
Professor Steve Dunnett
Emeritus Professor
- dunnettsb@cardiff.ac.uk
- +44 (0)29 2087 5541
- Fax:
- +44 (0)29 2087 6749
- Media commentator
Overview
Research overview
Advances in our understanding of mechanisms of cell death, plasticity and regeneration in the central nervous system offer new opportunities for remediation and repair in several of the most distressing neurodegenerative diseases of adulthood, in particular Parkinson's and Huntington's disease. In the Brain Repair Group, we are seeking to develop new strategies for therapy based on a multidisciplinary approach in several converging problems.
Division
Biography
I am a behavioural neuroscientist with a primary research interest in understanding mechanisms of degeneration and repair in the brain, with a particular focus on cell transplantation in models of Parkinson's and Huntington's disease.
With Professor Anne Rosser, I co-direct the Brain Repair group in the School of Biosciences.
Education
1957-68 | Eltham College, London SE9 | ||
1969-72 | BA(hons) | Churchill College, Cambridge | Mathematics |
1974-76 | DSW, CQSW | North London Polytechnic | Social Work |
1976 | MA | Churchill College, Cambridge | |
1978 | BSc(hons) | Birkbeck College, London | Psychology |
1981 | PhD | Clare College Cambridge | Experimental Psychology |
1999 | DSc | Cambridge University | Neurobiology |
Employment
- 1968-69: Office clerk, Muhlbach Papier, Geneva, Switzerland
- 1972-78: Social worker, London Borough of Southwark
- 1981-82: Visiting Research Scientist, University of Lund, Sweden
- 1982-83: Wellcome Trust Mental Health Research Fellowship, Cambridge University
- 1983-87: Demonstrator in Experimental Psychology, Cambridge University
- 1987-95: Lecturer in Experimental Psychology, Cambridge University
- 1992-99: Director of Scientific Programmes, MRC Centre for Brain Repair, Cambridge
- 1995-99: Reader in Neurobiology, Cambridge University
- 2000-05: Professorial Research Fellow, Cardiff University, Cardiff, Wales
- 2005- present: Full Professor, School of Biosciences, Cardiff University, Cardiff, Wales
Honours and awards
- 1969: Open Exhibition to Churchill College, Cambridge.
- 1978: Alexander Silberfield Prize (for top first) in the Faculty of Sciences, and Elaine Gladstone Prize (for top first) in Psychology, Birkbeck College, London.
- 1981: Fellowship, Clare College, Cambridge.
- 1988: Spearman medal of the British Psychological Society.
- 1989: Fellowship of the Royal Society of Medicine.
- 1992: Knight Visiting Professorship, University of Miami School of Medicine.
- 1998: Alfred Mayer medal of the British Neuropathological Society.
- 2001: Institute of Scientific Information, Philadelphia, 100 Most Highly Cited Researchers in the Neurosciences.
- 2001: Institute of Authors, London, Best science textbook of 2001 (second).
- 2002: Honorary Fellowship of the International Behavioural Neuroscience Society.
- 2003: Fellowship of the Academy of Medical Sciences.
- 2008: The NNOXe Pharmaceuticals Award in The Behavioral and Systems Neurosciences, International Behavioural Neuroscience Society.
Professional memberships
- Member of the Cardiff Institute of Tissue Engineering and Repair.
Publications
2020
- Precious, S. V. et al. 2020. Dopaminergic progenitors derived from epiblast stem cells function similarly to primary VM-derived progenitors when transplanted into a Parkinson’s disease model. Frontiers in Neuroscience 14, article number: 312. (10.3389/fnins.2020.00312)
2019
- Barker, R. A. et al. 2019. Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease. Nature Medicine 25(7), pp. 1045-1053. (10.1038/s41591-019-0507-2)
- Noakes, Z. et al. 2019. Human pluripotent stem cell-derived striatal interneurons: differentiation and maturation in vitro and in the rat brain. Stem Cell Reports 12(2), pp. 191-200. (10.1016/j.stemcr.2018.12.014)
2018
- Maxan, A. et al. 2018. Outcome of cell suspension allografts in a patient with Huntington's disease. Annals of Neurology 84(6), pp. 950-956. (10.1002/ana.25354)
- McWilliams, T. et al. 2018. Phosphorylation of Parkin at Serine65 is essential for its activation in vivo. Open Biology 8, article number: 180108. (10.1098/rsob.180108)
- Massey, T., McAllister, B. and Jones, L. 2018. Methods for assessing DNA repair and repeat expansion in Huntington's Disease. In: Precious, S. V., Rosser, A. E. and Dunnett, S. B. eds. Huntington’s Disease., Vol. 1780. Methods in Molecular Biology Humana Press, pp. 483-495., (10.1007/978-1-4939-7825-0_22)
- Holmans, P. and Stone, T. 2018. Using genomic data to find disease-modifying loci in Huntington's Disease (HD). In: Precious, S. V., Rosser, A. E. and Dunnett, S. eds. Huntington’s Disease., Vol. 1780. Methods in Molecular Biology Humana Press, pp. 443-461., (10.1007/978-1-4939-7825-0_20)
- Harrison, D., Roberton, V., Vinh, N., Brooks, S., Dunnett, S. and Rosser, A. 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27(2), pp. 230-244. (10.1177/0963689717744788)
2017
- Hensman Moss, D. J. et al. 2017. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurology 16(9), pp. 701-711. (10.1016/S1474-4422(17)30161-8)
- Precious, S. V., Zietlow, R., Dunnett, S. B., Kelly, C. and Rosser, A. E. 2017. Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?. Neurochemistry International 106, pp. 114-121. (10.1016/j.neuint.2017.01.016)
- Fjodorova, M., Torres, E. M. and Dunnett, S. B. 2017. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental Neurology 291, pp. 8-19. (10.1016/j.expneurol.2017.01.010)
- Dunnett, S. and Rosser, A. 2017. Reprogramming the diseased brain. Nature Biotechnology 35(5), pp. 426-428. (10.1038/nbt.3869)
- Dunnett, S. B. and Björklund, A. 2017. Mechanisms and use of neural transplants for brain repair. In: Dunnett, S. B. and Bjorklund, A. eds. Functional Neural Transplantation IV: Translation to Clinical Application, Part A., Vol. 230. Progress in Brain Research Elsevier, pp. 1-51., (10.1016/bs.pbr.2016.11.002)
- Trueman, R. C. et al. 2017. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism 37(4), pp. 1349-1361. (10.1177/0271678X16654921)
- Breger, L. S., Kienle, K., Smith, G. A., Dunnett, S. B. and Lane, E. L. 2017. Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity 61, pp. 155-164. (10.1016/j.bbi.2016.11.014)
- Ahmed, J., Dwyer, D., Farr, T. D., Harrison, D., Dunnett, S. and Trueman, R. C. 2017. Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism 37(3), pp. 755-761. (10.1177/0271678X16684141)
- Bragg, R. M. et al. 2017. Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease. Scientific Reports 7, article number: 41570. (10.1038/srep41570)
- Bowles, K. R., Stone, T. C., Holmans, P. A., Allen, N. D., Dunnett, S. B. and Jones, L. 2017. SMAD transcription factors are altered in cell models of HD and regulate HTT expression. Cellular Signalling 31, pp. 1-14. (10.1016/j.cellsig.2016.12.005)
- Kirkeby, A. et al. 2017. Predictive markers guide differentiation to improve graft outcome in clinical translation of hESC-based therapy for Parkinson's disease. Cell Stem Cell 20(1), pp. 135-148. (10.1016/j.stem.2016.09.004)
- Clinch, S., Busse-Morris, M., Döbrössy, M. D. and Dunnett, S. B. 2017. Rehabilitation training in neural restitution. In: Progress in Brain Research., Vol. 230. Elsevier, pp. 305-329., (10.1016/bs.pbr.2016.12.006)
2016
- Bowles, K. R., Brooks, S. P., Hughes, A., Dunnett, S. B. and Jones, L. 2016. Correction: Huntingtin Subcellular localisation is regulated by kinase signalling activity in the StHdhQ111 model of HD. PLoS ONE 11(10), article number: e0165069. (10.1371/journal.pone.0165069)
- Atassi, N. et al. 2016. Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?. Cytotherapy 18(12), pp. 1471-1475. (10.1016/j.jcyt.2016.08.005)
- Yhnell, E., Dunnett, S. and Brooks, S. 2016. A longitudinal operant assessment of cognitive and behavioural changes in the HdhQ111 mouse model of Huntington's Disease. PLoS ONE 11(10), article number: e0164072. (10.1371/journal.pone.0164072)
- Yhnell, E., Lelos, M. J., Dunnett, S. B. and Brooks, S. P. 2016. L30 Cognitive training improves disease symptoms in a mouse model of huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 87(Supp 1), pp. A100-A101. (10.1136/jnnp-2016-314597.285)
- Newland, B., Dunnett, S. B. and Dowd, E. 2016. Targeting delivery in Parkinson's disease. Drug Discovery Today 21(8), pp. 1313-1320. (10.1016/j.drudis.2016.06.003)
- Yhnell, E., Dunnett, S. B. and Brooks, S. P. 2016. A longitudinal motor characterisation of the HdhQ111 mouse model of Huntington's Disease. Journal of Huntington's Disease 5(2), pp. 149-161. (10.3233/JHD-160191)
- Yhnell, E., Dunnett, S. B. and Brooks, S. P. 2016. The utilisation of operant delayed matching and non-matching to position for probing cognitive flexibility and working memory in mouse models of Huntington's disease. Journal of Neuroscience Methods 265, pp. 72-80. (10.1016/j.jneumeth.2015.08.022)
- Bayram-Weston, Z., Olsen, E., Harrison, D., Dunnett, S. B. and Brooks, S. 2016. Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease. Journal of Neuroscience Methods 265, pp. 81-88. (10.1016/j.jneumeth.2015.09.033)
