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Dr Liming Gui

Research Fellow

Research overview

My research interest is mechanistic studies on maternal regulation of reprogramming.

Division

Pathophysiology and Repair

I completed undergraduate training in Medicine at Guiyang Medical College, China and obtained my PhD degree in Gynaecological Oncogene at the Medical Centre, Peking University, China. My PhD thesis was on the roles of K-ras mutant in endometrial carcinogenesis  using cell culture/mouse as model systems.

Upon completing my PhD, I came to the UK and worked as a post-doctoral researcher in the field of reproductive molecular biology and cell and developmental biology.  In October 2013 I took up a fellowship at the European Cancer Stem Cell Research Institute where my research aims to explore the possibility that maternal regulation of reprogramming could be exploited to induce cancerous cell differentiation with a potential benefit to develop a new strategy to treat cancers.

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Cancer is a problem of developmental biology. There are many molecular links between embryogenesis and oncogenesis. Some cancerous cells use a transcriptional programme that is active in embryonic stem cells. Uncovering the mechanistic similarity between early embryonic development and cancerous cell initiation may therefore help develop a new strategy to treat cancers.  

My previous studies focused upon tumorigenesis and oocyte-based developmental biology using cell culture and/or mice as model systems. My research interest is mechanistic studies on how epigenetic regulation of transcription program controls developmental differentiation. The proposed project is to explore the possibility that maternal regulation of transcription reprogramming could be exploited to induce cancerous cell differentiation.

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