Skip to content
Dr Michaela Serpi

Dr Michaela Serpi

Research Fellow

School of Pharmacy and Pharmaceutical Sciences

I graduated in Pharmaceutical Sciences in 1998 from Cagliari State University. After a brief traineeship at Rhone Poulenc Rorer in the Research Centre of Vitry Alfortville in Paris (FR) with the academic fellowship “Go for it” I joined the research group of Professor Roberto Pellicciari at the University of Perugia (Italy) with a Glaxo Welcome Fellowship. In the same group I then undertook my Ph.D. in Medicinal Chemistry, completed in 2005, with a study on constrained analogues of L-AP4, as ligands at group III metabotropic glutamate receptors, as potential lead structures to develop therapeutic agents for neurological disease. This work was in collaboration with the pharmaceutical company Lundbeck in Copenhagen (DK). During my Ph.D. I was awarded with a Marie Curie Training Site Fellowship, which gave me the opportunity to spend six months working at the Royal Danish School of Pharmacy in Copenhagen (DK). After my Ph.D., I then joined the medicinal chemistry group of Professor Chris McGuigan at Cardiff University working until January 2008 as post-doctoral on the carbohydrate chemistry of N-acetyl glucosamine analogues for an osteoarthritis drug discovery project sponsored by the pharmaceutical company Bioberica. From January 2008 to January 2011 I have worked at the design of acyclic nucleoside phosphonate analogues for the treatment of viral infections as a post doctoral fellow funded by NIH at the University of Southern California (LA, USA) in the Group of Professor Charles E. McKenna. Since 2011 I am back at Cardiff University working as Research Associate first for an antiviral project funded by Inhibitex (2011-2012) and then for an oncology programme sponsored by NuCana Biomed ( (2012-2017). During this time I was appointed as Part-Time Lecturer for the Independent Researcher Secondment Scheme. In January 2018 I was promoted to Research Fellow with NuCana sponsoring my fellowship to undertake research in the oncology area. Together with Dr Fabrizio Pertusati and Dr Magdalena Slusarczyk we are a medicinal chemistry group ( applying the phosphoramidate chemistry technology to transform some of the most widely prescribed chemotherapy agents into more effective and safer medicines. I am are also interested in several other research areas such as the design, synthesis, and biological evaluation of nucleoside analogues and small molecules as anti-infective, and anti-bacterial and anti-parasitic agents.