Professor Gavin Wilkinson
Emeritus Professor
Biography
- 1977 B.Sc. University of Edinburgh, Scotland.
- 1984: M.Sc. University of Warwick, UK.
- 1988 Ph.D. University of Warwick, UK.
Honours and awards
- Fellow of the Learned Society of Wales
Professional memberships
- Microbiology Society.
- British Society of Immunology
- Welsh Microbiological Society
Academic positions
- 2005- present. Professor of Molecular Virology, Department of Medical Microbiology, School of Medicine, Cardiff University
- 2000-2005. Reader. University of Wales College of Medicine.
- 1995-2000. Senior Lecturer, UWCM
- 1992-1995. Lecturer. UWCM.
- 1979- 1992. MLSO - Principal Grade Scientist, PHLS Centre for Applied Microbiology and Research. Porton Down, Salisbury
- 1987-1988. Postdoctoral Research Scientist, Stanford University School of Medicine, California
Speaking engagements
28-29 Nov 2016 Co-organiser of UK CMV meeting in Hinxton
Committees and reviewing
- Member of MRC Infection and Immunity Board
- Member of Scientific Advisory Board for Regional Centre for Applied Molecular Oncology (RECAMO) located in Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- External member of the Registry of the Institution: University of Crete.
- External Examiner Imperial College London, MSc on the Molecular Biology and Pathology of Viruses. 2013-present.
- External Examiner, Liverpool University MRes in Clinical Sciences, 2013-present.
Publications
2018
- Nightingale, K. et al. 2018. High-definition analysis of host protein stability during human cytomegalovirus infection reveals antiviral factors and viral evasion mechanisms. Cell Host and Microbe 24(3), pp. 447-460.e11. (10.1016/j.chom.2018.07.011)
- Wang, E. C. Y. et al. 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proceedings of the National Academy of Sciences 115(19), pp. 4998-5003. (10.1073/pnas.1720950115)
2017
- Suárez, N. M. et al. 2017. Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo. Virus Genes 53(4), pp. 650-655. (10.1007/s11262-017-1452-0)
- Murrell, I. et al. 2017. The pentameric complex drives immunologically covert cell -cell transmission of wild-type human cytomegalovirus. Proceedings of the National Academy of Sciences 114(23), pp. 6104-6109. (10.1073/pnas.1704809114)
- Fielding, C. A. et al. 2017. Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation. eLife 6, article number: e22206. (10.7554/eLife.22206)
2016
- Murrell, I. et al. 2016. Genetic stability of BAC-deerived human cytomegalovirus during culture in vitro. Journal of Virology 90(8), pp. 3929-3943. (10.1128/JVI.02858-15)
2015
- Wilkinson, G. W. G. et al. 2015. Human cytomegalovirus: taking the strain. Medical Microbiology and Immunology 204(3), pp. 273-284. (10.1007/s00430-015-0411-4)
- Hsu, J. et al. 2015. Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141. PLoS Pathogens 11(4), article number: e1004811. (10.1371/journal.ppat.1004811)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11(2), article number: e1004641. (10.1371/journal.ppat.1004641)
- McSharry, B. P. et al. 2015. Abrogation of the interferon response promotes more efficient human cytomegalovirus replication. Journal of Virology 89(2), pp. 1479-1483. (10.1128/JVI.02988-14)
- Pjechová, M., Hernychová, L., Tomasec, P., Wilkinson, G. and Vojtěšek, B. 2015. Adenoviral vectors in gene therapy. Klinicka onkologie 28(Suppl), pp. 2S75-2S80. (10.14735/amko20152S75)
2014
- Raybould, R., Fiander, A., Wilkinson, G. and Hibbitts, S. 2014. HPV integration detection in CaSki and SiHa using detection of integrated papillomavirus sequences and restriction-site PCR. Journal of Virological Methods 206, pp. 51-54. (10.1016/j.jviromet.2014.05.017)
- Stanton, R. J. et al. 2014. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells. Cell Host and Microbe 16(2), pp. 201-214. (10.1016/j.chom.2014.07.005)
- Weekes, M. et al. 2014. Quantitative temporal viromics: an approach to investigate host-pathogen interaction. Cell 157(6), pp. 1460-1472. (10.1016/j.cell.2014.04.028)
- Fielding, C. A. et al. 2014. Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. PLoS Pathogens 10(5), article number: e1004058. (10.1371/journal.ppat.1004058)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15(4), pp. 471-483. (10.1016/j.chom.2014.03.003)
- Seirafian, S., Prod'homme, V., Sugrue, D., Davies, J., Fielding, C., Tomasec, P. and Wilkinson, G. W. G. 2014. Human cytomegalovirus suppresses Fas expression and function. Journal of General Virology 95(4), pp. 933-939. (10.1099/vir.0.058313-0)
