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Professor David Lloyd

Professor David Lloyd

Honorary Professor

School of Biosciences

Overview

Research Overview

Studies in Professor David Lloyd's Laboratory include:

  • Biological timekeeping especially in the range seconds to hours in living organisms
  • Monitoring intracellular events by non-invasive methods such as mass spectrometry, fluorescence techniques and NMR
  • Using these approaches to solve medical, environmental and industrial problems
  • Microwave interactions with biological systems: separated electric and magnetic field effects, and putative non-thermal components.

Microbiology: Past, Present and Future (2019)

Tributes to Gregorio Weber 1916 - 1997

Biography

Timeline

  • 2015 - present Collaboration with US National Institute of Health on Aging, Baltimore, USA
  • 2008 - present Honorary Professor (Cardiff University)
  • 2008 – 2017 H.C. Andersen Professor of Biochemistry and Molecular Biology, (University of Southern Denmark, Odense, Denmark)
  • 2001 - present Collaboration with Department of Molecular Cardiobiology, Johns Hopkins Medical University, Baltimore, USA
  • 1978 - 2008 Professor of Microbiology (Cardiff University)
  • 2001 - 2009  (six 1 week visits)  Johns Hopkins University, Baltimore, USA, Department of Molecular Cardiobiology
  • 1999  (6 months) University of New South Wales, Australia, Department of Biochemistry
  • 1998 - 2009 (4 visits) AIST, Tsukuba City and Keio University, Japan
  • 1998  (3 months) Tata Institute of Fundamental Research, Mumbai, India, Department of Molecular Biology
  • 1997  (3 months) University of New South Wales, Australia, Department of Biochemistry
  • 1990  (4 months) Odense University (U.S. Denmark), Department of Biochemistry
  • 1986  (2 months) Harvard University, Biolabs, USA
  • 1985  (2 months) ATOMKI  Debrecen, Hungary
  • 1984  (1 month) INRA Bordeaux, France
  • 1982 - 1987 Head of the Microbiology Department, University College Cardiff, University of Wales
  • 1978   Personal Chair (University College of South Wales & Monmouthshire)
  • 1976 - 1978 Reader (University College of South Wales & Monmouthshire)
  • 1977   Guest Scientist (2 months) Rockefeller University, New York, USA
  • 1976   Senior Lecturer (University College of South Wales & Monmouthshire)
  • 1972   DSc (Sheffield)
  • 1969 - 1976 Lecturer (University College of South Wales & Monmouthshire)
  • 1968 - 1979 (4 visits Wellcome, Leverhulme & RS) University of Pennsylvania, USA
  • 1967   University of Pennsylvania, Philadelphia, USA, Department of Biophysics
  • 1967 - 1969 Research Assistant MRC Group (Microbial Structure & Function)
  • 1964 - 1967 ICI Research Fellowship (University College of South Wales & Monmouthshire)
  • 1964   PhD (Wales) (University College of South Wales & Monmouthshire)
  • 1961   BSc (Biochemistry, 1st Class Hons) (Sheffield University)

Honours and awards

  • Lifetime award: British Society of Protozoology
  • Lifetime award: International  Society of Protistology
  • Fellow of the Learned Society of Wales
  • 2008-present Honorary Professor, Cardiff University
  • 2008-2017 H.C. Andersen Professor of Biochemistry and Molecular Biology, University of Southern Denmark, Odense

Academic positions

  • 1978-2008 Professor of Microbiology, Cardiff University
  • 1982-1987 Head of the Microbiology Department, University College Cardiff, University of Wales
  • 1978  Personal Chair, University College Cardiff, University of Wales
  • 1976 -1978 Reader, University College of South Wales & Monmouthshire
  • 1977 Guest Scientist (2 months) Rockefeller University, New York
  • 1976 Senior Lecturer, University College of South Wales & Monmouthshire
  • 1969-1976 Lecturer, University College of South Wales & Monmouthshire
  • 1967-1969 Research Assistant MRC Group (Microbial Structure & Function), University College of South Wales & Monmouthshire
  • 1964-1967 ICI Research Fellowship, University College of South Wales & Monmouthshire

