Dr Emma Lane
Senior Lecturer in Neuropharmacology & Director of Postgraduate Research
School of Pharmacy and Pharmaceutical Sciences
- laneel@cardiff.ac.uk
- +44 (0)29 2087 4989
- Fax:
- +44 (0)29 2087 4149
- Media commentator
Overview
Qualifications
- B.Sc. in Pharmacology, University College London, 2000
- Ph.D. in Neuropharmacology, King's College London, 2004
External Positions and Activities
2013 2013- | Guest editor for special INTR12 issue of NeuroReport Editor for Pharmacology Research and Perspectives |
2012- 2012-13 | Society for Neuroscience Wales Chapter representative Member of expert group contributing to Guiding Principles for Behavioural Studies Using Animals (LASA/BAP/BNA/ESWAAP collaboration) |
2011- 2011- 2011-13 | President of Network for European CNS Transplantation and Restoration (NECTAR) Review Editor for Frontiers in Neuroscience Associate Editor for Restorative Neurology and Neuroscience |
Funding bodies which support my work
Community Engagement:
Relevant websites
- Brain Repair Group with the School of Biosciences
- NECTAR (Network of European CNS Transplantation and Restoration)
- STEMnet, STEM ambassador
- Cardiff University Neuroscience News
Biography
- 2015 – onwards Senior Lecturer in Pharmacology, School of Pharmacy and Pharmaceutical Sciences
- 2009-2015, Lecturer in Pharmacology, School of Pharmacy and Pharmaceutical Sciences
- 2006-2009, Post-Doctoral Research Associate, Brain Repair Centre, Department of Neuroscience, Cardiff University
Working with Prof Stephen Dunnett and Prof Anne Rosser I continued my work on L-dopa and post-transplantation dyskinesia contributing to two successful EU FP7 grant awards. - 2004-2006, Post-Doctoral Research Associate, Units of Neuronal Survival and Basal Ganglia Pathophysiology, Lund University, Sweden.
I spent 2 years in Sweden with the groups of Prof Patrik Brundin and Prof Angela Cenci developing, characterizing and working with a model of post-transplantation dyskinesia - 2000-2004, PhD, King's College London, UK
I had a BBSRC CASE award studentship with Prof Peter Jenner and Dr Sharon Cheetham (then Knoll Pharmaceuticals) on the potential of BTS 74398, a monoamine uptake inhibitor, as a possible anti-parkinsonian medication. - 1996-2000, Pharmacology B.Sc. Honours 1st Class with industrial placement, University College London, UK.
Specialising in neuropharmacology options and spending an industrial year at Knoll Pharmaceuticals working on the pharmacology of the anti-obesity agent sibutramine.
Honours and awards
Grant awards - research
£5 575 | Rivastigmine and quality of life in patients with Parkinson’s disease dementia, Role:PI Neurodem/NISCHR Research Development Group (2014 – ongoing) |
£12 500 | Optimising cell transplantation - BioE Sartre award, total award £25 000 from March 1st 2014 – ongoing: Role: Co-PI With J. Davies (Swansea University) |
£5 000 | Optimising MEMRI - Seed-corn funding from NMH RI – (2011) Role: Co-I with R. Trueman (BIOSI - PI) and S. Paisey (EMRIC) |
£14 978 | Scanning changes in functional brain activity associated with dyskinesia in parkinsonian rats, Parkinson’s Disease Society Innovations grant. Role: PI (2009-10) |
£41 622 | 1 year Wellcome Trust Value In People Award. 2008-2009 |
£338 975 | REPLACES: Restorative plasticity and corticostriatal excitatory synapses. EU FP7 small and medium collaborative research programme HEALTH 2007-2.2.1-7. Role: Co-I with expertise in L-DOPA induced dyskinesia and behavioural assessments, SB Dunnett PI Cardiff (2008-2012) |
£8 600 | Does the storage of embryonic tissue prior to transplantation affect immune responses to the graft and the development of graft induced dyskinesis Parkinsonfonden (Sweden) – Role: PI (2006-2009) |
£7 400 | Pharmacological investigation into amphetamine induced dyskinesia Parkinsonfonden (Sweden) Role: PI (2005-2007) |
Grant awards - public engagement