- Townhill, J. et al. 2016. Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note. Journal of Neuroscience Methods 265, pp. 13-18. (10.1016/j.jneumeth.2016.01.009)
- Bayram-Weston, Z., Jones, L., Dunnett, S. B. and Brooks, S. P. 2016. Comparison of mHTT antibodies in Huntington's disease mouse models reveal specific binding profiles and steady-state ubiquitin levels with disease development.. PloS One (10.1371/journal.pone.0155834)
- Yhnell, E., Lelos, M. J., Dunnett, S. B. and Brooks, S. P. 2016. Cognitive training modifies disease symptoms in a mouse model of Huntington's disease. Experimental Neurology 282, pp. 19-26. (10.1016/j.expneurol.2016.05.008)
- Lelos, M. J. et al. 2016. Direct comparison of rat- and human-derived ganglionic eminence tissue grafts on motor function. Cell Transplantation 25, pp. 665-675. (10.3727/096368915X690297)
- Lelos, M., Morgan, R. J., Kelly, C., Torres, E. M., Rosser, A. E. and Dunnett, S. B. 2016. Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease. Experimental Neurology 278, pp. 54-61. (10.1016/j.expneurol.2016.02.003)
- Harvey, A. K. et al. 2016. Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis. Journal of Rheumatic Diseases and Treatment 2(2), article number: 33. (10.23937/2469-5726/1510033)
2015
- Bayram-Weston, Z. et al. 2015. Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence. BMC Genomics 16, pp. -., article number: 1079. (10.1186/s12864-015-2251-4)
- Bowles, K. R., Brooks, S. P., Dunnett, S. B. and Jones, L. 2015. Huntingtin subcellular localisation is regulated by Kinase signalling activity in the StHdhQ111 model of HD. PLoS ONE 10(12), article number: e0144864. (10.1371/journal.pone.0144864)
- Wojtecki, L. et al. 2015. A prospective pilot trial for pallidal deep brain stimulation in Huntington's Disease. Frontiers in Neurology 6, article number: 177. (10.3389/fneur.2015.00177)
- Bagga, V., Dunnett, S. B. and Fricker, R. A. 2015. The 6-OHDA mouse model of Parkinson's disease - terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions. Behavioural Brain Research 288, pp. 107-117. (10.1016/j.bbr.2015.03.058)
- Arber, C. et al. 2015. Activin A directs striatal projection neuron differentiation of human pluripotent stem cells. Development 142(7), pp. 1375-1386. (10.1242/dev.117093)
- Torres, E. M., Trigano, M. and Dunnett, S. . B. 2015. Translation of cell therapies to the clinic: characteristics of cell suspensions in large diameter injection cannulae. Cell Transplantation 24(4), pp. 737-749. (10.3727/096368914X685429)
- Brooks, S. P. and Dunnett, S. B. 2015. Mouse models of Huntington's disease. In: Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease. Current Topics in Behavioral Neurosciences Vol. 22. Berlin: Springer, pp. 101-133., (10.1007/7854_2013_256)
2014
- Reddington, A. E., Rosser, A. E. and Dunnett, S. B. 2014. Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient. Frontiers in Cellular Neuroscience 8, article number: 398. (10.3389/fncel.2014.00398)
- Rosser, A. E. and Dunnett, S. B. 2014. Cell therapy for Huntington's Disease. Advances in Clinical Neuroscience and Rehabilitation 14(5), pp. 18-21.
- Yhnell, E., Dunnett, S. B. and Brooks, S. P. 2014. C04 A longitudinal behavioural characterisation of the HDHQ111 mouse model of Huntington's Disease. Journal of Neurology, Neurosurgery & Psychiatry 85(Supp 1), article number: A26. (10.1136/jnnp-2014-309032.77)
- Lindgren, H. S., Klein, A. and Dunnett, S. B. 2014. Nigral 6-hydroxydopamine lesion impairs performance in a lateralised choice reaction time task - impact of training and task parameters. Behavioural Brain Research 266, pp. 207-215. (10.1016/j.bbr.2014.02.043)
- Hughes, A., Mort, M. E., Elliston, L. A., Thomas, R. M., Brooks, S. P., Dunnett, S. B. and Jones, L. 2014. Identification of novel alternative splicing events in the Huntingtin gene and assessment of the functional consequences using structural protein homology modelling. Journal of Molecular Biology 426(7), pp. 1428-1438. (10.1016/j.jmb.2013.12.028)
- Lindgren, H. S., Demirbugen, M., Bergqvist, F., Lane, E. L. and Dunnett, S. B. 2014. The effect of additional noradrenergic and serotonergic depletion on a lateralised choice reaction time task in rats with nigral 6-OHDA lesions. Experimental Neurology 253, pp. 52-62. (10.1016/j.expneurol.2013.11.015)
- Yhnell, E., Dunnett, S. B. and Brooks, S. P. 2014. The development of operant delayed matching to position for Huntington's disease mouse models. Presented at: 12th meeting of the International Society for Neural Transplantation and Restoration, Vol. 25. Vol. 3. Lippincott, Williams & Wilkins pp. 163., (10.1097/01.wnr.0000443076.61006.22)
- Dascher-Nadel, C., Rosser, A. E. and Dunnett, S. B. 2014. Repair-HD: Human pluripotent stem cell differentiation, safety, and preparation for therapeutic transplantation in Huntington disease. HD Insights 8, pp. 9-10.
- Dunnett, S. B. and Rosser, A. E. 2014. Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease. Neurobiology of Disease 61, pp. 79-89. (10.1016/j.nbd.2013.05.004)
2013
- Murphy, E. M., Lelos, M. J., O'Neill, M. J., Lane, E. L. and Dunnett, S. B. 2013. Long-term restorative effects of bromocriptine on operant responding in the 6-hydroxydopamine-lesioned rat. NeuroReport 24(18), pp. 1019-1024. (10.1097/WNR.0000000000000060)
- Lane, E. L., Dunnett, S. B. and Fricker, R. A. 2013. The 12th meeting of the International Society for Neural Transplantation and Restoration. NeuroReport 24(18), pp. 997-999. (10.1097/WNR.0000000000000101)
- Roberton, V. H., Evans, A. E., Harrison, D. J., Precious, S. V., Dunnett, S. B., Kelly, C. and Rosser, A. E. 2013. Is the adult mouse striatum a hostile host for neural transplant survival?. NeuroReport 24(18), pp. 1010-1015. (10.1097/WNR.0000000000000066)
- Heuer, A., Lelos, M. J., Kelly, C., Torres, E. M. and Dunnett, S. B. 2013. Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats. Experimental Neurology 247, pp. 485-495. (10.1016/j.expneurol.2013.01.020)
- Lindgren, H. S., Wickens, R., Tait, D. S., Brown, V. J. and Dunnett, S. B. 2013. Lesions of the dorsomedial striatum impair formation of attentional set in rats. Neuropharmacology 71, pp. 148-153. (10.1016/j.neuropharm.2013.03.034)
- Rath, A. et al. 2013. Survival and functional restoration of human fetal ventral mesencephalon following transplantation in a rat model of Parkinson's Disease. Cell Transplantation 22(7), pp. 1281-1293. (10.3727/096368912X654984)
- Barker, R. A. et al. 2013. The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 84(6), pp. 657-665. (10.1136/jnnp-2012-302441)
- Heuer, A., Vinh, N. and Dunnett, S. B. 2013. Behavioural recovery on simple and complex tasks by means of cell replacement therapy in unilateral 6-hydroxydopamine-lesioned mice. European Journal of Neuroscience 37(10), pp. 1691-1704. (10.1111/ejn.12150)
- Lelos, M. J., Lane, E. and Dunnett, S. B. 2013. What helps can also hinder: A dissociation in the acute effect of levodopa treatment on motor and cognitive functions. Movement Disorders 28(5), pp. 563-564. (10.1002/mds.25294)
- Brooks, S. P. and Dunnett, S. B. 2013. Cognitive deficits in animal models of basal ganglia disorders. Brain Research Bulletin 92, pp. 29-40. (10.1016/j.brainresbull.2012.04.011)
- Breger, L. S., Dunnett, S. B. and Lane, E. L. 2013. Comparison of rating scales used to evaluate l-DOPA-induced dyskinesia in the 6-OHDA lesioned rat. Neurobiology of Disease 50, pp. 142-150. (10.1016/j.nbd.2012.10.013)
- Heuer, A. and Dunnett, S. B. 2013. Characterisation of spatial neglect induced by unilateral 6-OHDA lesions on a choice reaction time task in rats. Behavioural Brain Research 237, pp. 215-222. (10.1016/j.bbr.2012.09.038)
- Carri, A. D. et al. 2013. Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32(+) medium-sized spiny neurons. Development 140(2), pp. 301-312. (10.1242/dev.084608)
- Heuer, A., Smith, G. A. and Dunnett, S. B. 2013. Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice. European Journal of Neuroscience 37(2), pp. 294-302. (10.1111/ejn.12036)
- Harrison, D. J., Busse, M., Openshaw, R., Rosser, A. E., Dunnett, S. B. and Brooks, S. P. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248, pp. 457-469. (10.1016/j.expneurol.2013.07.014)
- Dunnett, S. B. 2013. Neural tissue transplantation, repair, and rehabilitation. Handbook of Clinical Neurology 110, pp. 43-59. (10.1016/B978-0-444-52901-5.00004-6)
- Klein, A., Lane, E. L. and Dunnett, S. B. 2013. Brain repair in a unilateral rat model of Huntington's Disease: new insights into impairment and restoration of forelimb movement patterns. Cell Transplantation 22(10), pp. 1735-1751. (10.3727/096368912X657918)
- Lelos, M. J., Harrison, D. J., Rosser, A. E. and Dunnett, S. B. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71, pp. 287-294. (10.1016/j.appet.2013.09.003)