Publications

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

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1988

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1986

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1984

1983

1982

1981

1980

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1978

1977

1976

1975

1974

1973

1972

1971

1970

1969

1968

1967

1966

1965

1964

Current Research

  1. Biology of the flagellate fish parasite, Spironucleus vortens (with Professor Jo Cable, BIOSI)
  2. Newly-synthesised fluorophores and phosphors as biological optical imaging agents [with Dr Simon J. A. Pope, Dr Ian A. Fallis and Dr Angelo J. Amoroso (Chemistry), Dr Catrin F. Williams (Engineering and BIOSI), and Dr Anthony J. Hayes (BIOSI Confocal)]
  3. Biological effects of microwaves with Dr Catrin F. Williams (Engineering and BIOSI) and Professor Adrian Porch (Engineering)
  4. Coupling of oscillatory behaviour in yeasts by intracellular water dynamics with Dr Lars Folke Olsen and Professor Luis A. Bagatolli (University of Southern Denmark)

Grants

Work supported by

  • EU Funding
  • NERC
  • BBSRC
  • Wellcome
  • The Royal Society
  • Ser Cymru

Collaborations

  • US National Institute of Health on Aging, Baltimore, USA 2015 - present
  • Keio University: Institute for Advanced Biosciences at Tsuruoka, Japan 2005
  • Johns Hopkins Medical School, Molecular Cardiobiology, Baltimore, USA 2002 to present
  • INTECH, Buenos Aires, Argentina 1998
  • Sabbatical at University of New South Wales, Australia 1999
  • National Institute for Biosciences/Human Technology, Tsukuba Science City, Japan 1997; 1998
  • University of New South Wales, Sydney, Australia 1997
  • University of Kebansang, Kuala Lumpur, Malaysia 1989
  • TATA Institute for Fundamental Research, Bombay, India 1989; 1991; 1993; 1995; 1997; 1998 to present
  • Harvard University, USA 1986
  • ATOMKI, Debrecen, Hungary 1984
  • INRA, Bordeaux, France 1984
  • Soviet Academy of Science, Moscow, USSR 1979
  • Moscow State University, USSR 1979
  • University of Southern Denmark at Odense, Denmark 1978 to present
  • Odense University, Denmark 1977; 1978; 1980; 1981; 1983; 1986; 1990; 1994; 1996
  • Rockefeller University, USA 1978
  • University of Pennsylvania, USA 1967; 1969; 1971; 1975; 1978; 1979

Industrial collaboration with more than 50 companies and institutes.

Associates

Professor Marc Roussel (on sabbatical leave from Lethbridge, Alberta) used membrane inlet mass spectrometry to reveal the strange attractor that underlies the respiratory dynamics of yeast in continuous culture. This required simultaneous monitoring of dissolved H2S, CO2 and O2; 40,000 points at 15s intervals were acquired in a 3 month continuous culture experiment. This is the first unequivocal demonstration of chaotic control in a biological system at whole cell level.

Dr Katey Lemar established mechanisms for the anti-candidal properties of selected garlic components, diallyldisulphide and allyl alcohol produce apoptotic cell death in this organism without being too toxic to humans. This affords a new way of tackling antibiotic resistance; there are no reported incidents of microorganisms becoming resistant to the garlic compounds.

Dr Catrin F. Williams with Neem Biotechnology (Dr David Williams, Dr Gareth Evans, Dr Robert Saunders and Dr MIchael Graz), Professor Jo Cable and Dr Michael P. Coogan studied the biochemistry and infectivity of the protozoan, Spironucleus vortens towards angelfish, especially sensitivity of the parasite to garlic comstituents.