£936 | Society for Neuroscience (US) Public engagement grant for the Brain Games, match funded with £1000 by NMHRI - PI |
£2000 | Royal Society Public engagement grant - Co-applicant (with lead Fiona Wyllie, BIOSI) |
Professional memberships
- 2009-current, Society for Neuroscience
- 2008-current, Fellow of the Higher Education Academy
- 2004-current, NECTAR (Network of European CNS Transplantation and Restoration)
Board member from 2009 - 2010 - President-elect of NECTAR
- 2000-current, British Neuroscience Association
Publications
2020
- Precious, S. V.et al. 2020. Dopaminergic progenitors derived from epiblast stem cells function similarly to primary VM-derived progenitors when transplanted into a Parkinson’s disease model. Frontiers in Neuroscience 14, article number: 312. (10.3389/fnins.2020.00312)
2019
- Orayj, K.et al. 2019. Association between levodopa and ischemic heart disease. International Journal of Population Data Science 4(3), article number: 11. (10.23889/ijpds.v4i3.1172)
- Orayj, K. and Lane, E. 2019. Patterns and determinants of prescribing for Parkinson's Disease: A systematic literature review. Parkinson's Disease 2019, article number: 9237181. (10.1155/2019/9237181)
- Lane, E. L. 2019. L-DOPA for Parkinson's disease-a bittersweet pill. European Journal of Neuroscience 49(3), pp. 384-398. (10.1111/ejn.14119)
2018
- Elabi, O.et al. 2018. The impact of ghrelin on the survival and efficacy of dopaminergic fetal grafts in the 6-OHDA-Lesioned rat. Neuroscience 395, pp. 13-21. (10.1016/j.neuroscience.2018.10.045)
2017
- Breger, L. S.et al. 2017. Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity 61, pp. 155-164. (10.1016/j.bbi.2016.11.014)
2016
- Rylander Ottosson, D. and Lane, E. L. 2016. Striatal plasticity in L-DOPA- and graft-induced dyskinesia:the common link?. Frontiers in Cellular Neuroscience 10, article number: 16. (10.3389/fncel.2016.00016)
2014
- Lindgren, H. S.et al. 2014. The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions. Experimental Neurology 253, pp. 52-62. (10.1016/j.expneurol.2013.11.015)
2013
- Murphy, E. M.et al. 2013. Long-term restorative effects of bromocriptine on operant responding in the 6-hydroxydopamine-lesioned rat. NeuroReport 24(18), pp. 1019-1024. (10.1097/WNR.0000000000000060)
- Lane, E. L., Dunnett, S. B. and Fricker, R. A. 2013. The 12th meeting of the International Society for Neural Transplantation and Restoration. NeuroReport 24(18), pp. 997-999. (10.1097/WNR.0000000000000101)
- Lelos, M. J., Lane, E. and Dunnett, S. B. 2013. What helps can also hinder: A dissociation in the acute effect of levodopa treatment on motor and cognitive functions. Movement Disorders 28(5), pp. 563-564. (10.1002/mds.25294)
- Breger, L. S., Dunnett, S. B. and Lane, E. L. 2013. Comparison of rating scales used to evaluate l-DOPA-induced dyskinesia in the 6-OHDA lesioned rat. Neurobiology of Disease 50, pp. 142-150. (10.1016/j.nbd.2012.10.013)
- Klein, A., Lane, E. L. and Dunnett, S. B. 2013. Brain repair in a unilateral rat model of Huntington's Disease: new insights into impairment and restoration of forelimb movement patterns. Cell Transplantation 22(10), pp. 1735-1751. (10.3727/096368912X657918)
2012
- Smith, G. A.et al. 2012. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63(5), pp. 818-828. (10.1016/j.neuropharm.2012.06.011)
- Smith, G. A., Dunnett, S. B. and Lane, E. L. 2012. Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat - Response to pharmacological modulation. Behavioural Brain Research 232(2), pp. 411-415. (10.1016/j.bbr.2012.04.003)
- Smith, G. A.et al. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: Predicting L-DOPA-induced dyskinesia. Behavioural Brain Research 226(1), pp. 281-292. (10.1016/j.bbr.2011.09.025)
- Heuer, A.et al. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228(1), pp. 30-43. (10.1016/j.bbr.2011.11.027)
- Smith, G. A.et al. 2012. L-dopa and graft-induced dyskinesia in the 6-OHDA-lesioned mouse [Abstract]. Cell Transplantation 21(4), pp. 792-792.
