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Professor Peter Collins

Professor Peter Collins

Professor of Haematology

School of Medicine

Email
peter.collins@wales.nhs.uk
Telephone
+44 (0)29 20744144
Campuses
Arthur Bloom Haemophilia Centre, UHW Main Building

My research focuses on the diagnosis and treatment of inherited and acquired bleeding disorders. The work spans both clinical studies and basic science and I collaborate with a number of groups at Cardiff and across the world.

My clinical work is based in the Cardiff Haemophilia Centre and involves treating people with inherited and acquired disorders of haemostasis and thrombosis.

Qualifications:

BA Hons Cantab, MBBS, MD (Lond), FRCP, FRCpath

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I teach medical and dental students about disorders of thrombosis and haemostasis through a programme of lectures.

Research overview

My research interests focus on blood clotting. This includes studies into the diagnosis and treatment of inherited and acquired bleeding and laboratory studies into understanding of mechanisms of how blood clots.

Research description

Mechanisms of coagulation

I work in a group of basic scientists and clinicians jointly led with Professor O’Donnell that is investigating mechanisms of blood coagulation. Projects include the role of oxidised phospholipids in supporting blood clotting reactions, mechanisms underlying the antiphospholipid syndrome, the effects of oxidised phospholipids in cardiovascular disease and how phospholipids support tissue factor function. This work is support by project and program grants from Wellcome and The British Heart Foundation and a clinical training fellowship from BHF.

In related studies Dr Meike Heurich is investigating the interaction and crosstalk between the complement system and coagulation supported by a NISCHR fellowship. The work is studying how two important innate defence mechanisms interact during normal physiology and disease processes.

Clinical studies

Bleeding at the time of childbirth

I collaborate with colleagues in obstetric and anaesthesia investigating mechanisms and treatment of bleeding at the time of childbirth. A number of our studies have been completed, for example OBS1 (obstetric bleeding study 1) and suggest an important role for the blood clotting factor fibrinogen in controlling bleeding. These studies have led on to our group being awarded funding for a multicentre, randomised, blinded study of fibrinogen versus placebo in the management of postpartum haemorrhage (OBS2). This work is being done in collaboration with Professor Judith Hall as part of the Critical Illness Research Group at Cardiff University and is very well supported by the South East Wales Trials Unit.

Acquired haemophilia A

I have a longstanding interest in the auto-immune disease acquired haemophilia A which presents with sudden onset of severe bleeding. It is caused by the development of an inhibitory antibody to coagulation factor VIII. Along with colleagues in a Europe-wide collaboration the cause and treatment of this disorder is being investigated through the European Acquired Haemophilia Registry (EACH2).

Factor VIII pharmacokinetics (PK) and the treatment of haemophilia A

I work with an international collaborative group investigating the role of factor VIII PK in the management of haemophilia, especially in the context of prophylaxis. A clinical trial is underway to evaluate the role of PK in patient management. The work is being extended to the measurement of factor VIII PK in the context of factor VIII inhibitors.

A further project with Dr Derrick Bowen is investigating mechanisms that predispose patients with severe haemophilia A to haemophilic arthropathy.

Bruising in children with and without inherited bleeding disorders

In collaboration with the Department of Child Health (Professor Alison Kemp and Dr Sabine Maguire) and paediatric haematologists in Edinburgh, Glasgow, Great Ormond Street, Newcastle and Toronto I am investigating the pattern of bruising in children with and without inherited bleeding disorders and comparing this to children who have suffered physical abuse. The work aims to improve the diagnosis of physical abuse and reduced the chance of misdiagnosis of bleeding disorders.

Clinical trials

The haemophilia centre in Cardiff is an active site for clinical trials in the field of inherited bleeding disorders.

Images

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