With Professor Adrian Porch (Engineering), Catrin currently studies effects and their mechanisms of 2.45 GHz microwaves on the bioluminescence of the marine bacterium, Vibrio fischeri and on cultured normal and cancerous human cell lines.

Recent Former Associates

Dr Stefanie Scheerer and Dr Francisco Gomez have established a stable continuous culture of Photobacterium fisheri. This can be used as an on-line monitor for toxic compounds (e.g. biocides) in environmental samples including water supplies. Miniaturization will lead to the development of personal protection systems. Effects of microwaves were studied.

Dr Simon Cottrell showed that freeze dried garlic powder is toxic to MRSA, and that synergistic affects in combination with oxycillin may provide a new chemotherapeutic strategy.

Dr Victoria Gray has shown that the morphology of Salmonella typhimurium and poona species is continually dependent on the tyrosine content of the growth medium. Various sources of the peptone used in the complex diagnostic media may be quite unsuitable on account of their tyrosine deficiency. Aflagellate organisms, unrecognisable as the pathogen, result if the medium is unsuitable.

Dr Kristina Harris investigated the effects of difluoro methylornithine on the growth, structure and function of Trichomonas vaginalis. Defective hydrogenosemes are one consequence of this ornithine decarboxylase inhibitor.

Dr Jonathan Wood investigated the application of garlic as an antibacterial specifically against MRSA. Resolution of effects required separation of the main toxic constituents; synergy with penicillin derivatives was researched.

Dr Coralie Millet investigated protozoal fish parasites Hexamita and Spironucleus spp.  Market for viticulture of aquarium fish is $7b/an. Pathogenicity and invasiveness; biodiversity was studied and compared with that of free living species.

Supervision

Past projects

Post-Graduate

No.

Name

Dates (Awarded)

Thesis Title (Funding Body) Joint Supervisors

66

Heather  Chick  2014-15 (2015)

Antimicrobial activity of Garlic vs. V. fischeri, S. Typhimurium, Burkholderia (KESS studentship)

with Colin Berry (BIOSI, Cardiff University) & Neem Biotech Ltd

65

Rhodri Williams

2013-14 (2014

Antimicrobial activity of Garlic vs. MRSA (Clostridium difficile) (KESS studentship

with Martin Day (BIOSI, Cardiff University) & Neem Biotech Ltd

64

Catrin F Williams

2013

Growth, Metabolism, Biochemistry and Chemotherapy of Spironucleus vortens (EPSRC Studentship)

with Dr David Williams (Neem Biotech Ltd)  with Jo Cable (BIOSI, Cardiff University)

63

Jon Wood

2009

Effects of garlic on MRSA with Sue Plummer (Cultech Port Talbot)

62

Coralie Millet

2009

Growth, metabolism, ultrastructure and chemotherapy of Spironucleus vortens (Morgan Parasitology PG Studentship)

with Jo Cable (BIOSI, Cardiff University)

61

Stephanie Scheerer

2008

Microbial biodeterioration of outdoor stone monuments: Assessment methods and control strategies

with Colin Gibson (UWCM) and Cymtox (Cardiff University)

60

Kristina Harris

2007

Determining the role of polyamine metabolism in two human pathogenic protozoa : Trichomonas vaginalis and Giardia intestinalis (Boehringer Ingelheim Fond and Bateman Trust)

with Burt Goldberg (New York University)

59

Victoria Gray

2006

Growth of Salmonella enterica on diverse media

with I.D. Watkins Merck Chemicals Ltd. (Newport; UK) and Merck KGaA (Darmstadt, Germany)

58

Katey Lemar

2005

Cell death in the human pathogen Candida albicans: effects of garlic (Allium sativum), and garlic constituents allyl alcohol and diallyl disulphide

with Sue Plummer (Cultech Baglan, Port Talbot)

57

David Pooley

2003

Biological effects of millimeter-wave radiation perturbation of Photobacterium in continuous culture
with Brian N Ellison (Rutherford Appleton Laboratory, Oxford University)