- Trueman, R. C., Klein, A., Lindgren, H. S., Lelos, M. J. and Dunnett, S. B. 2013. Repair of the CNS using endogenous and transplanted neural stem cells. Current Topics in Behavioural Neurosciences 15, pp. 357-398. (10.1007/7854_2012_223)
2012
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2012. Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. European Journal of Neuroscience 36(10), pp. 3420-3428. (10.1111/j.1460-9568.2012.08256.x)
- Corbett, A. et al. 2012. Drug repositioning for Alzheimer's disease. Nature Reviews Drug Discovery 11(11), pp. 833-846. (10.1038/nrd3869)
- Corbett, A. et al. 2012. Drug repositioning for Alzheimer's disease. Nature Reviews Drug Discovery 11(11), pp. 833-846. (10.1038/nrd3869)
- Smith, G. A., Isacson, O. and Dunnett, S. B. 2012. The search for genetic mouse models of prodromal Parkinson's disease. Experimental Neurology 237(2), pp. 267-273. (10.1016/j.expneurol.2012.06.035)
- Smith, G. A., Breger, L. S., Lane, E. L. and Dunnett, S. B. 2012. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63(5), pp. 818-828. (10.1016/j.neuropharm.2012.06.011)
- Lindgren, H. S., Lelos, M. J. and Dunnett, S. B. 2012. Do alpha-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?. Experimental Neurology 237(1), pp. 36-42. (10.1016/j.expneurol.2012.05.022)
- Kelly, C., Roberton, V. H., Dunnett, S. B. and Rosser, A. E. 2012. Reply to "Neonatal desensitization does not universally prevent xenograft rejection". Nature Methods 9(9), pp. 858. (10.1038/nmeth.2144)
- Dunnett, S. B., Borlongan, C. V. and Sanberg, P. R. 2012. Embryonic or Neural Stem Cells in Neurodegenerative Disease of the Central Nervous System (with Relevance to PD, HD, AD, MS, SCI, and Stroke). In: Warwick, R. M. and Brubaker, S. A. eds. Tissue and Cell Clinical Use: An Essential Guide. Chichester: Wiley-Blackwell, pp. 358-382., (10.1002/9781118498453.ch17)
- Smith, G. A., Dunnett, S. B. and Lane, E. L. 2012. Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat - Response to pharmacological modulation. Behavioural Brain Research 232(2), pp. 411-415. (10.1016/j.bbr.2012.04.003)
- Dunnett, S. B., Fuller, A., Rosser, A. E. and Brooks, S. P. 2012. A novel extended sequence learning task (ESLeT) for rodents: validation and the effects of amphetamine, scopolamine and striatal lesions. Brain Research Bulletin 88(2-3), pp. 237-250. (10.1016/j.brainresbull.2010.10.005)
- Deschepper, M. P., Hoogendoorn, B., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes. Brain Research Bulletin 88(2-3), pp. 210-222. (10.1016/j.brainresbull.2011.01.012)
- Dunnett, S. B., Heuer, A., Lelos, M. J., Brooks, S. P. and Rosser, A. E. 2012. Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats. Brain Research Bulletin 88(2-3), pp. 251-260. (10.1016/j.brainresbull.2011.04.002)
- Brooks, S. P., Higgs, G., Jones, L. and Dunnett, S. B. 2012. Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88(2-3), pp. 148-155. (10.1016/j.brainresbull.2010.05.003)
- Brooks, S. P., Higgs, G., Jones, L. and Dunnett, S. B. 2012. Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice. Brain Research Bulletin 88(2-3), pp. 182-188. (10.1016/j.brainresbull.2010.05.004)
- Bayram-Weston, Z., Torres, E. M., Jones, L., Dunnett, S. B. and Brooks, S. P. 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh((CAG)150) Huntington's disease knock-in mouse. Brain Research Bulletin 88(2-3), pp. 189-198. (10.1016/j.brainresbull.2011.03.014)
- Brooks, S. P., Higgs, G., Janghra, N., Jones, L. and Dunnett, S. B. 2012. Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88(2-3), pp. 113-120. (10.1016/j.brainresbull.2010.05.005)
- Brooks, S. P., Janghra, N., Workman, V. L., Bayram-Weston, Z., Jones, L. and Dunnett, S. B. 2012. Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice. Brain Research Bulletin 88(2-3), pp. 94-103. (10.1016/j.brainresbull.2011.01.010)
- Trueman, R. C., Dunnett, S. B., Jones, L. and Brooks, S. P. 2012. Five choice serial reaction time performance in the HdhQ92 mouse model of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 163-170. (10.1016/j.brainresbull.2011.10.019)
- Bayram-Weston, Z., Jones, L., Dunnett, S. B. and Brooks, S. P. 2012. Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice. Brain Research Bulletin 88(2-3), pp. 137-147. (10.1016/j.brainresbull.2011.05.005)
- Bayram-Weston, Z., Jones, L., Dunnett, S. B. and Brooks, S. P. 2012. Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice. Brain Research Bulletin 88(2-3), pp. 104-112. (10.1016/j.brainresbull.2011.07.009)
- Trueman, R. C., Jones, L., Dunnett, S. B. and Brooks, S. P. 2012. Early onset deficits on the delayed alternation task in the HdhQ92 knock-in mouse model of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 156-162. (10.1016/j.brainresbull.2011.03.012)
- Bayram-Weston, Z., Jones, L., Dunnett, S. B. and Brooks, S. P. 2012. Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice. Brain Research Bulletin 88(2-3), pp. 171-181. (10.1016/j.brainresbull.2011.03.013)
- Trueman, R. C., Dunnett, S. B. and Brooks, S. P. 2012. Operant-based instrumental learning for analysis of genetically modified models of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 261-275. (10.1016/j.brainresbull.2011.03.015)
- Brooks, S. P., Janghra, N., Higgs, G. V., Bayram-Weston, Z., Heuer, A., Jones, L. and Dunnett, S. B. 2012. Selective cognitive impairment in the YAC128 Huntington's disease mouse. Brain Research Bulletin 88(2-3), pp. 121-129. (10.1016/j.brainresbull.2011.05.010)
- Brooks, S. P., Jones, L. and Dunnett, S. B. 2012. Longitudinal analyses of operant performance on the serial implicit learning task (SILT) in the YAC128 Huntington's disease mouse line. Brain Research Bulletin 88(2-3), pp. 130-136. (10.1016/j.brainresbull.2011.06.008)
- Bowles, K. R., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Gene expression and behaviour in mouse models of HD. Brain Research Bulletin 88(2-3), pp. 276-284. (10.1016/j.brainresbull.2011.07.021)
- Fielding, S. A., Brooks, S. P., Klein, A., Bayram-Weston, Z., Jones, L. and Dunnett, S. B. 2012. Profiles of motor and cognitive impairment in the transgenic rat model of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 223-236. (10.1016/j.brainresbull.2011.09.011)
- Brooks, S. P., Jones, L. and Dunnett, S. B. 2012. Comparative analysis of pathology and behavioural phenotypes in mouse models of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 81-93. (10.1016/j.brainresbull.2011.10.002)
- Giles, P. J., Elliston, L. A., Higgs, G., Brooks, S. P., Dunnett, S. B. and Jones, L. 2012. Longitudinal analysis of gene expression and behaviour in the HdhQ150 mouse model of Huntington's disease. Brain Research Bulletin 88(2-3), pp. 199-209. (10.1016/j.brainresbull.2011.10.001)
- Zietlow, R., Precious, S. V., Kelly, C., Dunnett, S. B. and Rosser, A. E. 2012. Long-term expansion of human foetal neural progenitors leads to reduced graft viability in the neonatal rat brain. Experimental Neurology 235(2), pp. 563-573. (10.1016/j.expneurol.2012.03.010)
- Lindgren, H. S. and Dunnett, S. B. 2012. Cognitive dysfunction and depression in Parkinson's disease: what can be learned from rodent models?. European Journal of Neuroscience 35(12), pp. 1894-1907. (10.1111/j.1460-9568.2012.08162.x)
- Klein, A., Sacrey, L. R., Whishaw, I. Q. and Dunnett, S. B. 2012. The use of rodent skilled reaching as a translational model for investigating brain damage and disease. Neuroscience and Behavioural Reviews 36(3), pp. 1030-1042. (10.1016/j.neubiorev.2011.12.010)
- Smith, G. A., Heuer, A., Dunnett, S. B. and Lane, E. L. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: Predicting L-DOPA-induced dyskinesia. Behavioural Brain Research 226(1), pp. 281-292. (10.1016/j.bbr.2011.09.025)
- Heuer, A., Smith, G. A., Lelos, M. J., Lane, E. L. and Dunnett, S. B. 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228(1), pp. 30-43. (10.1016/j.bbr.2011.11.027)
- Klein, A. and Dunnett, S. B. 2012. Analysis of skilled forelimb movement in rats: the single pellet reaching test and staircase test. Current Protocols in Neuroscience 58, article number: 8.28.1-8.28.15. (10.1002/0471142301.ns0828s58)
- Torres, E. M. and Dunnett, S. B. 2012. 6-OHDA lesion models of Parkinson’s disease in the rat. In: Lane, E. L. and Dunnett, S. B. eds. Animal Models of Movement Disorders., Vol. 1. Neuromethods Vol. 61. New York: Humana Press, pp. 267-279., (10.1007/978-1-61779-298-4_13)
- Dunnett, S. B. and Björklund, A. 2012. Introduction (Part I). In: Progress in Brain Research., Vol. 200. Elsevier, pp. 3-5., (10.1016/B978-0-444-59575-1.00018-1)
- Lelos, M. J., Dowd, E. and Dunnett, S. B. 2012. Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?. In: Progress in Brain Research., Vol. 200. Elsevier, pp. 113-142., (10.1016/B978-0-444-59575-1.00006-5)
- Dunnett, S. B. and Björklund, A. 2012. Introduction (Part II). In: Progress in Brain Research., Vol. 201. Elsevier, pp. 3-6., (10.1016/B978-0-444-59544-7.00017-2)
- Smith, G. A. et al. 2012. L-dopa and graft-induced dyskinesia in the 6-OHDA-lesioned mouse [Abstract]. Cell Transplantation 21(4), pp. 792-792.
