Dr William Ford
Senior Lecturer
Overview
Qualifications
- B.Sc Hons: Applied Biological sciences
- PhD: Cardiovascular pharmacology
Member of the School's Pharmacology & Physiology Research Discipline.
Publication
2023
- Alotaibi, M. M., Hughes, L. and Ford, W. R. 2023. Assessing inhaler techniques of asthma patients using aerosol inhalation monitors (aim): a cross-sectional study. Healthcare 11(8), article number: 1125. (10.3390/healthcare11081125)
2022
- Alotaibi, M. M., Hughes, L., Bowen, J. L. and Ford, W. R. 2022. Stakeholders' views about the management of stable chronic conditions in community pharmacies. Pharmacy 10(3), article number: 59. (10.3390/pharmacy10030059)
2021
- Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)
2020
- Adner, M. et al. 2020. Back to the future: re-establishing guinea pig in vivo asthma models. Clinical Science 134(11), pp. 1219-1242. (10.1042/CS20200394)
2017
- Lowe, A. P. P., Thomas, R. S., Nials, A. T., Kidd, E. J., Broadley, K. J. and Ford, W. R. 2017. Route of administration affects corticosteroid sensitivity of a combined ovalbumin and lipopolysaccharide model of asthma exacerbation in guinea-pigs. Journal of Pharmacology and Experimental Therapeutics 362(2), pp. 327-337. (10.1124/jpet.117.241927)
- Turner, D. L., Ford, W. R., Kidd, E. J., Broadley, K. J. and Powell, C. 2017. Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. European Journal of Pharmacology 801, pp. 79-85. (10.1016/j.ejphar.2017.03.004)
2016
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
2015
- Lowe, A. P. P., Thomas, R., Nials, A. T., Kidd, E., Broadley, K. and Ford, W. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Evans, R. L. et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407)
- Lowe, A., Broadley, K. J., Nials, A. T., Ford, W. R. and Kidd, E. J. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007)
2013
- Ford, W. R., Blair, A. E., Evans, R. L., John, E., Bugert, J. J., Broadley, K. J. and Kidd, E. J. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130)
- Broadley, K. J., Fehler, M., Ford, W. R. and Kidd, E. J. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034)
- Anwar, M. A., Ford, W. R., Herbert, A. A. and Broadley, K. J. 2013. Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed. Vascular Pharmacology 58(1-2), pp. 140-149., article number: 10.1016/j.vph.2012.10.007. (10.1016/j.vph.2012.10.007)
2012
- Evans, R. L., Nials, A. T., Knowles, R. G., Kidd, E. J., Ford, W. R. and Broadley, K. J. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004)
- Turner, D. L. et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)
- Anwar, M. A., Ford, W. R., Broadley, K. J. and Herbert, A. A. 2012. Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine. British Journal of Pharmacology 165(7), pp. 2191-2202. (10.1111/j.1476-5381.2011.01706.x)
2011
- Natividad, G. M., Broadley, K. J., Kariuki, B., Kidd, E. J., Ford, W. R. and Simons, C. 2011. Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. Journal of Ethnopharmacology 137(1), pp. 808-816. (10.1016/j.jep.2011.06.042)
2010
- Broadley, K. J., Blair, A. E., Kidd, E. J., Bugert, J. J. and Ford, W. R. 2010. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. Journal of Pharmacology and Experimental Therapeutics 335(3), pp. 681-692. (10.1124/jpet.110.171876)
- Fehler, M., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by beta-phenylethylamine. Naunyn Schmiedeburgs Archives of Pharmacology 382(4), pp. 385-398. (10.1007/s00210-010-0554-1)
- Turner, D. L., Ferrari, N., Ford, W. R., Kidd, E. J., Paquet, L., Renzi, P. and Broadley, K. J. 2010. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. European Journal of Pharmacology 641(2-3), pp. 213-219. (10.1016/j.ejphar.2010.05.025)
- Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulmonary Pharmacology and Therapeutics 23(4), pp. 300-307. (10.1016/j.pupt.2010.03.001)