56

Simon Cottrell

1999-2002 (2003)

Garlic as antibacterial (Cultech)

with Carsten Muller (BIOSI, Cardiff University and  Sue Plummer (Cultech Baglan, Port Talbot)

55

Samuel Sheppard

1999-2002 (2002)

Sludge amendment of soil (NERC)

with Stuart Davies (BIOSI, Cardiff University)

54

Rosemary Fiera

1998-2001

Apoptosis and mitochondria (Tenovus)

with Ivor D. Bowen (Cardiff University)

53

Neil Turner

1998-2001

Acanthamoeba infections

with A. Denver Russell (Pharmacy, Cardiff University)

52

Eshanta Salgardo

1998-2001

Fusel oils and oscillations in yeast cultures (Allied Brewers, Burton on Trent)

with J.R. Dickinson (Cardiff University) and Allied Brewers (Burton on Trent)

51

Janine Harris

1997-2000

Garlic and Giardia (Cultech)

with Sue Plummer (Cultec, Baglan, Port Talbot)

50

Paul Allen

1997-2000

Giardia encystation (Thames Water)

49

Zoe Matheson

1997-2000

Giardia in Water Supplies (Thames Water)

48

Ceri Arthurs

1996-1999 (2000)

Cider lactobaccili

with Basil Jarvis (Bulmers)

47

Janine Morgan

1996-1999

Erythromycin fermentation

with  R.T.  Rowlands (Panlabs Taiwan) and I.H. Gilbert (Dundee University)

46

Jonathan Tammam

1996-1999

Lactobacilli in Cheese

with Alan G. Williams (Hannah Institute, Ayr)

45

Angela Berry

1996-1999

Peat bog methanogeneis (NERC)

with Stuart Davies (Cardiff University)

44

Burt Goldberg

1995-1998 (1998)

Trypanosome metabolism

with Nigel Yarlett (PACE University, NY, External)

43

Sarah White

1995-1998

Cider lactobaccili (MAFF)

with Basil Jarvis (Bulmers, Hereford)

42

George Cowie

1995-1998 (1999)

Gases in sediments (NERC)

41

Giancarlo Biagini

1994-1997 (1998)

Anaerobic protozoa free living in sediments (NERC)

with  Bland Finlay (NERC)

40

Marc Suller

1994-1997 (1998)

Flow cytometric, detecting antibiotic resistance (Welsh Office)

with J. Marshall Stark (Medical Microbiology, UWCM)

39

Joy Khunkitti

1993-1996 (1996)

Acanthamoeba biocides (Thai Government)

with  Y. Aoki (Khon Kaen University, Thailand) and A. Denver Russell (Pharmacy, Cardiff University)

38

Duncan Edlin

1993-1996 (1997)

Flavours and Fragrances: production using yeasts and filamentous fungi (AFRC)

with Arjan Narbad (ARC Food Institute, Norwich) and JR Dickinson (Cardiff University)

37

Ian Williams

1993-1996 (1996)

Plasmid loss in clinical isolates of Staphylococcus aureus (SERC-CASE, SmithKline Beecham)

with WA Venables (Cardiff University) Frank Paul, Ian Critchley and Robert Jepras (Beechams SKB)

36

Gwenda Dinsdale

1991-1992 (1995)

Yeast plasma membrane physiology and cider fermentation (SERC-CASE, Bulmers)

with Basil Jarvis (Bulmers, Hereford)

35

Fred Kippert

1990-1991 (1992)

Ultradian Cycles in Yeast (Self-financing)

34

Elizabeth Rees

1990-1993 (1995)

Metabolism of rumen chytidomyces (SERC-CASE, Hannah Institute)

with Alan G. Williams (Hannah Institute, Ayr)

33

David Mason

1990-1993 (1995)