- Bayram-Weston, Z., Jones, L., Dunnett, S. B. and Brooks, S. P. 2012. B08 Differential sensitivity of aggregate markers in HdhQ150 and YAC128 HD mouse models. Journal of Neurology, Neurosurgery & Psychiatry 83(Suppl), pp. A8-A8. (10.1136/jnnp-2012-303524.24)
2011
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2011. Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural Brain Research 225(2), pp. 522-528. (10.1016/j.bbr.2011.08.017)
- Dunnett, S. B. and Rosser, A. E. 2011. Clinical translation of cell transplantation in the brain. Current Opinion in Organ Transplantation 16(6), pp. 632-639. (10.1097/MOT.0b013e32834c2356)
- Torres, E. M., Lane, E. L., Heuer, A., Smith, G. A., Murphy, E. M. and Dunnett, S. B. 2011. Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates. Journal of Neuroscience Methods 200(1), pp. 29-35. (10.1016/j.jneumeth.2011.06.012)
- Madete, J. K., Klein, A., Dunnett, S. B. and Holt, C. A. 2011. Three-dimensional motion analysis of postural adjustments during over-ground locomotion in a rat model of Parkinson's disease. Behavioural Brain Research 220(1), pp. 119-125. (10.1016/j.bbr.2011.01.037)
- Lane, E. L., Daly, C. S., Smith, G. A. and Dunnett, S. B. 2011. Context-driven changes in 1-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiology of Disease 42(1), pp. 99-107. (10.1016/j.nbd.2011.01.010)
- Döbrössy, M., Klein, A., Janghra, N., Nikkhah, G. and Dunnett, S. B. 2011. Validating the use of M4-BAC-GFP mice as tissue donors in cell replacement therapies in a rodent model of Huntington's disease. Journal of Neuroscience Methods 197(1), pp. 6-13. (10.1016/j.jneumeth.2011.01.015)
- Klein, A., Sacrey, L., Dunnett, S. B., Whishaw, I. and Nikkhah, G. 2011. Proximal movements compensate for distal forelimb movement impairments in a reach-to-eat task in Huntington's disease: New insights into motor impairments in a real-world skill. Neurobiology of Disease 41(2), pp. 560-569. (10.1016/j.nbd.2010.11.002)
- Smith, G. A., Lane, E. L. and Dunnett, S. B. 2011. Graft-Induced Dyskinesia in Transplanted Hemiparkinsonian Mice and Rats: A Pharmacological Manipulation [Abstract]. Cell Transplantation 20(4), pp. 585-585.
- Smith, G. A., Breger, L. S., Dunnett, S. B. and Lane, E. L. 2011. Developments in Graft-Induced Dyskinesia [Abstract]. Cell Transplantation 20(4), pp. 584-585.
- Klein, A., Lane, E. L. and Dunnett, S. B. 2011. Skilled Reaching Behavior in a Rat Model of Huntington's Disease and the Effects of Neurorestorative Therapy [Abstract]. Cell Transplantation 20(4), pp. 567-567.
- Rosser, A. E., Kelly, C. and Dunnett, S. B. 2011. Cell transplantation for Huntington's disease: practical and clinical considerations. Future Neurology 6(1), pp. 45-62. (10.2217/fnl.10.78)
- Kelly, C. et al. 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20(4), pp. 503-513. (10.3727/096368910X546580)
- Freeman, T. B., Cicchetti, F. C., Bachoud-Lévi, A. C. and Dunnett, S. B. 2011. Technical factors that influence neural transplant safety in Huntington’s disease. Experimental Neurology 227(1), pp. 1-9. (10.1016/j.expneurol.2010.08.031)
- Trueman, R. C., Harrison, D. J., Dwyer, D. M., Dunnett, S. B., Hoehn, M. and Farr, T. D. 2011. A critical re-Examination of the intraluminal filament MCAO model: impact of External Carotid Artery transection. Translational Stroke Research 2(4), pp. 651-661. (10.1007/s12975-011-0102-4)
- Dunnett, S. B. and Torres, E. M. 2011. Rotation in the 6-OHDA-lesioned rat. In: Lane, E. L. and Dunnett, S. B. eds. Animal Models of Movement Disorders., Vol. 1. Neuromethods Vol. 61. New York: Humana Press, pp. 299-315., (10.1007/978-1-61779-298-4_15)
- Dunnett, S. B. and Rosser, A. E. 2011. Cell-based treatments for Huntington's disease. International Review of Neurobiology 98, pp. 483-508. (10.1016/B978-0-12-381328-2.00017-1)
- Lelos, M. J. and Dunnett, S. B. 2011. Aberrant dopamine transmission and cognitive dysfunction in animal models of Parkinson's disease. Journal of Parkinson's Disease 1(2), pp. 151-165.
- Lane, E. L. and Dunnett, S. B. 2011. Preface. In: Lane, E. L. and Dunnett, S. eds. Animal Models of Movement Disorders., Vol. 1. Neuromethods Vol. 61. New York, NY: Humana Press, pp. vii-viii.