- Aljayyoussi, G., Ford, W. R., McKeown, N. B. and Gumbleton, M. 2010. Differential transport of anionic PAMAM dendrimers across in vitro biological barriers [Abstract]. Drug Discovery Today 15(23-24), pp. 1114. (10.1016/j.drudis.2010.09.440)
2009
- Broadley, K. J. et al. 2009. Effects of dietary amines on the gut and its vasculature. British Journal of Nutrition 101(11), pp. 1645-1652. (10.1017/s0007114508123431)
2008
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6), pp. 589-597. (10.1007/s00210-008-0331-6)
- Fernandez-Rodriguez, S., Ford, W. R., Broadley, K. J. and Kidd, E. J. 2008. Establishing the phenotype in novel acute and chronic murine models of allergic asthma. International Immunopharmacology 8(5), pp. 756-763. (10.1016/j.intimp.2008.01.025)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Protective role of beta 2- and beta 3-adrenoceptors at reperfusion in isolated rat heart. Journal of Molecular and Cellular Cardiology 44(4), pp. 719-719. (10.1016/j.yjmcc.2008.02.020)
2007
- Penson, P. E., Ford, W. R. and Broadley, K. J. 2007. Vasopressors for cardiopulmonary resuscitation - Does pharmacological evidence support clinical practice?. Pharmacology and Therapeutics 115(1), pp. 37-55. (10.1016/j.pharmthera.2007.03.003)
2005
- Ford, W. R., Underdown, N. and Hiley, C. 2005. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. British Journal of Pharmacology 146(6), pp. 809-816. (10.1038/sj.bjp.0706391)
- Ford, W. R., Fletcher, A., Forhead, A. and Fowden, A. 2005. Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation. The Journal of Physiology 562(2), pp. 493-505. (10.1113/jphysiol.2004.074161)
2002
- Ford, W. R., Honan, S. A., White, R. and Hiley, C. R. 2002. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. British Journal of Pharmacology 135(5), pp. 1191-1198. (10.1038/sj.bjp.0704565)
2001
- White, R., Ho, W. V., Bottrill, F. E., Ford, W. R. and Hiley, C. R. 2001. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. British Journal of Pharmacology 134(4), pp. 921-929. (10.1038/sj.bjp.0704333)
Articles
- Alotaibi, M. M., Hughes, L. and Ford, W. R. 2023. Assessing inhaler techniques of asthma patients using aerosol inhalation monitors (aim): a cross-sectional study. Healthcare 11(8), article number: 1125. (10.3390/healthcare11081125)
- Alotaibi, M. M., Hughes, L., Bowen, J. L. and Ford, W. R. 2022. Stakeholders' views about the management of stable chronic conditions in community pharmacies. Pharmacy 10(3), article number: 59. (10.3390/pharmacy10030059)
- Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)
- Adner, M. et al. 2020. Back to the future: re-establishing guinea pig in vivo asthma models. Clinical Science 134(11), pp. 1219-1242. (10.1042/CS20200394)
- Lowe, A. P. P., Thomas, R. S., Nials, A. T., Kidd, E. J., Broadley, K. J. and Ford, W. R. 2017. Route of administration affects corticosteroid sensitivity of a combined ovalbumin and lipopolysaccharide model of asthma exacerbation in guinea-pigs. Journal of Pharmacology and Experimental Therapeutics 362(2), pp. 327-337. (10.1124/jpet.117.241927)
- Turner, D. L., Ford, W. R., Kidd, E. J., Broadley, K. J. and Powell, C. 2017. Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway. European Journal of Pharmacology 801, pp. 79-85. (10.1016/j.ejphar.2017.03.004)
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
- Lowe, A. P. P., Thomas, R., Nials, A. T., Kidd, E., Broadley, K. and Ford, W. 2015. Lipopolysaccharide exacerbates functional and inflammatory responses to ovalbumin and decreases sensitivity to inhaled fluticasone propionate in a guinea-pig model of asthma. British Journal of Pharmacology 172(10), pp. 2588-2603. (10.1111/bph.13080)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Evans, R. L. et al. 2015. Pulmonary oedema measured by MRI correlates with late-phase response to allergen challenge. Experimental Lung Research 41(4), pp. 189-198. (10.3109/01902148.2014.985407)
