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Dr Fabrizio Pertusati

Dr Fabrizio Pertusati

Lecturer

School of Pharmacy and Pharmaceutical Sciences

Alongside with Dr. Slusarczyk and Dr. Serpi we are the last members of the late Professor Chris McGuigan's group and it is our mission to continue his legacy for many years to come. Please visit our website for more recent and comprehensive information.

I hold a MSc degree in physical organic chemistry from Turin University (synthesis and characterisation of cationic surfactants) and a PhD in asymmetric organic chemistry from the Cardiff School of Chemistry, (atropisomeric bis-quinazolinones).

I conducted my post-doctoral training at Emory University (solid-phase synthesis of polymethine dyes) and in the laboratory of the Nobel laureate Prof. George Olah, at the University of Southern California, where I gain expertise in organofluorine, organoboron and polymer chemistry).

Since 2011, I have been working in Chris McGuigan’s group where I was involved in various medicinal chemistry projects. 

Research in our group involve the design and synthesis of small molecules as therapeutics against Rare diseases (congenital disorder of glycosylation, Mitochondrial depletion syndrome, Niemann-Pick), cancer, infectious diseases, and recently antimicrobial drug discovery

Key Expertises

  • Organofluorine, organoboron, and phosphorus synthetic chemistry.
  • Design and synthesis of nucleoside, nucleotide-base drugs and their phosphate/phosphonate prodrugs
  • Translational drug Discovery
  • Multisteps organic synthesis
  • Rare diseases drug discovery

I obtained my MSc degree in physical organic chemistry from Turin University (synthesis and characterisation of cationic surfactants). After three years spent in PCB industry as formulator scientist, I obtained my PhD in synthetic organic chemistry (Cardiff School of Chemistry, atropisomeric bis-quinazolinones as chiral auxiliaries for asymmetric synthesis). I conducted my post-doctoral training at Emory University (solid-phase synthesis of polymethine dyes) and in the laboratory of the Nobel laureate Prof. George Olah, at the University of Southern California (organofluorine, organoboron and polymer chemistry).

Since 2011, I have been working in Chris McGuigan’s group where I was involved in various medicinal chemistry projects spanning from diastereoselective synthesis of nucleosides (cyclic and acyclic) phosphoroamidate prodrugs, to fluorinated androgen-receptors antagonist for prostate cancer treatment, and design and synthesis of novel compounds acting on the Central Nervous System).

In 2016, I was promoted to Research Fellow in medicinal chemistry. My current research interests are in the synthesis of novel fluorinated antibiotics for the treatment of Gram-positive bacterial infections and biofilm formation (in collaboration with prof. Hans Steenackers at Leuven University) and in congenital disorders of glycosylation. I am also interested in drug design for the treatment of lysosomal storage disorders (Niemann-Pick, Huntington) in collaboration with Dr. Lloyd-Evans (Cardiff School of Bioscience).

Professional memberships

  • Member of Scientific Advisory Borad of Ichorion Therapeutics
  • Member of Glycobiology Society
  • Member of the Royal Society of Chemistry

2018

2017

2016

2015

2014

2013

2011

2007

At the Cardiff School of Chemistry:

  • CH0003 Chemistry of organic compounds
  • CH4207 Intoduction to the chemistry of life
  • CHT354 Drug Development from Laboratory to Clinic

Our research is mainly in synthetic organic chemistry aimed to solve a range of medicinal chemistry problems:

Rare Diseases

  • Lipid phosphate prodrugs as therapeutics for Niemann-Pick and related lysosomal storage diseases.

Inborn errors of metabolism

  • Synthesis of carbohydrate based compounds for the treatment of congenital disorder of glycosylation.
  • Nucleoside derivative for the treatment of Mitocondrial Depletion Syndrome.

Infectious diseases

  • Synthesis of nucleosides and non nucleoside scaffolds as novel antibacterial agents.
  • Fluorinated heterocycles as anti-biofilm and antimicrobial agents.
  • Fluorinated small molecules as novel antileishmaniasys drugs.

Synthetic Chemistry

-Synthesis of new acyclic nucleoside phosphate and phosphonate scaffolds as antiviral, anticancer and antibacterial drugs.

-Development of synthetic methodologies for the diasteroselective and enantioselective preparation of organophosphorus compounds via P(V) and P(III) chemistries.

Collaborators

Rare Diseases:

  • Dr Emyr Lloyd Evans (Lysosomal storage disease, School of Bioscience)
  • Professor Hudson Freeze (Congenital Disorder of Glycosylation, Sanford Burnham Institute, California)
  • Professor Michael W. Lawlor (Mitochondrial Depletion Syndrome, Medical College of Wisconsin)

Infectious diseases

Antibacterial and antibiofilm.

Antiviral

Neglected Infectious Diseases

External profiles