- Holcakova, J. et al. 2014. Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy. PLoS ONE 9(2), pp. 1-10., article number: e89228. (10.1371/journal.pone.0089228)
2013
- Aicheler, R., Wang, E., Tomasec, P., Wilkinson, G. W. G. and Stanton, R. J. 2013. Potential for natural killer cell-mediated antibody-dependent cellular cytotoxicity for control of human cytomegalovirus. Antibodies 2(4), pp. 617-635. (10.3390/antib2040617)
- Clark, S. R. et al. 2013. Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proceedings of the National Academy of Sciences of the United States of America 110(15), pp. 5875-5880. (10.1073/pnas.1222419110)
- Smith, W. et al. 2013. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host & Microbe 13(3), pp. 324-335. (10.1016/j.chom.2013.02.003)
2012
- Fielding, C. A. et al. 2012. A novel human cytomegalovirus gene function targets the natural killer cell activating ligand MICA for lysosomal degradation [Abstract]. Immunology 137(S1), pp. 154. (10.1111/imm.12001)
- Prod'homme, V. et al. 2012. Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18. The Journal of Immunology 188(6), pp. 2794-2804. (10.4049/jimmunol.1102068)
2011
- Gatherer, D. et al. 2011. High-resolution human cytomegalovirus transcriptome. Proceedings of the National Academy of Sciences of the United States of America 108(49), pp. 19755-19760. (10.1073/pnas.1115861108)
- Stacey, M. A., Marsden, M., Wang, E. C. Y., Wilkinson, G. W. G. and Humphreys, I. R. 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187(6), pp. 2944-2952. (10.4049/jimmunol.1101021)
2010
- Stanton, R. J. et al. 2010. Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication. Journal of Clinical Investigation 120(9), pp. 3191-3208. (10.1172/JCI42955)
- McLaren, J. E. et al. 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10), pp. 5827-5834. (10.4049/jimmunol.0903782)
- Dimitropoulou, P., Caswell, R. C., McSharry, B. P., Greaves, R. F., Spandidos, D. A., Wilkinson, G. W. G. and Sourvinos, G. 2010. Differential relocation and stability of PML-body components during productive human cytomegalovirus infection: Detailed characterization by live-cell imaging. European Journal of Cell Biology 89(10), pp. 757-768. (10.1016/j.ejcb.2010.05.006)
- Cunningham, C. et al. 2010. Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens. Journal of General Virology 91(3), pp. 605-615. (10.1099/vir.0.015891-0)
- Dargan, D. J. et al. 2010. Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture. Journal of General Virology 91(6), pp. 1535-1546. (10.1099/vir.0.018994-0)
- Prod'homme, V. et al. 2010. Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112. Journal of General Virology 91(8), pp. 2034-2039. (10.1099/vir.0.021931-0)
2009
- Wilkinson, G. W. G. and Lehner, P. J. 2009. Jenner's irony: cowpox taps into T cell evasion. Cell Host & Microbe 6(5), pp. 395-397. (10.1016/j.chom.2009.11.001)
- Bradley, A. J. et al. 2009. High-throughput sequence analysis of variants of human cytomegalovirus strains Towne and AD169. Journal of General Virology 90(10), pp. 2375-2380. (10.1099/vir.0.013250-0)
2008
- Stanton, R. J., McSharry, B. P., Armstrong, M. L., Tomasec, P. and Wilkinson, G. W. G. 2008. Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function. Biotechniques 45(6), pp. 659-668.
- Bradley, A. J. et al. 2008. Genotypic analysis of two hypervariable human cytomegalovirus genes. Journal of Medical Virology 80(9), pp. 1615-1623. (10.1002/jmv.21241)
- Lakdawala, S. S., Schwartz, R. A., Ferenchak, K., Carson, C. T., McSharry, B., Wilkinson, G. W. G. and Weitzman, M. D. 2008. Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. Journal of Virology 82(17), pp. 8362-8372. (10.1128/JVI.00900-08)
- McSharry, B. P. et al. 2008. Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B. Journal of Virology 82(9), pp. 4585-4594. (10.1128/JVI.02251-07)
- Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)
2007
- Stanton, R. J., McSharry, B. P., Rickards, C. R., Wang, E. C. Y., Tomasec, P. and Wilkinson, G. W. G. 2007. Cytomegalovirus destruction of focal adhesions revealed in a high-throughput Western blot analysis of cellular protein expression. Journal of Virology 81(15), pp. 7860-7872. (10.1128/JVI.02247-06)
- Reeves, M. B., Davies, A. A., McSharry, B. P., Wilkinson, G. W. G. and Sinclair, J. H. 2007. Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death. Science 316(5829), pp. 1345-1348. (10.1126/science.1142984)
- Prod'homme, V. et al. 2007. The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells. The Journal of Immunology 178(7), pp. 4473-4481.