- Lowe, A., Broadley, K. J., Nials, A. T., Ford, W. R. and Kidd, E. J. 2015. Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs. Journal of Pharmacological and Toxicological Methods 72, pp. 85-93. (10.1016/j.vascn.2014.10.007)
- Ford, W. R., Blair, A. E., Evans, R. L., John, E., Bugert, J. J., Broadley, K. J. and Kidd, E. J. 2013. Human parainfluenza type 3 virus impairs the efficacy of glucocorticoids to limit allergy-induced pulmonary inflammation in guinea-pigs. Clinical Science 125(10), pp. 471-482. (10.1042/CS20130130)
- Broadley, K. J., Fehler, M., Ford, W. R. and Kidd, E. J. 2013. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. European Journal of Pharmacology 715(1-3), pp. 370-380. (10.1016/j.ejphar.2013.04.034)
- Anwar, M. A., Ford, W. R., Herbert, A. A. and Broadley, K. J. 2013. Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed. Vascular Pharmacology 58(1-2), pp. 140-149., article number: 10.1016/j.vph.2012.10.007. (10.1016/j.vph.2012.10.007)
- Evans, R. L., Nials, A. T., Knowles, R. G., Kidd, E. J., Ford, W. R. and Broadley, K. J. 2012. A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma. Pulmonary Pharmacology & Therapeutics 25(6), pp. 453-464. (10.1016/j.pupt.2012.08.004)
- Turner, D. L. et al. 2012. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. British Journal of Pharmacology 167(3), pp. 515-526. (10.1111/j.1476-5381.2012.02016.x)
- Anwar, M. A., Ford, W. R., Broadley, K. J. and Herbert, A. A. 2012. Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine. British Journal of Pharmacology 165(7), pp. 2191-2202. (10.1111/j.1476-5381.2011.01706.x)
- Natividad, G. M., Broadley, K. J., Kariuki, B., Kidd, E. J., Ford, W. R. and Simons, C. 2011. Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea. Journal of Ethnopharmacology 137(1), pp. 808-816. (10.1016/j.jep.2011.06.042)
- Broadley, K. J., Blair, A. E., Kidd, E. J., Bugert, J. J. and Ford, W. R. 2010. Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity. Journal of Pharmacology and Experimental Therapeutics 335(3), pp. 681-692. (10.1124/jpet.110.171876)
- Fehler, M., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Identification of trace-amine-associated receptors (TAAR) in the rat aorta and their role in vasoconstriction by beta-phenylethylamine. Naunyn Schmiedeburgs Archives of Pharmacology 382(4), pp. 385-398. (10.1007/s00210-010-0554-1)
- Turner, D. L., Ferrari, N., Ford, W. R., Kidd, E. J., Paquet, L., Renzi, P. and Broadley, K. J. 2010. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. European Journal of Pharmacology 641(2-3), pp. 213-219. (10.1016/j.ejphar.2010.05.025)
- Fernandez-Rodriguez, S., Broadley, K. J., Ford, W. R. and Kidd, E. J. 2010. Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma. Pulmonary Pharmacology and Therapeutics 23(4), pp. 300-307. (10.1016/j.pupt.2010.03.001)
- Aljayyoussi, G., Ford, W. R., McKeown, N. B. and Gumbleton, M. 2010. Differential transport of anionic PAMAM dendrimers across in vitro biological barriers [Abstract]. Drug Discovery Today 15(23-24), pp. 1114. (10.1016/j.drudis.2010.09.440)
- Broadley, K. J. et al. 2009. Effects of dietary amines on the gut and its vasculature. British Journal of Nutrition 101(11), pp. 1645-1652. (10.1017/s0007114508123431)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Activation of beta-adrenoceptors mimics preconditioning of rat-isolated atria and ventricles against ischaemic contractile dysfunction. Naunyn-Schmiedeberg's Archives of Pharmacology 378(6), pp. 589-597. (10.1007/s00210-008-0331-6)
- Fernandez-Rodriguez, S., Ford, W. R., Broadley, K. J. and Kidd, E. J. 2008. Establishing the phenotype in novel acute and chronic murine models of allergic asthma. International Immunopharmacology 8(5), pp. 756-763. (10.1016/j.intimp.2008.01.025)