- Lindgren, H. S. and Lane, E. L. 2012. Rodent models of l-DOPA-induced dyskinesia. Neuromethods 61, pp. 337-351. (10.1007/978-1-61779-298-4_18)
2011
- Torres, E. M.et al. 2011. Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates. Journal of Neuroscience Methods 200(1), pp. 29-35. (10.1016/j.jneumeth.2011.06.012)
- Lane, E. L.et al. 2011. Context-driven changes in 1-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiology of Disease 42(1), pp. 99-107. (10.1016/j.nbd.2011.01.010)
- Klein, A., Lane, E. L. and Dunnett, S. B. 2011. Skilled Reaching Behavior in a Rat Model of Huntington's Disease and the Effects of Neurorestorative Therapy [Abstract]. Cell Transplantation 20(4), pp. 567-567.
- Smith, G. A., Lane, E. L. and Dunnett, S. B. 2011. Graft-Induced Dyskinesia in Transplanted Hemiparkinsonian Mice and Rats: A Pharmacological Manipulation [Abstract]. Cell Transplantation 20(4), pp. 585-585.
- Smith, G. A.et al. 2011. Developments in Graft-Induced Dyskinesia [Abstract]. Cell Transplantation 20(4), pp. 584-585.
- Kelly, C.et al. 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20(4), pp. 503-513. (10.3727/096368910X546580)
- Lane, E. L. 2011. Clinical and Experimental Experiences of Graft-Induced Dyskinesia. In: Brotchie, J., Bezard, E. and Jenner, P. eds. Pathophysiology, pharmacology and biochemistry of dyskinesia. International Review of Neurobiology Vol. 98. Kidlington, Oxford: Academic Press, pp. 173-186., (10.1016/B978-0-12-381328-2.00007-9)
- Johnston, T. H. and Lane, E. L. 2011. Experimental models of L-DOPA-induced dyskinesia. In: Brotchie, J., Bezard, E. and Jenner, P. eds. Pathophysiology, Pharmacology and Biochemistry of Dyskinesia. International Review of Neurobiology Vol. 98. London: Academic Press, pp. 55-93., (10.1016/B978-0-12-381328-2.00003-1)
- Lane, E. L. and Dunnett, S. B. 2011. Preface. In: Lane, E. L. and Dunnett, S. eds. Animal Models of Movement Disorders., Vol. 1. Neuromethods Vol. 61. New York, NY: Humana Press, pp. vii-viii.
