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Dr Harri Harrison
Research Associate, Dementia Research Institute
- HarrisonDJ2@cardiff.ac.uk
-
Sir Martin Evans Building, Room 4.01, Museum Avenue, Cardiff, CF10 3AX
Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
Overview
My research interests span from the very early life environment to later life diseases, such as Parkinson's disease and Huntington's disease, and how these may be linked. Key words that pique my interest include: Neurodegeneration, neurodevelopment, placenta, epigenetics, prenatal adversity, microglia, preclinical behaviour and cognition.
I also have a keen interest in laboratory animal welfare and am committed to the NC3Rs.
Publication
2024
- Tyson, H. R., Harrison, D. J., Higgs, M. J., Isles, A. R. and John, R. M. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18, article number: 1374781. (10.3389/fnins.2024.1374781)
2022
- Lane, E. L., Harrison, D. J., Ramos-Varas, E., Hills, R., Turner, S. and Lelos, M. J. 2022. Spontaneous graft-induced dyskinesias are independent of 5-HT neurons and levodopa priming in a model of Parkinson's disease. Movement Disorders 37(3), pp. 613-619. (10.1002/mds.28856)
2021
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30(19), pp. 1863-1880., article number: ddab154. (10.1093/hmg/ddab154)
2020
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14, article number: 313. (10.3389/fnins.2020.00313)
2018
- Harrison, D. J. 2018. Optimisation of transplantation methodology in mouse models of Huntington’s Disease. PhD Thesis, Cardiff University.
- Harrison, D., Roberton, V., Vinh, N., Brooks, S., Dunnett, S. and Rosser, A. 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27(2), pp. 230-244. (10.1177/0963689717744788)
- McNamara, G. I., Creeth, H. D. J., Harrison, D. J., Tansey, K. E., Andrews, R. M., Isles, A. R. and John, R. M. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27(3), pp. 440-450. (10.1093/hmg/ddx412)
2017
- Hensman Moss, D. J. et al. 2017. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurology 16(9), pp. 701-711. (10.1016/S1474-4422(17)30161-8)
- Trueman, R. C. et al. 2017. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism 37(4), pp. 1349-1361. (10.1177/0271678X16654921)
- Ahmed, J., Dwyer, D., Farr, T. D., Harrison, D., Dunnett, S. and Trueman, R. C. 2017. Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism 37(3), pp. 755-761. (10.1177/0271678X16684141)
2016
- Bayram-Weston, Z., Olsen, E., Harrison, D., Dunnett, S. B. and Brooks, S. 2016. Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease. Journal of Neuroscience Methods 265, pp. 81-88. (10.1016/j.jneumeth.2015.09.033)
2015
- Steventon, J., Harrison, D. J., Trueman, R. C., Rosser, A. E., Jones, D. K. and Brooks, S. P. 2015. In Vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's Disease mouse model. Journal of Huntington's Disease 4(2), pp. 149-160. (10.3233/JHD-150147)
2013
- Roberton, V. H., Evans, A. E., Harrison, D. J., Precious, S. V., Dunnett, S. B., Kelly, C. and Rosser, A. E. 2013. Is the adult mouse striatum a hostile host for neural transplant survival?. NeuroReport 24(18), pp. 1010-1015. (10.1097/WNR.0000000000000066)
- Harrison, D. J., Busse, M., Openshaw, R., Rosser, A. E., Dunnett, S. B. and Brooks, S. P. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248, pp. 457-469. (10.1016/j.expneurol.2013.07.014)
- Lelos, M. J., Harrison, D. J., Rosser, A. E. and Dunnett, S. B. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71, pp. 287-294. (10.1016/j.appet.2013.09.003)
2012
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2012. Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. European Journal of Neuroscience 36(10), pp. 3420-3428. (10.1111/j.1460-9568.2012.08256.x)
2011
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2011. Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural Brain Research 225(2), pp. 522-528. (10.1016/j.bbr.2011.08.017)
- Trueman, R. C., Harrison, D. J., Dwyer, D. M., Dunnett, S. B., Hoehn, M. and Farr, T. D. 2011. A critical re-Examination of the intraluminal filament MCAO model: impact of External Carotid Artery transection. Translational Stroke Research 2(4), pp. 651-661. (10.1007/s12975-011-0102-4)
2002
- Armit, C., O'Dea, S., Clarke, A. R. and Harrison, D. J. 2002. Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC Cell Biology 3(27) (10.1186/1471-2121-3-27)
- Menke, A. et al. 2002. Genetic interactions between the Wilms’ Tumor 1 Gene and the p53 Gene. Cancer Research 62(22), pp. 6615-6620.
