Dr Giusy Tornillo

2019

• French, R. and Tornillo, G. 2019. Heterogeneity of mammary stem cells. Advances in Experimental Medicine and Biology 1169, pp. 119-140. (10.1007/978-3-030-24108-7_7)
• Menendez Gonzalez, J.et al. 2019. Gata2 as a crucial regulator of stem cells in hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13(2), pp. 291-306. (10.1016/j.stemcr.2019.07.005)
• Ordonez, L. D.et al. 2019. Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. Oncotarget 10(27), pp. 2586-2606. (10.18632/oncotarget.26830)

2018

• Tornillo, G.et al. 2018. Dual mechanisms of LYN kinase dysregulation drive aggressive behaviour in breast cancer cells. Cell Reports 25(13), pp. 3674-3692. (10.1016/j.celrep.2018.11.103)
• Moriconi, C.et al. 2018. Caveolin-1, a driver of invasive phenotype in in-vitro 3D-spheroid assays comprised of high grade GBM cells association with an AKT-inhibited phenotype. Neuro-Oncology 20(S1), pp. i13-i13. (10.1093/neuonc/nox238.058)

2017

• Soady, K. J.et al. 2017. Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development 144(20), pp. 3777-3788. (10.1242/dev.149120)
• Moriconi, C.et al. 2017. INSIDIA: a FIJI macro delivering high-throughput and high-content spheroid invasion analysis. Biotechnology Journal 12(10), article number: 1700140. (10.1002/biot.201700140)
• Moriconi, C.et al. 2017. Caveolin-1 implicated as a pro-invasive gene in high-grade glioma cell models: implementation of a 3d spheroid matrix invasion assay. Neuro-Oncology 19(S1), pp. i21-i22. (10.1093/neuonc/now293.080)

2015

• Tornillo, G. and Smalley, M. J. 2015. ERrrr..Where are the progenitors? Hormone receptors and mammary cell heterogeneity. Journal of Mammary Gland Biology and Neoplasia 20(1), pp. 63-73. (10.1007/s10911-015-9336-1)
• Leal, M. d. P. C.et al. 2015. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Gene 562(1), pp. 1-7. (10.1016/j.gene.2015.02.027)

2014

• Fusella, F.et al. 2014. Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. The Journal of Pathology 234(2), pp. 152-163. (10.1002/path.4341)
• Pincini, A.et al. 2014. Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle 12(15), pp. 2409-2422. (10.4161/cc.25415)
• Tornillo, G., Defilippi, P. and Cabodi, S. 2014. Cas proteins: dodgy scaffolding in breast cancer. Breast Cancer Research 16(5), article number: 443. (10.1186/s13058-014-0443-5)
• Tornillo, G. and Cabodi, S. 2014. 3D mammary colony-forming cell assay. Bio-Protocol 4(7)
• Saoncella, S.et al. 2014. Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. Stem Cells 32(3), pp. 754-769. (10.1002/stem.1565)

2013

• Tornillo, G.et al. 2013. p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells 31(7), pp. 1422-1433. (10.1002/stem.1403)

2012

• Leal, M. d. P. C.et al. 2012. p130Cas over-expression impairs mammary branching morphogenesis in response to Estrogen and EGF. Plos One 7(12), article number: e49817. (10.1371/journal.pone.0049817)
• Bisaro, B.et al. 2012. p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Research 14(5), article number: R137. (10.1186/bcr3342)

2011

• D'Agostino, M.et al. 2011. Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8 alpha and promote its ubiquitylation and endocytosis. Journal of Cell Science 124(21), pp. 3545-3556. (10.1242/jcs.081224)
• Fusella, F.et al. 2011. P11.46 Morgana overexpression confers resistance from apoptotic cell death. Febs Journal 278(Supp 1), pp. 207-207. (10.1111/j.1742-4658.2011.08137.x)
• Camacho Leal, M. P.et al. 2011. p130Cas overexpression regulates normal mammary branching morphogenesis through estrogen receptor-alpha/ERk1/2 dependent signaling. Febs Journal 278(Supp 1), pp. 427-427. (10.1111/j.1742-4658.2011.08137.x)
• Tornillo, G.et al. 2011. p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. European Journal of Cell Biology 90(2-3), pp. 237-248. (10.1016/j.ejcb.2010.09.002)
• Di Stefano, P.et al. 2011. The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. American Journal of Cancer Research 1(5), pp. 663-673.

2010

• Cabodi, S.et al. 2010. p130Cas is an essential transducer element in ErbB2 transformation. The FASEB Journal 24(10), pp. 3796-3808. (10.1096/fj.10-157347)
• Cabodi, S.et al. 2010. Integrins and signal transduction. In: Becchetti, A. and Arcangeli, A. eds. Integrins and ion channels: Molecular complexes and signaling., Vol. 674. New York, NY: Landes Bioscience and Springer Science, pp. 43-54.