- Tomasec, P. et al. 2007. Adenovirus vector delivery stimulates natural killer cell recognition. Journal of General Virology 88(4), pp. 1103-1108. (10.1099/vir.0.82685-0)
2005
- Wills, M. R. et al. 2005. Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit NK cell lysis. J Immunol 175, pp. 7457-65.
- Griffin, C., Wang, E. C. Y., McSharry, B. P., Rickards, C. R., Browne, H., Wilkinson, G. W. G. and Tomasec, P. 2005. Characterization of a highly glycosylated form of the human cytomegalovirus HLA class I homologue gpUL18. Journal of General Virology 86(11), pp. 2999-3008. (10.1099/vir.0.81126-0)
- Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)
- Stanton, R. J., Westmoreland, D., Fox, J. D., Davison, A. J. and Wilkinson, G. W. G. 2005. Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients. Journal of Medical Virology 75(1), pp. 42-46. (10.1002/jmv.20235)
2004
- Dolan, A. et al. 2004. Genetic content of wild-type human cytomegalovirus. Journal of General Virology 85(5), pp. 1301-1312. (10.1099/vir.0.79888-0)
- Jacobs, S. C., Davison, A. J., Carr, S., Bennett, A. M., Phillpotts, R. and Wilkinson, G. W. G. 2004. Characterization and manipulation of the human adenovirus 4 genome. Journal of general virology 85(11), pp. 3361-3366. (10.1099/vir.0.80386-0)
2003
- Stanton, R. J., Wilkinson, G. W. G. and Fox, J. D. 2003. Analysis of human herpesvirus-6 IE1 sequence variation in clinical samples. Journal of Medical Virology 71(4), pp. 578-584. (10.1002/jmv.10508)
2002
- Wang, E. C. Y. et al. 2002. UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proceedings of the National Academy of Sciences 99(11), pp. 7570-7575. (10.1073/pnas.112680099)
- Braud, V. M., Tomasec, P. and Wilkinson, G. W. G. 2002. Viral evasion of natural killer cells during human cytomegalovirus infection. In: Koszinowski, U. H. and Hengel, H. eds. Viral Proteins Counteracting Host Defenses. Current Topics in Microbiology and Immunology Vol. 269. Berlin: Springer, pp. 117-129.
2000
- Tomasec, P. et al. 2000. Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40. Science 287(5455), pp. 1031-1033. (10.1126/science.287.5455.1031)
1997
- Nimako, M., Fiander, A. N., Wilkinson, G. W. G., Borysiewicz, L. K. and Man, S. T. 1997. Human papillomavirus-specific cytotoxic T lymphocytes in patients with cervical intraepithelial neoplasia grade III. Cancer Research 57(21), pp. 4855-4861.
- Fiander, A. N., Man, S. T., Borysiewicz, L. K. and Wilkinson, G. W. G. 1997. Therapeutic vaccines for cervical cancer: concept and clinical results. Biodrugs -Auckland- 8(5), pp. 331-338. (10.2165/00063030-199708050-00001)
1996
- Borysiewicz, L. K. et al. 1996. A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer. The Lancet 347(9014), pp. 1523-1527. (10.1016/s0140-6736(96)90674-1)
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Wilkinson, G. W. G. and Campbell, A. K. 1996. Agonist-stimulated free calcium in subcellular compartments - Delivery of recombinant aequorin to organelles using a replication deficient adenovirus vector. Cell Calcium 19(2), pp. 133-142. (10.1016/S0143-4160(96)90082-2)
1995
- Borysiewicz, L. K. et al. 1995. Development and initial clinical studies of TA-HPV in cervical cancer. European Journal of Cancer 31(supp 3), pp. 17-17. (10.1016/0959-8049(95)99882-z)
- Campbell, A. K., Badminton, M. N., Kendall, J. M., Sala-Newby, G. B. and Wilkinson, G. W. G. 1995. Free Ca2+ in cellular compartments studied using targeted aequorin [Abstract]. Journal of Physiology 487(P), pp. 7S.
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Wilkinson, G. W. G., Dormer, R. L. and Campbell, A. K. 1995. Changes in free Ca2+ in organelles monitored by targeted recombinant aequorin; use of replication-deficient adenovirus vectors [Communication]. Journal of Physiology 487, pp. 19P.