmacology 168(3), pp. 329-336.
- Lal, K. J. and Sewell, R. D. E. 1989. Possible role for endogenous opiates in the regulation of food intake in the newborn rat. Archives Internationales de Pharmacodynamie et de Therapie 301, pp. 91-99.
- Gumbleston, M., Taylor, G., Sewell, R. D. E. and Nicholls, P. J. 1989. Anaesthetic influences on brain haemodynamics in the rat and their significance to biochemical, neuropharmacological and drug disposition studies. Biochemical Pharmacology 38(16), pp. 2745-2748. (10.1016/0006-2952(89)90564-9)
1988
- Darmani, N. A., Sewell, R. D. E. and Nicholls, P. J. 1988. Effects of beclamide on isolation-induced aggression and locomotor activity in mice. Journal of Pharmacy and Pharmacology 40(12), pp. 891-893. (10.1111/j.2042-7158.1988.tb06297.x)
- Livingston, S. J., Sewell, R. D. E. and Smith, H. J. 1988. The effects of the enkelphalinase inhibitor acetorphan on spontaneous locomotor-activity. British Journal of Pharmacology 95, pp. P665-P665. (10.1111/j.1476-5381.1988.tb16615.x)
- Rooney, K. F., Sewell, R. D. E. and Spencer, P. S. J. 1988. Differential-effects of acute administration of selective opioid agonists upon Dopamine binding-site density in the rat. British Journal of Pharmacology 95, pp. P559-P559.
- Sewell, R. D. E., Gumbleston, M., Taylor, G. and Nicholls, P. J. 1988. Determination of differential-effects of anesthetics on brain hemodynamics using microspheres in the rat. British Journal of Pharmacology 95, pp. P612-P612.
- Darmani, N. A., Sewell, R. D. E. and Nicholls, P. J. 1988. Dopamine-mediated behaviour following chronic treatment with B-HT 920. Journal of Pharmacy and Pharmacology 40(7), pp. 523-524.
- Livingston, S. J., Sewell, R. D. E., Rooney, K. F. and Smith, H. J. 1988. Amelioration of naloxone-precipitated opioid withdrawal symptoms by peripheral administration of the enkephalinase inhibitor acetorphan. Psychopharmacology 94(4), pp. 540-544. (10.1007/BF00212852)
1987
- Barasi, S. et al. 1987. Dopamine receptor-mediated spinal antinociception in the normal and haloperidol pretreated rat: effects of sulpiride and SCH 23390. British Journal of Pharmacology 90(1), pp. 15-22. (10.1111/j.1476-5381.1987.tb16820.x)
- Aliyu, S. U. and Sewell, R. D. E. 1987. Effects of beta-phenylethylamine on locomotor activity, body temperature and ethanol blood concentrations during acute ethanol intoxication. Psychopharmacology 93(1), pp. 69-71.
Research interests
- Drug Dependence and Tolerance
- Mechanisms of Neurodegeneration and drug actions on memory
- Computer Assisted Learning (CAL)
Professor Sewell commenced his research career as an opioid neuropharmacologist studying analgesia, tolerance and dependence. He later developed an interest in non-receptor mediated membrane actions of benzodiazepines and consequently spent two years in Canada exploring this field of research. On return to the U.K, he became involved with studies on cotton contamination and its relevance to occupational lung disease but subsequently, he has focused on neurodegenerative diseases, early biomarkers of cognitive decline, memory enhancement and the development of neuroprotective agents. He has continually maintained a lasting interest in opioid dependence studies both at the clinical and experimental level.
Throughout, Professor Sewell has recognised the importance of teaching research particularly in the use of computers in the learning environment. He has taken an active role in the development of teaching packages for Pharmacy and Pharmacology students within the Pharmacy Consortium for Computer Aided Learning (PCCAL) since the early 1990s and he has numerous publications in the context of teaching research.