2010
- Lane, E. L. and Smith, G. A. 2010. Understanding graft-induced dyskinesia. Regenerative Medicine 5(5), pp. 787-797. (10.2217/rme.10.42)
- Lane, E. L.et al. 2010. Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia. In: Björklund, A. and Cenci, M. A. eds. Recent Advances in Parkinson’s Disease: Translational and Clinical Research. Progress in Brain Research Vol. 184. London: Elsevier, pp. 295-309., (10.1016/S0079-6123(10)84015-4)
- Lane, E. L. and Dunnett, S. B. 2010. Pretreatment with dopamine agonists influences L-dopa mediated rotations without affecting abnormal involuntary movements in the 6-OHDA lesioned rat. Behavioural Brain Research 213(1), pp. 66-72. (10.1016/j.bbr.2010.04.034)
- Lane, E. L.et al. 2010. Neural grafting in Parkinsons disease unraveling the mechnisams underlying graft-induced dyskinesia. Progress in Brain Research 184, pp. 295-309. (10.1016/S0079-6123(10)84015-4)
2009
- Lane, E. L.et al. 2009. Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats. Experimental Neurology 219(1), pp. 355-358. (10.1016/j.expneurol.2009.04.010)
- Lane, E. L., Brundin, P. and Cenci, M. A. 2009. Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease. Neurobiology of Disease 35(1), pp. 42-51. (10.1016/j.nbd.2009.03.014)
- Monville, C.et al. 2009. Genetic, temporal and diurnal influences on L-dopa-induced dyskinesia in the 6-OHDA model. Brain Research Bulletin 78(4-5), pp. 248-253. (10.1016/j.brainresbull.2008.11.007)
2008
- Lane, E. L.et al. 2008. Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease. Neurobiology of Disease 32(2), pp. 220-228. (10.1016/j.nbd.2008.06.011)
- Lane, E. L.et al. 2008. Potential cellular and regenerative approaches for the treatment of Parkinson's disease. Neuropsychiatric Disease and Treatment 4(5), pp. 835-845. (10.2147/NDT.S2013)
- Lane, E. L., Cheetham, S. and Jenner, P. 2008. Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398. Journal of Neural Transmission 115(3), pp. 423-429. (10.1007/s00702-007-0854-x)
- Lane, E. L. and Dunnett, S. B. 2008. Animal models of Parkinson's disease and L-dopa induced dyskinesia: How close are we to the clinic?. Psychopharmacology 199(3), pp. 303-312. (10.1007/s00213-007-0931-8)
- Zietlow, R.et al. 2008. Human stem cells for CNS repair. Cell and Tissue Research 331(1), pp. 301-322. (10.1007/s00441-007-0488-1)
- Lane, E. L.et al. 2008. Animal models of Parkinson's Disease. In: Conn, P. M. ed. 2008 Sourcebook of Models for Biomedical Research. Humana Press, pp. 313-322., (10.1007/978-1-59745-285-4_34)
2007
- Lane, E. L. and Dunnett, S. B. 2007. Long-term pre-administration of dopamine agonists alters L-dopa induced circling behavior in the 6-OHDA lesioned rat [Abstract]. Movement Disorders 22(S16), pp. S246. (10.1002/mds.21535)
2006
- Lane, E. L.et al. 2006. The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat. Neurobiology of Disease 22(2), pp. 334-345. (10.1016/j.nbd.2005.11.011)
- Lane, E. L., Cheetham, S. C. and Jenner, P. 2006. Does contraversive circling in the 6-OHDA-lesioned rat indicate an ability to induce motor complications as well as therapeutic effects in Parkinson's disease?. Experimental Neurology 197(2), pp. 284-290. (10.1016/j.expneurol.2005.06.006)
- Lane, E. L.et al. 2006. The importance of graft size in the development of graft-induced dyskinesia [Abstract]. Cell Transplantation 15(6), pp. 556-556.
2005
- Lane, E. L.et al. 2005. The importance of graft size in the onset of graft-induced dyskinesia [Abstract]. Experimental Neurology 193(1), pp. 250-251. (10.1016/j.expneurol.2005.02.005)
- Lane, E. L., Cheetham, S. and Jenner, P. 2005. Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D-1 and D-2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors. Journal of Pharmacology and Experimental Therapeutics 312(3), pp. 1124-1131. (10.1124/jpet.104.076554)
- Lane, E. L., Cheetham, S. C. and Jenner, P. 2005. Repeated administration of the monoamine reuptake inhibitor BTS 74398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours. European Journal of Neuroscience 21(1), pp. 179-186. (10.1111/j.1460-9568.2004.03834.x)
2003
- Lane, E. L.et al. 2003. Chronic administration of bts 74 398 does not induce abnormal movements in 6-OHDA lesioned rats [Abstract]. British Journal of Pharmacology 138, pp. U100.