Detection of Antibiotic Resistance in Bacteria (Welsh Office)

with M. Stark (Medical Microbiology, UWCM) and  R. Allman

32

Michelle Humphreys

1990-1993 (1994)

Metabolic Studies on Trichonomas vaginalis (SERC)

with R. Allman

31

Katie Thomas

1989-1992 (1993)

Mass spectrometric monitoring of gases in sediments (NERC)

with Kelvin L. Davies

30

Sarah Finney

1988-1991 (1992)

Biochemistry of Nematodes (SERC-CASE, Pfizer)

with Ken (Pfizer, Kent)

29

Julie Benstead

1987-1990 (1991)

Methanogenic cocultures: in species Ha transfer (SERC-IFR, Norwich)

with David B. Archer (Pfizer, Kent)

28

Jayne Ellis

1987-1990 (1990)

Metabolism of Rumen Ciliate Protozoa (SERC-Hannah)

with Alan G. Williams (Hannah Institute, Ayr)

27

Chandra Gopal

1985-1989 (1990)

Expressed recombinant genes and yeast energy metabolism (SERC-CASE, Celltech)

with D. Broad (Celltech, Slough)

26

Helen Jenkins

1984-1987 (1988)

Circadian and Ultradian Rhythms in Chlamydomonas and Euglena (SERC)

with Alan J. Griffiths (Cardiff University) and J Woody Hastings. (Harvard, USA)

25

Richard Allman

1984-1987 (1988)

Flow Cytometric analyses of bacteria (SERC-CASE, MOD, Porton)

with  A.P. Phillips (MOD Porton Down)

24

Kathryn J.P. Davies

1984-1987 (1987)

Denitrification (NERC)

with Lynne Boddy (Cardiff University) and W. Jack Payne (University of Georgia Athens, Georgia USA)

23

Eid Khalil

1985-1987 (1987)

Studies on Anaerobic Digestion (Egyptian Government)

with David E Hughes and Tim Whitmore (Cardiff University)

22

Timothy A. Paget

1983-1987 (1986)

Electron Transport in mitochondria of parasitic helminths (SERC-CASE, Wellcome)

with Mitchel Fry

21

Alan Chapman

1983-1986 (1987)

Studies on the Biochemistry of Trichomonas vaginalis (SERC-CASE Wellcome)

with David Linstead

20

Haifai Al' Obaidy

1982-1985 (1986)

Host defence mechanisms in CAPD: a laboratory and clinical investigation (Self-supported)

with Malcolm Davies (Renal Medicine, UWCM)

19

Kevin Hillman

1982-1985 (1987)

Studies on Rumen Ciliate Protozoa (SERC-CASE Hannah Institute)

with Alan G. Williams (Hannah Institute, Ayr)

18

David J. Hill

1981-1984 (1985)

Regulation of enzyme levels in Candida species (Cardiff University Studentship)

17

Richard O. Jenkins

1980-1983 (1984)

An investigation into the role of subcellular organelles in various species of yeasts (CNAA, Trent Polytechnic)

with Trevor G. Cartledge (Trent University, Nottingham)

16

Pershing Abdul

1982-1985 (1984)

Studies on Anaerobic Digestion (Iraqi Government)

with David E Hughes (Cardiff University)

15

Nigel Yarlett

1979-1982 (1982)

Metabolism of Dasytricha ruminantium, a rumen ciliate (SERC-CASE Hannah Institute)

with Alan G. Williams (Hannah Institute, Ayr)

14

David Wales

1977-1980 (1980)

Aspects of the Biochemistry of the Facultative Anaerobe Saccharomyces carlsbergensis (CNAA, Trent Polytechnic)

with Trevor G. Cartledge (Trent University, Nottingham)

13

Mark Unitt

1976-1979 (1980)

Energy Metabolism in Tetrahymena pyriformis Strain ST (SRC)

12

Zahra Toma

1976-1979 (1980)