2010
- Dobrossy, M., Busse, M., Piroth, T., Rosser, A. E., Dunnett, S. B. and Nikkhah, G. 2010. Review: Neurorehabilitation With Neural Transplantation. Neurorehabilitation and Neural Repair 24(8), pp. 692-701. (10.1177/1545968310363586)
- Brooks, S. P., Jones, L. and Dunnett, S. B. 2010. Frontostriatal pathology in the (C57BL/6J) YAC128 mouse uncovered by the operant delayed alternation task [Meeting abstract]. Journal of Neurology, Neurosurgery and Psychiatry 81(1), pp. A9-A10. (10.1136/jnnp.2010.222570.29)
- Twohig, J. P. et al. 2010. Age-dependent maintenance of motor controland corticostriatal innervation by death receptor 3. Journal of Neuroscience 30(10), pp. 3782-3792. (10.1523/JNEUROSCI.1928-09.2010)
- Lane, E. L., Björklund, A., Dunnett, S. B. and Winkler, C. 2010. Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia. In: Björklund, A. and Cenci, M. A. eds. Recent Advances in Parkinson’s Disease: Translational and Clinical Research. Progress in Brain Research Vol. 184. London: Elsevier, pp. 295-309., (10.1016/S0079-6123(10)84015-4)
- Dunnett, S. B. and Lelos, M. 2010. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease. In: Progress in Brain Research., Vol. 184. Elsevier, pp. 35-51., (10.1016/S0079-6123(10)84003-8)
- Mazzocchi-Jones, D., Döbrössy, M. and Dunnett, S. B. 2010. Environmental enrichment facilitates long-term potentiation in embryonic striatal grafts. Neurorehabilitation and Neural Repair 25(6), pp. 548-557. (10.1177/1545968311402090)
- Döbrössy, M., Busse, M., Piroth, T., Rosser, A. E., Dunnett, S. B. and Nikkhah, G. 2010. Neurorehabilitation and neural transplantation. Neurorehabilitation and Neural Repair 24(8), pp. 692-701. (10.1177/1545968310377604)
- Lane, E. L. and Dunnett, S. B. 2010. Pretreatment with dopamine agonists influences L-dopa mediated rotations without affecting abnormal involuntary movements in the 6-OHDA lesioned rat. Behavioural Brain Research 213(1), pp. 66-72. (10.1016/j.bbr.2010.04.034)
- Lane, E. L., Björklund, A., Dunnett, S. B. and Winkler, C. 2010. Neural grafting in Parkinsons disease unraveling the mechnisams underlying graft-induced dyskinesia. In: Progress in Brain Research., Vol. 184. Elsevier, pp. 295-309., (10.1016/S0079-6123(10)84015-4)
- Madete, J. K., Klein, A., Fuller, A., Trueman, R., Rosser, A. E., Dunnett, S. B. and Holt, C. A. 2010. Challenges facing quantification of rat locomotion along beams of varying widths. Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine 224(11), pp. 1257-1265. (10.1243/09544119JEIM779)
- Madete, J., Fuller, A., Klein, A., Trueman, R., Dunnett, S. B., Rosser, A. E. and Holt, C. A. 2010. Quantification of rat locomotion along beams of varying widths. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
- Madete, J. K., Fuller, A., Klein, A., Trueman, R., Dunnett, S. B., Rosser, A. E. and Holt, C. A. 2010. Postural adjustments of an animal model of Parkinson's disease during over-ground locomotion. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
2009
- Mazzocchi-Jones, D., Döbrössy, M. and Dunnett, S. B. 2009. Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington's disease. European Journal of Neuroscience 30(11), pp. 2134-2142. (10.1111/j.1460-9568.2009.07006.x)
- Brooks, S. P., Fielding, S. A., Döbrössy, M., von Hörsten, S. and Dunnett, S. B. 2009. Subtle but progressive cognitive deficits in the female tgHD hemizygote rat as demonstrated by operant SILT performance. Brain Research Bulletin 79(5), pp. 310-315. (10.1016/j.brainresbull.2009.03.003)
- Cunha, C., Angelucci, A., D'Antoni, A., Dobrossy, M. D., Dunnett, S. B., Berardi, N. and Brambilla, R. 2009. Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiology of Disease 33(3), pp. 358-368. (10.1016/j.nbd.2008.11.004)
- Kelly, C. M. et al. 2009. Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nature Methods 6(4), pp. 271-273. (10.1038/nmeth.1308)
- Monville, C., Torres, E. M., Pekarik, V., Lane, E. L. and Dunnett, S. B. 2009. Genetic, temporal and diurnal influences on L-dopa-induced dyskinesia in the 6-OHDA model. Brain Research Bulletin 78(4-5), pp. 248-253. (10.1016/j.brainresbull.2008.11.007)
- Brooks, S. P. and Dunnett, S. B. 2009. Lesions of the premotor and supplementary motor areas fail to prevent implicit learning in the operant serial implicit learning task. Brain Research 1284, pp. 116-124. (10.1016/j.brainres.2009.05.081)
- Kelly, C., Dunnett, S. B. and Rosser, A. E. 2009. Medium spiny neurons for transplantation in Huntington's disease. Biochemical Society Transactions 37(1), pp. 323-328. (10.1042/BST0370323)
- Paynter, S. J., Andrews, K., Vinh, N., Kelly, C., Rosser, A. E., Amso, N. N. J. and Dunnett, S. B. 2009. Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant. Cryobiology 58(3), pp. 308-314. (10.1016/j.cryobiol.2009.02.008)
- Trueman, R. C., Brooks, S. P., Jones, L. and Dunnett, S. B. 2009. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behavioural Brain Research 203(2), pp. 215-222. (10.1016/j.bbr.2009.05.006)
- Brooks, S. P. and Dunnett, S. B. 2009. Tests to assess motor phenotype in mice: a user's guide. Nature Reviews Neurosciences 10(7), pp. 519-529. (10.1038/nrn2652)
- Weyrauch, U. M., Torres, E. M., Baird, A. L. and Dunnett, S. B. 2009. A Simple Breeding Protocol for the Procurement of Accurately Staged Rat Donor Embryos for Neural Transplantation. Cell Transplantation 18(4), pp. 471-476. (10.3727/096368909788809802)
- Paynter, S. J., Andrews, K. J., Vinh, N., Kelly, C., Rosser, A. E., Amso, N. N. and Dunnett, S. B. 2009. Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant. Cryoletters 29(1), pp. 84.
- Madete, J., Holt, C. A., Lawrence, A., Ben-Hammada, A., Dunnett, S. B. and Rosser, A. E. 2009. Quantifying voluntary imitation of facial expressions. Presented at: Proceedings of the ISB Congress (ISB2009), Cape Town, South Africa.
- Dunnett, S. B. 2009. Neural transplantation. In: Finger, S., Boller, F. and Tyler, K. L. eds. History of Neurology. Handbook of Clinical Neurology Vol. 95. Edinburgh: Elsevier, pp. 885-912., (10.1016/S0072-9752(08)02155-6)
2008
- Hodges, A. K., Hughes, G., Brooks, S. P., Elliston, L. A., Holmans, P. A., Dunnett, S. B. and Jones, L. 2008. Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington's disease. Genes, Brain and Behavior 7(3), pp. 288-299. (10.1111/j.1601-183X.2007.00350.x)
- Lane, E. L., Handley, O. J., Rosser, A. E. and Dunnett, S. B. 2008. Potential cellular and regenerative approaches for the treatment of Parkinson's disease. Neuropsychiatric Disease and Treatment 4(5), pp. 835-845. (10.2147/NDT.S2013)
- Lane, E. L. and Dunnett, S. B. 2008. Animal models of Parkinson's disease and L-dopa induced dyskinesia: How close are we to the clinic?. Psychopharmacology 199(3), pp. 303-312. (10.1007/s00213-007-0931-8)
- Zietlow, R., Lane, E. L., Dunnett, S. B. and Rosser, A. E. 2008. Human stem cells for CNS repair. Cell and Tissue Research 331(1), pp. 301-322. (10.1007/s00441-007-0488-1)
- Bagga, V., Dunnett, S. B. and Fricker-Gates, R. A. 2008. Ascorbic acid increases the number of dopamine neurons in vitro and in transplants to the 6-OHDA-lesioned rat brain. Cell Transplantation 17(7), pp. 763-73. (10.3727/096368908786516774)
- Torres, E. M., Dowd, E. and Dunnett, S. B. 2008. Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson's disease. Neuroscience 154(2), pp. 631-640. (10.1016/j.neuroscience.2008.03.048)
- Torres, E. M., Weyrauch, U. M., Sutcliffe, R. and Dunnett, S. B. 2008. A rat embryo staging scale for the generation of donor tissue for neural transplantation. Cell Transplantation 17(5), pp. 535-542. (10.3727/096368908785096006)
- Workman, V. L., Dunnett, S. B., Kille, P. and Palmer, D. D. 2008. On-chip alginate microencapsulation of functional cells. Macromolecular Rapid Communications 29(2), pp. 165-170. (10.1002/marc.200700641)
- Trueman, R. C., Brooks, S. P., Jones, L. and Dunnett, S. B. 2008. Time course of choice reaction time deficits in the Hdh Q92/Q92 knock-in mouse model of Huntington's disease. Behavioural Brain Research 189(2), pp. 317-334. (10.1016/j.bbr.2008.01.020)
- Madete, J. K., Holt, C. A., Ben-Hammada, A., Lawrence, A. D., Dunnett, S. B. and Rosser, A. E. 2008. Quantifying voluntary imitation of facial expressions. Presented at: Proceedings of the International Society of Biomechanics, 3D Motion Analysis Meeting (3DMA2008), Santpoort-Amsterdam, Netherlands.
- Madete, J. K., Holt, C. A., White, A., Sprinz, P., Bruce., D. S. and Rosser, A. E. 2008. 3D motion capture of Parkinson's and Huntington's disease rat models. Presented at: Proceedings of the International Society of Biomechanics, 3D Motion Analysis Meeting (3DMA2008), Santpoort-Amsterdam, Netherlands.