2000
- Lane, E. L.et al. 2000. d-fenfluramine releases 5-HT from whole blood of rats as measured by in vitro microdialysis [Abstract]. British Journal of Pharmacology 129, pp. U85.
- Lane, E. L.et al. 2000. A simplified method for the measurement of endogenous 5-HT in rat whole blood using in vitro microdialysis [Abstract]. British Journal of Pharmacology 129, pp. U84.
Teaching
Undergraduate
Academic lead of MPharm (3rd year)
Member of Program Management Group. Assessment Steering Group (ASIG). PDP development team,
Module leader of PH3113 (Drugs and diseases II)
Personal Tutor
Contribution to MPharm modules:
- PH1124 Human Body Systems (Nervous Systems)
- PH1121 Molecule to Patient
- PH1122 The Role of the Pharmacist in Professional Practice
- PH3113 Drugs and Diseases II
- PH3202 Research Methodology
- PH4116 Pharmacy Research Project
- OSCE examination marker, pre/post-placement workshop facilitator
Postgraduate
Director of Post-graduate Research Studies
- Lectures on Research Students' Skills Development Programme:
- 'In Vivo Methods: An Introduction'
- PhD student supervision
Research interests
Member of the School's Medicines Optimisation and Health Outcomes and Experimental therapeutics and Pharmaceutical Sciences research disciplines.
Parkinson's disease
Parkinson's disease is a largely sporadic disorder which affects around 120 000 people in the UK. It is most commonly described as a motor disorder, with the cardinal features of resting tremor, rigidity, bradykinesia and postural instability. The main pathology is the loss of the melanised dopaminergic neurons of the nigrostriatal pathway and the development of protein accumulations immunopositive for the protein a-synuclein.
I have two main research interests, straddling the clinical and pre clinical research areas. I am interested in Parkinson’s patient outcomes and how clinical interventions can influence those outcomes. I work closely with clinical colleagues that run the Parkinson’s service in Cardiff and Vale and Abertawe Bro Morgannog University Health Boards. We have instituted a new electronic health record and ipad based pre assessment records. Research is focusing on how these clinical support tools are facilitating patient care.
Secondly I am interested in how therapeutic approaches to the treatment of Parkinson’s disease cause side effects. Many of the motor symptoms of Parkinson's disease can be well controlled in the early stages with dopaminergic drugs therapies, however as the disease develop, the main treatment for Parkinson's disease, L-dopa, causes the development of abnormal involuntary movements. These can be severely debilitating and there are currently few pharmaceutical interventions to prevent or ameliorate them. Understanding the features that predispose for the development of L-dopa induced dyskinesia may increase our ability to identify patients at greater risk and avoid or minimise them with careful management of medication. Furthermore, the effects of L-dopa may go beyond motor activation and I am interested in the possible effects of long-term L-dopa administration on motor learning and habit formation using in vivo models of PD and dyskinesia.
Not only do dyskinesia develop, but medication become less effective at treating the motor symptoms of PD as the disease progresses. Transplantation of foetal tissue into the striatum can replace the lost dopaminergic innervation and can produce remarkable improvements in motor function. However, clinical trials have identified issues that need to be carefully considered before further clinical trial of embryonic tissue or cells from alternative sources (ie stem cells) can be attempted, including reliability and reproducibility of positive results, access to sources of embryonic tissue and alternative cell types and most notably the issue of transplantation-induced side effects. Three clinical trials of transplantation with embryonic tissue have now reported the development of dyskinesia in transplanted patients unrelated to their medication, to the extent that several have required further surgical interventions to ameliorate their symptoms. The main focus of my research over the last few years has been in determining mechanisms and contributing risk factors for the development of post-transplantation dyskinesia in order that transplantation can proceed unhindered into the next phase of clinical trials. I am now moving towards furthering our understanding of how stem cell derived sources of dopaminergic neurons can be affected by the disease and the treatment of it.
