Dr Sahar Kandil

2021

• Kandil, S. B., Kariuki, B. M., McGuigan, C. and Westwell, A. D. 2021. Synthesis, biological evaluation and X-ray analysis of bicalutamide sulfoxide analogues for the potential treatment of prostate cancer. Bioorganic and Medicinal Chemistry Letters 36, article number: 127817. (10.1016/j.bmcl.2021.127817)
• Kandil, S. B., McGuigan, C. and Westwell, A. D. 2021. Synthesis and biological evaluation of bicalutamide analogues for the potential treatment of prostate cancer. Molecules 26(1), article number: 56. (10.3390/molecules26010056)

2020

• Kandil, S. B., Jones, S. R., Smith, S., Hiscox, S. E. and Westwell, A. D. 2020. Structure-based virtual screening, synthesis and biological evaluation of potential FAK-FAT domain inhibitors for treatment of metastatic cancer. Molecules 25(15), article number: 3488. (10.3390/molecules25153488)

2019

• Kandil, S., Pannecouque, C., Chapman, F. M., Westwell, A. D. and McGuigan, C. 2019. Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity. Bioorganic and Medicinal Chemistry Letters 29(24), article number: 126721. (10.1016/j.bmcl.2019.126721)
• Pertusati, F., Ferla, S., Bassetto, M., Brancale, A., Kandil, S., Westwell, A. D. and McGuigan, C. 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180, pp. 1-14. (10.1016/j.ejmech.2019.07.001)
• Kandil, S., Lee, K. Y., Davies, L., Rizzo, S. A., Dart, D. A. and Westwell, A. D. 2019. Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists. European Journal of Medicinal Chemistry 167, pp. 49-60. (10.1016/j.ejmech.2019.01.054)

2018

• Dart, D. A., Kandil, S., Tommasini-Ghelfi, S., Almeida, G. S. d., Bevan, C. L., Jiang, W. G. and Westwell, A. D. 2018. Novel trifluoromethylated enobosarm analogues with potent antiandrogenic activity in vitro and tissue selectivity in vivo. Molecular Cancer Therapeutics 17(9), pp. 1846-1858. (10.1158/1535-7163.MCT-18-0037)
• Kandil, S., Prencipe, F., Jones, S., Hiscox, S. and Westwell, A. D. 2018. The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer. Chemical Biology and Drug Design 91(1), pp. 314-321. (10.1111/cbdd.13083)

2016

• Kandil, S., Balzarini, J., Rat, S., Brancale, A., Westwell, A. D. and McGuigan, C. 2016. ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites. Biorganic and Medicinal Chemistry Letters 26(23), pp. 5618-5623. (10.1016/j.bmcl.2016.10.077)
• Bassetto, M., Ferla, S., Pertusati, F., Kandil, S., Westwell, A., Brancale, A. and McGuigan, C. 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118, pp. 230-243. (10.1016/j.ejmech.2016.04.052)
• Ferla, S., Bassetto, M., Pertusati, F., Kandil, S., Westwell, A. D., Brancale, A. and McGuigan, C. 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26(15), pp. 3636-3640. (10.1016/j.bmcl.2016.06.001)
• Kandil, S., Wymant, J., Kariuki, B., Jones, A. T., McGuigan, C. and Westwell, A. D. 2016. Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. European Journal of Medicinal Chemistry 110, pp. 311-325. (10.1016/j.ejmech.2015.12.037)
• Kandil, S., Westwell, A. D. and McGuigan, C. 2016. 7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer. Biorganic and Medicinal Chemistry Letters 26(8), pp. 2000-2004. (10.1016/j.bmcl.2016.02.088)

2014

• McGuigan, C. et al. 2014. ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents. Bioorganic and Medicinal Chemistry 22(9), pp. 2816-2824. (10.1016/j.bmc.2014.02.056)

2013

• McGuigan, C. et al. 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70, pp. 326-340. (10.1016/j.ejmech.2013.09.047)

2009

• Kandil, S. et al. 2009. Discovery of a novel HCV helicase inhibitor by a de novo drug design approach. Bioorganic & Medicinal Chemistry Letters 19(11), pp. 2935-2937. (10.1016/j.bmcl.2009.04.074)
• Kandil, S. 2009. Computer aided drug design. PhD Thesis, Cardiff University.

2008

• Romagnoli, R. et al. 2008. Synthesis and biological evaluation of 2-amino-3-(3 ',4 ',5 '-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno 2,3-c pyridi ne derivatives as antimitotic agents and inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry Letters 18(18), pp. 5041-5045. (10.1016/j.bmcl.2008.08.006)

2007

• La Regina, G. et al. 2007. Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry 50(12), pp. 2865-2874. (10.1021/jm061479u)