- Guo, J. et al. 2002. WT1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 11(6), pp. 651-659. (10.1093/hmg/11.6.651)
Articles
- Tyson, H. R., Harrison, D. J., Higgs, M. J., Isles, A. R. and John, R. M. 2024. Deficiency of the paternally-expressed imprinted Peg3 gene in mice has sexually dimorphic consequences for offspring communication and social behaviour. Frontiers in Neuroscience 18, article number: 1374781. (10.3389/fnins.2024.1374781)
- Lane, E. L., Harrison, D. J., Ramos-Varas, E., Hills, R., Turner, S. and Lelos, M. J. 2022. Spontaneous graft-induced dyskinesias are independent of 5-HT neurons and levodopa priming in a model of Parkinson's disease. Movement Disorders 37(3), pp. 613-619. (10.1002/mds.28856)
- Harrison, D. J. et al. 2021. Placental endocrine insufficiency programs anxiety, deficits in cognition and atypical social behaviour in offspring. Human Molecular Genetics 30(19), pp. 1863-1880., article number: ddab154. (10.1093/hmg/ddab154)
- Harrison, D. J. et al. 2020. Unified behavioral scoring for preclinical models. Frontiers in Neuroscience 14, article number: 313. (10.3389/fnins.2020.00313)
- Harrison, D., Roberton, V., Vinh, N., Brooks, S., Dunnett, S. and Rosser, A. 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27(2), pp. 230-244. (10.1177/0963689717744788)
- McNamara, G. I., Creeth, H. D. J., Harrison, D. J., Tansey, K. E., Andrews, R. M., Isles, A. R. and John, R. M. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27(3), pp. 440-450. (10.1093/hmg/ddx412)
- Hensman Moss, D. J. et al. 2017. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurology 16(9), pp. 701-711. (10.1016/S1474-4422(17)30161-8)
- Trueman, R. C. et al. 2017. Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: tests for long-term assessment. Journal of Cerebral Blood Flow and Metabolism 37(4), pp. 1349-1361. (10.1177/0271678X16654921)
- Ahmed, J., Dwyer, D., Farr, T. D., Harrison, D., Dunnett, S. and Trueman, R. C. 2017. Lickometry: a novel and sensitive method for assessing functional deficits in rats after stroke. Journal of Cerebral Blood Flow & Metabolism 37(3), pp. 755-761. (10.1177/0271678X16684141)
- Bayram-Weston, Z., Olsen, E., Harrison, D., Dunnett, S. B. and Brooks, S. 2016. Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease. Journal of Neuroscience Methods 265, pp. 81-88. (10.1016/j.jneumeth.2015.09.033)
- Steventon, J., Harrison, D. J., Trueman, R. C., Rosser, A. E., Jones, D. K. and Brooks, S. P. 2015. In Vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's Disease mouse model. Journal of Huntington's Disease 4(2), pp. 149-160. (10.3233/JHD-150147)
- Roberton, V. H., Evans, A. E., Harrison, D. J., Precious, S. V., Dunnett, S. B., Kelly, C. and Rosser, A. E. 2013. Is the adult mouse striatum a hostile host for neural transplant survival?. NeuroReport 24(18), pp. 1010-1015. (10.1097/WNR.0000000000000066)
- Harrison, D. J., Busse, M., Openshaw, R., Rosser, A. E., Dunnett, S. B. and Brooks, S. P. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248, pp. 457-469. (10.1016/j.expneurol.2013.07.014)
- Lelos, M. J., Harrison, D. J., Rosser, A. E. and Dunnett, S. B. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71, pp. 287-294. (10.1016/j.appet.2013.09.003)
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2012. Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. European Journal of Neuroscience 36(10), pp. 3420-3428. (10.1111/j.1460-9568.2012.08256.x)
- Lelos, M. J., Harrison, D. J. and Dunnett, S. B. 2011. Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum. Behavioural Brain Research 225(2), pp. 522-528. (10.1016/j.bbr.2011.08.017)
- Trueman, R. C., Harrison, D. J., Dwyer, D. M., Dunnett, S. B., Hoehn, M. and Farr, T. D. 2011. A critical re-Examination of the intraluminal filament MCAO model: impact of External Carotid Artery transection. Translational Stroke Research 2(4), pp. 651-661. (10.1007/s12975-011-0102-4)
- Armit, C., O'Dea, S., Clarke, A. R. and Harrison, D. J. 2002. Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest. BMC Cell Biology 3(27) (10.1186/1471-2121-3-27)
- Menke, A. et al. 2002. Genetic interactions between the Wilms’ Tumor 1 Gene and the p53 Gene. Cancer Research 62(22), pp. 6615-6620.
- Guo, J. et al. 2002. WT1 is a key regulator of podocyte function: Reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 11(6), pp. 651-659. (10.1093/hmg/11.6.651)
Thesis
- Harrison, D. J. 2018. Optimisation of transplantation methodology in mouse models of Huntington’s Disease. PhD Thesis, Cardiff University.