- Döbrössy, M. and Dunnett, S. B. 2008. Environmental housing and duration of exposure affect striatal graft morphology in a rodent model of Huntington's disease. Cell Transplantation 17(10), pp. 1125-1134. (10.3727/096368908787236558)
- Lane, E. L., Carlsson, T., Kirik, D. and Dunnett, S. B. 2008. Animal models of Parkinson's Disease. In: Conn, P. M. ed. 2008 Sourcebook of Models for Biomedical Research. Humana Press, pp. 313-322., (10.1007/978-1-59745-285-4_34)
2007
- Kuhn, A. et al. 2007. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics 16(15), pp. 1845-1861. (10.1093/hmg/ddm133)
- Dunnett, S. B. and Rosser, A. E. 2007. Cell transplantation for Huntington's disease: Should we continue?. Brain Research Bulletin 72(2-3), pp. 132-147. (10.1016/j.brainresbull.2006.10.019)
- Kelly, C., Precious, S. V., Penketh, R., Amso, N. N., Dunnett, S. B. and Rosser, A. E. 2007. Striatal graft projections are influencd by donor cell type and not the immunogenic background. Brain 130, pp. 1317-1329. (10.1093/brain/awm053)
- Kelly, C., Precious, S. V., Penketh, R., Amso, N. N., Dunnett, S. B. and Rosser, A. E. 2007. Striatal graft projections are influenced by donor cell type and not the immunogenic background. Brain 130(5), pp. 1317-1329. (10.1093/brain/awm053)
- Lane, E. L. and Dunnett, S. B. 2007. Long-term pre-administration of dopamine agonists alters L-dopa induced circling behavior in the 6-OHDA lesioned rat [Abstract]. Movement Disorders 22(S16), pp. S246. (10.1002/mds.21535)
- Brooks, S. P., Trueman, R. C. and Dunnett, S. B. 2007. Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task. Brain Research 1185, pp. 179-188. (10.1016/j.brainres.2007.09.017)
- Workman, V. L., Dunnett, S. B., Kille, P. and Palmer, D. D. 2007. Microfluidic chip-based synthesis of alginate microspheres for encapsulation of immortalized human cells. Biomicrofluidics 1(1), article number: 14105. (10.1063/1.2431860)
- Jay, J. R. and Dunnett, S. B. 2007. An operant serial implicit learning task (SILT) in rats: Task acquisition, performance and the effects of striatal lesions. Journal of Neuroscience Methods 163(2), pp. 235-244. (10.1016/j.jneumeth.2007.03.008)
- Torres, E. M., Monville, C., Gates, M. A., Bagga, V. and Dunnett, S. b. 2007. Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease. Neuroscience 146(4), pp. 1606-1617. (10.1016/j.neuroscience.2007.03.037)
- Döbrössy, M. D. and Dunnett, S. B. 2007. The corridor task: Striatal lesion effects and graft-mediated recovery in a model of Huntington's disease. Behavioural Brain Research 179(2), pp. 326-330. (10.1016/j.bbr.2007.02.030)
- Björklund, A. and Dunnett, S. B. 2007. Dopamine neuron systems in the brain: an update. Trends in Neurosciences 30(5), pp. 194-202. (10.1016/j.tins.2007.03.006)
- Björklund, A. and Dunnett, S. B. 2007. Fifty years of dopamine research. Trends in Neurosciences 30(5), pp. 185-187. (10.1016/j.tins.2007.03.004)
- Dunnett, S. B. and Dowd, E. 2007. Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions. Biochemical Society Transactions 35(2), pp. 428-432. (10.1042/BST0350428)
- Torres, E. M. and Dunnett, S. B. 2007. Amphetamine induced rotation in the assessment of lesions and grafts in the unilateral rat model of Parkinson's disease. European Neuropsychopharmacology 17(3), pp. 206-214. (10.1016/j.euroneuro.2006.04.009)
- Trueman, R. C., Brooks, S. P., Jones, L. and Dunnett, S. B. 2007. The operant serial implicit learning task reveals early onset motor learning deficits in the HdhQ92 knock-in mouse model of Huntington's disease. European Journal of Neuroscience 25(2), pp. 551-558. (10.1111/j.1460-9568.2007.05307.x)
- Dunnett, S. B. and Rosser, A. E. 2007. Neural transplantation in Parkinson's Disease. In: Halberstadt, C. and Emerich, D. eds. Cellular Transplantation: From Laboratory to Clinic. Amsterdam ; Boston: Elsevier Academic Press, pp. 439-454., (10.1016/B978-012369415-7/50026-0)
- Rosser, A. E. and Dunnett, S. B. 2007. Neural transplantation in Huntington's disease. In: Halberstadt, C. and Emerich, D. eds. Cellular Transplantation: From Laboratory to Clinic. Amsterdam; Boston: Elsevier Academic Press, pp. 417-437., (10.1016/B978-012369415-7/50025-9)
- Rosser, A. E., Zietlow, R. and Dunnett, S. B. 2007. Stem cell transplantation for neurodegenerative diseases. Current Opinion in Neurology 20(6), pp. 688-692. (10.1097/WCO.0b013e3282f132fc)
- Dunnett, S. B. and Rosser, A. E. 2007. Stem cell transplantation for Huntington's disease. Experimental Neurology 203(2), pp. 279-292. (10.1016/j.expneurol.2006.11.007)
2006
- Sloan, H. L., Dobrossy, M. and Dunnett, S. B. 2006. Hippocampal lesions impair performance on a conditional delayed matching and non-matching to position task in the rat. Behavioural Brain Research 171(2), pp. 240-250. (10.1016/j.bbr.2006.03.042)
- Jones, L. et al. 2006. Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data. BioMed Central Bioinformatics 7(1), article number: 211. (10.1186/1471-2105-7-211)
- Pittenger, C., Fasano, S., Mazzocchi-Jones, D. M., Dunnett, S. B., Kandel, E. R. and Brambilla, R. 2006. Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice. Journal of Neuroscience 26(10), pp. 2808-2813. (10.1523/JNEUROSCI.5406-05.2006)
- Sloan, H. L., Good, M. A. and Dunnett, S. B. 2006. Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task. Behavioural Brain Research 171(1), pp. 116-126. (10.1016/j.bbr.2006.03.030)
- Monville, C., Torres, E. M. and Dunnett, S. B. 2006. Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model. Journal of Neuroscience Methods 158(2), pp. 219-223. (10.1016/j.jneumeth.2006.06.001)
- Döbrössy, M. D. and Dunnett, S. B. 2006. Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise. European Journal of Neuroscience 24(11), pp. 3223-3233. (10.1111/j.1460-9568.2006.05182.x)
- Torres, E. M., Meldrum, A., Kirik, D. and Dunnett, S. B. 2006. An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections. Journal of Neuroscience Methods 158(1), pp. 64-74. (10.1016/j.jneumeth.2006.05.016)
- Farrington, M., Wreghitt, T. G., Lever, A. M. L., Dunnett, S. B., Rosser, A. E. and Barker, R. A. 2006. Neural transplantation in Huntington's disease: the NEST-UK Donor Tissue Microbiological Screening Program and review of the literature. Cell Transplantation 15(4), pp. 279-294. (10.3727/000000006783981927)
- Rosser, A. E. and Dunnett, S. B. 2006. Cell transplantation for Huntington's disease. The Lancet Neurology 5(4), pp. 284-285. (10.1016/S1474-4422(06)70385-4)
- Handley, O. J., Naji, J. J., Dunnett, S. B. and Rosser, A. E. 2006. Pharmaceutical, cellular and genetic therapies for Huntington's disease. Clinical Science 110(1), pp. 73-88. (10.1042/CS20050148)
- Gates, M. A., Torres, E. M., White, A., Fricker-Gates, R. A. and Dunnett, S. B. 2006. Re-examining the ontogeny of substantia nigra dopamine neurons. European Journal of Neuroscience 23(5), pp. 1384-1390. (10.1111/j.1460-9568.2006.04637.x)
2005
- Brooks, S. P., Higgs, G., Trueman, R. C., Dunnett, S. B., Cheng, P., Redfern, A. R. and Jones, L. 2005. Longitudinal behavioural characterisation of the Q92 mouse line. Journal of Neurology, Neurosurgery and Psychiatry 76, pp. A48-A48.
- Hughes, G. P. et al. 2005. Integrating behaviour and brain gene expression in Huntington's disease transgenic mouse models. Journal of Neurology, Neurosurgery and Psychiatry 76, pp. A41-A41.
