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Dr Tatyana Shelkovnikova

Dr Tatyana Shelkovnikova

Research Fellow

School of Biosciences

Email
shelkovnikovat@cardiff.ac.uk
Telephone
+44 (0)29 2022 511072
Campuses
Main Building, Park Place, Cardiff, CF10 3AT

Many neurodegenerative diseases are currently believed to be caused by altered RNA metabolism and, more specifically, abnormal composition and turnover of RNA granules. The most prominent examples of such diseases are amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

My group aims to provide insights into molecular underpinnings of RNA granule biology and its connection to human disease. Our goal is twofold:

  • to establish how altered composition and metabolism of the two types of RNA granules, stress granules and paraspeckles, contribute to the pathogenesis of ALS and FTD;
  • to identify druggable targets for these devastating and currently incurable conditions.

I have been involved in biomedical research since 2008. My PhD project conducted at the Institute of Physiologically Active Compounds (Russian Federation) was aimed at development and validation of in vitro and in vivo models for testing the effects of neuroprotective compounds. In 2012, after completion of PhD studies and a short-term EMBO fellowship, I joined Prof Buchman’s laboratory at Cardiff University as a postdoctoral researcher. In 2012-2015, I was working on the molecular mechanisms of Parkinson’s disease and amyotrophic laterals sclerosis (ALS). Wishing to focus on the previously overlooked link between a specific nuclear RNA granule, the paraspeckle, and ALS pathogenesis, in 2015 I obtained funding from Medical Research Foundation (3-year fellowship).  In September 2018, I started as a Motor Neurone Disease Association Senior Non-Clinical Fellow and independent group leader at the Medicines Discovery Institute. I am also a part of the cell biology team and the Early Neuroscience group within the Institute.

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