- Penson, P. E., Ford, W. R., Kidd, E. J. and Broadley, K. J. 2008. Protective role of beta 2- and beta 3-adrenoceptors at reperfusion in isolated rat heart. Journal of Molecular and Cellular Cardiology 44(4), pp. 719-719. (10.1016/j.yjmcc.2008.02.020)
- Penson, P. E., Ford, W. R. and Broadley, K. J. 2007. Vasopressors for cardiopulmonary resuscitation - Does pharmacological evidence support clinical practice?. Pharmacology and Therapeutics 115(1), pp. 37-55. (10.1016/j.pharmthera.2007.03.003)
- Ford, W. R., Underdown, N. and Hiley, C. 2005. Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism. British Journal of Pharmacology 146(6), pp. 809-816. (10.1038/sj.bjp.0706391)
- Ford, W. R., Fletcher, A., Forhead, A. and Fowden, A. 2005. Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langendorff preparation. The Journal of Physiology 562(2), pp. 493-505. (10.1113/jphysiol.2004.074161)
- Ford, W. R., Honan, S. A., White, R. and Hiley, C. R. 2002. Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. British Journal of Pharmacology 135(5), pp. 1191-1198. (10.1038/sj.bjp.0704565)
- White, R., Ho, W. V., Bottrill, F. E., Ford, W. R. and Hiley, C. R. 2001. Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries. British Journal of Pharmacology 134(4), pp. 921-929. (10.1038/sj.bjp.0704333)
Research
Member of the School's Pharmacology & Physiology Research Discipline.
Research interests
My research interests are spread across three main areas with common threads running through each area. Historically my background has been in cardiovascular pharmacology and more specifically in myocardial ischaemia-reperfusion injury. I have studied the how the rennin-angiotensin system affects short- and long-term recovery from myocardial ischaemia-reperfusion injury. More recently, I am engaged in investigating cardiovascular responses to endocannabinoids and trace amines. I am also involved in pulmonary research where we are studying the effects of modifying components of the inflammatory response (including the use of endocannabinoids) to reduce inflammation and allergen-induced bronchoconstriction. Study of the endocannainoid system also forms the basis of a new collaboration with Norgine to study inflammatory bowel disease.
Cannabinoids in the cardiovascular system
The body is capable of making and releasing compounds (endocannabinoids) similar to those found in extracts of Cannabis sativa. We are interested in identifying the receptors that link these endocannabinoids to cardiovascular response. Our work has identified cardiovascular responses that appear to be mediated by one or more novel sites of action. As we and others have shown that endocannabinoids mediate important cardiovascular responses ,such as protection from ischaemia-reperfusion injury, these novel sites of action represent potential therapeutic targets.
Cannabinoids in the gastro-intestinal tract
Observations of cannabis users suggest that endocannabinoids might have a beneficial role to play in the treatment of inflammatory bowel disease (IBD). We are currently investigating the potential exploitation of the endocannabinoid system for the treatment of IBD in collaboration with an industrial partner.
Pulmonary inflammation
Dysregulated pulmonary inflammation underlies human lung disease such as asthma and chronic pulmonary obstructive disease (COPD). We have models of ovalbumin-induced guinea-pig and murine pulmonary inflammation. In both of these models early and late phase bronchoconstriction to inhaled allergen can be observed. In the guinea-pig, we have also generated a model of pulmonary inflammation to PIV-3 and influenza viral infection as well as virally-induced exacerbation of allergic (ovalbumin-induced) asthma. In addition to further characterization of these models, we are interested in the effects of endocannabinoids, bradykinin and trace amines on pulmonary function and inflammation.
