Dr Martin Schepelmann

2022

• Schepelmann, M. et al. 2022. Impaired mineral ion metabolism in a mouse model of targeted calcium-sensing receptor (CaSR) deletion from vascular smooth muscle cells. Journal of the American Society of Nephrology 33(7), pp. 1323-1340. (10.1681/ASN.2021040585)

2021

• Pasqualetto, G., Pileggi, E., Schepelmann, M., Varricchio, C., Rozanowska, M., Brancale, A. and Bassetto, M. 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226, article number: 113841. (10.1016/j.ejmech.2021.113841)
• Yarova, P. L. et al. 2021. Characterisation of negative allosteric modulators of the calcium-sensing receptor, CaSR, for repurposing as a treatment for asthma. Journal of Pharmacology and Experimental Therapeutics 376(1), pp. 51-63. (10.1124/jpet.120.000281)

2020

• Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25(21), article number: 4904. (10.3390/molecules25214904)

2019

• Scott Roberts, M. et al. 2019. Treatment of autosomal dominant hypocalcemia Type 1 with the calcilytic NPSP795 (SHP635). Journal of Bone and Mineral Research 34(9), pp. 1609-1618. (10.1002/jbmr.3747)
• Pasqualetto, G. et al. 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases. Presented at: 2019 ARVO Annual Meeting, Vancouver, Canada, 28 April - 02 May 2019Investigative ophthalmology & visual science, Vol. 60. Vol. 9. ARVO

2016

• Graca, J. et al. 2016. Comparative expression of the extracellular calcium sensing receptor in rat, mouse and human kidney. American Journal of Physiology-Renal Physiology 310(6), article number: F518-F533. (10.1152/ajprenal.00208.2015)
• Schepelmann, M. et al. 2016. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. American Journal of Physiology - Cell Physiology 310(3), pp. C193-C204. (10.1152/ajpcell.00248.2015)

2015

• Lopez-Fernandez, I., Schepelmann, M., Brennan, S. C., Yarova, P. L. and Riccardi, D. 2015. The calcium-sensing receptor: one of a kind. Experimental Physiology 100(12), pp. 1392-1399. (10.1113/EP085137)
• Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)

2014

• Brennan, S. C., Davies, T. S., Schepelmann, M. and Riccardi, D. 2014. Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion. British Journal of Nutrition 111(S1), pp. S16-S22. (10.1017/S0007114513002250)
• Schepelmann, M. 2014. Determining the role of the calcium sensing receptor in vascular smooth muscle cells via targeted gene deletion. PhD Thesis, Cardiff University.