- Dunnett, S. B., Meldrum, A. and Muir, J. L. 2005. Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat. Neuroscience, pp. 1055-1065. (10.1016/j.neuroscience.2005.07.033)
- Brooks, S. P., Pask, T., Jones, L. and Dunnett, S. B. 2005. Behavioural profiles of inbred mouse strains used as transgenic backgrounds. II: cognitive tests. Genes, Brain and Behavior 4(5), pp. 307-317. (10.1111/j.1601-183X.2004.00109.x)
- Morton, A. J., Hunt, M. J., Hodges, A. K., Lewis, P. D., Redfern, A. J., Dunnett, S. B. and Jones, L. 2005. A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease. European Journal of Neuroscience 21(4), pp. 855-870. (10.1111/j.1460-9568.2005.03895.x)
- Kelly, C., Tyers, P., Borg, M. t., Svendsen, C. N., Dunnett, S. B. and Rosser, A. E. 2005. EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS. Brain Research Bulletin 68(1-2), pp. 83-94. (10.1016/j.brainresbull.2005.08.020)
- Zietlow, R., Pekarik, V., Armstrong, R. J. E., Tyers, P., Dunnett, S. B. and Rosser, A. E. 2005. The survival of neural precursor cell grafts is influenced by in vitro expansion. Journal of Anatomy 207(3), pp. 227-240. (10.1111/j.1469-7580.2005.00449.x)
- Torres, E. M., Monville, C., Lowenstein, P. R., Castro, M. G. and Dunnett, S. B. 2005. Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors. Brain Research Bulletin 68(1-2), pp. 31-41. (10.1016/j.brainresbull.2005.08.021)
- Dowd, E., Monville, C., Torres, E. M. and Dunnett, S. B. 2005. The Corridor Task: A simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum. Brain Research Bulletin 68(1-2), pp. 24-30. (10.1016/j.brainresbull.2005.08.009)
- Monville, C., Torres, E. M. and Dunnett, S. B. 2005. Validation of the l-dopa-induced dyskinesia in the 6-OHDA model and evaluation of the effects of selective dopamine receptor agonists and antagonists. Brain Research Bulletin 68(1-2), pp. 16-23. (10.1016/j.brainresbull.2004.10.011)
- Dowd, E., Monville, C., Torres, E. M., Wong, L., Azzouz, M., Mazarakis, N. D. and Dunnett, S. B. 2005. Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. European Journal of Neuroscience 22(10), pp. 2587-2595. (10.1111/j.1460-9568.2005.04414.x)
- Torres, E. M., Monville, C., Lowenstein, P. R., Castro, M. G. and Dunnett, S. b. 2005. In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system. Molecular Brain Research 137(1-2), pp. 1-10. (10.1016/j.molbrainres.2004.10.046)
2004
- Gates, M. A., Coupe, V. M., Torres, E. M., Fricker-Gates, R. A. and Dunnett, S. B. 2004. Spatially and temporally restricted chemoattractive and chemorepulsive cues direct the formation of the nigro-striatal circuit. European Journal of Neuroscience 19(4), pp. 831-844. (10.1111/j.1460-9568.2004.03213.x)
- Dunnett, S. B. and Rosser, A. E. 2004. Cell therapy in Huntington's disease. NeuroRX 1(4), pp. 394-405. (10.1602/neurorx.1.4.394)
- Monville, C. et al. 2004. HSV vector-delivery of GDNF in a rat model of PD: partial efficacy obscured by vector toxicity. Brain Research 1024(1-2), pp. 1-15. (10.1016/j.brainres.2004.06.082)
2003
- Rosser, A. E. and Dunnett, S. B. 2003. Neural transplantation in patients with Huntington's disease. CNS Drugs 17(12), pp. 853-867. (10.2165/00023210-200317120-00001)
- Rosser, A. E. et al. 2003. Staging and preparation of human fetal striatal tissue for neural transplantation in huntington's disease. Cell Transplantation 12(7), pp. 679-686. (10.3727/000000003108747299)
- Hurelbrink, C. B., Tyers, P., Armstrong, R. J., Dunnett, S. B., Barker, R. A. and Rosser, A. E. 2003. Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival:implications for clinical trials in huntington's disease. Cell Transplantation 12(7), pp. 687-695. (10.3727/000000003108747307)
2002
- Rosser, A. E. et al. 2002. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475. Journal of neurology neurosurgery and psychiatry 73(6), pp. 678-685. (10.1136/jnnp.73.6.678)
- Rosser, A. E. et al. 2002. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report (ISRCTN no 36485475). Journal of neurology neurosurgery and psychiatry, pp. 678-685. (10.1136/JNNP.73.6.678)
- Armstrong, R. J. E. et al. 2002. The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease. Experimental neurology 175(1), pp. 98-111. (10.1006/exnr.2002.7889)
- Rosser, A. and Dunnett, S. 2002. New drugs for Huntington's disease. NeuroReport 13(2), pp. A21-A22.
2001
- Hurelbrink, C. B., Armstrong, R. J., Luheshi, L. M., Dunnett, S., Rosser, A. E. and Barker, R. A. 2001. Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation. Exp Neurol 171(1), pp. 46-58., article number: 11520120.
- Baunez, C., Humby, T., Eagle, D. M., Ryan, L. J., Dunnett, S. B. and Robbins, T. W. 2001. Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection. European Journal of Neuroscience 13(8), pp. 1609-1616. (10.1046/j.0953-816x.2001.01521.x)
- , . and , . 2001. Latency associated promoter transgene expression in the central nervous system after stereotaxic delivery of replication-defective HSV-1-based vectors. Gene Therapy 8(14), pp. 1057-1071. (10.1038/sj.gt.3301497)
2000
- Bucher, K. et al. 2000. The T cell oncogene Tal2 is necessary for normal development of the mouse brain. Developmental Biology 227(2), pp. 533-544. (10.1006/dbio.2000.9920)
- Besret, L., Caldwell, M. A., Torres, E. M. and Dunnett, S. B. 2000. Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats. European Journal of Pharmacology 408(1), pp. 35-39. (10.1016/S0014-2999(00)00747-0)
- Brasted, P. J., Watts, C., Torres, E. M., Robbins, T. W. and Dunnett, S. B. 2000. Behavioral recovery after transplantation into a rat model of Huntington's disease: Dependence on anatomical connectivity and extensive postoperative training. Behavioral Neuroscience 114(2), pp. 431-436. (10.1037//0735-7044.114.2.431)
1999
- Eagle, D. M., Humby, T., Dunnett, S. B. and Robbins, T. W. 1999. Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats. Behavioral Neuroscience 113(4), pp. 718-731. (10.1037/0735-7044.113.4.718)
- Eagle, D. M., Humby, T., Howman, M., Reid-Henry, A., Dunnett, S. B. and Robbins, T. W. 1999. Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrast in rats. Psychobiology 27(2), pp. 267-276.
- Carter, R. J. et al. 1999. Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. The Journal of Neuroscience 19(8), pp. 3248-3257.
- Kiernan, B. W. et al. 1999. Myelination and behaviour of tenascin-C null transgenic mice. European Journal of Neuroscience 11(9), pp. 3082-3089. (10.1046/j.1460-9568.1999.00729.x)
- Henderson, J. M., Annett, L. E., Ryan, L. J., Chiang, W., Hidaka, S., Torres, E. M. and Dunnett, S. B. 1999. Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat. European Journal of Neuroscience 11(8), pp. 2749-2757. (10.1046/j.1460-9568.1999.00692.x)
1998
- Eagle, D. M., Humby, T., Robbins, T. W. and Dunnett, S. B. 1998. A progressive ratio study of response to reward following striatal damage [Abstract]. European Journal of Neuroscience 10(S), pp. 418.
- Dunnett, S. B., Torres, E. M., Richards, H. and Barker, R. A. 1998. Effects of surgical anaesthesia on the viability of nigral grafts in the rat striatum. Cell Transplantation 7(6), pp. 567-572. (10.1016/S0963-6897(98)00038-4)
- Dunnett, S. B. et al. 1998. Striatal transplantation in a transgenic mouse model of Huntington's Disease. Experimental Neurology 154(1), pp. 31-40. (10.1006/exnr.1998.6926)
- Kendall, A. L., Rayment, F. D., Torres, E. M., Baker, H. F., Ridley, R. M. and Dunnett, S. B. 1998. Functional integration of striatal allografts in a primate model of Huntington's disease. Nature Medicine 4(6), pp. 727-729. (10.1038/nm0698-727)
- Dunnett, S. B., Torres, E. M. and Annett, L. E. 1998. A lateralised grip strength test to evaluate unilateral nigrostriatal lesions in rats. Neuroscience Letters 246(1), pp. 1-4. (10.1016/S0304-3940(98)00194-3)
- Henderson, J. M., Annett, L. E., Torres, E. M. and Dunnett, S. B. 1998. Behavioural effects of subthalamic nucleus lesions in the hemiparkinsonian marmoset (Callithrix jacchus). European Journal of Neuroscience 10(2), pp. 689-698. (10.1046/j.1460-9568.1998.00077.x)
1997
- Brasted, P. J., Humby, T., Dunnett, S. B. and Robbins, T. W. 1997. Unilateral lesions of the dorsal striatum in rats disrupt responding in egocentric space. The Journal of Neuroscience 17(22), pp. 8919-8926.
- Annett, L. et al. 1997. Survival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo age. Cell Transplantation 6(6), pp. 557-569. (10.1016/S0963-6897(97)00079-1)
- Fricker, R. A., Torres, E. M. and Dunnett, S. B. 1997. The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain: I. Morphological characteristics. Neuroscience 79(3), pp. 695-710. (10.1016/S0306-4522(96)00656-2)
- Fricker, R. A. et al. 1997. The effects of donor stage on the survival and function of embryonic striatal grafts in the adult rat brain. Neuroscience 79(3), pp. 711-721. (10.1016/S0306-4522(96)00657-4)
1996
- Fricker, R. A., Annett, L. E., Torres, E. M. and Dunnett, S. B. 1996. The placement of a striatal ibotenic acid lesion affects skilled forelimb use and the direction of drug-induced rotation. Brain Research Bulletin 41(6), pp. 409-416. (10.1016/S0361-9230(96)00083-4)
1995
- Annett, L. E., Torres, E. M., Ridley, R. M., Baker, H. F. and Dunnett, S. B. 1995. A comparison of the behavioural effects of embryonic nigral grafts in the caudate nucleus and in the putamen of marmosets with unilateral 6-OHDA lesions. Experimental Brain Research 103(3), pp. 355-371. (10.1007/BF00241495)
1994
- Torres, E. M., Perry, T. A., Blokland, A., Wilkinson, L. S., Wiley, R. G., Lappi, D. A. and Dunnett, S. B. 1994. Behavioural, histochemical and biochemical consequences of selective immunolesions in discrete regions of the basal forebrain cholinergic system. Neuroscience 63(1), pp. 95-122. (10.1016/0306-4522(94)90010-8)
1993
- Annett, L. E., Reading, P. J., Tharumaratnam, D., Abrous, D. N., Torres, E. M. and Dunnett, S. B. 1993. Conditioning versus priming of dopaminergic grafts by amphetamine. Experimental Brain Research 93(1), pp. 46-54. (10.1007/BF00227779)
1992
- Abrous, D. N., Torres, E. M., Annett, L. E., Reading, P. J. and Dunnett, S. B. 1992. Intrastriatal dopamine-rich grafts induce a hyperexpression of Fos protein when challenged with amphetamine. Experimental Brain Research 91(2), pp. 181-190. (10.1007/BF00231653)
Advances in our understanding of mechanisms of cell death, plasticity and regeneration in the central nervous system offer new opportunities for remediation and repair in several of the most distressing neurodegenerative diseases of adulthood, in particular Parkinson's and Huntington's disease. In the Brain Repair Group, we are seeking to develop new strategies for therapy based on a multidisciplinary approach in several converging problems:
Models of disease
We require valid models of disease in order to evaluate novel treatments. We compare neurochemical, excitotoxic, metabolic and transgenic strategies, both in vitro and in vivo, for their accuracy in reproducing the specific patterns of neuropathology and mechanisms of cell death observed in human disease, and for their reliability in providing stable models within which to compare different treatments strategies.
