Professor Ole Petersen CBE FRS

Professor Ole Petersen CBE FRS

Director of the Cardiff University - Academia Europaea Knowledge Hub

Email:
petersenoh@cardiff.ac.uk
Telephone:
+44 (0)29 2068 8249

Research overview

Director of research programme investigating the role of Ca2+ in the pathophysiology of pancreatitis supported by MRC Programme Grant.

Division

Biomedicine

Honours and awards

2018The American Physiological Society's Walter B Cannon Memorial Award Lecturer. The Plenary Award Lecture to be delivered at Experimental Biology in San Diego, USA on 21st April 2018
2017Elected Honorary Member of the German Society for Gastroenterology, Digestive and Metabolic Diseases. Award Lecture at the 72nd Annual Meeting of the Society in Dresden, September 2017
2015Appointed Vice-President of Academia Europaea
2015Elected Honorary Member of The Physiological Society
2014Elected Vice-President (Science, Technology and Medicine) of The Learned Society of Wales for 3 years, beginning at The Society's AGM on 14th May 2014
2013Opening Plenary Lecture at the 2013 Annual Congress of the Brazilian Society of Physiology in Sao Paulo
2013Keynote Lecture at the 37th International Congress of Physiological Sciences (IUPS2013), Birmingham, UK http://www.voicesfromoxford.org/video/the-role-of-calcium-in-pancreatic-disease/397
2013The American Physiological Society's Horace W Davenport Distinguished Lectureship, Experimental Biology 2013, Boston, Massachusetts, USA
2012MRC Professorship and MRC Programme Grant renewed (2012 – 2017)
2012Public (Inaugural) Lecture as Member of the German National Academy of Sciences, Leopoldina, Halle, Germany
2011Honorary Professor at College of Medicine, Jinan National University, Guangzhou, China
2011Elected Fellow of the Learned Society of Wales
2010Elected Member of the German National Academy of Sciences Leopoldina
2010Appointed Chair of HEFCE's Biological Sciences Sub-panel, REF2014
2010Appointed Member of the Welsh Government's Science Advisory Council for Wales
2010Lifetime Achievement Award, European Pancreatic Club
2009American Gastroenterological Association's State-of-the-Art Lecture, Digestive Diseases Week 2009, Chicago, USA
2008  Appointed Commander of the Order of the British Empire (CBE) in The Queen's New Year Honours list for 'Services to Science'
2008Appointed Chair of the European Research Council's Starting Grant Panel LS4 (2009-2011)
2008Keynote Lecture at 4th Covian Symposium, University of Sao Paulo, Brazil
2008MRC Professorship and MRC Programme Grant renewed (2008 - 2012)
2006President of The Physiological Society, UK (2006 – 2008)
2005Vice-President of The Royal Society (2005 – 2006)
2005Plenary Keynote Lecture, 82nd Annual Meeting of the Physiological Society of Japan, Sendai
2005JA Young Memorial Lecture, Gordon Research Conference on Salivary Glands, California, USA
2004Elected Honorary Member of the Hungarian Academy of Sciences
2003Purkyne Medal from the Academy of Sciences of the Czech Republic
2003The Keynote Lecture, Gordon Research Conference on Calcium Signaling, Mass., USA
2003Chair of Physiological Review's European Editorial Committee (2003 – 2011)
2003MRC Professorship and MRC Programme Grant renewed (2003 – 2008)
2001Secretary General of the International Union of Physiological Sciences (IUPS) (2001 – 2009)
2000Elected Fellow of The Royal Society (FRS)

Lay summary of plans for research work funded by MRC Programme Grant (2012 – 2017)

Calcium signalling, organelle dysfunction and pancreatitis

The pancreas secretes the enzymes needed for the breakdown in the gut of proteins, fats and carbohydrates. However, the enzymes needed for digestion can, if inappropriately activated inside the cells in the pancreas, also digest the pancreas itself. This is what happens in the painful human disease acute pancreatitis, which is mostly caused by gallstones and excessive alcohol intake. The incidence has been steadily increasing over the last 25 years in both the UK and the US (now about 100 per 100,000 people per year) and there is a significant mortality (about 5%). The NHS expenditure on intensive care treatment for acute pancreatitis is more than £100 million per year. There is currently no specific therapy. Repeated attacks of acute pancreatitis may lead to chronic pancreatitis, which increases markedly the risk of developing pancreatic cancer. In the UK there are ~8000 patients diagnosed annually with pancreatic cancer, which has the lowest 5-year survival (about 3%) of all common cancers. So far, there has been disappointingly little progress with regard to prevention and treatment of this cancer.

We have recently shown that the digestive enzyme activation inside the cells, which starts the process leading to acute pancreatitis, is due to excessive release of calcium ions from internal stores and have identified the molecules which allow this transport. We have also discovered an unexpected intrinsic protective mechanism due to a calcium-binding molecule, which is normally present inside cells. Most importantly, we have been able to use a specific calcium-like molecule to boost the intrinsic protection against inappropriate enzyme activation inside the pancreatic cells. These recent findings promise new opportunities for the development of preventive and therapeutic measures and this is the basis for the work programme proposed.

We plan systematic tests of the ability of calcium-like molecules to protect against enzyme activation inside the enzyme-producing cells in the pancreas under a variety of circumstances relevant to the real disease situation. These studies will involve experiments on isolated cells and small cell clusters as well as larger pieces of pancreas in which the protective effects of calcium-like molecules against the actions of a variety of agents known to start the process of developing pancreatitis (fatty acids and combinations of fatty acids and alcohol, alcohol alone as well as bile acids)  will be tested.

Release of calcium ions inside cells and flow of calcium ions into the cells from the outside are complex processes. We are aiming at identifying critical control points and ways and means of interfering with these, to develop additional strategies for prevention and/or treatment of acute pancreatitis.

An entirely novel aspect of the work proposed is a study of a special cell type in the pancreas called the stellate cell. Stellate cells are known to become activated during the development of chronic pancreatitis and are responsible for the production of the so-called stromal matrix - a complex of fibres and substances secreted into the spaces between cells - which is critically important for the development of pancreatic cancer. It is therefore essential to understand the mechanisms by which these stellate cells are controlled in order finally to be able to make progress with prevention and treatment of pancreatic cancer. Calcium ions are known to be important for stellate cell function, but the detailed mechanisms of their transport and function in these cells are obscure and almost nothing is known about nervous control. Building on the detailed knowledge and experience we have developed in work on calcium ion - dependent control of the enzyme-secreting cells in the pancreas, we shall now study the nervous and chemical control of stellate cells and develop procedures to inhibit their excessive secretion of cancer-promoting materials.

Affiliated staff

Postgraduate research students

Academic Schools