β-adrenoceptor stimulation and myocardial ischaemia-reperfusion injury
Adrenaline has been given for many years to try to resuscitate asystolic patients. The pharmacological justification for such an intervention is weak. However, we have been investigating the potential that activation of one or more β-adrenoceptors can protect the heart from ischaemia-reperfusion injury. Potentially, this research might lead to a treatment for myocardial ischaemia-reperfusion injury.
Collaborators
- Collaboration with Dr Joachim Bugert in the Medical Microbiology Department of the Medical School on viral infection of the airways. We are particularly interested in influenza and para-influenza-3 virus infection and the mechanisms of lung inflammation and its effects on lung function.
- Dr Tony Nials, GlaxoSmithKline who has co-supervised 4 PhD students with Prof Broadley supported by the company over the past 10 years.
- We are in the final stages of submitting a proposal with Dr Audrey Long, a consultant gynaecologist with Cardiff and Vale NHS trust to study the role of endocannabinoids in pregnancy-induced changes to the circulation.
- I have established collaborations with Prof Broadley and Dr Kidd (pulmonary and cardiovascular research). I am also developing collaborative projects with Prof Baxter (cardiovascular research), who has recently joined the School, and Dr Mark Gumbleton (gastrointestinal research)
Post doc: Dr M Akhtar Anwar
Key expertise
- Langendorff heart perfusion
- Isolated cardiac tissue function
- In vivo study of the cardiovascular system
- Plethysmographical measurement of pulmonary function
Research funding
- Collaborative BBSRC Studentships with GlaxoSmithKline (2006-9) to study the pulmonary effects of chronic ovalbumin sensitization.
- British Heart Foundation studentship (2004-8) to study the role of β-adrenoceptor subtypes in severity of myocardial ischaemia-reperfusion injury and a project grant (2002-5) to investigate the potential that endocannabinoids might reduce myocardial ischaemia-reperfusion injury.
- Contract research for Ferring research Ltd investigating novel anti-inflammatory compounds on airway inflammation.
- Industrial-sponsored studentships with Topigen (2006-9) to investigate the effects of nitric-oxide donating compounds on airway inflammation and Norgine (2008-2011) to study the potential role of endocannabinoids in inflammatory bowel disease.
Teaching
- PH1122 The role of the pharmacist in professional practice
- PH1124 Human body systems
- PH1125 Chemical and biological properties of drug molecules
- PH2112 Principles of drug design
- PH2113 Diseases and drugs I
- PH2203 Drug disposition
- PH3110 Optimisation of pharmaceutical care
- PH3113 Diseases and drugs II
- PH3202 Research methodology
- PH4116 Pharmacy research or scholarship project
- PH4118 Pharmaceutical sciences, pharmacy practice and the patient
Biography
Career profile
- 2002 - Cardiff University (Cardiff, UK) Lecturer in the Welsh School of Pharmacy. (promoted to Senior Lecturer in 2010)
- 1998-2002 - University of Cambridge (Cambridge, UK) Department of Pharmacology Fellowship. Five year appointment with departmental operating grant (£72,000 over 5 years). Salary: £24,227
- 1996-1998 - University of Alberta (Edmonton, Canada): Postdoctoral fellowship with Dr BI Jugdutt researching the pharmacology of angiotensin II in post-myocardial infarction remodeling, ischaemia-reperfusion injury and myocardial energy substrate metabolism.
- 1994-96 - University of Alberta (Edmonton, Canada): Ciba-Giegy postdoctoral fellowship with Dr AS Clanachan, Dr R Schulz and Dr GD Lopaschuk. Researched adenosine A1 receptor and KATP-channel pharmacology in cardioprotection from ischaemia-reperfusion injury and myocardial energy substrate metabolism.
Scientific service
- Editor in chief for Autonomic and Autacoid Pharmacology
- Member of the editorial board for Autonomic and Autocoid Pharmacology
Honours and awards
Robert Beamish award, Best paper of 1998
Recipient of the Robert Beamish award for the paper 'Effect of the novel angiotensin II type 1 receptor antagonist L-158,809 on acute infarct expansion and acute anterior myocardial infarction in the dog' published in the Canadian Journal of Cardiology
Heart and Stroke Foundation of Canada Fellowship award (1997)