Mechanisms of enzyme instability in yeasts (Iraqi Government)

11

Steven W. Edwards

1975-1978 (1978)

The Physiology of Growth of Acanthamoeba castellanii (MRC)

with Alan J. Griffiths (Cardiff University)

10

Ghassan El' Khayat

1976-1979 (1980)

Changes in Energy Conservation Systems During Growth and Starvation of Schizosaccharomyces pombe (Syrian Government)

9

Carol Phillips

1972-1975 (1976)

The Cell Cycle of Tetrahymena pyriformis Strain ST (Cardiff University)

8

Merril Hammil

1972-1975 (1976)

Studies of the Mitochondrial genome in Saccharomyces cerevisiae (Cardiff University)

7

Jalil Kader

1972-1975 (1978)

Studies on synchronous cultures of Candida utilis (Malaysian Government)

6

Clive Edwards

1971-1974 (1978)

Crithidia fasciculata (SRC)

5

Robert K. Poole

1970-1973 (1973)

Structure and Function of the Fission yeast Schizosaccharomyces pombe (SRC)

4

Trevor G. Cartledge

1969-1972 (1972)

Structure and Function of the yeast Saccharomyces carlsbergensis (MRC)

3

Rosemary Cooper

1968-1971 (1971)

Structure and Function of the yeast Saccharomyces carlsbergensis (MRC)

2

Geoffrey Turner

1967-1970 (1970)

The mitochondria of Tetrahymena pyriformis (MRC)

1

David A. Evans

1965-1969 (1969)

Structure and Function in the colourless alga Polytomella caeca (MRC)

with David E Hughes (Cardiff University)

Post-Doctoral

No.

Name

Dates

Project

22

Victoria Gray

2007-2011

Modern Water Continuous environmental monitoring of water quality using bioluminescent bacteria.

21

David Pooley

2010

Software development

20

Francisco Gomez

2008-2010

Construction and maintenance of hardware and wireless operation for this monitor

19

Louise Thomas

2002 (6 months)

Acanthameoba :treatment of eye infections

18

Douglas Murray

1998-2000

Yeast fermentation

17

Manfred Beckman

1998-2001

Peat bog gases

16

Alexander Dorofeev

1997-1998

Bioenergetis of synchronous yeast chemostat cultures (Royal Society/

15

David Horner

1995-1997

Early branching eukaryotes (with Natural History Museum)

13

Katie Thomas

1993-1996

Methanogenesis in peat bogs

12

Simon Avery

1992-1995

Temperature adaptation in Acanthamoeba castellanii (NERC)

12

Andrew Rutter

1993-1996

Microsomal fatty acid desaturation (SERC)

11

Julie Benstead

1992-1993

Methanogenesis in peat bogs (NERC)

10

Jayne Ellis

1990-1992

Metronidazole and Giardia lamblia (Wellcome)

9

Lesley Jones

1989-1991

Temperature adaptation and membrane lipids of Acanthamoeba (NERC)

8

Richard Allman

1989-1991

Rapid detection of bacteria by flow cytometry (MOD)

7

Timothy A. Paget

1986-1989

Metabolism and Chemotherapy of Giardia lamblia (Wellcome)

6

Kevin Hillman

1988-1989

Brettanomyces: spoilage of soft drinks (AFRC)

5

David Gaunt

1986-1988

Brettanomyces: a spoilage of soft drinks (AFRC Cadbury-Schweppes)

4

Timothy Whitmore

1984-1987

Mass spectrometric monitoring and control of anaerobic digestion (AFRC)

3

Nigel Yarlett

1983-1985

Metronidazole action and resistance in Trichomonas vaginalis (Cardiff University)

2

Robert Scott

1981-1983

Continuous monitoring of dissolved gases by mass spectrometry (SERC Biotech.)

1

Steven W. Edwards

1978-1980

Oscillatory dynamics in Acanthamoeba castellanii Cell Cycle (Cardiff University)