Neural transplantation
Improving the yield of surviving cells has turned out to be a key factor in viability of neural transplantation in Parkinson's disease, and this is likely to be of equal importance when applied to other neurodegenerative diseases such as Huntington's disease or multiple sclerosis. We are working to refine the methods for neural transplantation into the nervous system to yield optimal survival and growth of the implanted cells. Critical factors involve identification, dissection and handling of embryonic donor cells, and the surgical implantation protocols that maximise accuracy of placement and minimise trauma both to the host and to the implants.
Alternative cells for therapy
The successful clinical trials of transplantation have to date all used embryonic donor tissues. However, whereas surgeries based on using human embryonic tissues can provide a 'proof of principle' the long term development and wider availability of neural transplantation is critically dependent on the identification of more readily available alternative sources of cells. We are actively exploring expanded populations of human stem cells, xenografts, and genetically manipulated cells and cell lines for their ability to provide safer and more readily available alternative to primary embryonic neurones for transplantation.
Neuroprotection
A complementary approach to cell transplantation (which involves replacing cells once already lost) is to protect damaged or traumatised neurones of the host brain from the assault of injury or disease. A wide number of compounds have been identified which have the potential to block processes of cell death and to promote regrowth of damaged cells, including growth factors, antiapoptotic agents, antioxidants and transcription factors. However a common problem for their use is that they don't get into the brain when injected or ingested peripherally. We are developing ways to deliver neuroprotective agents into precise sites in the brain both by engineering cells for transplantation ('ex vivo gene therapy') and by using viral vectors for direct intracerebral delivery ('in vivo gene therapy').
Neurological assessment
The viability of each strategy needs to be evaluated in functional models of the disease. This requires development of behavioural and other functional models of assessment that are both sensitive to the neuroanatomical systems under investigation and relevant to the specific diseases targeted. A key component of our programme is to refine methods of functional analysis according to these dual goals, with a particular focus on objective operant tests of motor and cognitive function. We are also actively developing new strategies for imaging neurodegeneration and cell-based therapies in vivo, using the School's new 9.4T high field MR scanner.
Tissue engineering and repair expertise
Experimental and clinical cell transplantation in the brain. Development of animal models of Parkinson’s and Huntington’s disease for assessing cell transplantation repair, with a focus on anatomical reconstruction and behavioural recovery of function. We are interested in providing the research basis for clinical trials of cell transplantation in PD and HD, and co-ordinate the first UK clinical trial of fetal striatal cell transplantation in HD. A large proportion of the experimental work in the lab is (a) developing and refining genetic animal models of human disease (b) developing and refining behavioural assessment protocols for use in animal models that are valid to the pathology and symptoms of human disease (c) identifying alternatives to human fetal cells as a source for clinical transplantation, with a substantial interest in stem cells (incl. neuronal embryonic precursors, ES cells and adult stem cells) and in using viral vectors for gene therapy, and a supplementary interest in xenotransplantation.
Grants
2013
- EU FP7 cooperation grant (E Cattaneo, Milano, coordinator with SB Dunnett as partner). FP7–HEALTH–2013–INNOVATION–602245-2. NeuroStemcellRepair: € 6,000,000 (Cardiff: €385,000) over 4 years from 1 Sept 2013.
- EU FP7 cooperation grant (AE Rosser & SB Dunnett, coordinators). FP7–HEALTH–2013–INNOVATION–602245-2. Repair-HD: Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington's disease € 6,000,000 (Cardiff: €1,900,000) over 4 years from 1 Oct 2013.
- National Institute of Social Care and Health Research (NISCHR), Senior faculty award to S B Dunnett. £!5,000 p.a. 3 years commencing June 2013.
2012
- MRC Centenary awards (Z Bayram-Weston & SB Dunnett). Longitudinal characterisation of neuropathology in transgenic and knock-in Huntington's disease mouse lines, £18,500. 6 months commencing Oct 2012.
- Welsh Office or Research & Development (WORD) Translational Health Research Platform programme. (SB Dunnett & AE Rosser). TRP08-007. Quality-assured human tissues for clinical trials of novel cell transplantation therapies in Wales. £65,000 extension to grant ,12 months commencing Jan 2013.
- CHDI research contract (SP Brooks, L Jones & SB Dunnett). Comparative behavioural, anatomical and molecular changes in mouse models of Huntington's disease. £904,000. 3 years commencing Jan 2012.
- Society of Catholic Mothers (Llandaff branch). Donation to Parkinson's disease research in the Brain Repair group. £1,000. 25 March 2012.
- Parkinson's UK. Project grant (AE Rosser, SB Dunnett & P Kemp) G1105. Are astrocytes required for dopaminergic neuron graft survival? £184,787. 3 years commencing June 2011.
- EHDN. Pilot study grant (SP Brooks, SB Dunnett, AE Rosser & M Busse). A translational study on the beneficial effects of exercise on HD symptomatology. € 50,000 (£41,015). 1 year commencing Feb 2011.
2010
- Medical Research Council. Project grant (SB Dunnett & AE Rosser) G1001257. Cell transplantation for basal ganglia disorders: Basic science and preclinical development. £1,119,161. 3 years commencing Feb 2011.
2009
- EHDN network contract (AE Rosser & SB Dunnett). Euro HD Network. £845,414. 5 year commencing 01 Jan 2010.
- Welsh Office or Research & Development (WORD) Translational Health Research Platform programme. (SB Dunnett & AE Rosser). TRP08-007. Quality-assured human tissues for clinical trials of novel cell transplantation therapies in Wales. £249,934 5 years commencing April 2009.
- MRC Centre grant (MJ Owen et al). G0801418. The MRC Centre for Neuropsychiatric Genetics and Genomics. £2,434,604. 1st April 2009 for 5 years.
- EU FP7 large collaborative research project HEALTH-2009-1.4-1 (RA Barker, SB Dunnett and others) HEALTH-F5-2008-222943. TRANSEURO: Neural transplantation in the treatment of patients with Parkinson's disease. €1,180,414 (£873,507) over 4 years from 1 Jan 2010.
2008
- EU FP7 large collaborative research project HEALTH-2007-1.4-6 (E Cataneo, SB Dunnett and others). HEALTH-F5-2008-222943. NeuroStemCell: Stem cell lines for cell-based therapies. €675,000 (£516,093). 4 years commencing Dec 2008.
- EU FP7 small and medium collaborative research programme (P Calabresi, SB Dunnett and others) HEALTH 2007-2.2.1-7. REPLACES: Restorative plasticity and corticostriatal excitatory synapses. €443,568 (£338,975). 4 years commencing Sept 2008
2006
- EU FP6 specific targeted research project (Z Kokaia, A Smith, M Hoehn, L Minicello, SB Dunnett & L Wikström) LSHB-CT-2006-037526. Towards a stem cell therapy for stroke. €385,797 (£262,342) over 3 years, starting 1 Jan 2007.
Collaborations
International
- Prof Anders Björklund & Dr Deriiz Kirik, University of Lund, Sweden.
- Drs Marc Peschanski & Philippe Hantraye, INSERM/CNRS, Paris, France.
- Prof Deniz Kokaia & O Lindvall, University of Lund, Sweden.
- Prof Patrik Brundin, University of Lund, Sweden.
- Profs I Mendez and H Robertson, Dalhousie University, Halifax, Nova Scotia.
- Prof Elena Cataneo, University of Milan, Italy.
- Prof Paulo Calabresi, University of Rome, Italy.
- Prof Bernhard Landwehrmeyer, University of Ulm, Germany.
- Prof Guido Nikkhah & M Döbrössy, University of Freiburg, Germany.
UK
- Dr Roger Barker, Prof John Pickard & Dr Jenny Morton, University of Cambridge.
- Dr Lesley Jones & Dr Eddie Wang, School of Medicine, Cardiff University.
- Drs Monte Gates & Rosemary Fricker Gates, Keele University