Dr Giusy Tornillo

2022

• Routledge, D. et al. 2022. The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer. eLife 11, article number: e77376. (10.7554/elife.77376)

2021

• Castro, J. et al. 2021. A nuclear-directed ribonuclease variant targets cancer stem cells and inhibits migration and invasion of breast cancer cells. Cancers 13(17), article number: 4350. (10.3390/cancers13174350)
• Metcalfe, R. S. et al. 2021. Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities. European Journal of Applied Physiology and Occupational Physiology 121(8), pp. 2107–2124. (10.1007/s00421-021-04680-x)
• Dimitriou, P., Li, J., Tornillo, G., McCloy, T. and Barrow, D. 2021. Droplet microfluidics for tumor drug-related studies and programmable artificial cells. Global Challenges 5(7), article number: 2000123. (10.1002/gch2.202000123)
• Ordonez, L. D. et al. 2021. Reproductive history determines ErbB2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model. Disease Models and Mechanisms 14(5), article number: dmm048736. (10.1242/dmm.048736)

2020

• Newland, B. et al. 2020. Focal drug administration via heparin-containing cryogel microcarriers reduces cancer growth and metastasis. Carbohydrate Polymers 245, article number: 116504. (10.1016/j.carbpol.2020.116504)

2019

• French, R. and Tornillo, G. 2019. Heterogeneity of mammary stem cells. Advances in Experimental Medicine and Biology 1169, pp. 119-140. (10.1007/978-3-030-24108-7_7)
• Menendez Gonzalez, J. B. et al. 2019. Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13(2), pp. 291-306. (10.1016/j.stemcr.2019.07.005)
• Ordonez, L. D. et al. 2019. Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. Oncotarget 10(27), pp. 2586-2606. (10.18632/oncotarget.26830)

2018

• Tornillo, G. et al. 2018. Dual mechanisms of LYN kinase dysregulation drive aggressive behaviour in breast cancer cells. Cell Reports 25(13), pp. 3674-3692. (10.1016/j.celrep.2018.11.103)
• Moriconi, C., Palmieri, V., Tornillo, G., Fillmore, H., Pilkington, G. J. and Gumbleton, M. 2018. Caveolin-1, a driver of invasive phenotype in in-vitro 3D-spheroid assays comprised of high grade GBM cells association with an AKT-inhibited phenotype. Neuro-Oncology 20(S1), pp. i13-i13. (10.1093/neuonc/nox238.058)

2017

• Soady, K. J. et al. 2017. Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development 144(20), pp. 3777-3788. (10.1242/dev.149120)
• Moriconi, C. et al. 2017. INSIDIA: a FIJI macro delivering high-throughput and high-content spheroid invasion analysis. Biotechnology Journal 12(10), article number: 1700140. (10.1002/biot.201700140)
• Moriconi, C., Palmieri, V., Tornillo, G., Fillmore, H., Pilkington, G. and Gumbleton, M. 2017. Caveolin-1 implicated as a pro-invasive gene in high-grade glioma cell models: implementation of a 3d spheroid matrix invasion assay. Neuro-Oncology 19(S1), pp. i21-i22. (10.1093/neuonc/now293.080)

2015

• Tornillo, G. and Smalley, M. J. 2015. ERrrr..Where are the progenitors? Hormone receptors and mammary cell heterogeneity. Journal of Mammary Gland Biology and Neoplasia 20(1), pp. 63-73. (10.1007/s10911-015-9336-1)
• Leal, M. d. P. C., Sciortino, M., Tornillo, G., Colombo, S., Defilippi, P. and Cabodi, S. 2015. p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis. Gene 562(1), pp. 1-7. (10.1016/j.gene.2015.02.027)

2014

• Fusella, F. et al. 2014. Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. The Journal of Pathology 234(2), pp. 152-163. (10.1002/path.4341)
• Pincini, A. et al. 2014. Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle 12(15), pp. 2409-2422. (10.4161/cc.25415)
• Tornillo, G., Defilippi, P. and Cabodi, S. 2014. Cas proteins: dodgy scaffolding in breast cancer. Breast Cancer Research 16(5), article number: 443. (10.1186/s13058-014-0443-5)
• Tornillo, G. and Cabodi, S. 2014. 3D mammary colony-forming cell assay. Bio-Protocol 4(7)
• Saoncella, S. et al. 2014. Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway. Stem Cells 32(3), pp. 754-769. (10.1002/stem.1565)

2013

• Tornillo, G. et al. 2013. p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells 31(7), pp. 1422-1433. (10.1002/stem.1403)

2012

• Leal, M. d. P. C. et al. 2012. p130Cas over-expression impairs mammary branching morphogenesis in response to Estrogen and EGF. Plos One 7(12), article number: e49817. (10.1371/journal.pone.0049817)
• Bisaro, B. et al. 2012. p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Research 14(5), article number: R137. (10.1186/bcr3342)

2011

• D'Agostino, M., Tornillo, G., Caporaso, M. G., Barone, M. V., Ghigo, E., Bonatti, S. and Mottola, G. 2011. Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8 alpha and promote its ubiquitylation and endocytosis. Journal of Cell Science 124(21), pp. 3545-3556. (10.1242/jcs.081224)
• Fusella, F. et al. 2011. P11.46 Morgana overexpression confers resistance from apoptotic cell death. Febs Journal 278(Supp 1), pp. 207-207. (10.1111/j.1742-4658.2011.08137.x)
• Camacho Leal, M. P., Fiorito, E., Pincini, A. and Tornillo, G. 2011. p130Cas overexpression regulates normal mammary branching morphogenesis through estrogen receptor-alpha/ERk1/2 dependent signaling. Febs Journal 278(Supp 1), pp. 427-427. (10.1111/j.1742-4658.2011.08137.x)
• Tornillo, G. et al. 2011. p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1. European Journal of Cell Biology 90(2-3), pp. 237-248. (10.1016/j.ejcb.2010.09.002)
• Di Stefano, P. et al. 2011. The adaptor proteins p140CAP and p130CAS as molecular hubs in cell migration and invasion of cancer cells. American Journal of Cancer Research 1(5), pp. 663-673.

2010

• Cabodi, S. et al. 2010. p130Cas is an essential transducer element in ErbB2 transformation. The FASEB Journal 24(10), pp. 3796-3808. (10.1096/fj.10-157347)
• Cabodi, S. et al. 2010. Integrins and signal transduction. In: Becchetti, A. and Arcangeli, A. eds. Integrins and ion channels: Molecular complexes and signaling., Vol. 674. New York, NY: Landes Bioscience and Springer Science, pp. 43-54.